Reweightable Leish 12-criteria query and components thereof
Posted by Greg Crowther on 2009-03-26 15:57:12
WARNING: This list was made prior to the version 4 release of TDR
Targets (Aug, 2010). Some queries included in this list may not work properly.
Most likely reasons for this are changes in parameters, and/or data updates. If you
experience any problem, please try re-running each search from the search
page. You can also access the previous version of the database at
v3.tdrtargets.org
This is an update of a previously published query set, done mostly to take advantage of the reweighting feature option in the new database (version 3). The criteria remain the same as before, i.e., enzymes (100), MW < 100 kDa (20), no TM domains (20), PDB structure (50), Modbase model (30), present in all TriTryps (25), not in humans (25), essential in at least one model organism (40), genetic validation in Leishmania (50), druggability > 0.6 (35), compound desirability > 0.3 (35), and PubMed publications (35).
