WARNING: This list was made prior to the version 4 release of TDR
Targets (Aug, 2010). Some queries included in this list may not work properly.
Most likely reasons for this are changes in parameters, and/or data updates. If you
experience any problem, please try re-running each search from the search
page. You can also access the previous version of the database at
v3.tdrtargets.org
Genomic scale ranking of L. major genes demonstrating that combining a wide range of criteria can be quiet useful in target prioritization work. Using this set of queries two different lists were generated - one without including essentiality data and another including essentiality data.
Score for genes in query #100 (Lma modbase): 30
Score for genes in query #101 (Lma not in humans): 25
Score for genes in query #102 (Lma any genetic validation): 50
Score for genes in query #103 (Lma any essentiality evidence): 50
Score for genes in query #104 (Lma dindex >=0.6): 35
Score for genes in query #105 (Lma Compd desirability >0.3): 35
Score for genes in query #106 (Lma assayable): 35
Score for genes in query #107 (Lma all proteins): 1
Score for genes in query #110 (Lma in Tbr and Tcr): 25
Score for genes in query #95 (Lma enz (EC + func. Categ.)): 100
Score for genes in query #96 (Lma Pubmed): 35
Score for genes in query #97 (Lma mwt <100kDa): 20
Score for genes in query #98 (Lma no TM domain): 20
Score for genes in query #99 (Lma PDB): 50
