Target list

Search results for query: Union of (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #2 (is enzyme): 20
  • Score for genes in query #4 (3D model): 10
  • Score for genes in query #3 (3D structure): 10
  • Score for genes in query #7 (druggability > .5): 60
  • Score for genes in query #1 (amastigote expression >= 2 spectra / 2 peptides): 20
  • Score for genes in query #14 (tcruzi reagent availability): 30
  • Score for genes in query #5 (any evidence of essentiality): 50
  • Score for genes in query #12 (tcruzi in leish): 90
  • Score for genes in query #11 (tcruzi not in humans): 80
  • Score for genes in query #6 (> 3 paralogs): -30
  • Score for genes in query #8 (bibrefs): 25
  • Score for genes in query #10 (tcruzi all genes): 1
  • Score for genes in query #9 (low molecular weight (< 100 kDa)): 25
  • Score for genes in query #15 (tcruzi assay available): 30
  • Score for genes in query #13 (tcruzi not in tbrucei): 150

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18628 records found | Showing page 1 of 746 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.508111.30   OG5_126857   glutamate dehydrogenase, putative 466
T. cruzi   TcCLB.510879.80   OG5_128713   serine acetyltransferase, putative 466
T. cruzi   TcCLB.504013.40   OG5_128713   serine acetyltransferase, putative 466
T. cruzi   TcCLB.507875.20   OG5_126857   glutamate dehydrogenase, putative 456
T. cruzi   TcCLB.511277.600   OG5_133772   UDP-galactopyranose mutase 436
T. cruzi   TcCLB.510187.100   OG5_138843   glucokinase 421
T. cruzi   TcCLB.503745.30   OG5_128717   ascorbate peroxidase 416
T. cruzi   TcCLB.511461.20   OG5_128985   tyrosine aminotransferase 411
T. cruzi   TcCLB.510187.50   OG5_128985   tyrosine aminotransferase 411
T. cruzi   TcCLB.506193.60   OG5_128717   ascorbate peroxidase, putative 406
T. cruzi   TcCLB.508699.120   OG5_136591   dipeptidyl-peptidase, putative 406
T. cruzi   TcCLB.507993.160   OG5_133772   UDP-galactopyranose mutase 406
T. cruzi   TcCLB.509205.120   OG5_136591   hypothetical protein, conserved 406
T. cruzi   TcCLB.510187.40   OG5_128985   tyrosine aminotransferase 401
T. cruzi   TcCLB.509073.70   OG5_171867   phosphatidate cytidylyltransferase-like protein, putative 396
T. cruzi   TcCLB.508707.140   OG5_171867   phosphatidate cytidylyltransferase-like protein, putative 396
T. cruzi   TcCLB.509287.20   OG5_127425   serine/threonine-protein kinase NAK, putative 386
T. cruzi   TcCLB.506577.60   OG5_155636   hypothetical protein, conserved 386
T. cruzi   TcCLB.506953.30   OG5_127425   serine/threonine-protein kinase NAK, putative 386
T. cruzi   TcCLB.508637.90   OG5_127226   phosphoglucomutase 381
T. cruzi   TcCLB.506839.60   OG5_128637   tyrosine specific protein phosphatase, putative 381
T. cruzi   TcCLB.511277.210   OG5_129459   peroxisomal enoyl-coa hydratase, putative 381
T. cruzi   TcCLB.510187.70   OG5_128985   tyrosine aminotransferase, putative 381
T. cruzi   TcCLB.506737.20   OG5_166691   CMGC/MAPK protein kinase, putative 381
T. cruzi   TcCLB.508717.10   OG5_128637   tyrosine specific protein phosphatase, putative 381

Showing page 1 (records 1-25) of 746