TDR Targets Releases

Current major release: 3

TDR Targets Release 3, March 2009
Release notes:
  • Data:
    • 3D models are now available at Modbase and have been integrated for searching in TDR Targets for Schistosoma, Brugia malayi, and its endosymbiont Wolbachia and M. leprae. Contributed by Ursula Pieper and Andrej Sali (UCSF).
    • Pathways (1089 genes), EC numbers (637 genes) and updated literature references for Brugia malayi.
    • Curated data on assays, and production of recombinant proteins from BRENDA
    • Arabidopsis thaliana is now available in phylogenetic queries as a representative of the Viridiplantae phylum. This now allows searching for targets with/without orthologs in plants.
    • Survey entries and references updated based on user input (Paul Michels)
  • Functionality:
    • it's now easier to revise the weighting/scoring strategy of a ranked UNION.
    • it's now possible to run a prioritization session (multi-step search) from the search page, without having to see the results of each intermediate search query
    • support for user roles has been added (moderator, admin), and an initial set of user input forms has been layed out (comments associated with genes/targets, which moderators have to approve).
    • Links out to Tuberculist now go to their new site.
    • Lots of minor bugfixes and some other major (but too technical) changes.
TDR Targets Release 2, June 2008
Release notes:
  • Schistosoma mansoni. A new helminth genome has been incorporated into TDR Targets. Version 4.0 of the S. mansoni genome is now in TDR Targets.
  • New slideshow tutorials. Starting with this release we will be providing short slideshow tutorials on different aspects of the site functionality and/or usage.
  • Drug Targets Survey. In this release we have integrated the data from the Human African Trypanosomiasis survey on drug targets. All entries have been incorporated and linked to the corresponding targets and bibliographic references.
  • New functional classification. genes have been classified in three main categories (enzymes, receptors, transporters). This manual classification (described in the documentation) complements the other classification schemes available (metabolic pathways, GO slims), providing more search options.
  • Query history page. You can now export smarter spreadsheets that will allow you to re-prioritize datasets on the fly by changing weights to each criteria. There is also a new interface for easier subtraction between queries, and other minor changes to the history UI we expect will make your life easier.
  • More PDB structures for Mycobacterium tuberculosis. We have updated the list of PDB structures available for M. tuberculosis. All these structures are also available for M. leprae.
  • Curated target information for M. tuberculosis and M. leprae. As part of the ongoing curation effort, we have loaded curated information for M. tuberculosis.
  • Result tables. You can now re-sort the results of queries, and also specify the number of records that should be displayed per page.
  • Bugfixes. Lots of bugfixes are included in this release. Keep sending your bug reports!
TDR Targets Release 1, April 2007
Release notes:
  • Presentation of TDR Targets. TDR Targets was unveiled on April 16th in Geneva at a meeting of TDR's Drug Discovery committee.
  • First genomes. The first genomes included in TDR Targets are those of: Plasmodium falciparum, Mycobacterium tuberculosis, Trypanosoma brucei, Leishmania major and Trypanosoma cruzi.