Detailed information for compound 1000884
Basic information
Technical information
- Name: Unnamed compound
- MW: 297.211 | Formula: C12H7F4N5
-
H donors: 1
H acceptors: 3
LogP: 2.77
Rotable bonds: 2
Rule of 5 violations (Lipinski): 1 - SMILES: Cc1cc(Nc2c(F)c(F)cc(c2F)F)n2c(n1)ncn2
- InChi: 1S/C12H7F4N5/c1-5-2-8(21-12(19-5)17-4-18-21)20-11-9(15)6(13)3-7(14)10(11)16/h2-4,20H,1H3
- InChiKey: KAGCULZRDUQOKH-UHFFFAOYSA-N
Network
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Synonyms
No synonyms found for this compound
Targets
Known targets for this compound
No curated genes were found associated with this compound
Predicted pathogen targets for this compound
By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type oxidoreductase | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.0165 | 1 | 1 |
| Leishmania major | short chain dehydrogenase-like protein | 0.0165 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0165 | 1 | 1 |
| Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0165 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0165 | 1 | 1 |
| Leishmania major | 3-keto-dihydrosphingosine reductase | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | conserved hypothetical protein | 0.0165 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Loa Loa (eye worm) | dehydrogenase | 0.0165 | 1 | 1 |
| Toxoplasma gondii | 3-ketoacyl-CoA reductase, putative | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 9 | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Possible fatty acyl-CoA reductase | 0.0165 | 1 | 0.5 |
| Echinococcus granulosus | WW domain containing oxidoreductase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0165 | 1 | 1 |
| Schistosoma mansoni | carbonyl reductase | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.0165 | 1 | 1 |
| Onchocerca volvulus | Sepiapterin reductase homolog | 0.0165 | 1 | 0.5 |
| Toxoplasma gondii | sterol carrier protein-2 HAD-2SCP-2 | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0165 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Echinococcus granulosus | Dehydrogenase:reductase SDR family | 0.0165 | 1 | 1 |
| Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | quinonoid dihydropteridine reductase, putative | 0.0165 | 1 | 1 |
| Toxoplasma gondii | carbonyl reductase 1, putative | 0.0165 | 1 | 1 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0165 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Mycobacterium leprae | Probable oxidoreductase | 0.0165 | 1 | 0.5 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | oxidoreductase | 0.0165 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain membrane-associated dehydrogenase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short chain alcohol dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0165 | 1 | 1 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Leishmania major | pteridine reductase 1 | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.1746 | 0.1746 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0165 | 1 | 1 |
| Echinococcus granulosus | hypothetical protein | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0165 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Echinococcus multilocularis | epidermal retinal dehydrogenase 2 | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Plasmodium falciparum | oxidoreductase, short-chain dehydrogenase family, putative | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | oxidoreductase short chain dehydrogenase/reductase family | 0.0165 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0165 | 1 | 1 |
| Echinococcus granulosus | 3 ketodihydrosphingosine reductase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Leishmania major | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Brugia malayi | dehydrogenases, short chain protein 2 | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Possible short-chain dehydrogenase EphD | 0.0165 | 1 | 0.5 |
| Toxoplasma gondii | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Plasmodium vivax | steroid dehydrogenase, putative | 0.0165 | 1 | 1 |
| Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | short chain dehydrogenase/reductase, putative | 0.0165 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Entamoeba histolytica | short chain dehydrogenase family protein | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.0165 | 1 | 0.5 |
| Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable shortchain dehydrogenase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0165 | 1 | 1 |
| Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0165 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Giardia lamblia | Short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | carbonyl reductase | 0.0165 | 1 | 1 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Leishmania major | short chain dehydrogenase/reductase, putative | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Echinococcus granulosus | retinol dehydrogenase 11 | 0.0165 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Leishmania major | oxidoreductase-like protein | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | ketoacyl reductase | 0.0165 | 1 | 0.5 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Entamoeba histolytica | hypothetical protein | 0.0165 | 1 | 0.5 |
| Leishmania major | dehydrogenase-like protein | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Plasmodium vivax | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.1746 | 0.1746 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | 3-ketoacyl-CoA reductase, putative | 0.0165 | 1 | 1 |
| Leishmania major | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Echinococcus multilocularis | retinol dehydrogenase 11 | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | retinal dehydrogenase | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Giardia lamblia | Reductase, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0165 | 1 | 1 |
| Mycobacterium leprae | Possible short-chain dehydrogenase EphD | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Brugia malayi | Retinol dehydrogenase 12 | 0.0165 | 1 | 1 |
| Echinococcus granulosus | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | Dehydrogenase:reductase SDR family | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | carveol-like dehydrogenase | 0.0165 | 1 | 0.5 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | steroid dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0165 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0165 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 1 homolog | 0.0165 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | oxidoreductase | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Entamoeba histolytica | hypothetical protein, conserved | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Echinococcus granulosus | oxidoreductase | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | dehydrogenase/decarboxylase protein | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Plasmodium falciparum | steroid dehydrogenase, putative | 0.0165 | 1 | 1 |
| Mycobacterium leprae | ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE | 0.0165 | 1 | 0.5 |
| Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Decaprenylphosphoryl-D-2-keto erythro pentose reductase | 0.0165 | 1 | 0.5 |
| Brugia malayi | Dehydrogenases, short chain protein 30 | 0.0165 | 1 | 1 |
| Trypanosoma brucei | oxidoreductase-like protein | 0.0165 | 1 | 1 |
| Onchocerca volvulus | Dehydrogenase\/reductase SDR family member 13 homolog | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short-chain dehydrogenase/reductase | 0.0165 | 1 | 1 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0165 | 1 | 1 |
| Toxoplasma gondii | oxidoreductase, putative | 0.0165 | 1 | 1 |
| Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | oxidoreductase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable dehydrogenase | 0.0165 | 1 | 0.5 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Echinococcus multilocularis | transient receptor potential cation channel | 0.0165 | 1 | 1 |
| Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Echinococcus multilocularis | retinol dehydrogenase 13 | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Leishmania major | quinonoid dihydropteridine reductase | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Mycobacterium tuberculosis | Possible ketoacyl reductase | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | NAD(P)-dependent oxidoreductase, putative | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | 3-keto-dihydrosphingosine reductase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Schistosoma mansoni | 3-keto-dihydrosphingosine reductase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type oxidoreductase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | 3-ketoacyl-ACP reductase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0165 | 1 | 0.5 |
| Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Possible iron-regulated short-chain dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | dehydrogenase | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | 3 ketodihydrosphingosine reductase | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | beta-ketoacyl-ACP reductase 2, putative | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0165 | 1 | 1 |
| Brugia malayi | Dehydrogenases, short chain protein 2 | 0.0165 | 1 | 1 |
| Mycobacterium leprae | PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE | 0.0165 | 1 | 0.5 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.0165 | 1 | 0.5 |
| Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Echinococcus multilocularis | estradiol 17 beta dehydrogenase 12 | 0.0165 | 1 | 1 |
| Echinococcus granulosus | epidermal retinal dehydrogenase 2 | 0.0165 | 1 | 1 |
| Onchocerca volvulus | 0.0165 | 1 | 0.5 | |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Schistosoma mansoni | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Possible oxidoreductase | 0.0165 | 1 | 0.5 |
| Echinococcus multilocularis | steroid dehydrogenase | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | short chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Brugia malayi | hypothetical protein | 0.0165 | 1 | 1 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Mycobacterium tuberculosis | Probable oxidoreductase | 0.0165 | 1 | 0.5 |
| Echinococcus granulosus | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Schistosoma mansoni | short chain dehydrogenase | 0.0165 | 1 | 1 |
| Trypanosoma cruzi | short-chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
| Leishmania major | short chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Mycobacterium leprae | Probable short-chain type dehydrogenase/reductase | 0.0165 | 1 | 0.5 |
| Echinococcus multilocularis | carbonyl reductase 1 | 0.0165 | 1 | 1 |
| Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.0165 | 1 | 1 |
| Giardia lamblia | Hypothetical protein | 0.0165 | 1 | 0.5 |
| Trypanosoma brucei | short-chain dehydrogenase, putative | 0.0165 | 1 | 1 |
| Mycobacterium ulcerans | short chain dehydrogenase | 0.0165 | 1 | 0.5 |
| Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0165 | 1 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0165 | 1 | 1 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| EC50 (functional) | > 50 uM | Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake | ChEMBL. | 19296651 |
| IC50 (binding) | Inhibition of human DHODH | ChEMBL. | 19296651 | |
| IC50 (binding) | > 100 uM | Inhibition of Plasmodium falciparum DHODH | ChEMBL. | 19296651 |
| IC50 (binding) | > 100 uM | Inhibition of Plasmodium berghei ANKA DHODH | ChEMBL. | 19296651 |
Phenotypes
Whole-cell/tissue/organism interactions
We have no records of whole-cell/tissue assays done with this compound
What does this mean?
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL508404
Bibliographic References
1 literature reference was collected for this gene.
If you have references for this compound, please enter them in a user comment (below) or Contact us.