Detailed information for compound 1004609

Basic information

Technical information
  • TDR Targets ID: 1004609
  • Name: (5Z)-3-amino-5-[(4-hydroxyphenyl)methylidene] -2-sulfanylidene-1,3-thiazolidin-4-one
  • MW: 252.313 | Formula: C10H8N2O2S2
  • H donors: 2 H acceptors: 2 LogP: 1.88 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NN1C(=S)S/C(=C\c2ccc(cc2)O)/C1=O
  • InChi: 1S/C10H8N2O2S2/c11-12-9(14)8(16-10(12)15)5-6-1-3-7(13)4-2-6/h1-5,13H,11H2/b8-5-
  • InChiKey: NAOGRRHCIZUJCA-YVMONPNESA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-amino-5-[(4-hydroxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5Z)-3-amino-5-[(4-hydroxyphenyl)methylene]-2-thioxo-thiazolidin-4-one
  • 3-amino-5-[(4-hydroxyphenyl)methylene]-2-thioxo-thiazolidin-4-one
  • 3-amino-5-[(4-hydroxyphenyl)methylene]-2-thioxo-4-thiazolidinone
  • (5Z)-3-amino-5-[(4-hydroxyphenyl)methylene]-2-thioxo-4-thiazolidinone
  • 3-amino-5-(4-hydroxybenzylidene)-2-thioxo-thiazolidin-4-one
  • (5Z)-3-amino-5-(4-hydroxybenzylidene)-2-thioxo-thiazolidin-4-one
  • ZINC01108172

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus N-acetyltransferase 2 (arylamine N-acetyltransferase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans arylamine N-acetyltransferase Nat Get druggable targets OG5_131280 All targets in OG5_131280
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) Get druggable targets OG5_131280 All targets in OG5_131280
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.026 0.6433
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0612
Loa Loa (eye worm) hypothetical protein 0.0106 0.1026 0.3626
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0003 0.0029
Onchocerca volvulus 0.0035 0.026 0.1422
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0494 0.4395
Mycobacterium tuberculosis Arylamine N-acetyltransferase Nat (arylamine acetylase) 0.0763 0.8154 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0347
Treponema pallidum DNA ligase (lig) 0.0011 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0479 0.1694
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.026 0.0216
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0098 0.3775
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0405 0.143
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0173 0.1565
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0057 0.0494 0.1748
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0003 0.0012
Echinococcus granulosus replication factor c subunit 1 0.0011 0.00000034704 0.00000084743
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0347
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0003 0.0012
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0098 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0003 0.0012
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0098 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0612
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.026 0.6433
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0173 0.665
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0405 0.143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0003 0.0012
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1125 1
Echinococcus multilocularis expressed conserved protein 0.0106 0.1032 0.1032
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0003 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0003 0.0029
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.026 0.6433
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0003 0.0012
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.3426
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.092
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0003 0.0003
Mycobacterium tuberculosis Conserved protein 0.0035 0.026 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0003 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0003 0.0012
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.026 0.0216
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0409 0.0409
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.00000034704 0.000008579
Mycobacterium leprae Probable lipase LipE 0.0035 0.026 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0347
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.3633
Echinococcus multilocularis tumor protein p63 0.0389 0.4095 0.4095
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0347
Brugia malayi CHE-14 protein 0.0049 0.0405 0.143
Loa Loa (eye worm) hypothetical protein 0.0155 0.1557 0.5505
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.183 1
Brugia malayi nuclear hormone receptor 0.0012 0.0003 0.0012
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.1106 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.026 0.0635
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0003 0.0029
Onchocerca volvulus 0.0035 0.026 0.1422
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0098 0.012
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0326 0.0326
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000034704 0.000008579
Loa Loa (eye worm) hypothetical protein 0.006 0.0523 0.1849
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0041 0.0326 0.2949
Brugia malayi beta-lactamase family protein 0.0035 0.026 0.092
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.026 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0272 0.2829 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0003 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0409 0.1445
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0003 0.0003
Onchocerca volvulus 0.0057 0.0494 0.2703
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0612
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.026 0.2313
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0003 0.0008
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1634 0.3989
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0003 0.0012
Echinococcus granulosus GPCR family 2 0.0049 0.0409 0.0998
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0405 0.0988
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0173 0.665
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.092
Entamoeba histolytica hypothetical protein 0.0041 0.0326 0.2949
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0003 0.0012
Loa Loa (eye worm) beta-lactamase 0.0035 0.026 0.092
Schistosoma mansoni hypothetical protein 0.0056 0.0479 0.4259
Echinococcus multilocularis protein dispatched 1 0.0056 0.0479 0.0479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0003 0.0012
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0173 0.0108
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.092
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.1026 0.3626
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.026 0.092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0409 0.0409
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.026 0.026
Mycobacterium tuberculosis Conserved protein 0.0035 0.026 0.0216
Schistosoma mansoni coup transcription factor 0.0012 0.0003 0.0029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.1557 0.5505
Onchocerca volvulus 0.0035 0.026 0.1422
Entamoeba histolytica hypothetical protein 0.0041 0.0326 0.2949
Onchocerca volvulus 0.0012 0.0006 0.0033
Mycobacterium ulcerans lipase LipD 0.0035 0.026 0.0319
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.3426
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0405 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0003 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0326 0.2899
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0173 0.1565
Brugia malayi hypothetical protein 0.0272 0.2829 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0326 0.0797
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0173 0.0212
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.002 0.0098 0.0347
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1634 0.1634
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0003 0.0012
Brugia malayi nuclear receptor NHR-88 0.0012 0.0003 0.0012
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.3633
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0003 0.0029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0003 0.0018
Onchocerca volvulus 0.0012 0.0003 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Brugia malayi N-terminal motif family protein 0.018 0.183 0.6467
Mycobacterium ulcerans beta-lactamase 0.0035 0.026 0.0319
Schistosoma mansoni patched 1 0.0049 0.0405 0.3595
Brugia malayi hypothetical protein 0.0041 0.0326 0.1153
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0098 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0409 0.1445
Loa Loa (eye worm) hypothetical protein 0.018 0.183 0.6467
Schistosoma mansoni survival motor neuron protein 0.0056 0.0479 0.4259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0003 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0003 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.026 0.0216
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.3426
Brugia malayi ecdysteroid receptor 0.0012 0.0003 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0035 0.026 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0003 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.026 0.0216
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.00000034704 0.0000031374
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.1106 0.391
Echinococcus granulosus survival motor neuron protein 1 0.0272 0.2829 0.6908
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.3633
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0173 0.0612
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.1106 0.2701
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.1557 0.5505
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0003 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0003 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0003 0.0012
Entamoeba histolytica hypothetical protein 0.0041 0.0326 0.2949
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0173 0.0108
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0003 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.026 0.0216
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.00000034704 0.0000030844
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0003 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0173 0.1565
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.026 0.6433
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0003 0.0029
Brugia malayi steroid hormone receptor 0.0012 0.0003 0.0012
Schistosoma mansoni hypothetical protein 0.0041 0.0326 0.2899
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.026 0.0216
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.026 0.092
Toxoplasma gondii ABC1 family protein 0.0035 0.026 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0173 0.0212
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2325 0.2775
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0003 0.0012
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0173 0.0212
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.026 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0003 0.0012
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.026 0.6433
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.026 0.0216
Echinococcus granulosus tumor protein p63 0.0389 0.4095 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0409 0.0998
Echinococcus multilocularis survival motor neuron protein 1 0.0272 0.2829 0.2829
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0405 0.0405
Mycobacterium ulcerans hypothetical protein 0.0035 0.026 0.0319
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0003 0.0029
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0113 0.1106 0.391
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0003 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0003 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.092
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0173 0.0212
Mycobacterium ulcerans arylamine N-acetyltransferase Nat 0.0763 0.8154 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0409 0.1445
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0173 0.0612
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0173 0.0212
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.092
Schistosoma mansoni hypothetical protein 0.0047 0.0386 0.3426
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.026 0.2313
Giardia lamblia Replication factor C, subunit 1 0.0011 0.00000034704 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0003 0.0003
Brugia malayi beta-lactamase family protein 0.0035 0.026 0.092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.026 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0173 0.0212
Echinococcus multilocularis protein patched 0.0049 0.0405 0.0405
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.00000034704 0.00000034704
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.00000034704 0.000008579
Schistosoma mansoni hypothetical protein 0.0049 0.0409 0.3633
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0003 0.0008
Onchocerca volvulus 0.0027 0.0173 0.0946
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0003 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0173 0.0212
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0003 0.0029
Echinococcus multilocularis GPCR, family 2 0.0049 0.0409 0.0409
Leishmania major hypothetical protein, conserved 0.0035 0.026 1
Mycobacterium leprae conserved hypothetical protein 0.0035 0.026 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0173 0.0612
Mycobacterium tuberculosis Conserved protein 0.0035 0.026 0.0216
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.026 0.0319
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0409 0.0998
Schistosoma mansoni hypothetical protein 0.0106 0.1026 0.9117
Echinococcus granulosus expressed conserved protein 0.0106 0.1032 0.2519
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0003 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0173 0.0212
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.1557 0.5505
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.026 0.0319
Loa Loa (eye worm) hypothetical protein 0.0035 0.026 0.092
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0003 0.0008
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0405 0.0988
Trichomonas vaginalis esterase, putative 0.0035 0.026 0.6433
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.1106 0.1106
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0409 0.1445
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0003 0.0008
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0003 0.0008
Brugia malayi beta-lactamase 0.0035 0.026 0.092
Loa Loa (eye worm) hypothetical protein 0.0012 0.0003 0.0012
Onchocerca volvulus 0.0056 0.0479 0.2619
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0003 0.0012

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10.1 uM Inhibition of mouse recombinant NAT2 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method ChEMBL. 19059786

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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