Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0104 | 0.0613 | 0.0384 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0191 | 0.1528 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0613 | 0.0553 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0295 | 0.2611 | 1 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0104 | 0.0613 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0104 | 0.0613 | 0.1578 |
Giardia lamblia | Kinase, CMGC CK2 | 0.0068 | 0.0238 | 0.5 |
Toxoplasma gondii | aminopeptidase N protein | 0.0104 | 0.0613 | 0.4323 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0295 | 0.2611 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.008 | 0.0362 | 0.0521 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0295 | 0.2611 | 1 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0613 | 0.0384 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0104 | 0.0613 | 1 |
Mycobacterium ulcerans | arylamine N-acetyltransferase Nat | 0.0763 | 0.7508 | 1 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0145 | 0.1045 | 0.3399 |
Loa Loa (eye worm) | hypothetical protein | 0.0898 | 0.8916 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0104 | 0.0613 | 0.4323 |
Echinococcus granulosus | aminopeptidase N | 0.1001 | 1 | 1 |
Trypanosoma brucei | aminopeptidase, putative | 0.0104 | 0.0613 | 0.1578 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2431 |
Brugia malayi | TATA binding protein associated factor | 0.0104 | 0.0613 | 0.0384 |
Mycobacterium tuberculosis | Arylamine N-acetyltransferase Nat (arylamine acetylase) | 0.0763 | 0.7508 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0069 | 0.025 | 0.0047 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0295 | 0.2611 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2431 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0295 | 0.2611 | 1 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.0151 | 0.1104 | 1 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0104 | 0.0613 | 0.0613 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.008 | 0.0362 | 0.0127 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0145 | 0.1045 | 0.3399 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0104 | 0.0613 | 0.0553 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0104 | 0.0613 | 0.0613 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.081 | 0.8001 | 0.8959 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2611 |
Loa Loa (eye worm) | aminopeptidase N | 0.0295 | 0.2611 | 0.2827 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2611 |
Brugia malayi | WGR domain containing protein | 0.008 | 0.0362 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1528 | 0.1594 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0145 | 0.1045 | 0.0826 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0104 | 0.0613 | 0.0553 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0295 | 0.2611 | 0.2431 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0613 | 0.0553 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0191 | 0.1528 | 0.5433 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0104 | 0.0613 | 0.1578 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0295 | 0.2611 | 1 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0104 | 0.0613 | 0.4323 |
Echinococcus granulosus | casein kinase ii subunit alpha | 0.0068 | 0.0238 | 0.0238 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0104 | 0.0613 | 0.1578 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0295 | 0.2611 | 1 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0104 | 0.0613 | 1 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0104 | 0.0613 | 0.1578 |
Brugia malayi | Peptidase family M1 containing protein | 0.0104 | 0.0613 | 0.0384 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0104 | 0.0613 | 0.1578 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0104 | 0.0613 | 0.1578 |
Brugia malayi | Peptidase family M1 containing protein | 0.0295 | 0.2611 | 0.2431 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0191 | 0.1528 | 0.5433 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2431 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0104 | 0.0613 | 0.1578 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0295 | 0.2611 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0707 | 0.6918 | 0.7726 |
Onchocerca volvulus | 0.0295 | 0.2611 | 0.2129 | |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.008 | 0.0362 | 0.0521 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0295 | 0.2611 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2431 |
Echinococcus multilocularis | aminopeptidase N | 0.1001 | 1 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0145 | 0.1045 | 0.1045 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2431 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0104 | 0.0613 | 0.1578 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0104 | 0.0613 | 0.1578 |
Brugia malayi | WGR domain containing protein | 0.0145 | 0.1045 | 0.0826 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1528 | 0.1594 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0613 | 0.0553 |
Loa Loa (eye worm) | CMGC/CK2 protein kinase | 0.0068 | 0.0238 | 0.0127 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0104 | 0.0613 | 1 |
Onchocerca volvulus | 0.1001 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0362 | 0.0268 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0295 | 0.2611 | 0.2898 |
Brugia malayi | hypothetical protein | 0.0295 | 0.2611 | 0.2431 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2611 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0683 | 0.0633 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0295 | 0.2611 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.008 | 0.0362 | 0.0521 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0295 | 0.2611 | 1 |
Entamoeba histolytica | aminopeptidase, putative | 0.0295 | 0.2611 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0104 | 0.0613 | 0.1578 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.008 | 0.0362 | 0.0521 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.008 | 0.0362 | 0.0362 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0104 | 0.0613 | 0.0613 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0295 | 0.2611 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0295 | 0.2611 | 0.2611 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0104 | 0.0613 | 0.1578 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | Inhibition of mouse recombinant NAT2 assessed as hydrolysis of acetyl coA using PABA as substrate by Ellman's method | ChEMBL. | 19059786 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.