Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.1694 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0083 | 0.0196 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0736 | 0.422 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.1694 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0736 | 0.422 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.1694 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0 | 0.5 |
Mycobacterium leprae | Isocitrate lyase | 0.0794 | 0.4573 | 0.4573 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0083 | 0.0196 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.1694 | 1 | 1 |
Onchocerca volvulus | 0.0036 | 0 | 0.5 | |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0736 | 0.422 | 1 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0736 | 0.422 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0736 | 0.422 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.1159 | 0.1159 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0083 | 0.0196 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0083 | 0.0196 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.1694 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.