TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 285.364 | Formula: C15H15N3OS
H donors: 3 H acceptors: 1 LogP: 3.17 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: S=C(Nc1ccc(cc1)C)N/N=C/c1ccc(cc1)O
InChi: 1S/C15H15N3OS/c1-11-2-6-13(7-3-11)17-15(20)18-16-10-12-4-8-14(19)9-5-12/h2-10,19H,1H3,(H2,17,18,20)/b16-10+
InChiKey: ZFTGSQDGEHIOBY-MHWRWJLKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ribonucleotide reductase M1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	ribonucleoside-diphosphate reductase, large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Cryptosporidium hominis	ribonucleoside-diphosphate reductase large chain (ribonucleotide reductase R1 subunit)	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania braziliensis	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania infantum	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium berghei	ribonucleoside-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma congolense	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Babesia bovis	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	Get druggable targets OG5_126839	All targets in OG5_126839
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Schistosoma japonicum	ko:K00525 ribonucleoside-diphosphate reductase alpha chain [EC1.17.4.1A], putative	Get druggable targets OG5_126839	All targets in OG5_126839
Theileria parva	ribonucleotide-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania donovani	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	Get druggable targets OG5_126839	All targets in OG5_126839
Cryptosporidium parvum	ribonucleotide-diphosphate reductase large chain; RIR1; c-terminal PFL-like glycyl radical enzymes-like fold	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Echinococcus granulosus	ribonucleoside diphosphate reductase large	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium knowlesi	ribonucleoside-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Candida albicans	one of two likely ribonucleotide reductase large subunit genes similar to S. cerevisiae RNR1 (YER070W) and RNR3 (YIL066C)	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania mexicana	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	Get druggable targets OG5_126839	All targets in OG5_126839
Plasmodium yoelii	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	Get druggable targets OG5_126839	All targets in OG5_126839
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma brucei gambiense	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Trypanosoma congolense	ribonucleoside-diphosphate reductase large chain	Get druggable targets OG5_126839	All targets in OG5_126839
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	Get druggable targets OG5_126839	All targets in OG5_126839

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	chromobox protein	0.0076	0.225	0.2316
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.1182	0.1301
Mycobacterium tuberculosis	Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase)	0.0037	0.0859	0.1346
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0033	0.0716	0.1157
Loa Loa (eye worm)	hypothetical protein	0.0034	0.076	0.0894
Echinococcus granulosus	chromobox protein 1	0.0076	0.225	0.3635
Mycobacterium tuberculosis	Probable transcriptional regulatory protein NrdR	0.0019	0.0232	0.0054
Trypanosoma brucei	PAB1-binding protein , putative	0.0053	0.1434	0.1254
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.1437	0.2322
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.2791	0.451
Mycobacterium ulcerans	transcriptional regulator NrdR	0.0019	0.0232	0.0054
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0174	0.5721	0.6297
Mycobacterium leprae	RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN)	0.0102	0.3174	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1068	0.1256
Chlamydia trachomatis	ribonucleoside-diphosphate reductase subunit alpha	0.0121	0.3846	1
Echinococcus multilocularis	ribonucleoside diphosphate reductase large	0.0121	0.3846	0.6215
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.1209	0.1422
Loa Loa (eye worm)	transcription factor SMAD2	0.0115	0.3634	0.4275
Schistosoma mansoni	chromobox protein	0.0076	0.225	0.2316
Toxoplasma gondii	hypothetical protein	0.0048	0.1244	0.3234
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.014	0.4501	0.4385
Brugia malayi	hypothetical protein	0.0053	0.1434	0.1686
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.2791	0.3283
Trichomonas vaginalis	set domain proteins, putative	0.027	0.9085	1
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.1028	0.0839
Brugia malayi	mbt repeat family protein	0.0047	0.1209	0.1422
Schistosoma mansoni	hypothetical protein	0.0287	0.9714	1
Trichomonas vaginalis	ribonucleoside-diphosphate reductase alpha chain, putative	0.0102	0.3174	0.3493
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.1209	0.1244
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1437	0.169
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0024	0.04	0.0647
Echinococcus multilocularis	chromobox protein 1	0.0076	0.225	0.3635
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	1	1
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.4501	0.4385
Brugia malayi	SET domain containing protein	0.0014	0.0044	0.0052
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.1437	0.2322
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.225	0.2476
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.1068	0.1175
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.076	0.0783
Schistosoma mansoni	hypothetical protein	0.0024	0.04	0.0412
Onchocerca volvulus		0.0012	0.00000005028	0.000000055344
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0031	0.0668	0.0473
Brugia malayi	hypothetical protein	0.0034	0.0769	0.0905
Trichomonas vaginalis	chromobox protein, putative	0.0076	0.225	0.2476
Trichomonas vaginalis	chromobox protein, putative	0.0046	0.1182	0.1301
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0206	0.0535
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.1028	0.0839
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.076	0.0783
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.2791	0.451
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0066	0.1904	0.3077
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0034	0.076	0.1228
Plasmodium falciparum	ribonucleoside-diphosphate reductase large subunit, putative	0.0121	0.3846	1
Brugia malayi	N-terminal motif family protein	0.0174	0.5721	0.6729
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0742	0.0873
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.1209	0.1953
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0034	0.076	0.1228
Brugia malayi	Pre-SET motif family protein	0.0034	0.076	0.0894
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0237	0.7929	0.9326
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0066	0.1904	0.3499
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.1209	0.1953
Brugia malayi	chromobox protein homolog 3	0.0043	0.1068	0.1256
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.1437	0.1479
Echinococcus granulosus	Chromobox protein 3	0.0012	0.00000005028	0.000000081254
Plasmodium vivax	ataxin-2 like protein, putative	0.0053	0.1434	0.3728
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1068	0.1175
Loa Loa (eye worm)	hypothetical protein	0.0194	0.6408	0.7537
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1904	0.3499
Toxoplasma gondii	exonuclease III APE	0.0018	0.0206	0.0535
Echinococcus granulosus	chromobox protein 1	0.0076	0.225	0.3635
Wolbachia endosymbiont of Brugia malayi	ribonucleotide-diphosphate reductase subunit alpha	0.0102	0.3174	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0046	0.1182	0.1301
Brugia malayi	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.3846	0.4524
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0194	0.6408	0.7537
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.1209	0.1244
Brugia malayi	follicle stimulating hormone receptor	0.0253	0.8502	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.014	0.4501	0.4385
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.1028	0.0839
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.00000005028	0.000000081254
Brugia malayi	Heterochromatin protein 1	0.0076	0.225	0.2646
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.2791	0.2873
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.1209	0.133
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0046	0.12	0.1236
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0034	0.076	0.1976
Toxoplasma gondii	ribonucleoside-diphosphate reductase large chain	0.0121	0.3846	1
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.1437	0.169
Loa Loa (eye worm)	hypothetical protein	0.0053	0.1434	0.1686
Leishmania major	hypothetical protein, conserved	0.0053	0.1434	0.1254
Loa Loa (eye worm)	MH2 domain-containing protein	0.0115	0.3634	0.4275
Loa Loa (eye worm)	ribonucleoside-diphosphate reductase large subunit	0.0121	0.3846	0.4524
Loa Loa (eye worm)	heterochromatin protein 1	0.0076	0.225	0.2646
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.1437	0.2322
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1904	0.3499
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0188	0.6188	1
Brugia malayi	mbt repeat family protein	0.0047	0.1209	0.1422
Toxoplasma gondii	aldehyde dehydrogenase	0.0066	0.1904	0.4951
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0034	0.076	0.0783
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0206	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1904	0.196
Onchocerca volvulus		0.027	0.9085	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0066	0.1904	0.1734
Schistosoma mansoni	ap endonuclease	0.0018	0.0206	0.0212
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.2791	0.451
Schistosoma mansoni	ap endonuclease	0.0018	0.0206	0.0212
Trichomonas vaginalis	conserved hypothetical protein	0.0189	0.622	0.6847
Schistosoma mansoni	aldehyde dehydrogenase	0.0066	0.1904	0.196
Echinococcus granulosus	ribonucleoside diphosphate reductase large	0.0121	0.3846	0.6215
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0206	0.0226
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.1209	0.1953
Toxoplasma gondii	LsmAD domain-containing protein	0.0053	0.1434	0.3728
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0156	0.5059	1
Onchocerca volvulus		0.0033	0.0742	0.0817
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1068	0.1175
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0253	0.8502	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.2791	0.451
Leishmania major	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.3846	0.3717
Onchocerca volvulus		0.0047	0.1209	0.133
Onchocerca volvulus		0.0046	0.12	0.1321
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.1434	0.1254
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0188	0.6188	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.2791	0.3283
Mycobacterium ulcerans	ribonucleotide-diphosphate reductase subunit alpha	0.0102	0.3174	0.6116
Echinococcus granulosus	histone lysine methyltransferase setb	0.0034	0.076	0.1228
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0066	0.1904	0.3077
Loa Loa (eye worm)	MBCTL1	0.0053	0.1437	0.169
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0206	0.0242
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0206	0.0535
Plasmodium vivax	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.3846	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.1434	0.3728
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.1437	0.2322
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0066	0.1904	0.3499
Echinococcus multilocularis	chromobox protein 1	0.0076	0.225	0.3635
Treponema pallidum	ribonucleotide-diphosphate reductase subunit alpha	0.0121	0.3846	1
Mycobacterium ulcerans	hypothetical protein	0.0156	0.5059	1
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0627	0.0691
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0206	0.0332
Plasmodium vivax	SET domain protein, putative	0.0034	0.076	0.1976
Plasmodium falciparum	ataxin-2 like protein, putative	0.0053	0.1434	0.3728
Mycobacterium tuberculosis	Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein)	0.0102	0.3174	0.6116
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.1028	0.0839
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0206	0.0332
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1209	0.1422
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.2791	0.2873
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.1209	0.1244
Brugia malayi	Pre-SET motif family protein	0.0237	0.7929	0.9326
Loa Loa (eye worm)	hypothetical protein	0.0174	0.5721	0.6729
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0206	0.0242
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.2791	0.2873
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0296	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.1349	0.1167
Schistosoma mansoni	ribonucleoside-diphosphate reductase alpha subunit	0.0121	0.3846	0.3959
Trypanosoma brucei	ribonucleoside-diphosphate reductase large chain	0.0121	0.3846	0.3717
Trypanosoma cruzi	PAB1-binding protein , putative	0.0053	0.1434	0.1254
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0627	0.0691
Trypanosoma cruzi	ribonucleoside-diphosphate reductase large chain, putative	0.0121	0.3846	0.3717
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0296	1	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0206	0.0226
Brugia malayi	MH2 domain containing protein	0.0115	0.3634	0.4275
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0206	1
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.1209	0.1953
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0024	0.04	0.0647

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.848	Inhibition of N-terminal 6xHis-tagged Homo sapiens (human) recombinant ribonucleotide reductase M2/M1 expressed in Escherichia coli BL21 (DE3) using [3H]CDP as substrate after 30 min	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL512376

Bibliographic References

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Detailed information for compound 1009443