TDR Targets

Basic information

Technical information

TDR Targets ID: 1019217
Name: [3-[5-methyl-2-[(3,4,5-trimethoxyphenyl)amino ]imidazo[5,1-f][1,2,4]triazin-7-yl]phenyl]-ph enylmethanone
MW: 495.529 | Formula: C28H25N5O4
H donors: 1 H acceptors: 4 LogP: 4.96 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(Nc2ncc3n(n2)c(nc3C)c2cccc(c2)C(=O)c2ccccc2)cc(c1OC)OC
InChi: 1S/C28H25N5O4/c1-17-22-16-29-28(31-21-14-23(35-2)26(37-4)24(15-21)36-3)32-33(22)27(30-17)20-12-8-11-19(13-20)25(34)18-9-6-5-7-10-18/h5-16H,1-4H3,(H,31,32)
InChiKey: WCWSPMSEMFFBKI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[3-[5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]imidazo[5,1-f][1,2,4]triazin-7-yl]phenyl]-phenyl-methanone
[3-[5-methyl-2-[(3,4,5-trimethoxyphenyl)amino]-7-imidazo[5,1-f][1,2,4]triazinyl]phenyl]-phenylmethanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0061	0.2528	0.3459
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.542	1
Onchocerca volvulus	Putative alcohol dehydrogenase	0.0143	0.6967	0.6912
Schistosoma mansoni	neurotransmitter gated ion channel	0.0028	0.0755	0.0848
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0028	0.0755	0.0848
Onchocerca volvulus		0.0026	0.0661	0.049
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.2915	0.522
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0568	1
Brugia malayi	hypothetical protein	0.0025	0.0568	0.0568
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0279	0.5
Echinococcus granulosus	glycine receptor subunit beta	0.0061	0.2528	0.2391
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.2298	0.4042
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0033	0.101	0.1223
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0568	0.0568
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0033	0.101	0.1223
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0061	0.2528	0.2391
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0061	0.2528	0.2391
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.4185	0.4079
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.542	0.5336
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0028	0.0755	0.0755
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0061	0.2528	0.2528
Schistosoma mansoni	nAChR subunit	0.0061	0.2528	0.3459
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0568	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Echinococcus multilocularis	chromobox protein 1	0.0068	0.2915	0.2785
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0199	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.2915	0.522
Schistosoma mansoni	nAChR subunit	0.0061	0.2528	0.3459
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0017	0.018	0.018
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.542	1
Onchocerca volvulus		0.0028	0.0755	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.1299	0.2136
Giardia lamblia	Kinase, PLK	0.0114	0.542	1
Echinococcus granulosus	nAChR subunit	0.0061	0.2528	0.2391
Loa Loa (eye worm)	hypothetical protein	0.013	0.6264	0.6264
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0279	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0279	0.0189
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0568	1
Schistosoma mansoni	nAChR subunit	0.0028	0.0755	0.0848
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0279	0.0101
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0635	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Mycobacterium tuberculosis	Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase)	0.0143	0.6967	1
Onchocerca volvulus		0.0028	0.0755	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Echinococcus granulosus	chromobox protein 1	0.0068	0.2915	0.2785
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.1456	0.2434
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0028	0.0755	0.0755
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.542	0.7721
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0061	0.2528	0.2391
Loa Loa (eye worm)	hypothetical protein	0.0017	0.018	0.018
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0279	0.0189
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0028	0.0755	0.0755
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0061	0.2528	0.2391
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0199	1	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0033	0.101	0.101
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.542	1
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0061	0.2528	0.2528
Schistosoma mansoni	lamin	0.0026	0.0661	0.0709
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.542	1
Echinococcus granulosus	nAChR subunit	0.0033	0.101	0.0845
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0199	1	1
Schistosoma mansoni	neurotransmitter gated ion channel	0.0033	0.101	0.1223
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.4185	0.5901
Schistosoma mansoni	kinase	0.0058	0.238	0.3241
Mycobacterium leprae	Probable S-nitrosomycothiol reductase MscR	0.0143	0.6967	1
Schistosoma mansoni	lamin	0.0026	0.0661	0.0709
Mycobacterium tuberculosis	Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1	0.0125	0.6025	0.8612
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.1456	0.1299
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.1456	0.2434
Mycobacterium ulcerans	zinc-containing alcohol dehydrogenase NAD-dependent AdhB	0.0143	0.6967	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Onchocerca volvulus		0.013	0.6264	0.6195
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.4185	0.5901
Echinococcus granulosus	chromobox protein 1	0.0068	0.2915	0.2785
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Schistosoma mansoni	nAChR subunit	0.0061	0.2528	0.3459
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0061	0.2528	0.2528
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.1299	0.114
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0091	0.4185	0.4185
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0279	0.0146
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0028	0.0755	0.0586
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.542	0.542
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0199	1	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Schistosoma mansoni	nAChR subunit	0.0028	0.0755	0.0848
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.542	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0279	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.1299	0.2136
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.013	0.6264	0.8964
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0091	0.4185	0.4079
Onchocerca volvulus	Putative nachr subunit	0.0199	1	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.2528	0.2528
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0061	0.2528	0.2528
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.542	0.5336
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0697	0.0987
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0279	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0091	0.4185	0.5901
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.542	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0279	0.0279
Schistosoma mansoni	acetylcholine receptor-related	0.0028	0.0755	0.0848
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0028	0.0755	0.0586
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0091	0.4185	0.4185
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0028	0.0755	0.0586
Schistosoma mansoni	ap endonuclease	0.0019	0.0279	0.0146
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0061	0.2528	0.2528
Echinococcus multilocularis	glycine receptor subunit beta	0.0061	0.2528	0.2391
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.4185	0.4079
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.2528	0.2528
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0568	0.0741
Brugia malayi	Alcohol dehydrogenase class III	0.0143	0.6967	0.6967
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0755	0.0755
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0279	0.0189
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.542	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0279	0.0146
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.013	0.6264	0.8964
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Brugia malayi	intermediate filament protein	0.0026	0.0661	0.0661
Loa Loa (eye worm)	GABA receptor subunit	0.0033	0.101	0.101
Onchocerca volvulus		0.003	0.0854	0.0686
Brugia malayi	hypothetical protein	0.0028	0.0755	0.0755
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.542	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1299	0.1299
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0279	0.0189
Echinococcus multilocularis	musashi	0.0026	0.0661	0.049
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Entamoeba histolytica	hypothetical protein	0.0033	0.101	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0061	0.2528	0.2391
Echinococcus multilocularis	glycine receptor subunit beta	0.0061	0.2528	0.2391
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0568	0.0572
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0279	0.0279
Onchocerca volvulus		0.0061	0.2528	0.2391
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Mycobacterium ulcerans	zinc-dependent alcohol dehydrogenase AdhE2	0.0143	0.6967	1
Echinococcus granulosus	lamin	0.0026	0.0661	0.049
Echinococcus granulosus	intermediate filament protein	0.0026	0.0661	0.049
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0033	0.101	0.101
Onchocerca volvulus		0.0033	0.101	0.0845
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0028	0.0755	0.0755
Brugia malayi	hypothetical protein	0.0016	0.0096	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0102	0.4746	0.4746
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0755	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Onchocerca volvulus		0.0028	0.0755	0.0586
Mycobacterium ulcerans	zinc-dependent alcohol dehydrogenase	0.0143	0.6967	1
Mycobacterium tuberculosis	Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB	0.0125	0.6025	0.8612
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0061	0.2528	0.2528
Onchocerca volvulus		0.0026	0.0661	0.049
Loa Loa (eye worm)	ACC-1 protein	0.0061	0.2528	0.2528
Echinococcus multilocularis	nAChR subunit	0.0033	0.101	0.0845
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0199	1	1
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0028	0.0755	0.0755
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0061	0.2528	0.2528
Schistosoma mansoni	alcohol dehydrogenase	0.0143	0.6967	1
Brugia malayi	hypothetical protein	0.0028	0.0755	0.0755
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.542	1
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0061	0.2528	0.2391
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0061	0.2528	0.2528
Brugia malayi	Cation transporter family protein	0.0061	0.2528	0.2528
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.542	0.5336
Brugia malayi	Heterochromatin protein 1	0.0068	0.2915	0.2915
Schistosoma mansoni	ap endonuclease	0.0019	0.0279	0.0146
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0061	0.2528	0.2391
Schistosoma mansoni	nAChR subunit	0.0061	0.2528	0.3459
Echinococcus granulosus	lamin dm0	0.0026	0.0661	0.049
Brugia malayi	hypothetical protein	0.0028	0.0755	0.0755
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0061	0.2528	0.2391
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0017	0.018	0.018
Onchocerca volvulus		0.013	0.6264	0.6195
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.542	1
Loa Loa (eye worm)	LGC-31 protein	0.0061	0.2528	0.2528
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0661	0.0661
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0661	0.0661
Schistosoma mansoni	neurotransmitter gated ion channel	0.0028	0.0755	0.0848
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0061	0.2528	0.2528
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0061	0.2528	0.2528
Schistosoma mansoni	nAChR subunit	0.0061	0.2528	0.3459
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.542	1
Mycobacterium ulcerans	zinc-containing alcohol dehydrogenase NAD dependent AdhB	0.0143	0.6967	1
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.2298	0.4042
Loa Loa (eye worm)	hypothetical protein	0.0017	0.018	0.018
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0028	0.0755	0.0755
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0279	0.0101
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0061	0.2528	0.3459
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0028	0.0755	0.0586
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0028	0.0755	0.0586
Loa Loa (eye worm)	hypothetical protein	0.003	0.0854	0.0854
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0061	0.2528	0.2528
Schistosoma mansoni	chromobox protein	0.0068	0.2915	0.403
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0661	0.0709
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0061	0.2528	0.2391
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0697	0.0987
Onchocerca volvulus		0.0061	0.2528	0.2391
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0061	0.2528	0.2528
Schistosoma mansoni	nAChR subunit	0.0061	0.2528	0.3459
Leishmania major	hypothetical protein, conserved	0.0025	0.0568	0.0741
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0061	0.2528	0.2391
Loa Loa (eye worm)	hypothetical protein	0.0199	1	1
Onchocerca volvulus		0.0033	0.101	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0017	0.018	0.018
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0568	0.0741
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0279	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0755	0.0755
Echinococcus granulosus	glycine receptor subunit beta	0.0061	0.2528	0.2391
Onchocerca volvulus		0.013	0.6264	0.6195
Brugia malayi	Cation transporter family protein	0.013	0.6264	0.6264
Loa Loa (eye worm)	alcohol dehydrogenase class III	0.0143	0.6967	0.6967
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0061	0.2528	0.3459
Brugia malayi	hypothetical protein	0.0028	0.0755	0.0755
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.542	0.542
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0061	0.2528	0.2391
Mycobacterium ulcerans	zinc-type alcohol dehydrogenase AdhD	0.0143	0.6967	1
Loa Loa (eye worm)	ACC-1 protein	0.0061	0.2528	0.2528
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0568	0.0741
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Echinococcus multilocularis	lamin	0.0026	0.0661	0.049
Echinococcus multilocularis	lamin dm0	0.0026	0.0661	0.049
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0061	0.2528	0.2528
Brugia malayi	excitatory GABA receptor EXP-1A	0.0061	0.2528	0.2528
Brugia malayi	hypothetical protein	0.0028	0.0755	0.0755
Echinococcus multilocularis	nAChR subunit	0.0061	0.2528	0.2391
Loa Loa (eye worm)	hypothetical protein	0.0033	0.101	0.101
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0661	0.0661
Schistosoma mansoni	chromobox protein	0.0068	0.2915	0.403
Brugia malayi	chromobox protein homolog 3	0.0038	0.1299	0.1299
Brugia malayi	Cation transporter family protein	0.0061	0.2528	0.2528
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0199	1	1
Toxoplasma gondii	Zn-containing alcohol dehydrogenase	0.0143	0.6967	1
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0061	0.2528	0.3459
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0091	0.4185	0.4079
Echinococcus multilocularis	chromobox protein 1	0.0068	0.2915	0.2785
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0661	0.0661
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0061	0.2528	0.2391
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0061	0.2528	0.2391
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0033	0.101	0.101
Onchocerca volvulus		0.0061	0.2528	0.2391
Loa Loa (eye worm)	hypothetical protein	0.0061	0.2528	0.2528
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0061	0.2528	0.2391
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0199	1	1
Schistosoma mansoni	nAChR subunit	0.0061	0.2528	0.3459
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0033	0.101	0.101
Trypanosoma brucei	polo-like protein kinase	0.0114	0.542	1
Toxoplasma gondii	exonuclease III APE	0.0019	0.0279	0.0146
Loa Loa (eye worm)	hypothetical protein	0.013	0.6264	0.6264
Loa Loa (eye worm)	acetylcholine receptor protein	0.0028	0.0755	0.0755
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0061	0.2528	0.2391
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.2915	0.2915

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.41 uM	Inhibition of PLK1 expressed in baculovirus infected Trichoplusia ni cells	ChEMBL.	18929484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL519880

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1019217