Detailed information for compound 1022352

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1648.55 | Formula: C52H85N3O46S5
  • H donors: 15 H acceptors: 28 LogP: -8.83 Rotable bonds: 45
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCOC(=O)C1OC(OC2C(COS(=O)(=O)O)OC(C(C2O)NC(=O)C)O/C(=C/C(=O)OCCCC)/CO)C(C(C1OC1OC(COS(=O)(=O)O)C(C(C1NC(=O)C)O)OC1OC(C(=O)OCCCC)C(C(C1OS(=O)(=O)O)O)OC1OC(COS(=O)(=O)O)C(C(C1NC(=O)C)O)O)O)OS(=O)(=O)O
  • InChi: 1S/C52H85N3O46S5/c1-7-10-13-84-28(60)16-24(17-56)90-48-30(54-22(5)58)34(63)38(26(92-48)19-88-103(72,73)74)94-51-43(101-106(81,82)83)37(66)41(45(99-51)47(68)86-15-12-9-3)97-50-31(55-23(6)59)35(64)39(27(93-50)20-89-104(75,76)77)95-52-42(100-105(78,79)80)36(65)40(44(98-52)46(67)85-14-11-8-2)96-49-29(53-21(4)57)33(62)32(61)25(91-49)18-87-102(69,70)71/h16,25-27,29-45,48-52,56,61-66H,7-15,17-20H2,1-6H3,(H,53,57)(H,54,58)(H,55,59)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)(H,81,82,83)/b24-16+
  • InChiKey: GUKGNUPHQJMHHM-LFVJCYFKSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0716 0.3323 0.3323
Brugia malayi Cathepsin L-like precursor 0.0914 0.4282 0.4282
Trichomonas vaginalis glutaminase, putative 0.027 0.1158 0.18
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Trypanosoma cruzi cysteine peptidase, putative 0.1338 0.6337 0.6329
Loa Loa (eye worm) ctsf protein 0.1338 0.6337 0.6337
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Onchocerca volvulus 0.0248 0.1056 0.1638
Entamoeba histolytica cysteine protease, putative 0.0292 0.1268 0.1957
Entamoeba histolytica cysteine proteinase 1, putative 0.0716 0.3323 0.5218
Echinococcus granulosus cathepsin l1 0.0914 0.4282 0.4282
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0226 0.5
Onchocerca volvulus 0.1338 0.6337 1
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Trypanosoma cruzi cysteine peptidase, putative 0.1338 0.6337 0.6329
Plasmodium vivax unspecified product 0.0424 0.1906 0.2984
Onchocerca volvulus 0.1338 0.6337 1
Brugia malayi beta-lactamase family protein 0.0035 0.0021 0.0021
Onchocerca volvulus 0.0914 0.4282 0.6746
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Trypanosoma cruzi cysteine peptidase, putative 0.0716 0.3323 0.3309
Brugia malayi fibroinase precursor 0.0292 0.1268 0.1268
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0226 0.5
Echinococcus multilocularis microtubule associated protein 2 0.0728 0.3379 0.3379
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0226 0.0324
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0292 0.1268 0.1268
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0914 0.4282 0.427
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0716 0.3323 0.3323
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Onchocerca volvulus 0.0292 0.1268 0.1974
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0035 0.0035
Plasmodium vivax unspecified product 0.0716 0.3323 0.5228
Loa Loa (eye worm) hypothetical protein 0.0424 0.1906 0.1906
Giardia lamblia Cathepsin B precursor 0.0849 0.3969 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1338 0.6337 1
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0292 0.1268 0.1974
Onchocerca volvulus 0.1338 0.6337 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0292 0.1268 0.1268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0085 0.0085
Brugia malayi Cathepsin L-like precursor 0.0914 0.4282 0.4282
Schistosoma mansoni cathepsin S (C01 family) 0.0292 0.1268 0.1268
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0424 0.1906 0.1906
Plasmodium falciparum serine repeat antigen 4 0.0292 0.1268 0.1705
Loa Loa (eye worm) hypothetical protein 0.0292 0.1268 0.1268
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.1268 0.1974
Entamoeba histolytica hypothetical protein 0.0292 0.1268 0.1957
Loa Loa (eye worm) hypothetical protein 0.2093 1 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.1268 0.1268
Plasmodium vivax vivapain-1 0.0716 0.3323 0.5228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0226 0.0226
Brugia malayi Papain family cysteine protease containing protein 0.0292 0.1268 0.1268
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0323 0.0323
Brugia malayi Cytochrome P450 family protein 0.0048 0.0082 0.0082
Brugia malayi Cathepsin L-like precursor 0.1338 0.6337 0.6337
Echinococcus granulosus cathepsin L cysteine proteinase 0.1338 0.6337 0.6337
Loa Loa (eye worm) hypothetical protein 0.0914 0.4282 0.4282
Loa Loa (eye worm) hypothetical protein 0.0424 0.1906 0.1906
Loa Loa (eye worm) hypothetical protein 0.1338 0.6337 0.6337
Schistosoma mansoni glutaminase 0.027 0.1158 0.1158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0292 0.1268 0.1974
Loa Loa (eye worm) hypothetical protein 0.0292 0.1268 0.1268
Trypanosoma cruzi cysteine peptidase, putative 0.1338 0.6337 0.6329
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0292 0.1268 0.1974
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.094 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0248 0.1056 0.1056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2093 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.1268 0.1268
Plasmodium vivax vivapain-3 0.0716 0.3323 0.5228
Schistosoma mansoni cathepsin B (C01 family) 0.0292 0.1268 0.1268
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0097 0.0097
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0292 0.1268 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0716 0.3323 0.5228
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0292 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0097 0.0323 0.0323
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0226 0.1803
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0849 0.3969 0.625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0085 0.0085
Plasmodium falciparum serine repeat antigen 5 0.0292 0.1268 0.1705
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0097 0.0823
Brugia malayi Cathepsin L-like precursor 0.1338 0.6337 0.6337
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0292 0.1268 0.1705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0097 0.0097
Echinococcus granulosus survival motor neuron protein 1 0.0249 0.106 0.106
Loa Loa (eye worm) hypothetical protein 0.0077 0.0226 0.0226
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0292 0.1268 0.1974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0292 0.1268 0.1974
Loa Loa (eye worm) hypothetical protein 0.0067 0.0173 0.0173
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Entamoeba histolytica cysteine proteinase, putative 0.0716 0.3323 0.5218
Schistosoma mansoni microtubule-associated protein tau 0.0728 0.3379 0.3379
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Echinococcus multilocularis geminin 0.0333 0.1464 0.1464
Onchocerca volvulus 0.1338 0.6337 1
Onchocerca volvulus 0.0051 0.0097 0.0121
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Toxoplasma gondii cathepsin CPC1 0.0292 0.1268 0.1974
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1338 0.6337 0.6337
Trypanosoma brucei cysteine peptidase C (CPC) 0.0849 0.3969 0.625
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0292 0.1268 0.1974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0021
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Entamoeba histolytica cysteine proteinase, putative 0.1338 0.6337 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0292 0.1268 0.1957
Schistosoma mansoni hypothetical protein 0.0333 0.1464 0.1464
Echinococcus granulosus cathepsin L 0.0716 0.3323 0.3323
Entamoeba histolytica cysteine proteinase, putative 0.1338 0.6337 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0716 0.3323 0.3323
Echinococcus granulosus cathepsin l1 0.1338 0.6337 0.6337
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0292 0.1268 0.1974
Brugia malayi hypothetical protein 0.0038 0.0035 0.0035
Brugia malayi beta-lactamase family protein 0.0035 0.0021 0.0021
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0292 0.1268 0.1268
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1338 0.6337 1
Trypanosoma cruzi cysteine protease, putative 0.0716 0.3323 0.3309
Loa Loa (eye worm) hypothetical protein 0.0248 0.1056 0.1056
Plasmodium falciparum serine repeat antigen 6 0.0292 0.1268 0.1705
Brugia malayi Papain family cysteine protease containing protein 0.1338 0.6337 0.6337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0424 0.1906 0.1906
Plasmodium falciparum cysteine proteinase falcipain 1 0.0716 0.3323 0.5068
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0292 0.1268 0.1974
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0097 0.0823
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0292 0.1268 0.1974
Brugia malayi cathepsin L precursor 0.0292 0.1268 0.1268
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0292 0.1268 0.1268
Onchocerca volvulus Cathepsin L homolog 0.1338 0.6337 1
Echinococcus granulosus geminin 0.0333 0.1464 0.1464
Brugia malayi Papain family cysteine protease containing protein 0.0716 0.3323 0.3323
Giardia lamblia Cathepsin B precursor 0.0849 0.3969 1
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Entamoeba histolytica cysteine protease, putative 0.1338 0.6337 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0226 0.0226
Loa Loa (eye worm) fibroinase 0.1338 0.6337 0.6337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.1268 0.1974
Brugia malayi cathepsin Z-like cysteine proteinase 0.0292 0.1268 0.1268
Trypanosoma cruzi cysteine peptidase, putative 0.1338 0.6337 0.6329
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Brugia malayi Papain family cysteine protease containing protein 0.0292 0.1268 0.1268
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0085 0.0085
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0716 0.3323 0.3309
Plasmodium vivax serine-repeat antigen (SERA) 0.0292 0.1268 0.1974
Loa Loa (eye worm) cysteine protease 0.1338 0.6337 0.6337
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2093 1 1
Brugia malayi beta-lactamase 0.0035 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0051 0.0097 0.0097
Brugia malayi hypothetical protein 0.0249 0.106 0.106
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Loa Loa (eye worm) hypothetical protein 0.0914 0.4282 0.4282
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0226 0.0324
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0097 0.0097
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Trypanosoma cruzi cruzipain precursor, putative 0.1338 0.6337 0.6329
Brugia malayi Cathepsin L-like precursor 0.1338 0.6337 0.6337
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0085 0.0085
Echinococcus multilocularis cathepsin L 0.0292 0.1268 0.1268
Brugia malayi Cathepsin L-like precursor 0.1338 0.6337 0.6337
Echinococcus granulosus microtubule associated protein 2 0.0728 0.3379 0.3379
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1338 0.6337 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0292 0.1268 0.1974
Onchocerca volvulus Cathepsin L homolog 0.0292 0.1268 0.1974
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0292 0.1268 0.1974
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1338 0.6337 0.6337
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0173 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0085 0.0085
Loa Loa (eye worm) beta-lactamase 0.0035 0.0021 0.0021
Toxoplasma gondii cathepsin CPL 0.1338 0.6337 1
Loa Loa (eye worm) cathepsin B 0.0849 0.3969 0.3969
Entamoeba histolytica cysteine proteinase, putative 0.0716 0.3323 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0292 0.1268 0.1974
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0021 0.0021
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2093 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0292 0.1268 0.1974
Schistosoma mansoni hypothetical protein 0.0038 0.0035 0.0035
Entamoeba histolytica cysteine proteinase, putative 0.0716 0.3323 0.5218
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0226 0.0226
Echinococcus multilocularis cathepsin L cysteine protease 0.1338 0.6337 0.6337
Schistosoma mansoni cathepsin s 0.0424 0.1906 0.1906
Onchocerca volvulus 0.1338 0.6337 1
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0292 0.1268 0.1268
Entamoeba histolytica cysteine protease, putative 0.0292 0.1268 0.1957
Entamoeba histolytica cysteine protease, putative 0.0292 0.1268 0.1957
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0226 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0292 0.1268 0.1268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0292 0.1268 0.1974
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0716 0.3323 0.5228
Trypanosoma cruzi cysteine proteinase, putative 0.0716 0.3323 0.3309
Loa Loa (eye worm) hypothetical protein 0.0914 0.4282 0.4282
Giardia lamblia Cathepsin B precursor 0.0849 0.3969 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0323 0.0323
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0226 0.1803
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1338 0.6337 0.6337
Brugia malayi Cathepsin L-like cysteine proteinase 0.0914 0.4282 0.4282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.1268 0.1974
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0292 0.1268 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0914 0.4282 0.6746
Brugia malayi Cathepsin L-like precursor 0.0424 0.1906 0.1906
Loa Loa (eye worm) hypothetical protein 0.0424 0.1906 0.1906
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0716 0.3323 0.5228
Echinococcus multilocularis survival motor neuron protein 1 0.0249 0.106 0.106
Echinococcus multilocularis cysteine protease 0.1338 0.6337 0.6337
Brugia malayi cathepsin L-like precursor 0.0914 0.4282 0.4282
Plasmodium falciparum serine repeat antigen 3 0.0292 0.1268 0.1705
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0226 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1338 0.6337 1
Echinococcus multilocularis cathepsin b 0.2093 1 1
Plasmodium falciparum serine repeat antigen 8 0.0292 0.1268 0.1705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0292 0.1268 0.1268
Schistosoma mansoni cathepsin F (C01 family) 0.1338 0.6337 0.6337
Entamoeba histolytica cysteine proteinase, putative 0.0914 0.4282 0.6739
Toxoplasma gondii cathepsin B 0.0849 0.3969 0.625
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0292 0.1268 0.1974
Brugia malayi Papain family cysteine protease containing protein 0.0292 0.1268 0.1268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Echinococcus granulosus cathepsin L cysteine protease 0.0716 0.3323 0.3323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Brugia malayi Papain family cysteine protease containing protein 0.0716 0.3323 0.3323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0292 0.1268 0.1974
Leishmania major cathepsin L-like protease 0.1338 0.6337 1
Trypanosoma cruzi cysteine proteinase, putative 0.0716 0.3323 0.3309
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0849 0.3969 0.625
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0097 0.369
Trypanosoma cruzi major cysteine proteinase, putative 0.0292 0.1268 0.1249
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Schistosoma mansoni cathepsin F (C01 family) 0.0914 0.4282 0.4282
Echinococcus granulosus cathepsin L 0.0292 0.1268 0.1268
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Echinococcus multilocularis cysteine protease 0.1338 0.6337 0.6337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Entamoeba histolytica cysteine proteinase 2 0.0716 0.3323 0.5218
Onchocerca volvulus Cathepsin F homolog 0.1338 0.6337 1
Leishmania major cysteine peptidase A (CPA) 0.1338 0.6337 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.1268 0.1974
Schistosoma mansoni hypothetical protein 0.0333 0.1464 0.1464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0292 0.1268 0.1974
Trypanosoma cruzi major cysteine proteinase, putative 0.0292 0.1268 0.1249
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Echinococcus multilocularis cathepsin b 0.2093 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0716 0.3323 0.5228
Brugia malayi Cathepsin L-like precursor 0.1338 0.6337 0.6337
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0292 0.1268 0.1974
Plasmodium vivax serine-repeat antigen (SERA) 0.0292 0.1268 0.1974
Plasmodium falciparum serine repeat antigen 2 0.0292 0.1268 0.1705
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2093 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0292 0.1268 0.1974
Trichomonas vaginalis conserved hypothetical protein 0.0292 0.1268 0.1974
Echinococcus granulosus cathepsin b 0.2093 1 1
Plasmodium vivax unspecified product 0.0292 0.1268 0.1974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0082 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0021
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0323 0.0323
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.1268 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Entamoeba histolytica cysteine proteinase, putative 0.0716 0.3323 0.5218
Loa Loa (eye worm) hypothetical protein 0.0249 0.106 0.106
Loa Loa (eye worm) glutaminase 2 0.027 0.1158 0.1158
Trichomonas vaginalis conserved hypothetical protein 0.0292 0.1268 0.1974
Brugia malayi glutaminase DH11.1 0.027 0.1158 0.1158
Plasmodium vivax vivapain-2 0.1338 0.6337 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0021 0.0021
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1602 0.7622 0.7622
Loa Loa (eye worm) hypothetical protein 0.0292 0.1268 0.1268
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0085 0.0085
Loa Loa (eye worm) glutaminase 0.027 0.1158 0.1158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0226 0.0324
Onchocerca volvulus 0.1338 0.6337 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2093 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1338 0.6337 0.6337
Brugia malayi Trypsin family protein 0.0248 0.1056 0.1056
Schistosoma mansoni cathepsin F (C01 family) 0.1338 0.6337 0.6337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0085 0.0085
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0248 0.1056 0.1056
Plasmodium vivax vivapain-2 0.1338 0.6337 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0292 0.1268 0.1705
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0292 0.1268 0.1974
Echinococcus multilocularis cathepsin L cysteine protease 0.1338 0.6337 0.6337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1338 0.6337 1
Loa Loa (eye worm) hypothetical protein 0.0292 0.1268 0.1268
Onchocerca volvulus 0.0228 0.0958 0.1483
Brugia malayi Cathepsin L-like precursor 0.1338 0.6337 0.6337
Loa Loa (eye worm) hypothetical protein 0.0248 0.1056 0.1056
Echinococcus multilocularis cathepsin L 0.0716 0.3323 0.3323
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1338 0.6337 0.6337
Onchocerca volvulus Cathepsin L homolog 0.1338 0.6337 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0292 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0035 0.0021 0.0021
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0021 0.0021
Plasmodium falciparum serine repeat antigen 1 0.0292 0.1268 0.1705
Plasmodium falciparum serine repeat antigen 9 0.0292 0.1268 0.1705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.1268 0.1974
Schistosoma mansoni hypothetical protein 0.0067 0.0173 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1338 0.6337 1
Entamoeba histolytica cysteine protease, putative 0.0292 0.1268 0.1957
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1338 0.6337 1
Mycobacterium ulcerans glutaminase 0.027 0.1158 1
Entamoeba histolytica cysteine protease, putative 0.0716 0.3323 0.5218
Brugia malayi Probable ClpP-like protease 0.0077 0.0226 0.0226
Echinococcus granulosus cysteine protease 0.0716 0.3323 0.3323
Trypanosoma cruzi cruzipain precursor, putative 0.0424 0.1906 0.1889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0914 0.4282 0.6746
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0021 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Onchocerca volvulus 0.1338 0.6337 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0292 0.1268 0.1974
Brugia malayi cathepsin F-like cysteine proteinase 0.0424 0.1906 0.1906
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.1268 0.1268
Schistosoma mansoni survival motor neuron protein 0.0051 0.0097 0.0097
Toxoplasma gondii cathepsin CPC2 0.0292 0.1268 0.1974
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0035 0.0035
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0085 0.0085
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0226 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0849 0.3969 0.3969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0292 0.1268 0.1974
Echinococcus granulosus cathepsin b 0.2093 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0292 0.1268 0.1268
Loa Loa (eye worm) hypothetical protein 0.0292 0.1268 0.1268
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0292 0.1268 0.1957
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0579 0.2658 0.2658
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1338 0.6337 1
Entamoeba histolytica cysteine protease, putative 0.0292 0.1268 0.1957
Trypanosoma cruzi cysteine peptidase, putative 0.0424 0.1906 0.1889
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0292 0.1268 0.1705
Entamoeba histolytica cysteine protease, putative 0.0292 0.1268 0.1957
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0292 0.1268 0.1974
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0849 0.3969 0.3956
Schistosoma mansoni cathepsin C 0.0292 0.1268 0.1268
Plasmodium falciparum serine repeat antigen 7 0.0292 0.1268 0.1705
Echinococcus granulosus tachykinin peptides receptor 99D 0.0579 0.2658 0.2658

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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