Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.0509 | 0.0495 |
Trypanosoma brucei | unspecified product | 0.0041 | 0.0159 | 0.0209 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.006 | 0.0384 | 0.0915 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.2483 | 0.6121 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0136 | 0.1326 | 0.2868 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0148 | 0.1478 | 0.1465 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0136 | 0.1326 | 0.1313 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0305 | 0.342 | 0.4488 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0325 | 0.3667 | 0.9057 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0038 | 0.0055 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0355 | 0.4047 | 0.5211 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0136 | 0.1326 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0062 | 0.0409 | 0.0976 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Echinococcus multilocularis | muscleblind protein | 0.0148 | 0.1478 | 0.1465 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0093 | 0.0193 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0644 | 0.762 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0136 | 0.1326 | 0.325 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0136 | 0.1326 | 0.3 |
Brugia malayi | glutaminase DH11.1 | 0.0287 | 0.3202 | 0.7903 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0355 | 0.4047 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0136 | 0.1326 | 0.325 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1326 | 0.325 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0098 | 0.0856 | 0.2086 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.2875 | 0.6986 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0355 | 0.4047 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0053 | 0.0093 |
Onchocerca volvulus | 0.0261 | 0.2875 | 1 | |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0033 | 0.0053 | 0.0093 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.006 | 0.0384 | 0.0578 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.006 | 0.0384 | 0.0915 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0305 | 0.342 | 0.437 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0509 | 0.1225 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0355 | 0.4047 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.006 | 0.0384 | 0.0578 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0053 | 0.0093 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0355 | 0.4047 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.007 | 0.0517 | 0.0678 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0339 | 0.3846 | 0.9482 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1478 | 0.3627 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0509 | 0.1225 |
Brugia malayi | TAR-binding protein | 0.007 | 0.0509 | 0.1225 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Trichomonas vaginalis | glutaminase, putative | 0.0287 | 0.3202 | 0.7825 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0136 | 0.1326 | 0.325 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.006 | 0.0384 | 0.0301 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0098 | 0.0856 | 0.0842 |
Schistosoma mansoni | DNA polymerase eta | 0.007 | 0.0517 | 0.1243 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0093 | 0.0193 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0355 | 0.4047 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0509 | 0.1225 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.011 | 0.1012 | 0.1143 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0136 | 0.1326 | 0.325 |
Echinococcus granulosus | dna polymerase kappa | 0.0041 | 0.0159 | 0.0357 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0093 | 0.0193 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.006 | 0.0384 | 0.0504 |
Brugia malayi | protein ZK524.3 | 0.0136 | 0.1326 | 0.325 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Toxoplasma gondii | exonuclease III APE | 0.006 | 0.0384 | 0.0915 |
Giardia lamblia | DINP protein human, muc B family | 0.0041 | 0.0159 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1326 | 0.325 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0136 | 0.1326 | 0.1564 |
Schistosoma mansoni | glutaminase | 0.0287 | 0.3202 | 0.7903 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0355 | 0.4047 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0136 | 0.1326 | 0.325 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0355 | 0.4047 | 1 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0355 | 0.4047 | 1 |
Brugia malayi | methionyl-tRNA synthetase | 0.0355 | 0.4047 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0091 | 0.0767 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0517 | 0.1243 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.0509 | 0.1225 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.2483 | 0.6121 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.1326 | 0.325 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.006 | 0.0384 | 0.0915 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.007 | 0.0517 | 0.1243 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0355 | 0.4047 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0159 | 0.0209 |
Onchocerca volvulus | 0.022 | 0.2367 | 0.8223 | |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0041 | 0.0159 | 0.0357 |
Mycobacterium ulcerans | glutaminase | 0.0287 | 0.3202 | 0.7825 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0053 | 0.0093 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0042 | 0.0162 | 0.0004 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0644 | 0.762 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0339 | 0.3846 | 0.9482 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0159 | 0.0209 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.006 | 0.0384 | 0.0915 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0509 | 0.1225 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0136 | 0.1326 | 0.5 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0355 | 0.4047 | 0.4038 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.0509 | 0.1225 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Leishmania major | DNA polymerase eta, putative | 0.0042 | 0.0162 | 0.0004 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0355 | 0.4047 | 0.5312 |
Schistosoma mansoni | jumonji domain containing protein | 0.0078 | 0.0608 | 0.1469 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0355 | 0.4047 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0041 | 0.0159 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1478 | 0.3627 |
Onchocerca volvulus | 0.0168 | 0.1725 | 0.5977 | |
Treponema pallidum | methionyl-tRNA synthetase | 0.0136 | 0.1326 | 0.2868 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.007 | 0.0517 | 0.0479 |
Echinococcus multilocularis | dna polymerase eta | 0.007 | 0.0517 | 0.0502 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0033 | 0.0053 | 0.0093 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.0509 | 0.1225 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0136 | 0.1326 | 0.3325 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0355 | 0.4047 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0279 | 0.0655 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0053 | 0.0093 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0644 | 0.762 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0159 | 0.0357 |
Onchocerca volvulus | 0.0033 | 0.0053 | 0.0131 | |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0041 | 0.0159 | 0.0357 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0093 | 0.0193 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0355 | 0.4047 | 0.5211 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0053 | 0.0093 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.006 | 0.0384 | 0.0301 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0091 | 0.0767 | 0.0814 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0042 | 0.0162 | 0.0364 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 1 |
Loa Loa (eye worm) | glutaminase 2 | 0.0287 | 0.3202 | 0.7903 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0644 | 0.762 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0053 | 0.0093 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.006 | 0.0384 | 0.0915 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0136 | 0.1326 | 0.325 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0041 | 0.0159 | 0.0209 |
Brugia malayi | RNA binding protein | 0.007 | 0.0509 | 0.1225 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0041 | 0.0159 | 0.0144 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.006 | 0.0384 | 0.037 |
Toxoplasma gondii | hypothetical protein | 0.0104 | 0.0932 | 0.2273 |
Loa Loa (eye worm) | hypothetical protein | 0.0168 | 0.1725 | 0.424 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0305 | 0.342 | 0.437 |
Trichomonas vaginalis | ap endonuclease, putative | 0.006 | 0.0384 | 0.0578 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.006 | 0.0384 | 0.0641 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.0509 | 0.1225 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.006 | 0.0384 | 0.0915 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.0509 | 0.1225 |
Brugia malayi | jmjC domain containing protein | 0.0098 | 0.0856 | 0.2086 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0093 | 0.0078 |
Loa Loa (eye worm) | tyrosyl-tRNA synthetase | 0.022 | 0.2367 | 0.5833 |
Echinococcus multilocularis | dna polymerase kappa | 0.0041 | 0.0159 | 0.0144 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Loa Loa (eye worm) | glutaminase | 0.0287 | 0.3202 | 0.7903 |
Brugia malayi | Muscleblind-like protein | 0.0148 | 0.1478 | 0.3627 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0093 | 0.0193 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0091 | 0.0767 | 0.1006 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0136 | 0.1326 | 0.2571 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.006 | 0.0384 | 0.0578 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0159 | 0.161 | 0.3731 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.0509 | 0.1225 |
Schistosoma mansoni | ap endonuclease | 0.006 | 0.0384 | 0.0915 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0091 | 0.0767 | 0.0814 |
Schistosoma mansoni | ap endonuclease | 0.006 | 0.0384 | 0.0915 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0355 | 0.4047 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.006 | 0.0384 | 0.0301 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0042 | 0.016 | 0.0145 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0136 | 0.1326 | 0.325 |
Echinococcus granulosus | muscleblind protein | 0.0148 | 0.1478 | 0.3627 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Brugia malayi | hypothetical protein | 0.0168 | 0.1725 | 0.424 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0053 | 0.0037 |
Echinococcus granulosus | dna polymerase eta | 0.007 | 0.0517 | 0.1243 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0033 | 0.0053 | 0.0037 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0159 | 0.161 | 0.3731 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0136 | 0.1326 | 0.325 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0053 | 0.0093 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0136 | 0.1326 | 0.1313 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0325 | 0.3667 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0136 | 0.1326 | 0.325 |
Echinococcus granulosus | jumonji domain containing protein | 0.0042 | 0.016 | 0.0359 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0041 | 0.0159 | 0.0209 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0041 | 0.0159 | 0.0357 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0325 | 0.3667 | 0.9022 |
Leishmania major | DNA polymerase eta, putative | 0.007 | 0.0517 | 0.0479 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.