Detailed information for compound 1037114

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 745.393 | Formula: C33H53ClN6O7S2
  • H donors: 5 H acceptors: 6 LogP: 4.99 Rotable bonds: 19
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@@H](C([C@H](CC1CCCCC1)N)O)OC(=O)[C@H](Cc1csc(n1)N)NC(=O)[C@@H](NS(=O)(=O)N1CCOCC1)Cc1ccccc1)C.Cl
  • InChi: 1S/C33H52N6O7S2.ClH/c1-22(2)17-29(30(40)26(34)18-23-9-5-3-6-10-23)46-32(42)28(20-25-21-47-33(35)36-25)37-31(41)27(19-24-11-7-4-8-12-24)38-48(43,44)39-13-15-45-16-14-39;/h4,7-8,11-12,21-23,26-30,38,40H,3,5-6,9-10,13-20,34H2,1-2H3,(H2,35,36)(H,37,41);1H/t26-,27-,28-,29-,30?;/m0./s1
  • InChiKey: QPVVVVIBSDTYKT-JVAYVQGTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0408 0.564 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Leishmania major hypothetical protein, conserved 0.0025 0.019 0.0237
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.1257 0.2148
Onchocerca volvulus Cathepsin F homolog 0.0033 0.0309 0.0272
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0508 0.0839
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0309 0.045
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.01 0.1257 0.2148
Schistosoma mansoni SET domain protein 0.0015 0.0046 0.0015
Brugia malayi mbt repeat family protein 0.0047 0.0508 0.0538
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1346 0.2336
Brugia malayi Protein kinase domain containing protein 0.0015 0.005 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Schistosoma mansoni patched 1 0.0046 0.0489 0.0806
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0389 0.0402
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0189 0.2529 0.3945
Leishmania major cathepsin L-like protease 0.0126 0.1632 0.2821
Loa Loa (eye worm) hypothetical protein 0.0084 0.1034 0.1141
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.019 0.0237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Brugia malayi adenosine monophosphate deaminase 0.0091 0.1136 0.1259
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.2848 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0309 0.0461
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0245 0.0245
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0295 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0097 0.0071
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1257 0.1257
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0081 0.0049
Echinococcus granulosus chromobox protein 1 0.0068 0.0805 0.1215
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0153 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0153 0.0153
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0298 0.0298
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0508 0.0538
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0222 0.0222
Loa Loa (eye worm) PHD-finger family protein 0.0043 0.0444 0.0465
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.018
Brugia malayi hypothetical protein 0.0025 0.019 0.0175
Entamoeba histolytica hypothetical protein 0.0035 0.0341 0.0518
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0389 0.0593
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.2005 0.3116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1632 0.2821
Plasmodium vivax vivapain-1 0.0017 0.0081 0.0076
Brugia malayi chromobox protein homolog 3 0.0038 0.038 0.0392
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0295 0.0459
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.028 0.3824 0.676
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0191 0.0238
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0341 0.0541
Plasmodium vivax vivapain-3 0.0017 0.0081 0.0076
Onchocerca volvulus 0.0091 0.1136 0.1103
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Loa Loa (eye worm) hypothetical protein 0.0015 0.0055 0.0021
Trypanosoma cruzi cysteine protease, putative 0.0017 0.0081 0.0041
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0339 0.0477
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0092 0.1144 0.1977
Brugia malayi Heterochromatin protein 1 0.0068 0.0805 0.0879
Brugia malayi CHE-14 protein 0.0046 0.0489 0.0517
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0309 0.0311
Echinococcus multilocularis chromobox protein 1 0.0068 0.0805 0.1215
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.1158 0.1971
Schistosoma mansoni cpg binding protein 0.0103 0.1302 0.2258
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0408 0.564 0.5641
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0158 0.0158
Entamoeba histolytica cysteine protease, putative 0.0033 0.0309 0.0461
Toxoplasma gondii ABC1 family protein 0.0039 0.0389 0.063
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1346 0.1346
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1346 0.2308
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0295 0.046
Onchocerca volvulus 0.0033 0.0309 0.0272
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0295 0.0426
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.01 0.1257 0.2148
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.1158 0.1774
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.068 0.1148
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0055 0.0021
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0058 0.0035
Schistosoma mansoni hypothetical protein 0.037 0.5099 0.9035
Leishmania major AMP deaminase, putative 0.0091 0.1136 0.1933
Echinococcus multilocularis tumor protein p63 0.033 0.4526 0.7107
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.1158 0.1283
Echinococcus granulosus geminin 0.037 0.5099 0.8015
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Entamoeba histolytica adenosylhomocysteinase, putative 0.0408 0.564 1
Schistosoma mansoni myst-related protein 0.0015 0.0051 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0216 0.0283
Leishmania major cathepsin L-like protease 0.0033 0.0309 0.045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.3357 0.5911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Entamoeba histolytica cysteine proteinase 1, putative 0.0017 0.0081 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0295 0.0358
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.01 0.1257 0.2179
Schistosoma mansoni zinc finger protein 0.0032 0.0287 0.0446
Toxoplasma gondii histone lysine methyltransferase SET1 0.0186 0.2479 0.4359
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0508 0.0744
Schistosoma mansoni adenosylhomocysteinase 0.0253 0.3428 0.6053
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0634 0.0944
Plasmodium vivax importin-beta 2, putative 0.0031 0.0273 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Brugia malayi Adenosylhomocysteinase 0.0408 0.564 0.6416
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0295 1
Mycobacterium tuberculosis Conserved protein 0.0039 0.0389 0.0593
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1346 0.1346
Toxoplasma gondii thioredoxin reductase 0.0093 0.1158 0.2002
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0634 0.1032
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0245 0.0347
Trypanosoma cruzi adenosine monophosphate deaminase-like protein, putative 0.0091 0.1136 0.1933
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0081 0.0052
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1346 0.3351
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.1158 0.1999
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0273 0.0386
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.068 0.1116
Loa Loa (eye worm) hypothetical protein 0.0189 0.2525 0.285
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.2848 0.4684
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0158 0.0214
Trichomonas vaginalis adenosine deaminase, putative 0.028 0.3824 0.3825
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1346 0.1346
Schistosoma mansoni adenosine deaminase 0.028 0.3824 0.6759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0295 0.0426
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0298 0.0298
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0245 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Echinococcus multilocularis adenosylhomocysteinase 0.0408 0.564 0.8872
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0245 0.037
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0032
Trypanosoma cruzi ISWI complex protein 0.0032 0.0287 0.0411
Onchocerca volvulus Adenosine deaminase homolog 0.028 0.3824 0.3801
Schistosoma mansoni hypothetical protein 0.0035 0.0341 0.0541
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0153 0.0182
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0309 0.043
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.1355 0.1509
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0115 0.1477 0.2542
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0295 1
Schistosoma mansoni adenosine deaminase-related 0.028 0.3824 0.6759
Leishmania major importin beta-1 subunit, putative 0.0025 0.0191 0.0238
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0389 0.0593
Trypanosoma cruzi AMP deaminase 2, putative 0.0091 0.1136 0.1933
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.068 0.1018
Echinococcus multilocularis cysteine protease 0.0033 0.0309 0.043
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0081 0.0041
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0389 0.0593
Echinococcus multilocularis cathepsin L cysteine protease 0.0033 0.0309 0.043
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0055 0.0028
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.019 0.0248
Brugia malayi Pre-SET motif family protein 0.0628 0.8769 1
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0389 0.0593
Schistosoma mansoni myst-related protein 0.0015 0.0051 0.0025
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.019 0.0237
Brugia malayi PHD-finger family protein 0.0057 0.0645 0.0696
Loa Loa (eye worm) hypothetical protein 0.0079 0.0964 0.1061
Echinococcus granulosus Ankyrin 0.0014 0.0039 0.0003
Leishmania major adenine aminohydrolase 0.028 0.3824 0.6747
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0033 0.0309 0.0311
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0295 0.0408
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0634 0.1065
Plasmodium falciparum adenosine deaminase 0.028 0.3824 0.6751
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.01 0.1257 0.1396
Echinococcus granulosus tumor protein p63 0.033 0.4526 0.7107
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0309 0.0272
Brugia malayi Death domain containing protein 0.0014 0.0037 0.000000074496
Brugia malayi Muscleblind-like protein 0.0319 0.4377 0.497
Echinococcus multilocularis Ankyrin 0.0014 0.0039 0.0003
Mycobacterium tuberculosis Probable reductase 0.0212 0.2848 0.5
Trypanosoma brucei trypanothione reductase 0.0093 0.1158 0.1971
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.068 0.1052
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1346 0.2253
Trypanosoma brucei protein kinase, putative 0.01 0.1257 0.2148
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.1378 0.2393
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0389 0.0402
Echinococcus multilocularis cpg binding protein 0.0103 0.1302 0.2003
Loa Loa (eye worm) hypothetical protein 0.003 0.0263 0.0258
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0235 0.3184 0.5324
Brugia malayi Bromodomain containing protein 0.0079 0.0962 0.1059
Schistosoma mansoni ap endonuclease 0.0018 0.0097 0.0107
Entamoeba histolytica adenosine deaminase, putative 0.028 0.3824 0.6751
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0634 0.1032
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0158 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.0127 0.1644 0.2545
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0634 0.0968
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0245 0.0245
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0191 0.0191
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.1158 0.1774
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.2848 0.5
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0058 0.0011
Plasmodium falciparum thioredoxin reductase 0.0093 0.1158 0.198
Brugia malayi Cathepsin L-like precursor 0.0033 0.0309 0.0311
Echinococcus multilocularis expressed conserved protein 0.01 0.1263 0.194
Plasmodium vivax adenosine deaminase, putative 0.028 0.3824 0.6759
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0138
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0273 0.0386
Schistosoma mansoni hypothetical protein 0.0044 0.0465 0.0764
Plasmodium vivax vivapain-2 0.0033 0.0309 0.0483
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0634 0.0968
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1346 0.2317
Onchocerca volvulus 0.0033 0.0309 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Brugia malayi Pre-SET motif family protein 0.0092 0.1144 0.1267
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0081 0.0052
Leishmania major cathepsin L-like protease 0.0033 0.0309 0.045
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0058 0.0032
Loa Loa (eye worm) bromodomain containing protein 0.0036 0.0357 0.0365
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1257 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0489 0.0489
Echinococcus granulosus cathepsin l1 0.0033 0.0309 0.043
Trypanosoma brucei AMP deaminase, putative 0.0091 0.1136 0.1933
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0525 0.0558
Onchocerca volvulus 0.0033 0.0309 0.0272
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0508 0.0744
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.058 0.0622
Brugia malayi RNA, U transporter 1 0.0087 0.1075 0.1188
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0081 0.0077
Schistosoma mansoni hypothetical protein 0.0044 0.0465 0.0764
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0309 0.043
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1346 0.2308
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.068 0.1116
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.0133
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0628 0.8769 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.06 0.0891
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0341 0.048
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0245 0.0245
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0297 0.0411
Mycobacterium leprae Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE) 0.028 0.3824 0.6542
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1346 0.2308
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.01 0.1257 0.2148
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0158 0.0158
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0408 0.564 1
Onchocerca volvulus AMP deaminase 2 homolog 0.0091 0.1136 0.1103
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0245 0.0245
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.019 0.0237
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0081 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0389 0.0389
Schistosoma mansoni serine/threonine protein kinase 0.01 0.1257 0.2176
Plasmodium falciparum cysteine proteinase falcipain 3 0.0033 0.0309 0.0461
Loa Loa (eye worm) hypothetical protein 0.0189 0.2525 0.285
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0245 0.0347
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0408 0.564 1
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1346 0.2072
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1257 0.1257
Onchocerca volvulus 0.0047 0.0508 0.0472
Brugia malayi mbt repeat family protein 0.0047 0.0508 0.0538
Brugia malayi hypothetical protein 0.0016 0.0065 0.0032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0389 0.0556
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0103 0.1302 0.2257
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0295 0.0426
Echinococcus multilocularis GPCR, family 2 0.0015 0.0055 0.0028
Leishmania major cathepsin L-like protease 0.0033 0.0309 0.045
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0245 0.0245
Brugia malayi beta-lactamase 0.0039 0.0389 0.0402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0189 0.2525 0.285
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0134 0.0111
Trypanosoma cruzi AMP deaminase, putative 0.0091 0.1136 0.1933
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0408 0.564 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.004 0.0002
Brugia malayi glutathione reductase 0.0093 0.1158 0.1283
Brugia malayi beta-lactamase family protein 0.0039 0.0389 0.0402
Brugia malayi hypothetical protein 0.0035 0.0341 0.0347
Loa Loa (eye worm) MBCTL1 0.0054 0.06 0.0645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0081 0.0041
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1488 0.1661
Brugia malayi 6-phosphofructokinase 0.0106 0.1346 0.1499
Leishmania major cathepsin L-like protease 0.0126 0.1632 0.2821
Onchocerca volvulus 0.0039 0.0389 0.0353
Echinococcus multilocularis mitogen activated protein kinase 3 0.01 0.1257 0.1931
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0081 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0298 0.0298
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0245 0.0374
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0489 0.0715
Entamoeba histolytica Ran family GTPase 0.0023 0.0158 0.0191
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0408 0.564 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0097 0.0095
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0037 0.0000001161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Loa Loa (eye worm) hypothetical protein 0.0048 0.0525 0.0558
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1346 0.1499
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0055 0.0028
Loa Loa (eye worm) hypothetical protein 0.0038 0.038 0.0392
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.2005 0.3116
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.1644 0.2868
Loa Loa (eye worm) hypothetical protein 0.0319 0.4377 0.497
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0092 0.1144 0.1975
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0295 0.0463
Echinococcus granulosus dnaJ subfamily B 0.0399 0.5512 0.867
Loa Loa (eye worm) hypothetical protein 0.0319 0.4377 0.497
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0081 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.068 0.1148
Brugia malayi Cathepsin L-like precursor 0.0033 0.0309 0.0311
Loa Loa (eye worm) glutathione reductase 0.0093 0.1158 0.1283
Leishmania major adenosine monophosphate deaminase, putative,AMP deaminase, putative 0.0091 0.1136 0.1933
Brugia malayi MH2 domain containing protein 0.0116 0.1488 0.1661
Trypanosoma cruzi cruzipain precursor, putative 0.0126 0.1632 0.2821
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0298 0.0298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0097 0.0071
Brugia malayi F/Y-rich N-terminus family protein 0.0036 0.0348 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.0133
Loa Loa (eye worm) hypothetical protein 0.0146 0.1914 0.2149
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0295 0.0358
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0489 0.0517
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.019 0.0275
Echinococcus granulosus cathepsin L 0.0017 0.0081 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0298 0.0298
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0097 0.0071
Brugia malayi MAP kinase sur-1 0.01 0.1257 0.1396
Trypanosoma brucei adenosine monophosphate deaminase, putative 0.0091 0.1136 0.1933
Brugia malayi CHD4 protein 0.002 0.0128 0.0104
Onchocerca volvulus 0.0033 0.0309 0.0272
Schistosoma mansoni chromobox protein 0.0068 0.0805 0.1369
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.2848 0.5
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0245 0.0374
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0058 0.0032
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.0081 0.0041
Trichomonas vaginalis adenosine deaminase, putative 0.028 0.3824 0.3825
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0389 0.0526
Schistosoma mansoni ran 0.0023 0.0158 0.0215
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.068 0.1052
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0222 0.0222
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0339 0.0477
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.0133
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.1355 0.2332
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0389 0.0593
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0055 0.0021
Leishmania major hypothetical protein, conserved 0.0032 0.0287 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0134 0.0134
Plasmodium vivax SET domain protein, putative 0.0092 0.1144 0.1974
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.06 0.0645
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0153 0.0207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0129 0.1666 0.2579
Schistosoma mansoni hypothetical protein 0.0044 0.0465 0.0764
Schistosoma mansoni hypothetical protein 0.0327 0.448 0.793
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0027 0.0216 0.0283
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0308 0.0309
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0097 0.0105
Echinococcus granulosus fetal alzheimer antigen falz 0.0052 0.0576 0.0852
Loa Loa (eye worm) hypothetical protein 0.0039 0.0389 0.0402
Toxoplasma gondii Adenosine/AMP deaminase domain-containing protein 0.028 0.3824 0.676
Trypanosoma cruzi ISWI complex protein 0.0032 0.0287 0.0411
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0189 0.2529 0.3945
Onchocerca volvulus 0.0039 0.0389 0.0353
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0295 0.0426
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0389 0.0389
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0158 0.0191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Schistosoma mansoni ap endonuclease 0.0018 0.0097 0.0107
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0508 0.0839
Schistosoma mansoni hypothetical protein 0.0015 0.0055 0.0032
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0339 0.0537
Leishmania major GTP-binding protein, putative 0.0023 0.0158 0.018
Schistosoma mansoni importin beta-1 0.0031 0.0273 0.042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0058 0.0036
Plasmodium vivax unspecified product 0.0017 0.0081 0.0076
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0058 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0094 0.117 0.1298
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1346 0.1346
Loa Loa (eye worm) RecQ helicase 0.0021 0.0134 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Mycobacterium tuberculosis Probable adenosine deaminase Add (adenosine aminohydrolase) 0.028 0.3824 0.6747
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1346 0.2072
Echinococcus granulosus neuropeptide s receptor 0.0458 0.6352 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.002 0.0128 0.0144
Toxoplasma gondii AMP deaminase 0.0091 0.1136 0.1964
Echinococcus granulosus cysteine protease 0.0017 0.0081 0.0068
Trypanosoma cruzi major cysteine proteinase, putative 0.0099 0.1248 0.2133
Echinococcus multilocularis muscleblind protein 1 0.0319 0.4377 0.6872
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0508 0.0744
Loa Loa (eye worm) hypothetical protein 0.031 0.4239 0.4812
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0202 0.2711 0.4773
Mycobacterium ulcerans adenosine deaminase 0.028 0.3824 0.6724
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0027 0.0216 0.0319
Loa Loa (eye worm) hypothetical protein 0.0046 0.0489 0.0517
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0127 0.1644 0.2545
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0191 0.0191
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0055 0.0028
Schistosoma mansoni hypothetical protein 0.037 0.5099 0.9035
Brugia malayi isocitrate dehydrogenase 0.0015 0.0058 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0309 0.0309
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0389 0.0626
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Onchocerca volvulus 0.0033 0.0309 0.0272
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0138
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0421 0.0421
Echinococcus multilocularis protein dispatched 1 0.0052 0.0581 0.086
Trypanosoma cruzi adenosine monophosphate deaminase, putative 0.0091 0.1136 0.1933
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0174 0.0156
Loa Loa (eye worm) fibroinase 0.0033 0.0309 0.0311
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0634 0.0683
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.019 0.0271
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0893 0.1354
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0245 0.0398
Brugia malayi SET domain containing protein 0.0016 0.0072 0.004
Trichomonas vaginalis ran, putative 0.0023 0.0158 0.0158
Onchocerca volvulus Cathepsin L homolog 0.0033 0.0309 0.0272
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0032
Schistosoma mansoni cpg binding protein 0.0103 0.1302 0.2258
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.014 0.014
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0134 0.0153
Schistosoma mansoni adenosylhomocysteinase 0.0253 0.3428 0.6053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0389 0.0593
Trypanosoma cruzi AMP deaminase, putative 0.0091 0.1136 0.1933
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0097 0.0071
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0408 0.564 1
Loa Loa (eye worm) beta-lactamase 0.0039 0.0389 0.0402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0081 0.0081
Trypanosoma brucei AMP deaminase, putative 0.0091 0.1136 0.1933
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.0081 0.0041
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0134 0.0134
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1632 0.2821
Echinococcus multilocularis cysteine protease 0.0033 0.0309 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Onchocerca volvulus 0.003 0.0263 0.0226
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0295 0.0408
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0389 0.0526
Brugia malayi CXXC zinc finger family protein 0.0094 0.117 0.1298
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0295 0.1709
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0052 0.0576 0.0852
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0039 0.0003
Echinococcus multilocularis geminin 0.037 0.5099 0.8015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0389 0.0593
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0097 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.038 0.038
Brugia malayi Bromodomain containing protein 0.016 0.2115 0.238
Brugia malayi Cathepsin L-like precursor 0.0022 0.0153 0.0133
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0295 0.0463
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0295 0.0295
Brugia malayi Thioredoxin reductase 0.0093 0.1158 0.1283
Brugia malayi Cathepsin L-like precursor 0.0033 0.0309 0.0311
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0273 0.0373
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0389 0.0627
Mycobacterium tuberculosis Conserved protein 0.0039 0.0389 0.0593
Mycobacterium tuberculosis Conserved protein 0.0039 0.0389 0.0593
Brugia malayi SET domain containing protein 0.0015 0.0046 0.001
Trypanosoma cruzi AMP deaminase, putative 0.0091 0.1136 0.1933
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0295 0.0437
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0389 0.0389
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0245 0.1279
Echinococcus multilocularis mitogen activated protein kinase 0.01 0.1257 0.1931
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0058 0.0039
Entamoeba histolytica cysteine proteinase 2 0.0017 0.0081 0.0052
Onchocerca volvulus 0.0094 0.117 0.1137
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0309 0.0485
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.002 0.0128 0.0144
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0421 0.0421
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.068 0.115
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0508 0.0839
Plasmodium falciparum thioredoxin reductase 0.0032 0.0295 0.0437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Plasmodium vivax adenosine/AMP deaminase, putative 0.0091 0.1136 0.1961
Trypanosoma cruzi cysteine peptidase, putative 0.0126 0.1632 0.2821
Plasmodium falciparum importin beta, putative 0.0031 0.0273 0.0396
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0245 0.037
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0191 0.0191
Leishmania major S-adenosylhomocysteine hydrolase 0.0408 0.564 1
Echinococcus granulosus expressed conserved protein 0.01 0.1263 0.194
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.01 0.1257 0.2148
Loa Loa (eye worm) hypothetical protein 0.0056 0.0635 0.0685
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Leishmania major cathepsin L-like protease 0.0033 0.0309 0.045
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0805 0.0879
Echinococcus multilocularis AMP deaminase 2 0.0091 0.1136 0.174
Entamoeba histolytica hypothetical protein 0.0025 0.0191 0.0249
Echinococcus granulosus cpg binding protein 0.0103 0.1302 0.2003
Schistosoma mansoni bromodomain containing protein 0.0014 0.004 0.0004
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0097 0.0097
Mycobacterium ulcerans lipase LipD 0.0039 0.0389 0.0526
Leishmania major cysteine peptidase A (CPA) 0.0033 0.0309 0.045
Treponema pallidum NADH oxidase 0.0032 0.0295 0.0532
Plasmodium falciparum adenosylhomocysteinase 0.0408 0.564 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.019 0.0248
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0295 0.0437
Echinococcus granulosus snurportin 1 0.0327 0.448 0.7035
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0097 0.0068
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0295 0.0426
Echinococcus granulosus AMP deaminase 2 0.0091 0.1136 0.174
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0525 0.0558
Trichomonas vaginalis set domain proteins, putative 0.0715 0.9998 1
Plasmodium vivax glutathione reductase, putative 0.0093 0.1158 0.1999
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Loa Loa (eye worm) hypothetical protein 0.0039 0.0389 0.0402
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0055 0.0021
Onchocerca volvulus 0.0048 0.0524 0.0488
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0097 0.0082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0136 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Echinococcus granulosus cathepsin L cysteine proteinase 0.0033 0.0309 0.043
Schistosoma mansoni chromobox protein 0.0068 0.0805 0.1369
Plasmodium vivax vivapain-2 0.0033 0.0309 0.0483
Brugia malayi Cathepsin L-like precursor 0.0033 0.0309 0.0311
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0158 0.0218
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.6352 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0033 0.0309 0.043
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1488 0.1661
Schistosoma mansoni hypothetical protein 0.0044 0.0465 0.0764
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0055 0.0028
Brugia malayi Cathepsin L-like precursor 0.0033 0.0309 0.0311
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0525
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1346 0.2336
Trypanosoma brucei AMP deaminase, putative 0.0091 0.1136 0.1933
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0092 0.1144 0.1752
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0273 0.0423
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.018
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0525 0.0558
Trichomonas vaginalis helicase, putative 0.0021 0.014 0.014
Leishmania major trypanothione reductase 0.0093 0.1158 0.1971
Entamoeba histolytica hypothetical protein 0.0035 0.0341 0.0518
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1346 0.1499
Loa Loa (eye worm) hypothetical protein 0.0107 0.1355 0.1509
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.06 0.0891
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0295 0.0426
Loa Loa (eye worm) hypothetical protein 0.028 0.3824 0.4337
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.6352 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.0309 0.0311
Trypanosoma brucei ISWI complex protein 0.0032 0.0287 0.0411
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.01 0.1257 0.2148
Echinococcus granulosus chromobox protein 1 0.0068 0.0805 0.1215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Loa Loa (eye worm) adenosylhomocysteinase 0.0408 0.564 0.6416
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0295 0.0295
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1346 0.2317
Schistosoma mansoni ran 0.0023 0.0158 0.0215
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0097 0.0068
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0037 0.000000103
Onchocerca volvulus 0.0033 0.0309 0.0272
Mycobacterium ulcerans hypothetical protein 0.0039 0.0389 0.0526
Echinococcus granulosus bloom syndrome protein 0.0021 0.0134 0.0153
Schistosoma mansoni cathepsin F (C01 family) 0.0033 0.0309 0.0485
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0421 0.0385
Mycobacterium ulcerans beta-lactamase 0.0039 0.0389 0.0526
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0339 0.0537
Loa Loa (eye worm) hypothetical protein 0.0031 0.0273 0.027
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.06 0.0891
Giardia lamblia Kinase, CMGC MAPK 0.01 0.1257 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0033 0.0309 0.0311
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0408 0.564 0.5641
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0058 0.0039
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0341 0.048
Loa Loa (eye worm) histone methyltransferase 0.0032 0.0297 0.0297
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0097 0.0071
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0058 0.0023
Loa Loa (eye worm) hypothetical protein 0.0047 0.0508 0.0538
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0245 0.0245
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0037 0.000000103
Echinococcus granulosus GPCR family 2 0.0015 0.0055 0.0028
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0295 0.0426
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0091 0.1136 0.1259
Echinococcus granulosus zinc finger protein 0.0046 0.0489 0.0714
Plasmodium falciparum glutathione reductase 0.0093 0.1158 0.198
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0389 0.0389
Echinococcus granulosus cathepsin l1 0.0022 0.0153 0.0183
Brugia malayi Cathepsin L-like precursor 0.0022 0.0153 0.0133
Leishmania major AMP deaminase, putative,amp deaminase-like protein 0.0091 0.1136 0.1933
Entamoeba histolytica hypothetical protein 0.0035 0.0341 0.0518
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0052 0.0576 0.0961
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0032 0.0298 0.0298
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0081 0.0077
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0158 0.018
Schistosoma mansoni hypothetical protein 0.0043 0.0444 0.0725
Loa Loa (eye worm) hypothetical protein 0.0039 0.0389 0.0402
Brugia malayi phosphofructokinase 0.0106 0.1346 0.1499
Loa Loa (eye worm) hypothetical protein 0.0025 0.019 0.0175
Echinococcus granulosus adenosine deaminase 0.028 0.3824 0.5996
Toxoplasma gondii adenosylhomocysteinase, putative 0.0408 0.564 1
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0128 0.1659 0.1659
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0097 0.0095
Loa Loa (eye worm) cysteine protease 0.0033 0.0309 0.0311
Leishmania major cathepsin L-like protease 0.0033 0.0309 0.045
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0081 0.0041
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.1355 0.2086
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0805 0.0805
Brugia malayi Adenosine/AMP deaminase family protein 0.028 0.3824 0.4337
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0295 1
Entamoeba histolytica hypothetical protein 0.0035 0.0341 0.0518
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0489 0.0715
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.1068 0.1632
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0309 0.0311
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0129 0.1666 0.2579
Brugia malayi beta-lactamase family protein 0.0039 0.0389 0.0402
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0235 0.3184 0.5601
Onchocerca volvulus 0.0022 0.0153 0.0116
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1346 0.1823
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Entamoeba histolytica adenosine deaminase, putative 0.028 0.3824 0.6751
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0033 0.0309 0.0461
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0245 0.0347
Schistosoma mansoni zinc finger protein 0.0046 0.0489 0.0805
Schistosoma mansoni hypothetical protein 0.029 0.396 0.7003
Plasmodium falciparum cysteine proteinase falcipain 1 0.0017 0.0081 0.0052
Echinococcus multilocularis snurportin 1 0.0327 0.448 0.7035
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0295 0.0358
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.068 0.1018
Echinococcus multilocularis chromobox protein 1 0.0068 0.0805 0.1215
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0245 0.0374
Schistosoma mansoni cpg binding protein 0.0094 0.117 0.2022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0076 0.0069
Brugia malayi cathepsin L-like precursor 0.0022 0.0153 0.0133
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0298 0.0298
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.5512 0.867
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.0128 0.0162
Echinococcus granulosus adenosylhomocysteinase 0.0408 0.564 0.8872
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0297 0.0411
Echinococcus granulosus cathepsin l cysteine peptidase 0.0033 0.0309 0.043
Schistosoma mansoni hypothetical protein 0.0033 0.0308 0.0482
Loa Loa (eye worm) hypothetical protein 0.0033 0.0308 0.0309
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0805 0.0805
Toxoplasma gondii cathepsin CPL 0.0033 0.0309 0.0487
Schistosoma mansoni hypothetical protein 0.0032 0.0287 0.0446
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0389 0.0556
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0508 0.0472
Brugia malayi Uncoordinated protein 44 0.0014 0.0037 0.000000074496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.0081 0.0041
Loa Loa (eye worm) AMP deaminase 0.0091 0.1136 0.1259
Leishmania major hypothetical protein, conserved 0.0039 0.0389 0.0593
Onchocerca volvulus 0.0039 0.0389 0.0353
Loa Loa (eye worm) hypothetical protein 0.0039 0.0389 0.0402
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0389 0.0389
Schistosoma mansoni bromodomain containing protein 0.0136 0.1771 0.3095
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0389 0.0593
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.448 0.5088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Plasmodium falciparum AMP deaminase, putative 0.0091 0.1136 0.1942
Echinococcus granulosus importin subunit beta 1 0.0031 0.0273 0.0373
Brugia malayi Importin beta-1 subunit 0.0031 0.0273 0.027
Echinococcus multilocularis muscleblind protein 0.0319 0.4377 0.6872
Leishmania major hypothetical protein, conserved 0.0091 0.1136 0.1933
Echinococcus granulosus mitogen activated protein kinase 0.01 0.1257 0.1931
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0032
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.1355 0.2086
Plasmodium falciparum glutathione reductase 0.0032 0.0295 0.0437
Loa Loa (eye worm) hypothetical protein 0.0093 0.1166 0.1292
Entamoeba histolytica AMP deaminase, putative 0.0091 0.1136 0.1942
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0508 0.0744
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0408 0.564 1
Trichomonas vaginalis esterase, putative 0.0039 0.0389 0.0389
Leishmania major cathepsin L-like protease 0.0126 0.1632 0.2821
Loa Loa (eye worm) hypothetical protein 0.0189 0.2525 0.285
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0081 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0033 0.0309 0.0309
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.086 0.1302
Loa Loa (eye worm) hypothetical protein 0.0017 0.0074 0.0042
Entamoeba histolytica cysteine proteinase, putative 0.0033 0.0309 0.0461
Echinococcus granulosus mitogen activated protein kinase 3 0.01 0.1257 0.1931
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0524 0.0869
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0389 0.0627
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.06 0.1005
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.01 0.1257 0.2148
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.2848 0.5
Echinococcus multilocularis adenosine deaminase 0.028 0.3824 0.5996
Echinococcus granulosus mixed lineage leukemia protein mll 0.0027 0.0216 0.0283
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.2848 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0389 0.0402
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.6352 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0216 0.0283
Treponema pallidum adenosine deaminase 0.028 0.3824 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0295 0.0426
Loa Loa (eye worm) hypothetical protein 0.0014 0.0039 0.0002
Leishmania major AMP deaminase, putative,adenosine monophosphate deaminase-like protein 0.0091 0.1136 0.1933
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0033 0.0309 0.0309
Schistosoma mansoni adenosylhomocysteinase 0.0253 0.3428 0.6053
Loa Loa (eye worm) CHromoDomain protein family member 0.002 0.0128 0.0104
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0295 0.0295
Echinococcus multilocularis protein patched 0.0046 0.0489 0.0715
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.038 0.038
Brugia malayi hypothetical protein 0.0119 0.1527 0.1706
Trypanosoma cruzi AMP deaminase, putative 0.0091 0.1136 0.1933
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Onchocerca volvulus 0.0103 0.1302 0.1269
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.0081 0.0077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0893 0.1354
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0033 0.0309 0.0461
Entamoeba histolytica AMP deaminase, putative 0.0091 0.1136 0.1942
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.068 0.1052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0524 0.0557
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0389 0.0593
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.06 0.0891
Loa Loa (eye worm) hypothetical protein 0.0054 0.06 0.0645
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0072 0.0061
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0235 0.3184 0.5601
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.038 0.0344
Entamoeba histolytica cysteine protease, putative 0.0017 0.0081 0.0052
Echinococcus multilocularis zinc finger protein 0.0046 0.0489 0.0714
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0174 0.0156
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0295 0.0459
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.086 0.1302
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0127 0.1644 0.2868
Schistosoma mansoni adenosylhomocysteinase 0.0253 0.3428 0.6053
Schistosoma mansoni AMP deaminase 0.0091 0.1136 0.1962
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0634 0.0944
Onchocerca volvulus 0.0033 0.0309 0.0272
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0408 0.564 1
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1346 0.1499
Loa Loa (eye worm) hypothetical protein 0.0039 0.0389 0.0402
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.1158 0.1971
Schistosoma mansoni hypothetical protein 0.0399 0.5512 0.9773
Loa Loa (eye worm) hypothetical protein 0.0127 0.1644 0.184
Echinococcus granulosus muscleblind protein 0.0319 0.4377 0.6872
Mycobacterium tuberculosis Probable oxidoreductase 0.0235 0.3184 0.5601
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0098 0.0084
Onchocerca volvulus 0.0015 0.0046 0.0009
Trichomonas vaginalis CMGC family protein kinase 0.01 0.1257 0.1257
Toxoplasma gondii exonuclease III APE 0.0018 0.0097 0.0109
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0489 0.0715
Echinococcus multilocularis cathepsin L 0.0017 0.0081 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0126 0.1632 0.2821
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1346 0.2308
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0058 0.0032
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0295 0.0426
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0389 0.0593
Trypanosoma cruzi AMP deaminase, putative 0.0091 0.1136 0.1933
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.0081 0.0068
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0158 0.0191
Brugia malayi 6-phosphofructokinase 0.0106 0.1346 0.1499
Schistosoma mansoni adenosylhomocysteinase 0.0408 0.564 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0032 0.0298 0.0298
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0295 0.0426
Loa Loa (eye worm) ctsf protein 0.0033 0.0309 0.0311
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0033 0.0309 0.0309
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1346 0.2317

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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