Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | glyceraldehyde-3-phosphate dehydrogenase | 0.2252 | 0.8573 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Trypanosoma brucei | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.1439 | 0.5464 | 0.9454 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.0428 | 0.0741 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0075 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0075 | 0.0129 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0506 | 0.0591 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH2 | 0.2252 | 0.8573 | 1 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0735 | 0.0858 |
Brugia malayi | steroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.1439 | 0.5464 | 0.5979 |
Loa Loa (eye worm) | steroid hormone receptor | 0.001 | 0.0002 | 0.0003 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0.0002 | 0.002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.0813 | 0.3073 | 0.2886 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0.0002 | 0.002 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.001 | 0.0002 | 0.0002 |
Mycobacterium ulcerans | glyceraldehyde 3-phosphate dehydrogenase Gap | 0.2252 | 0.8573 | 0.5 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0735 | 0.1272 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Brugia malayi | nuclear receptor NHR-88 | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.021 | 0.0245 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.021 | 0.0245 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.023 | 0.0842 | 1 | |
Echinococcus granulosus | glyceraldehyde 3 phosphate dehydrogenase | 0.1439 | 0.5464 | 0.6374 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0142 | 0.0506 | 0.0591 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.0428 | 0.0741 |
Brugia malayi | RNA binding protein | 0.0064 | 0.021 | 0.0245 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.001 | 0.0002 | 0.0002 |
Mycobacterium tuberculosis | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0708 | 0.2672 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | glyceraldehyde-3-phosphate dehydrogenase, GapA | 0.2252 | 0.8573 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0071 | 0.0083 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.001 | 0.0002 | 0.0002 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0075 | 0.0087 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.1522 | 0.578 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.1439 | 0.5464 | 0.5979 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.001 | 0.0002 | 0.0003 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.021 | 0.0245 |
Plasmodium vivax | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.021 | 0.0364 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.001 | 0.0002 | 0.0003 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.021 | 0.0364 |
Loa Loa (eye worm) | glyceraldehyde 3-phosphate dehydrogenase | 0.1439 | 0.5464 | 0.9454 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0506 | 0.0591 |
Onchocerca volvulus | 0.001 | 0.0002 | 0.002 | |
Treponema pallidum | glyceraldehyde 3-phosphate dehydrogenase (gap) | 0.2252 | 0.8573 | 0.5 |
Plasmodium falciparum | glyceraldehyde-3-phosphate dehydrogenase | 0.2252 | 0.8573 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.021 | 0.0364 |
Toxoplasma gondii | glyceraldehyde-3-phosphate dehydrogenase GAPDH1 | 0.2252 | 0.8573 | 1 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | glyceraldehyde 3-phosphate dehydrogenase | 0.0731 | 0.2757 | 0.3216 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.021 | 0.0245 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0075 | 0.0087 |
Schistosoma mansoni | coup transcription factor | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | FTZ F1 alpha | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0142 | 0.0506 | 0.0876 |
Trypanosoma cruzi | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2626 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.001 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0029 | 0.0075 | 0.0889 | |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Mycobacterium leprae | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH) | 0.0708 | 0.2672 | 0.5 |
Giardia lamblia | Glyceraldehyde 3-phosphate dehydrogenase | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.1439 | 0.5464 | 0.9454 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.001 | 0.0002 | 0.0002 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0075 | 0.0087 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | FTZ F1 alpha | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.001 | 0.0002 | 0.0003 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.0428 | 0.05 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.001 | 0.0002 | 0.0002 |
Brugia malayi | ecdysteroid receptor | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0142 | 0.0506 | 0.0591 |
Schistosoma mansoni | thyroid hormone receptor | 0.001 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.001 | 0.0002 | 0.0003 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0142 | 0.0506 | 0.0591 |
Loa Loa (eye worm) | glyceraldehyde-3-phosphate dehydrogenase | 0.1522 | 0.578 | 1 |
Brugia malayi | nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0142 | 0.0506 | 0.0591 |
Entamoeba histolytica | glyceraldehyde-3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0075 | 0.0087 |
Brugia malayi | Glyceraldehyde 3-phosphate dehydrogenase | 0.0813 | 0.3073 | 0.3584 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0075 | 0.0087 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.021 | 0.0245 |
Trichomonas vaginalis | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.001 | 0.0002 | 0.0002 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, putative | 0.2252 | 0.8573 | 0.803 |
Trypanosoma cruzi | glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative | 0.2252 | 0.8573 | 0.803 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.001 | 0.0002 | 0.0002 |
Echinococcus multilocularis | glyceraldehyde 3 phosphate dehydrogenase | 0.1439 | 0.5464 | 0.6374 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0.0002 | 0.002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.