Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1166 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1166 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0571 | 0.3968 | 0.5946 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0267 | 0.0886 | 0.0886 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0485 | 0.3093 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0485 | 0.3093 | 0.3093 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0447 | 0.2706 | 0.2706 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0447 | 0.2706 | 0.4054 |
Plasmodium vivax | vivapain-2 | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0838 | 0.6674 | 0.6674 |
Echinococcus multilocularis | cathepsin b | 0.1166 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0702 | 0.5298 | 0.5298 |
Echinococcus granulosus | cathepsin L | 0.0447 | 0.2706 | 0.2706 |
Echinococcus multilocularis | cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0886 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0069 | 0.0069 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0447 | 0.2706 | 0.2706 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0267 | 0.0886 | 0.0886 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | fibroinase | 0.0838 | 0.6674 | 0.6674 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Echinococcus multilocularis | cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Loa Loa (eye worm) | cathepsin B | 0.0485 | 0.3093 | 0.3093 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0838 | 0.6674 | 0.6674 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0838 | 0.6674 | 1 |
Brugia malayi | hypothetical protein | 0.0228 | 0.0495 | 0.0495 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0186 | 0.0069 | 0.0069 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 0.0495 | 0.0495 |
Leishmania major | cysteine peptidase A (CPA) | 0.0838 | 0.6674 | 1 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0267 | 0.0886 | 0.0886 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.3838 | 0.3838 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.3968 | 0.3968 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0838 | 0.6674 | 0.6674 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0267 | 0.0886 | 0.0886 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0447 | 0.2706 | 0.2706 |
Plasmodium vivax | vivapain-3 | 0.0447 | 0.2706 | 0.4054 |
Onchocerca volvulus | Cathepsin F homolog | 0.0838 | 0.6674 | 1 |
Echinococcus granulosus | cathepsin b | 0.1166 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0571 | 0.3968 | 0.5946 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0447 | 0.2706 | 0.4054 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0838 | 0.6674 | 0.6674 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1166 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0186 | 0.0069 | 0.0069 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0485 | 0.3093 | 0.3093 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0485 | 0.3093 | 0.0976 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0267 | 0.0886 | 0.0886 |
Plasmodium vivax | vivapain-1 | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0571 | 0.3968 | 0.3968 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.2706 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.3968 | 0.3968 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0447 | 0.2706 | 0.2706 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1166 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0447 | 0.2706 | 0.2706 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0838 | 0.6674 | 0.6674 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0186 | 0.0069 | 0.0069 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0643 | 0.4699 | 0.4699 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0366 | 0.189 | 0.189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0267 | 0.0886 | 0.0886 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0601 | 0.427 | 0.6399 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0447 | 0.2706 | 0.2706 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0571 | 0.3968 | 0.5946 |
Entamoeba histolytica | cysteine protease, putative | 0.0838 | 0.6674 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0447 | 0.2706 | 0.2706 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0838 | 0.6674 | 0.6674 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Brugia malayi | Cathepsin L-like precursor | 0.0571 | 0.3968 | 0.3968 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Onchocerca volvulus | Cathepsin L homolog | 0.0838 | 0.6674 | 1 |
Toxoplasma gondii | cathepsin B | 0.0485 | 0.3093 | 0.4634 |
Loa Loa (eye worm) | ctsf protein | 0.0838 | 0.6674 | 0.6674 |
Echinococcus multilocularis | cathepsin L | 0.0447 | 0.2706 | 0.2706 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0571 | 0.3968 | 0.3968 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0643 | 0.4699 | 0.4699 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0447 | 0.2706 | 0.4054 |
Giardia lamblia | Cathepsin B precursor | 0.0485 | 0.3093 | 1 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Onchocerca volvulus | 0.0571 | 0.3968 | 0.5946 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0571 | 0.3968 | 0.3968 |
Plasmodium vivax | unspecified product | 0.0267 | 0.0886 | 0.1328 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0886 | 0.0886 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0601 | 0.427 | 0.6399 |
Echinococcus multilocularis | tumor protein p63 | 0.0366 | 0.189 | 0.189 |
Loa Loa (eye worm) | hypothetical protein | 0.0571 | 0.3968 | 0.3968 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0447 | 0.2706 | 0.2706 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0643 | 0.4699 | 0.4699 |
Loa Loa (eye worm) | hypothetical protein | 0.0838 | 0.6674 | 0.6674 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Echinococcus granulosus | cathepsin l1 | 0.0571 | 0.3968 | 0.3968 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 0.0495 | 0.0495 |
Schistosoma mansoni | cathepsin s | 0.0267 | 0.0886 | 0.0886 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1166 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.1166 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0838 | 0.6674 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0643 | 0.4699 | 0.4699 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0886 | 0.0886 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0838 | 0.6674 | 0.6674 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Plasmodium vivax | vivapain-2 | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0485 | 0.3093 | 0.4634 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0447 | 0.2706 | 0.2706 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Toxoplasma gondii | cathepsin CPL | 0.0838 | 0.6674 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0571 | 0.3968 | 0.3968 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0702 | 0.5298 | 0.5298 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0838 | 0.6674 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.2706 |
Leishmania major | cathepsin L-like protease | 0.0838 | 0.6674 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0838 | 0.6674 | 0.6674 |
Giardia lamblia | Cathepsin B precursor | 0.0485 | 0.3093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1166 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0447 | 0.2706 | 0.4054 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0571 | 0.3968 | 0.3968 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0838 | 0.6674 | 0.6674 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0838 | 0.6674 | 1 |
Onchocerca volvulus | 0.0838 | 0.6674 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0447 | 0.2706 | 0.4054 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0186 | 0.0069 | 0.0069 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 0.0495 | 0.0495 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Echinococcus multilocularis | cathepsin b | 0.1166 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0447 | 0.2706 | 0.2706 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0838 | 0.6674 | 0.6674 |
Plasmodium vivax | unspecified product | 0.0447 | 0.2706 | 0.4054 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 29 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.