TDR Targets

Basic information

Technical information

TDR Targets ID: 1043337
Name: 5,7-dihydroxy-8-methoxy-2-(2-methoxyphenyl)ch romen-4-one
MW: 314.289 | Formula: C17H14O6
H donors: 2 H acceptors: 3 LogP: 2.96 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1c1cc(=O)c2c(o1)c(OC)c(cc2O)O
InChi: 1S/C17H14O6/c1-21-13-6-4-3-5-9(13)14-8-11(19)15-10(18)7-12(20)16(22-2)17(15)23-14/h3-8,18,20H,1-2H3
InChiKey: YHZJRFKTTMDPDF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5,7-dihydroxy-8-methoxy-2-(2-methoxyphenyl)-4-chromenone
5,7-dihydroxy-8-methoxy-2-(2-methoxyphenyl)chromone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	Cathepsin L-like precursor	0.0578	0.3995	0.3995
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.027	0.0801	0.0801
Loa Loa (eye worm)	hypothetical protein	0.027	0.0801	0.0801
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0848	0.6806	0.6806
Loa Loa (eye worm)	cathepsin B	0.0482	0.3005	0.3005
Giardia lamblia	Cathepsin B precursor	0.0482	0.3005	0.5
Loa Loa (eye worm)	hypothetical protein	0.027	0.0801	0.0801
Entamoeba histolytica	cysteine proteinase, putative	0.0848	0.6806	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0848	0.6806	0.6528
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1156	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1156	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0848	0.6806	0.6806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Loa Loa (eye worm)	hypothetical protein	0.0848	0.6806	0.6806
Onchocerca volvulus		0.0848	0.6806	1
Echinococcus granulosus	cathepsin L	0.0452	0.2683	0.2683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0452	0.2683	0.2683
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Echinococcus multilocularis	cysteine protease	0.0848	0.6806	0.6806
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0452	0.2683	0.2683
Echinococcus multilocularis	cathepsin L cysteine protease	0.0848	0.6806	0.6806
Onchocerca volvulus	Cathepsin L homolog	0.0848	0.6806	1
Onchocerca volvulus		0.0848	0.6806	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1156	1	1
Echinococcus granulosus	cysteine protease	0.0452	0.2683	0.2683
Schistosoma mansoni	voltage-gated potassium channel	0.0729	0.5565	0.5565
Plasmodium vivax	vivapain-2	0.0848	0.6806	1
Loa Loa (eye worm)	cysteine protease	0.0848	0.6806	0.6806
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Echinococcus granulosus	cathepsin l1	0.0578	0.3995	0.3995
Schistosoma mansoni	cathepsin F (C01 family)	0.0848	0.6806	0.6806
Plasmodium vivax	vivapain-3	0.0452	0.2683	0.3135
Echinococcus multilocularis	cathepsin L	0.0452	0.2683	0.2683
Giardia lamblia	Cathepsin B precursor	0.0482	0.3005	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0848	0.6806	0.6806
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Entamoeba histolytica	cysteine proteinase, putative	0.0848	0.6806	1
Plasmodium vivax	unspecified product	0.0452	0.2683	0.3135
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0482	0.3005	0.0779
Onchocerca volvulus	Cathepsin F homolog	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0482	0.3005	0.0779
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Entamoeba histolytica	cysteine protease, putative	0.0848	0.6806	1
Echinococcus multilocularis	cysteine protease	0.0848	0.6806	0.6806
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Loa Loa (eye worm)	hypothetical protein	0.0578	0.3995	0.3995
Brugia malayi	Cathepsin L-like precursor	0.027	0.0801	0.0801
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Echinococcus granulosus	cathepsin b	0.1156	1	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Echinococcus multilocularis	cathepsin b	0.1156	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0578	0.3995	0.3182
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0624	0.4471	0.4336
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Trypanosoma cruzi	cysteine protease, putative	0.0452	0.2683	0.2046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Toxoplasma gondii	cathepsin CPL	0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0452	0.2683	0.2046
Loa Loa (eye worm)	hypothetical protein	0.0578	0.3995	0.3995
Onchocerca volvulus		0.0848	0.6806	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.027	0.0801	0.0801
Echinococcus multilocularis	cathepsin b	0.1156	1	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0848	0.6806	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0848	0.6806	0.6806
Loa Loa (eye worm)	hypothetical protein	0.027	0.0801	0.0801
Loa Loa (eye worm)	fibroinase	0.0848	0.6806	0.6806
Schistosoma mansoni	cathepsin F (C01 family)	0.0578	0.3995	0.3995
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0848	0.6806	0.6806
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0667	0.4927	0.4927
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.027	0.0801	0.0801
Loa Loa (eye worm)	ctsf protein	0.0848	0.6806	0.6806
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0578	0.3995	0.3472
Entamoeba histolytica	cysteine proteinase, putative	0.0578	0.3995	0.3182
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0848	0.6806	0.6806
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0848	0.6806	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0452	0.2683	0.2683
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0848	0.6806	0.6806
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Brugia malayi	cathepsin L-like precursor	0.0578	0.3995	0.3995
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0624	0.4471	0.4336
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0452	0.2683	0.2046
Loa Loa (eye worm)	hypothetical protein	0.0578	0.3995	0.3995
Loa Loa (eye worm)	hypothetical protein	0.0579	0.4011	0.4011
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Plasmodium vivax	vivapain-2	0.0848	0.6806	1
Giardia lamblia	Cathepsin B precursor	0.0482	0.3005	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Leishmania major	cysteine peptidase A (CPA)	0.0848	0.6806	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0667	0.4927	0.4927
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0482	0.3005	0.3005
Plasmodium vivax	vivapain-1	0.0452	0.2683	0.3135
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Echinococcus granulosus	cathepsin l1	0.0848	0.6806	0.6806
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0667	0.4927	0.4927
Onchocerca volvulus		0.0848	0.6806	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0848	0.6806	0.6806
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Onchocerca volvulus		0.0848	0.6806	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0452	0.2683	0.2683
Onchocerca volvulus	Cathepsin L homolog	0.0848	0.6806	1
Brugia malayi	Cathepsin L-like precursor	0.0578	0.3995	0.3995
Onchocerca volvulus		0.0848	0.6806	1
Onchocerca volvulus		0.0848	0.6806	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0667	0.4927	0.4927
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Echinococcus granulosus	cathepsin b	0.1156	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1156	1	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Brugia malayi	Papain family cysteine protease containing protein	0.0848	0.6806	0.6806
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0578	0.3995	0.3995
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Brugia malayi	Cathepsin L-like precursor	0.0848	0.6806	0.6806
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0482	0.3005	0.2396
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1156	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0452	0.2683	0.2046
Trypanosoma cruzi	cysteine proteinase, putative	0.0452	0.2683	0.2046
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Brugia malayi	Papain family cysteine protease containing protein	0.0452	0.2683	0.2683
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Loa Loa (eye worm)	hypothetical protein	0.1156	1	1
Schistosoma mansoni	cathepsin s	0.027	0.0801	0.0801
Trypanosoma cruzi	cysteine peptidase, putative	0.0848	0.6806	0.6528
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0848	0.6806	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0578	0.3995	0.3182
Schistosoma mansoni	voltage-gated potassium channel	0.0729	0.5565	0.5565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0848	0.6806	1
Leishmania major	cathepsin L-like protease	0.0848	0.6806	1
Brugia malayi	Papain family cysteine protease containing protein	0.0452	0.2683	0.2683

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL549356

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1043337