TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 703.733 | Formula: C34H45N3O13
H donors: 5 H acceptors: 9 LogP: 3.76 Rotable bonds: 25
Rule of 5 violations (Lipinski): 2
SMILES: COCCC(C(=O)O)CN(C(=O)C(=O)O)c1ccc(cc1)CC(C(=O)NCCCCOc1cccc(c1C(=O)OC)O)NC(=O)OC(C)(C)C
InChi: 1S/C34H45N3O13/c1-34(2,3)50-33(46)36-24(28(39)35-16-6-7-17-49-26-10-8-9-25(38)27(26)32(45)48-5)19-21-11-13-23(14-12-21)37(29(40)31(43)44)20-22(30(41)42)15-18-47-4/h8-14,22,24,38H,6-7,15-20H2,1-5H3,(H,35,39)(H,36,46)(H,41,42)(H,43,44)
InChiKey: BCGYMXXGBPUVOR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein tyrosine phosphatase, non-receptor type 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma japonicum	expressed protein	Get druggable targets OG5_133865	All targets in OG5_133865
Brugia malayi	Protein-tyrosine phosphatase containing protein	Get druggable targets OG5_133865	All targets in OG5_133865
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	Get druggable targets OG5_133865	All targets in OG5_133865
Loa Loa (eye worm)	protein-tyrosine phosphatase	Get druggable targets OG5_133865	All targets in OG5_133865

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase, putative	0.0423	0.2634	0.4054
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0423	0.2633	0.2633
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0423	0.2634	0.2623
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0171	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0541	0.3856	0.5946
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0794	0.6475	0.6475
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Onchocerca volvulus		0.0794	0.6475	1
Loa Loa (eye worm)	hypothetical protein	0.0507	0.3503	0.3503
Brugia malayi	Papain family cysteine protease containing protein	0.0171	0.0015	0.0015
Brugia malayi	Cathepsin L-like precursor	0.0253	0.0863	0.0863
Leishmania major	cysteine peptidase A (CPA)	0.0794	0.6475	1
Schistosoma mansoni	cathepsin s	0.0253	0.0863	0.0863
Schistosoma mansoni	cathepsin B (C01 family)	0.0171	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Brugia malayi	Cathepsin L-like precursor	0.0794	0.6475	0.6475
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0794	0.6475	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.0015	0.0015
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Onchocerca volvulus	Cathepsin F homolog	0.0794	0.6475	1
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0863	0.0863
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0171	0.0015	0.0015
Schistosoma mansoni	cathepsin S (C01 family)	0.0171	0.0015	0.0015
Echinococcus granulosus	cathepsin L	0.0171	0.0015	0.0015
Brugia malayi	cathepsin L-like cysteine proteinase	0.0171	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0469	0.3103	0.3093
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.0015	0.0015
Entamoeba histolytica	cysteine proteinase, putative	0.0541	0.3856	0.5946
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Onchocerca volvulus		0.0794	0.6475	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0171	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0423	0.2634	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0253	0.0863	0.0849
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Giardia lamblia	Cathepsin B precursor	0.0469	0.3103	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0794	0.6475	0.6475
Onchocerca volvulus		0.0794	0.6475	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0171	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0469	0.3103	0.4781
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0171	0.0015	0.0015
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1134	1	1
Toxoplasma gondii	cathepsin CPL	0.0794	0.6475	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.6475	0.6469
Echinococcus granulosus	cathepsin L	0.0423	0.2634	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0541	0.3856	0.3856
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Echinococcus granulosus	cathepsin b	0.1134	1	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0015	0.0015
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0423	0.2633	0.2633
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0171	0.0015	0.0015
Giardia lamblia	Cathepsin B precursor	0.0469	0.3103	1
Giardia lamblia	Cathepsin B precursor	0.0469	0.3103	1
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0863	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0794	0.6475	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.6475	0.6469
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0794	0.6475	1
Echinococcus granulosus	cathepsin l1	0.0794	0.6475	0.6475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0541	0.3856	0.5946
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.6475	0.6469
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0171	0.0015	0.0015
Brugia malayi	cathepsin F-like cysteine proteinase	0.0171	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.1134	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Echinococcus granulosus	cysteine protease	0.0423	0.2634	0.2634
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0171	0.0015	0.0015
Echinococcus multilocularis	cathepsin b	0.1134	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0794	0.6475	0.6475
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0171	0.0015	0.0015
Plasmodium vivax	vivapain-2	0.0794	0.6475	1
Loa Loa (eye worm)	ctsf protein	0.0794	0.6475	0.6475
Loa Loa (eye worm)	cysteine protease	0.0794	0.6475	0.6475
Plasmodium vivax	vivapain-3	0.0423	0.2634	0.4054
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0423	0.2633	0.2633
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0423	0.2633	0.2633
Echinococcus multilocularis	cathepsin L cysteine protease	0.0794	0.6475	0.6475
Brugia malayi	fibroinase precursor	0.0171	0.0015	0.0015
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0253	0.0863	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0794	0.6475	0.6475
Schistosoma mansoni	voltage-gated potassium channel	0.0638	0.486	0.486
Brugia malayi	Papain family cysteine protease containing protein	0.0423	0.2634	0.2634
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1134	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0794	0.6475	0.6469
Entamoeba histolytica	cysteine protease, putative	0.0794	0.6475	1
Loa Loa (eye worm)	hypothetical protein	0.0794	0.6475	0.6475
Entamoeba histolytica	cysteine proteinase 1, putative	0.0423	0.2634	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0423	0.2634	0.2634
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0469	0.3103	0.3103
Entamoeba histolytica	cysteine proteinase, putative	0.0423	0.2634	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Entamoeba histolytica	cysteine proteinase, putative	0.0794	0.6475	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0794	0.6475	0.6475
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0794	0.6475	0.6475
Schistosoma mansoni	cathepsin F (C01 family)	0.0794	0.6475	0.6475
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0863	0.0863
Brugia malayi	Cathepsin L-like precursor	0.0794	0.6475	0.6475
Entamoeba histolytica	cysteine proteinase, putative	0.0423	0.2634	0.4054
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0584	0.4304	0.4304
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Onchocerca volvulus	Cathepsin L homolog	0.0794	0.6475	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1134	1	1
Echinococcus multilocularis	cathepsin b	0.1134	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0253	0.0863	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0015	0.0015
Echinococcus multilocularis	cathepsin L	0.0171	0.0015	0.0015
Schistosoma mansoni	cathepsin C	0.0171	0.0015	0.0015
Schistosoma mansoni	cathepsin F (C01 family)	0.0541	0.3856	0.3856
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0015	0.0015
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0794	0.6475	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0584	0.4304	0.4304
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0794	0.6475	0.6475
Brugia malayi	Papain family cysteine protease containing protein	0.0423	0.2634	0.2634
Onchocerca volvulus		0.0794	0.6475	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0423	0.2634	0.2623
Echinococcus granulosus	cathepsin b	0.1134	1	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0794	0.6475	0.6475
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Brugia malayi	cathepsin L precursor	0.0171	0.0015	0.0015
Plasmodium vivax	unspecified product	0.0253	0.0863	0.1313
Brugia malayi	Cathepsin L-like precursor	0.0794	0.6475	0.6475
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Brugia malayi	Cathepsin L-like precursor	0.0541	0.3856	0.3856
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.0015	0.0015
Brugia malayi	Papain family cysteine protease containing protein	0.0171	0.0015	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0423	0.2634	0.4054
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0469	0.3103	0.1222
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1134	1	1
Onchocerca volvulus		0.0794	0.6475	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0423	0.2634	0.4054
Schistosoma mansoni	voltage-gated potassium channel	0.0638	0.486	0.486
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Onchocerca volvulus		0.0541	0.3856	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0794	0.6475	0.6475
Trypanosoma cruzi	cruzipain precursor, putative	0.0794	0.6475	0.6469
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0423	0.2633	0.2633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Onchocerca volvulus	Cathepsin L homolog	0.0794	0.6475	1
Echinococcus multilocularis	cysteine protease	0.0794	0.6475	0.6475
Entamoeba histolytica	cysteine proteinase, putative	0.0794	0.6475	1
Trypanosoma cruzi	cysteine protease, putative	0.0423	0.2634	0.2623
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0794	0.6475	0.6475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0541	0.3856	0.3856
Trypanosoma cruzi	cysteine proteinase, putative	0.0423	0.2634	0.2623
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0794	0.6475	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0546	0.3905	0.6022
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0423	0.2634	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0584	0.4304	0.4304
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0171	0.0015	0.0015
Plasmodium vivax	vivapain-2	0.0794	0.6475	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0794	0.6475	1
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Echinococcus multilocularis	cathepsin L	0.0423	0.2634	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0015	0.0015
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0794	0.6475	0.6475
Onchocerca volvulus		0.0794	0.6475	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1134	1	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0423	0.2634	0.2623
Brugia malayi	Cathepsin L-like precursor	0.0541	0.3856	0.3856
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Loa Loa (eye worm)	hypothetical protein	0.0171	0.0015	0.0015
Plasmodium vivax	unspecified product	0.0423	0.2634	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0423	0.2634	0.2634
Loa Loa (eye worm)	hypothetical protein	0.0541	0.3856	0.3856
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0546	0.3905	0.6022
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0253	0.0863	0.0863
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0253	0.0863	0.0863
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0794	0.6475	1
Brugia malayi	cathepsin L-like precursor	0.0541	0.3856	0.3856
Echinococcus granulosus	cathepsin l1	0.0541	0.3856	0.3856
Echinococcus multilocularis	cysteine protease	0.0794	0.6475	0.6475
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0423	0.2634	0.2634
Toxoplasma gondii	cathepsin B	0.0469	0.3103	0.4781
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0584	0.4304	0.4304
Leishmania major	cathepsin L-like protease	0.0794	0.6475	1
Entamoeba histolytica	cysteine protease, putative	0.0423	0.2634	0.4054
Entamoeba histolytica	cysteine proteinase 2	0.0423	0.2634	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0794	0.6475	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0171	0.0015	0.0015
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0541	0.3856	0.3847
Plasmodium vivax	vivapain-1	0.0423	0.2634	0.4054
Loa Loa (eye worm)	fibroinase	0.0794	0.6475	0.6475
Loa Loa (eye worm)	cathepsin B	0.0469	0.3103	0.3103
Brugia malayi	Cathepsin L-like precursor	0.0794	0.6475	0.6475
Onchocerca volvulus		0.0794	0.6475	1
Loa Loa (eye worm)	hypothetical protein	0.0541	0.3856	0.3856
Brugia malayi	Papain family cysteine protease containing protein	0.0171	0.0015	0.0015
Echinococcus granulosus	cathepsin L cysteine protease	0.0423	0.2634	0.2634

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 5.1	Inhibition of PTP1B	ChEMBL.	19385614

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL553907

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1047726