Detailed information for compound 1048876

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 378.363 | Formula: C20H18F4N2O
  • H donors: 0 H acceptors: 1 LogP: 3.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCN(CC1)Cc1ccc(c(c1)F)F)/C=C/c1c(F)cccc1F
  • InChi: 1S/C20H18F4N2O/c21-16-2-1-3-17(22)15(16)5-7-20(27)26-10-8-25(9-11-26)13-14-4-6-18(23)19(24)12-14/h1-7,12H,8-11,13H2/b7-5+
  • InChiKey: WCNQDAWLEHCLNB-FNORWQNLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0085 0.0332 0.1067
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0065 0.0217
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0232 0.0778
Echinococcus multilocularis 0.0089 0.0359 0.116
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0534 0.2996 1
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Plasmodium falciparum plasmepsin X 0.0091 0.0368 0.123
Loa Loa (eye worm) TK/INSR protein kinase 0.0093 0.0383 0.1277
Brugia malayi TAR-binding protein 0.0072 0.0256 0.0855
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0056 0.0143
Plasmodium falciparum plasmepsin I 0.0164 0.0804 0.2682
Brugia malayi hypothetical protein 0.0035 0.0037 0.0125
Brugia malayi ribonucleotide reductase 2 0.0137 0.0645 0.2153
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0091 0.0368 0.123
Brugia malayi flavodoxin family protein 0.0032 0.0022 0.0075
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0019 0.002
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0044 0.0091 0.0053
Schistosoma mansoni cathepsin D (A01 family) 0.0351 0.1914 0.1884
Loa Loa (eye worm) hypothetical protein 0.0091 0.0368 0.123
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0534 0.2996 1
Toxoplasma gondii aspartyl protease ASP3 0.0091 0.0368 0.123
Giardia lamblia Hypothetical protein 0.0075 0.0275 0.5
Onchocerca volvulus 0.0149 0.0714 1
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0236 0.0787
Echinococcus multilocularis glutamate receptor 2 0.004 0.0065 0.0173
Brugia malayi Eukaryotic aspartyl protease family protein 0.0091 0.0368 0.123
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0534 0.2996 1
Plasmodium vivax ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Echinococcus granulosus aminopeptidase N 0.0149 0.0714 0.2348
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain) 0.0137 0.0645 0.2046
Brugia malayi Peptidase family M1 containing protein 0.0068 0.0232 0.0773
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0164 0.0804 0.2682
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0486 0.2714 1
Echinococcus granulosus tyrosine kinase 0.0034 0.0035 0.0072
Echinococcus multilocularis epidermal growth factor receptor 0.0289 0.1545 0.5134
Schistosoma mansoni cathepsin D (A01 family) 0.0351 0.1914 0.1884
Plasmodium falciparum plasmepsin VII 0.0091 0.0368 0.123
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0035 0.0072
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0065 0.0028
Plasmodium vivax subtilisin-like protease 1 0.0357 0.1947 0.6499
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.2153
Schistosoma mansoni NADPH flavin oxidoreductase 0.0043 0.0083 0.0046
Loa Loa (eye worm) flavodoxin family protein 0.0032 0.0022 0.0075
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0087 0.0246
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0085 0.0332 0.1067
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0047 0.0107 0.0356
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Toxoplasma gondii ribonucleoside-diphosphate reductase small subunit 0.0137 0.0645 0.2153
Plasmodium vivax aspartyl proteinase, putative 0.0091 0.0368 0.123
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0085 0.0332 0.1107
Echinococcus multilocularis glutamate receptor 2 0.0043 0.0087 0.0246
Plasmodium vivax aspartyl protease, putative 0.0091 0.0368 0.123
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0087 0.0246
Brugia malayi hypothetical protein 0.0091 0.0368 0.123
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0534 0.2996 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0038 0.0054 0.0135
Plasmodium falciparum plasmepsin III 0.0091 0.0368 0.123
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0035 0.0072
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0093 0.0383 0.1238
Trypanosoma brucei trypanothione synthetase 0.0068 0.0236 0.0787
Echinococcus granulosus nmda type glutamate receptor 0.0038 0.0054 0.0135
Echinococcus granulosus glutamate NMDA receptor subunit 0.004 0.0065 0.0173
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0056 0.0143
Echinococcus granulosus tar DNA binding protein 0.0072 0.0256 0.0814
Plasmodium falciparum plasmepsin IV 0.0164 0.0804 0.2682
Loa Loa (eye worm) hypothetical protein 0.0091 0.0368 0.123
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0085 0.0332 0.1107
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0486 0.2714 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Echinococcus multilocularis methionine synthase reductase 0.0052 0.014 0.0425
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0037 0.0081
Brugia malayi FAD binding domain containing protein 0.0085 0.0332 0.1107
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Trypanosoma cruzi Aminopeptidase M1, putative 0.0068 0.0232 0.0773
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0232 0.0773
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Plasmodium vivax aspartyl protease, putative 0.0091 0.0368 0.123
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0068 0.0232 0.0773
Schistosoma mansoni glutamate receptor kainate 0.004 0.0065 0.0028
Brugia malayi flavodoxin family protein 0.0085 0.0332 0.1107
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0032 0.0022 0.0075
Brugia malayi Protein kinase domain containing protein 0.0093 0.0383 0.1277
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.024 0.1251 0.4148
Echinococcus granulosus epidermal growth factor receptor 0.0289 0.1545 0.5134
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Loa Loa (eye worm) hypothetical protein 0.0125 0.0573 0.1912
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0052 0.014 0.0103
Toxoplasma gondii flavodoxin domain-containing protein 0.0042 0.0079 0.0265
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0087 0.0246
Brugia malayi Pepsin A precursor 0.0091 0.0368 0.123
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0232 0.0773
Loa Loa (eye worm) TK protein kinase 0.0031 0.0013 0.0045
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0164 0.0804 0.0769
Onchocerca volvulus 0.0091 0.0368 0.2837
Plasmodium vivax plasmepsin V, putative 0.0091 0.0368 0.123
Schistosoma mansoni tyrosine kinase 0.0093 0.0383 0.0346
Plasmodium falciparum plasmepsin II 0.0164 0.0804 0.2682
Echinococcus multilocularis ribonucleoside diphosphate reductase subunit 0.0137 0.0645 0.2118
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Brugia malayi SRC-1 0.0038 0.0056 0.0187
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (beta chain) NrdF1 (ribonucleotide reductase small subunit) (R2F protein) 0.0137 0.0645 0.2046
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0037 0.0081
Echinococcus granulosus epidermal growth factor receptor 0.0156 0.0755 0.2485
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0068 0.0232 0.0732
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0093 0.0383 0.1238
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0032 0.0022 0.0075
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0087 0.0246
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Loa Loa (eye worm) TK/EGFR protein kinase 0.0289 0.1545 0.5156
Loa Loa (eye worm) TK protein kinase 0.0034 0.0035 0.0117
Plasmodium falciparum subtilisin-like protease 1 0.0357 0.1947 0.6499
Entamoeba histolytica type A flavoprotein, putative 0.0032 0.0022 0.0409
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Plasmodium falciparum plasmepsin VIII, putative 0.0091 0.0368 0.123
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0035 0.0072
Trypanosoma brucei trypanothione synthetase, putative 0.0068 0.0236 0.0787
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0043 0.0087 0.0246
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0056 0.0143
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0019 0.002
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0056 0.0143
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Echinococcus multilocularis insulin receptor 0.0093 0.0383 0.1238
Plasmodium vivax flavodoxin domain containing protein 0.0075 0.0275 0.0917
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0085 0.0332 0.1067
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0035 0.0072
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0056 0.0143
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0075 0.0275 0.0938
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0065 0.0028
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.004 0.0065 0.0173
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0068 0.0232 0.0195
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0486 0.2714 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0068 0.0232 0.0773
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0224 0.1156 0.1123
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0056 0.0143
Chlamydia trachomatis sulfite reductase 0.0052 0.014 0.0094
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0534 0.2996 0.297
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.0087 0.0246
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Toxoplasma gondii subtilisin SUB1 0.0357 0.1947 0.6499
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Leishmania major trypanothione synthetase, putative 0.0068 0.0236 0.0787
Entamoeba histolytica aminopeptidase, putative 0.0068 0.0232 1
Echinococcus granulosus palmitoyl protein thioesterase 1 0.0084 0.0327 0.1052
Plasmodium vivax aspartyl proteinase, putative 0.0164 0.0804 0.2682
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0032 0.0022 0.0075
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0056 0.0143
Loa Loa (eye worm) ribonucleotide reductase M2 B 0.0137 0.0645 0.2153
Schistosoma mansoni glutamate receptor NMDA 0.0043 0.0087 0.005
Toxoplasma gondii aspartyl protease 0.0091 0.0368 0.123
Plasmodium falciparum plasmepsin VI 0.0164 0.0804 0.2682
Mycobacterium ulcerans aminopeptidase N PepN 0.0068 0.0232 0.0479
Loa Loa (eye worm) aminopeptidase N 0.0068 0.0232 0.0773
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0056 0.0143
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0164 0.0804 0.2649
Schistosoma mansoni tyrosine kinase 0.0153 0.0739 0.0704
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0043 0.0087 0.0246
Brugia malayi FAD binding domain containing protein 0.0052 0.014 0.0468
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0065 0.0217
Schistosoma mansoni tyrosine kinase 0.0156 0.0755 0.072
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Trichomonas vaginalis sulfite reductase, putative 0.0085 0.0332 0.1149
Plasmodium vivax aspartyl protease, putative 0.0091 0.0368 0.123
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Schistosoma mansoni tyrosine kinase 0.0153 0.0739 0.0704
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.0087 0.0246
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0091 0.0368 0.123
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0032 0.0022 0.0075
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0085 0.0332 0.1107
Leishmania major cytochrome P450 reductase, putative 0.0075 0.0275 0.0917
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0085 0.0332 0.1067
Schistosoma mansoni tyrosine kinase 0.0038 0.0056 0.0019
Echinococcus multilocularis aminopeptidase N 0.0149 0.0714 0.2348
Loa Loa (eye worm) hypothetical protein 0.0081 0.0313 0.1044
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0044 0.0091 0.0259
Brugia malayi hypothetical protein 0.0091 0.0368 0.123
Leishmania major hypothetical protein, conserved 0.0032 0.0022 0.0075
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0156 0.0755 0.2485
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0236 0.0787
Brugia malayi aspartic protease BmAsp-1, identical 0.0091 0.0368 0.123
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Plasmodium vivax plasmepsin IV, putative 0.0164 0.0804 0.2682
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0032 0.0022 0.0075
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Brugia malayi protein-tyrosine kinase 0.0034 0.0035 0.0117
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0085 0.0332 0.1107
Schistosoma mansoni tyrosine kinase 0.0153 0.0739 0.0704
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.123 0.712 0.7109
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0356 0.1939 0.6472
Giardia lamblia Nitric oxide synthase, inducible 0.0075 0.0275 0.5
Schistosoma mansoni tyrosine kinase 0.0093 0.0383 0.0346
Loa Loa (eye worm) hypothetical protein 0.0044 0.0091 0.0303
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0056 0.0143
Loa Loa (eye worm) RNA binding protein 0.0072 0.0256 0.0855
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0164 0.0804 0.2903
Toxoplasma gondii flavodoxin domain-containing protein 0.0042 0.0079 0.0265
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0091 0.0368 0.0332
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0534 0.2996 1
Leishmania major p450 reductase, putative 0.0085 0.0332 0.1107
Schistosoma mansoni tyrosine kinase 0.0156 0.0755 0.072
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0534 0.2996 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.0256 0.0855
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0068 0.0232 0.0195
Echinococcus multilocularis palmitoyl protein thioesterase 1 0.0084 0.0327 0.1052
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.024 0.1251 0.1218
Loa Loa (eye worm) FAD binding domain-containing protein 0.0052 0.014 0.0468
Schistosoma mansoni diflavin oxidoreductase 0.0042 0.0079 0.0042
Loa Loa (eye worm) peptidase family M1 containing protein 0.0105 0.0454 0.1515
Echinococcus granulosus ribonucleoside diphosphate reductase subunit 0.0137 0.0645 0.2118
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Brugia malayi Peptidase family M1 containing protein 0.0149 0.0714 0.2382
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0068 0.0232 0.0773
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0486 0.2714 1
Brugia malayi Furin-like cysteine rich region family protein 0.0289 0.1545 0.5156
Loa Loa (eye worm) palmitoyl-protein thioesterase 1 0.0084 0.0327 0.1092
Echinococcus granulosus insulin receptor 0.0093 0.0383 0.1238
Loa Loa (eye worm) hypothetical protein 0.0085 0.0332 0.1107
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0164 0.0804 0.2682
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0047 0.0107 0.0356
Brugia malayi Palmitoyl-protein thioesterase 1 precursor 0.0084 0.0327 0.1092
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0044 0.0091 0.0303
Loa Loa (eye worm) SRC-1 0.0038 0.0056 0.0187
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Trypanosoma cruzi p450 reductase, putative 0.0085 0.0332 0.1107
Loa Loa (eye worm) hypothetical protein 0.0164 0.0804 0.2682
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0534 0.2996 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0068 0.0232 0.0778
Schistosoma mansoni cytochrome P450 reductase 0.0085 0.0332 0.0295
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0032 0.0022 0.0075
Mycobacterium ulcerans transcriptional regulator NrdR 0.0048 0.0113 0.0024
Entamoeba histolytica hypothetical protein 0.0035 0.0037 0.1102
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0056 0.0143
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0085 0.0332 0.1107
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.2153
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0534 0.2996 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Echinococcus granulosus methionine synthase reductase 0.0052 0.014 0.0425
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0065 0.0028
Schistosoma mansoni palmitoyl-protein thioesterase 0.0084 0.0327 0.0291
Trypanosoma brucei Aminopeptidase M1, putative 0.0068 0.0232 0.0773
Brugia malayi hypothetical protein 0.0068 0.0232 0.0773
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0164 0.0804 0.2649
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0035 0.0072
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0085 0.0332 0.1107
Loa Loa (eye worm) TAR-binding protein 0.0072 0.0256 0.0855
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0056 0.0143
Brugia malayi aspartic protease BmAsp-2, identical 0.0091 0.0368 0.123
Schistosoma mansoni tyrosine kinase 0.0038 0.0056 0.0019
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit beta 0.0137 0.0645 0.1845
Schistosoma mansoni tyrosine kinase 0.0289 0.1545 0.1513
Mycobacterium tuberculosis Probable ribonucleoside-diphosphate reductase (large subunit) NrdZ (ribonucleotide reductase) 0.0175 0.0867 0.29
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0149 0.0715 0.2387
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0068 0.0232 0.0732
Plasmodium falciparum ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0486 0.2714 1
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0065 0.0028
Schistosoma mansoni ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.061
Loa Loa (eye worm) aspartyl protease 6 0.0091 0.0368 0.123
Echinococcus multilocularis nmda type glutamate receptor 0.0038 0.0054 0.0135
Plasmodium vivax ribonucleotide reductase small subunit, putative 0.0047 0.0107 0.0356
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0065 0.0217
Mycobacterium leprae conserved hypothetical protein 0.0048 0.0113 0.0024
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0534 0.2996 1
Trypanosoma cruzi aminopeptidase, putative 0.0068 0.0232 0.0773
Toxoplasma gondii aspartyl protease ASP1 0.0164 0.0804 0.2682
Loa Loa (eye worm) FAD binding domain-containing protein 0.0085 0.0332 0.1107
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0022 0.0075
Schistosoma mansoni glutamate receptor kainate 0.004 0.0065 0.0028
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0065 0.0217
Trypanosoma brucei ribonucleoside-diphosphate reductase small chain 0.0137 0.0645 0.2153
Echinococcus granulosus glutamate receptor 2 0.0043 0.0087 0.0246
Schistosoma mansoni glutamate receptor kainate 0.004 0.0065 0.0028
Echinococcus multilocularis tar DNA binding protein 0.0072 0.0256 0.0814
Plasmodium falciparum plasmepsin IX 0.0091 0.0368 0.123
Plasmodium falciparum nitric oxide synthase, putative 0.0085 0.0332 0.1107
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0056 0.0143
Leishmania major ribonucleoside-diphosphate reductase small chain, putative 0.0137 0.0645 0.2153
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0085 0.0332 0.0863
Plasmodium falciparum plasmepsin V 0.0091 0.0368 0.123
Loa Loa (eye worm) hypothetical protein 0.0044 0.0091 0.0303
Echinococcus multilocularis epidermal growth factor receptor 0.0156 0.0755 0.2485
Echinococcus granulosus thyrotropin releasing hormone receptor 0.024 0.1251 0.4148
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.0256 0.0855
Brugia malayi RNA binding protein 0.0072 0.0256 0.0855
Treponema pallidum ribonucleotide-diphosphate reductase subunit beta 0.0137 0.0645 0.2094
Onchocerca volvulus 0.0091 0.0368 0.2837
Schistosoma mansoni tar DNA-binding protein 0.0072 0.0256 0.0219

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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