TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.357 | Formula: C19H19Cl2N5O2S
H donors: 1 H acceptors: 5 LogP: 4.28 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CS(=O)(=O)c1ccc2c(c1)c(NCc1ccccc1)nc(n2)n1cncc1.Cl.Cl
InChi: 1S/C19H17N5O2S.2ClH/c1-27(25,26)15-7-8-17-16(11-15)18(21-12-14-5-3-2-4-6-14)23-19(22-17)24-10-9-20-13-24;;/h2-11,13H,12H2,1H3,(H,21,22,23);2*1H
InChiKey: LZDXQGDLZHJYJN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 5A, cGMP-specific	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Papain family cysteine protease containing protein	0.0054	0.1367	0.1367
Trypanosoma cruzi	heat shock protein 90, putative	0.0033	0.0589	0.0589
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1367	1
Echinococcus granulosus	cathepsin l1	0.0039	0.0813	0.0813
Brugia malayi	Endoplasmin precursor	0.0033	0.0589	0.0589
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Giardia lamblia	Cathepsin B precursor	0.0101	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0813	0.0813
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0054	0.1367	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Onchocerca volvulus		0.0054	0.1367	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0032	0.0554	0.0554
Toxoplasma gondii	hypothetical protein	0.0065	0.1767	0.5715
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0554	0.0554
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1367	0.1367
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Leishmania major	cysteine peptidase A (CPA)	0.0054	0.1367	0.3723
Plasmodium falciparum	heat shock protein 90	0.0033	0.0589	0.431
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1367	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.2102	0.6796
Schistosoma mansoni	cathepsin F (C01 family)	0.0054	0.1367	0.1367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Echinococcus granulosus	endoplasmin	0.0026	0.0343	0.0343
Loa Loa (eye worm)	hypothetical protein	0.0054	0.1367	0.1367
Schistosoma mansoni	cathepsin F (C01 family)	0.0039	0.0813	0.0813
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Echinococcus granulosus	cathepsin l1	0.0054	0.1367	0.1367
Echinococcus multilocularis	heat shock protein	0.0033	0.0589	0.0589
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Onchocerca volvulus		0.0054	0.1367	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Plasmodium vivax	hypothetical protein, conserved	0.0023	0.0248	0.1815
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.2102	0.6096
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0248	0.0248
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0122	0.0395
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Mycobacterium ulcerans	heat shock protein 90	0.0026	0.0343	0.3862
Toxoplasma gondii	cathepsin CPL	0.0054	0.1367	0.4419
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0343	0.1109
Onchocerca volvulus		0.0054	0.1367	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Plasmodium falciparum	endoplasmin, putative	0.002	0.0122	0.0894
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0554	0.0554
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0813	0.2627
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Echinococcus granulosus	cathepsin b	0.0288	1	1
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0122	0.0395
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0589	0.0589
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0813	0.0813
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0589	0.431
Echinococcus multilocularis	cathepsin b	0.0288	1	1
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trypanosoma cruzi	cruzipain precursor, putative	0.0054	0.1367	0.1367
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0033	0.0589	0.1904
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.0582
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Loa Loa (eye worm)	endoplasmin	0.0033	0.0589	0.0589
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0074	0.2102	0.2102
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1767	0.5715
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0343	0.1109
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0813	0.0813
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2102	0.2102
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Toxoplasma gondii	heat shock protein 90, putative	0.0033	0.0589	0.1904
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0033	0.0582	0.1883
Giardia lamblia	Cathepsin B precursor	0.0101	0.3093	1
Toxoplasma gondii	cathepsin B	0.0101	0.3093	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0054	0.1367	1
Toxoplasma gondii	hypothetical protein	0.0023	0.0248	0.0802
Entamoeba histolytica	cysteine proteinase, putative	0.0054	0.1367	1
Plasmodium vivax	heat shock protein 86, putative	0.0033	0.0589	0.431
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0343	0.0343
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.005	0.1235	0.1235
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0026	0.0343	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Giardia lamblia	Grp94/Hsp90	0.0026	0.0343	0.1109
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0074	0.2102	0.6096
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1367	0.1367
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.2102	0.6796
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0054	0.1367	0.1367
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0054	0.1367	0.1367
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.005	0.1235	0.3994
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1767	0.5715
Toxoplasma gondii	heat shock protein HSP90	0.0033	0.0589	0.1904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0039	0.0813	0.2627
Onchocerca volvulus		0.0054	0.1367	1
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0288	1	1
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0074	0.2102	0.2102
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0039	0.0813	0.0813
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0589	0.0589
Onchocerca volvulus		0.0054	0.1367	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Echinococcus granulosus	heat shock protein 90	0.0033	0.0589	0.0589
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Onchocerca volvulus		0.0054	0.1367	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Treponema pallidum	heat shock protein 90	0.0026	0.0343	0.5
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0033	0.0582	0.0582
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Giardia lamblia	Cathepsin B precursor	0.0101	0.3093	1
Onchocerca volvulus	Cathepsin F homolog	0.0054	0.1367	1
Schistosoma mansoni	endoplasmin	0.0033	0.0589	0.0589
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0033	0.0582	0.0582
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0589	0.0138
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.1767	0.5715
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Schistosoma mansoni	heat shock protein	0.0033	0.0589	0.0589
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0589	0.0589
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Loa Loa (eye worm)	cathepsin B	0.0101	0.3093	0.3093
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2102	0.2102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Entamoeba histolytica	cysteine proteinase, putative	0.0039	0.0813	0.5946
Onchocerca volvulus		0.0054	0.1367	1
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0094	0.0094
Loa Loa (eye worm)	cysteine protease	0.0054	0.1367	0.1367
Loa Loa (eye worm)	fibroinase	0.0054	0.1367	0.1367
Onchocerca volvulus		0.0039	0.0813	0.5946
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0343	0.1109
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0032	0.0554	0.0554
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.0343	0.0343
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0589	0.1904
Echinococcus multilocularis	cysteine protease	0.0054	0.1367	0.1367
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0033	0.0582	0.1883
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0033	0.0582	0.0582
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.003	0.0494	1
Echinococcus multilocularis	cathepsin b	0.0288	1	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.005	0.1235	0.3994
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0054	0.1367	0.1367
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Schistosoma mansoni	endoplasmin	0.0033	0.0589	0.0589
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Echinococcus multilocularis	cathepsin L	0.0032	0.0554	0.0554
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Entamoeba histolytica	cysteine proteinase 2	0.0032	0.0554	0.4054
Echinococcus granulosus	cathepsin L	0.0032	0.0554	0.0554
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Schistosoma mansoni	heat shock protein	0.0033	0.0589	0.0589
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Brugia malayi	cathepsin L-like precursor	0.0039	0.0813	0.0813
Echinococcus multilocularis	cysteine protease	0.0054	0.1367	0.1367
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0101	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0032	0.0554	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0054	0.1367	0.1367
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0101	0.3093	1
Brugia malayi	Cathepsin L-like precursor	0.0054	0.1367	0.1367
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0288	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0554	0.1791
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0033	0.0582	0.0582
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Plasmodium vivax	vivapain-2	0.0054	0.1367	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.003	0.0494	1
Leishmania major	cathepsin L-like protease	0.0054	0.1367	0.3723
Loa Loa (eye worm)	ctsf protein	0.0054	0.1367	0.1367
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0589	0.0138
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0101	0.3093	1
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0554	0.0554
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0288	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0039	0.0813	0.0813
Plasmodium vivax	vivapain-2	0.0054	0.1367	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Brugia malayi	Cathepsin L-like precursor	0.0039	0.0813	0.0813
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0343	0.0343
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0054	0.1367	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0589	0.431
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0074	0.2102	0.2102
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0554	0.0554
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0054	0.1367	0.4419
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0032	0.0554	0.0554
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0074	0.2102	0.6796
Plasmodium falciparum	GAF domain-related protein, putative	0.0023	0.0248	0.1815
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Toxoplasma gondii	GAF domain-containing protein	0.0023	0.0248	0.0802
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1367	0.1367
Echinococcus granulosus	cathepsin b	0.0288	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0054	0.1367	0.3201
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0248	0.0802
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Toxoplasma gondii	hypothetical protein	0.0023	0.0248	0.0802
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Plasmodium vivax	vivapain-1	0.0032	0.0554	0.4054
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Plasmodium vivax	vivapain-3	0.0032	0.0554	0.4054
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0288	1	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0288	1	1
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Plasmodium vivax	unspecified product	0.0032	0.0554	0.4054
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0343	0.0343
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0074	0.2102	0.2102
Trypanosoma cruzi	cysteine proteinase, putative	0.0032	0.0554	0.0554
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0101	0.3093	0.3093
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Echinococcus multilocularis	endoplasmin	0.0026	0.0343	0.0343
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0032	0.0554	0.0554
Echinococcus granulosus	heat shock protein 90	0.0026	0.0343	0.0343
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0026	0.0343	0.5
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0813	0.0813
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0074	0.2102	0.6796
Echinococcus granulosus	cathepsin L cysteine protease	0.0032	0.0554	0.0554
Entamoeba histolytica	cysteine proteinase, putative	0.0032	0.0554	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0032	0.0554	0.0554
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0054	0.1367	0.4419
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0033	0.0582	0.1883
Echinococcus granulosus	cysteine protease	0.0032	0.0554	0.0554
Trypanosoma brucei	Heat shock protein 83, putative	0.0033	0.0589	0.0138
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0288	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Onchocerca volvulus	Cathepsin L homolog	0.0054	0.1367	1
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0033	0.0582	0.0582
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0589	0.0138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Entamoeba histolytica	cysteine proteinase 1, putative	0.0032	0.0554	0.4054
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.003	0.0494	1
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Loa Loa (eye worm)	heat shock protein 90	0.0033	0.0589	0.0589
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Entamoeba histolytica	cysteine protease, putative	0.0032	0.0554	0.4054
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0074	0.2102	0.6796
Trypanosoma cruzi	Heat shock protein 83, putative	0.0033	0.0589	0.0589
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Echinococcus granulosus	heat shock protein	0.0033	0.0589	0.0589
Brugia malayi	heat shock protein 90	0.0033	0.0589	0.0589
Plasmodium vivax	endoplasmin, putative	0.0033	0.0589	0.431
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0032	0.0554	0.1791
Leishmania major	heat shock protein 83-1	0.0033	0.0589	0.0894
Entamoeba histolytica	cysteine protease, putative	0.0054	0.1367	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0054	0.1367	0.4419
Echinococcus multilocularis	cathepsin L cysteine protease	0.0054	0.1367	0.1367
Trypanosoma cruzi	cysteine peptidase, putative	0.0054	0.1367	0.1367
Echinococcus multilocularis	heat shock protein 90	0.0033	0.0589	0.0589
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0054	0.1367	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0026	0.0343	0.1109
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0101	0.3093	0.3093

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.11 uM	Inhibitory activity against phosphodiesterase 5 from human platelets	ChEMBL.	7658441

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL554051

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1048980