Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin F (C01 family) | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0027 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0144 | 1 | 1 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Echinococcus granulosus | cathepsin b | 0.0144 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus multilocularis | cysteine protease | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0274 | 0.0274 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0144 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus multilocularis | cysteine protease | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.005 | 0.2688 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.0027 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0027 | 0.086 | 0.086 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0027 | 0.086 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0027 | 0.086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0027 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0027 | 0.086 | 0.086 |
Giardia lamblia | Cathepsin B precursor | 0.005 | 0.2688 | 0.5 |
Brugia malayi | cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Entamoeba histolytica | cysteine protease, putative | 0.0027 | 0.086 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0027 | 0.086 | 0.0603 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0027 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0274 | 0.1018 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin b | 0.0144 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0274 | 0.1018 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Giardia lamblia | Cathepsin B precursor | 0.005 | 0.2688 | 0.5 |
Giardia lamblia | Cathepsin B precursor | 0.005 | 0.2688 | 0.5 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0019 | 0.0274 | 0.0274 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0027 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin l1 | 0.0027 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0027 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0274 | 0.0274 |
Onchocerca volvulus | Cathepsin F homolog | 0.0027 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0027 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.005 | 0.2688 | 0.2688 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.005 | 0.2688 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0027 | 0.086 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0274 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0144 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0027 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Loa Loa (eye worm) | fibroinase | 0.0027 | 0.086 | 0.0603 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0027 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Toxoplasma gondii | cathepsin B | 0.005 | 0.2688 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.005 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0144 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0027 | 0.086 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.005 | 0.2688 | 0.2688 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0027 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0274 | 0.0274 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.005 | 0.2688 | 0.2482 |
Onchocerca volvulus | 0.0027 | 0.086 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0027 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0027 | 0.086 | 0.086 |
Echinococcus multilocularis | cathepsin b | 0.0144 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0027 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0027 | 0.086 | 0.3201 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0027 | 0.086 | 0.086 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0027 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0144 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0027 | 0.086 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 2 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.