TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.401 | Formula: C19H22F2N4O
H donors: 1 H acceptors: 3 LogP: 1.6 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)N1CCC(CC1)NC(c1ccc(cc1F)F)c1cnccn1
InChi: 1S/C19H22F2N4O/c1-2-18(26)25-9-5-14(6-10-25)24-19(17-12-22-7-8-23-17)15-4-3-13(20)11-16(15)21/h3-4,7-8,11-12,14,19,24H,2,5-6,9-10H2,1H3
InChiKey: QMQUQQHRKGHSDC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	cysteine proteinase, putative	0.0633	0.2645	0.2626
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0633	0.2645	0.2645
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Giardia lamblia	Cathepsin L precursor	0.0271	0.1048	0.2696
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.1152	0.4937	0.4937
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0039	0.0026	0.0026
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Brugia malayi	Cathepsin L-like precursor	0.1152	0.4937	0.4937
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0271	0.1048	0.2023
Plasmodium falciparum	serine repeat antigen 7	0.0271	0.1048	0.2051
Loa Loa (eye worm)	hypothetical protein	0.0791	0.3341	0.3341
Loa Loa (eye worm)	hypothetical protein	0.1152	0.4937	0.4937
Toxoplasma gondii	cathepsin CPL	0.1152	0.4937	1
Trichomonas vaginalis	glutaminase, putative	0.0279	0.1083	0.2153
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Plasmodium falciparum	serine repeat antigen 4	0.0271	0.1048	0.2051
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.2299	1	1
Leishmania major	cathepsin L-like protease	0.1152	0.4937	0.6777
Brugia malayi	follicle stimulating hormone receptor	0.0228	0.0857	0.0857
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.1048	0.2081
Brugia malayi	glutaminase DH11.1	0.0279	0.1083	0.1083
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.2299	1	1
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Schistosoma mansoni	cathepsin C	0.0271	0.1048	0.1048
Entamoeba histolytica	hypothetical protein	0.0271	0.1048	0.2081
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Toxoplasma gondii	cathepsin CPC1	0.0466	0.191	0.3789
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0362	0.1449	0.1426
Echinococcus multilocularis	cysteine protease	0.1152	0.4937	0.4924
Trypanosoma cruzi	cysteine peptidase, putative	0.0633	0.2645	0.2626
Leishmania major	cathepsin L-like protease	0.1152	0.4937	0.6777
Trypanosoma cruzi	cruzipain precursor, putative	0.1681	0.7273	0.7266
Trypanosoma cruzi	cysteine peptidase, putative	0.1152	0.4937	0.4924
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0076	0.0076
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0076	0.005
Echinococcus granulosus	cathepsin L	0.0271	0.1048	0.1025
Plasmodium vivax	serine-repeat antigen (SERA)	0.0271	0.1048	0.2023
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.1152	0.4937	0.4937
Loa Loa (eye worm)	fibroinase	0.1152	0.4937	0.4937
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0791	0.3341	0.3341
Onchocerca volvulus		0.0271	0.1048	0.2078
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0087	0.0234	0.0353
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.1048	0.1048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0271	0.1048	0.2023
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0482	0.1979	0.1979
Brugia malayi	Cathepsin L-like precursor	0.1152	0.4937	0.4937
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0157	0.0546	0.0521
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1152	0.4937	1
Brugia malayi	Intermediate filament tail domain containing protein	0.006	0.0116	0.0116
Plasmodium falciparum	serine repeat antigen 5	0.0271	0.1048	0.2051
Echinococcus multilocularis	cathepsin b	0.2299	1	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.0062	0.0036
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.0062	0.0073
Loa Loa (eye worm)	glutaminase 2	0.0279	0.1083	0.1083
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.006	0.0116	0.0116
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.2645	0.3614
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0791	0.3341	0.6749
Schistosoma mansoni	cathepsin F (C01 family)	0.1152	0.4937	0.4937
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0076	0.005
Brugia malayi	Probable ClpP-like protease	0.0087	0.0234	0.0234
Schistosoma mansoni	chromobox protein	0.0071	0.0166	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Schistosoma mansoni	cathepsin s	0.0362	0.1449	0.1449
Loa Loa (eye worm)	hypothetical protein	0.0271	0.1048	0.1048
Trypanosoma cruzi	major cysteine proteinase, putative	0.0271	0.1048	0.1025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0898	0.3817	0.3801
Leishmania major	cathepsin L-like protease	0.1152	0.4937	0.6777
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0041	0.0031
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0271	0.1048	0.2081
Brugia malayi	chromobox protein homolog 3	0.004	0.0028	0.0028
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0633	0.2645	0.5314
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0466	0.191	0.3789
Giardia lamblia	Cathepsin B precursor	0.0898	0.3817	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0482	0.1979	0.1979
Loa Loa (eye worm)	hypothetical protein	0.0271	0.1048	0.1048
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0898	0.3817	0.3817
Entamoeba histolytica	cysteine protease, putative	0.0271	0.1048	0.2081
Onchocerca volvulus	Cathepsin F homolog	0.1152	0.4937	1
Giardia lamblia	Cathepsin L precursor	0.0271	0.1048	0.2696
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0087	0.0234	0.5
Brugia malayi	Cathepsin L-like precursor	0.0791	0.3341	0.3341
Toxoplasma gondii	cathepsin B	0.0898	0.3817	0.7701
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.2645	0.5332
Plasmodium vivax	unspecified product	0.0633	0.2645	0.5297
Plasmodium vivax	unspecified product	0.0271	0.1048	0.2023
Entamoeba histolytica	cysteine protease, putative	0.0271	0.1048	0.2081
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0162	0.0566	0.0566
Trichomonas vaginalis	conserved hypothetical protein	0.0271	0.1048	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0362	0.1449	0.1449
Mycobacterium ulcerans	glutaminase	0.0279	0.1083	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0466	0.191	0.3812
Giardia lamblia	Hypothetical protein	0.0271	0.1048	0.2696
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0087	0.0234	0.0353
Entamoeba histolytica	cysteine protease, putative	0.1152	0.4937	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.1152	0.4937	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0057	0.0102	0.0077
Trypanosoma cruzi	major cysteine proteinase, putative	0.08	0.3384	0.3366
Entamoeba histolytica	cysteine proteinase, putative	0.0633	0.2645	0.5332
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0087	0.0234	0.0387
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0482	0.1979	0.1979
Giardia lamblia	Cysteine protease	0.0271	0.1048	0.2696
Trypanosoma cruzi	cysteine peptidase, putative	0.1681	0.7273	0.7266
Brugia malayi	Papain family cysteine protease containing protein	0.0271	0.1048	0.1048
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0087	0.0234	0.5
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.132	0.5676	0.5665
Giardia lamblia	Encystation-specific protease	0.0345	0.1375	0.3559
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0271	0.1048	0.1048
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0271	0.1048	0.2023
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0068	0.0068
Echinococcus granulosus	lamin dm0	0.006	0.0116	0.009
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.1048	0.1048
Giardia lamblia	Cathepsin B precursor	0.0482	0.1979	0.5153
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.1048	0.2081
Loa Loa (eye worm)	hypothetical protein	0.0791	0.3341	0.3341
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0271	0.1048	0.2023
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0068	0.0068
Plasmodium falciparum	serine repeat antigen 6	0.0271	0.1048	0.2051
Giardia lamblia	Cysteine protease	0.0271	0.1048	0.2696
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0045	0.0049
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0482	0.1979	0.3977
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.1048	0.2081
Plasmodium falciparum	serine repeat antigen 1	0.0271	0.1048	0.2051
Leishmania major	cathepsin L-like protease	0.1152	0.4937	0.6777
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0271	0.1048	0.2081
Plasmodium falciparum	serine repeat antigen 2	0.0271	0.1048	0.2051
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0482	0.1979	0.3977
Giardia lamblia	Cathepsin L precursor	0.0271	0.1048	0.2696
Schistosoma mansoni	glutaminase	0.0279	0.1083	0.1083
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2299	1	1
Onchocerca volvulus		0.1152	0.4937	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0791	0.3341	0.3341
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0166	0.0285
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0228	0.0857	0.0857
Schistosoma mansoni	lamin	0.006	0.0116	0.0116
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Giardia lamblia	Cathepsin L-like protease	0.0271	0.1048	0.2696
Onchocerca volvulus		0.006	0.0116	0.0179
Brugia malayi	fibroinase precursor	0.0271	0.1048	0.1048
Schistosoma mansoni	cathepsin F (C01 family)	0.1152	0.4937	0.4937
Schistosoma mansoni	lamin	0.006	0.0116	0.0116
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Plasmodium falciparum	serine repeat antigen 8	0.0271	0.1048	0.2051
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0271	0.1048	0.1048
Giardia lamblia	Cathepsin L-like protease	0.0271	0.1048	0.2696
Schistosoma mansoni	cathepsin S (C01 family)	0.0271	0.1048	0.1048
Trypanosoma cruzi	cysteine protease, putative	0.0633	0.2645	0.2626
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Entamoeba histolytica	cysteine protease, putative	0.0271	0.1048	0.2081
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0271	0.1048	0.2696
Brugia malayi	intermediate filament protein	0.006	0.0116	0.0116
Echinococcus multilocularis	lamin	0.006	0.0116	0.009
Echinococcus granulosus	microtubule associated protein 2	0.1378	0.5933	0.5922
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0271	0.1048	0.2023
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0345	0.1375	0.3559
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2299	1	1
Echinococcus granulosus	intermediate filament protein	0.006	0.0116	0.009
Brugia malayi	cathepsin F-like cysteine proteinase	0.0362	0.1449	0.1449
Loa Loa (eye worm)	hypothetical protein	0.2299	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0271	0.1048	0.2081
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0271	0.1048	0.2081
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Giardia lamblia	Cathepsin B precursor	0.0271	0.1048	0.2696
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.1048	0.1048
Brugia malayi	Papain family cysteine protease containing protein	0.0271	0.1048	0.1048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.0062	0.0073
Giardia lamblia	Hypothetical protein	0.0271	0.1048	0.2696
Onchocerca volvulus		0.1152	0.4937	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0068	0.0068
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0271	0.1048	0.2081
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Giardia lamblia	Cysteine protease	0.0271	0.1048	0.2696
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Echinococcus multilocularis	lamin dm0	0.006	0.0116	0.009
Giardia lamblia	Cathepsin B precursor	0.0271	0.1048	0.2696
Loa Loa (eye worm)	ctsf protein	0.1152	0.4937	0.4937
Echinococcus granulosus	cathepsin b	0.2299	1	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0087	0.0234	0.0234
Echinococcus multilocularis	cathepsin L cysteine protease	0.1152	0.4937	0.4924
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0466	0.191	0.3812
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Echinococcus multilocularis	cysteine protease	0.1152	0.4937	0.4924
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0116	0.0116
Giardia lamblia	Cysteine protease	0.0271	0.1048	0.2696
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0162	0.0566	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0362	0.1449	0.1449
Brugia malayi	Papain family cysteine protease containing protein	0.1152	0.4937	0.4937
Brugia malayi	Papain family cysteine protease containing protein	0.0633	0.2645	0.2645
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0271	0.1048	0.1048
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.2299	1	1
Loa Loa (eye worm)	hypothetical protein	0.0271	0.1048	0.1048
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0271	0.1048	0.2081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.1048	0.2081
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0466	0.191	0.3789
Brugia malayi	Papain family cysteine protease containing protein	0.0271	0.1048	0.1048
Loa Loa (eye worm)	intermediate filament protein	0.006	0.0116	0.0116
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.1048	0.1048
Brugia malayi	cathepsin L-like precursor	0.0791	0.3341	0.3341
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0057	0.0102	0.5
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0041	0.0027
Brugia malayi	Cathepsin L-like precursor	0.1152	0.4937	0.4937
Plasmodium falciparum	serine repeat antigen 9	0.0271	0.1048	0.2051
Echinococcus granulosus	peptidase Clp S14 family	0.0057	0.0102	0.0077
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0271	0.1048	0.1048
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0271	0.1048	0.2081
Brugia malayi	cathepsin F-like cysteine proteinase	0.0271	0.1048	0.1048
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0087	0.0234	0.5
Loa Loa (eye worm)	hypothetical protein	0.0271	0.1048	0.1048
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0633	0.2645	0.2645
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0068	0.0068
Echinococcus multilocularis	cathepsin b	0.2299	1	1
Echinococcus multilocularis	cathepsin L	0.0271	0.1048	0.1025
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0039	0.0026	0.0026
Schistosoma mansoni	intermediate filament proteins	0.006	0.0116	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0111	0.0111
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Onchocerca volvulus	Cathepsin L homolog	0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.1048	0.2081
Giardia lamblia	Cathepsin L precursor	0.0271	0.1048	0.2696
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.1048	0.2081
Brugia malayi	cathepsin L precursor	0.0271	0.1048	0.1048
Onchocerca volvulus	Cathepsin L homolog	0.1152	0.4937	1
Entamoeba histolytica	cysteine protease, putative	0.0271	0.1048	0.2081
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Giardia lamblia	Cathepsin L precursor	0.0271	0.1048	0.2696
Loa Loa (eye worm)	cathepsin B	0.0898	0.3817	0.3817
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0076	0.0076
Echinococcus multilocularis	cathepsin L cysteine protease	0.1152	0.4937	0.4924
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0482	0.1979	0.3977
Onchocerca volvulus		0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.1152	0.4937	1
Loa Loa (eye worm)	acetyltransferase	0.0162	0.0566	0.0566
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1152	0.4937	0.4924
Giardia lamblia	Cathepsin B precursor	0.0898	0.3817	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0271	0.1048	0.2081
Entamoeba histolytica	cysteine proteinase 1, putative	0.0633	0.2645	0.5332
Giardia lamblia	Cathepsin B precursor	0.0271	0.1048	0.2696
Entamoeba histolytica	cysteine proteinase, putative	0.1152	0.4937	1
Echinococcus granulosus	cathepsin L	0.0633	0.2645	0.2626
Schistosoma mansoni	microtubule-associated protein tau	0.1378	0.5933	0.5933
Onchocerca volvulus		0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Loa Loa (eye worm)	hypothetical protein	0.0271	0.1048	0.1048
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0898	0.3817	0.5231
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0028
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0633	0.2645	0.5332
Plasmodium falciparum	serine repeat antigen 3	0.0271	0.1048	0.2051
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0898	0.3817	0.7718
Plasmodium vivax	serine-repeat antigen (SERA)	0.0271	0.1048	0.2023
Entamoeba histolytica	cysteine proteinase, putative	0.1152	0.4937	1
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0166	0.014
Onchocerca volvulus	Cathepsin L homolog	0.0271	0.1048	0.2078
Onchocerca volvulus		0.1152	0.4937	1
Plasmodium vivax	vivapain-2	0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0791	0.3341	0.6749
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0466	0.191	0.3789
Echinococcus multilocularis	musashi	0.006	0.0116	0.009
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Brugia malayi	cathepsin L-like cysteine proteinase	0.0271	0.1048	0.1048
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0041	0.0031
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0362	0.1449	0.1449
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0898	0.3817	0.5231
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0633	0.2645	0.2645
Leishmania major	cathepsin L-like protease	0.1681	0.7273	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Loa Loa (eye worm)	hypothetical protein	0.0791	0.3341	0.3341
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0087	0.0234	0.5
Brugia malayi	acetyltransferase, GNAT family protein	0.0162	0.0566	0.0566
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0271	0.1048	0.1048
Plasmodium vivax	vivapain-3	0.0633	0.2645	0.5297
Leishmania major	cathepsin L-like protease	0.1152	0.4937	0.6777
Echinococcus granulosus	cathepsin L cysteine proteinase	0.1152	0.4937	0.4924
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0166	0.0285
Leishmania major	cysteine peptidase A (CPA)	0.1152	0.4937	0.6777
Toxoplasma gondii	cathepsin CPC2	0.0345	0.1375	0.2693
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0345	0.1375	0.3559
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0028	0.0004
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0087	0.0234	0.0209
Brugia malayi	Cathepsin L-like precursor	0.1152	0.4937	0.4937
Loa Loa (eye worm)	cysteine protease	0.1152	0.4937	0.4937
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1681	0.7273	1
Entamoeba histolytica	cysteine proteinase, putative	0.0791	0.3341	0.6749
Plasmodium vivax	vivapain-1	0.0633	0.2645	0.5297
Plasmodium falciparum	cysteine proteinase falcipain 3	0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0392	0.1583	0.317
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0045	0.0038
Echinococcus granulosus	cysteine protease	0.0633	0.2645	0.2626
Loa Loa (eye worm)	glutaminase	0.0279	0.1083	0.1083
Leishmania major	cathepsin L-like protease	0.1681	0.7273	1
Brugia malayi	Cathepsin L-like precursor	0.0362	0.1449	0.1449
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0345	0.1375	0.2693
Plasmodium vivax	unspecified product	0.0362	0.1449	0.2844
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0087	0.0234	0.0353
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0633	0.2645	0.3614
Echinococcus granulosus	cathepsin l1	0.0791	0.3341	0.3323
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Trichomonas vaginalis	conserved hypothetical protein	0.0271	0.1048	0.2081
Schistosoma mansoni	chromobox protein	0.0071	0.0166	0.0166
Echinococcus multilocularis	microtubule associated protein 2	0.1378	0.5933	0.5922
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.1152	0.4937	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Plasmodium vivax	vivapain-2	0.1152	0.4937	1
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0234	0.0234
Brugia malayi	Heterochromatin protein 1	0.0071	0.0166	0.0166
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0076	0.005
Giardia lamblia	Cathepsin B precursor	0.0898	0.3817	1
Entamoeba histolytica	cysteine protease, putative	0.0633	0.2645	0.5332
Loa Loa (eye worm)	hypothetical protein	0.0271	0.1048	0.1048
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.0166	0.0166
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0076	0.0076
Echinococcus granulosus	cathepsin b	0.2299	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1681	0.7273	0.7266
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0271	0.1048	0.2023
Brugia malayi	Papain family cysteine protease containing protein	0.0633	0.2645	0.2645
Onchocerca volvulus		0.006	0.0116	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0362	0.1449	0.1449
Onchocerca volvulus		0.0791	0.3341	0.6748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0345	0.1375	0.2719
Brugia malayi	Cathepsin L-like precursor	0.1152	0.4937	0.4937
Trypanosoma cruzi	cysteine peptidase, putative	0.0362	0.1449	0.1426
Echinococcus granulosus	chromobox protein 1	0.0071	0.0166	0.014
Entamoeba histolytica	cysteine proteinase, putative	0.0633	0.2645	0.5332
Echinococcus granulosus	cathepsin l cysteine peptidase	0.1152	0.4937	0.4924
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0466	0.191	0.4969
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0633	0.2645	0.2626
Brugia malayi	Cathepsin L-like precursor	0.0791	0.3341	0.3341
Entamoeba histolytica	cysteine proteinase, putative	0.0633	0.2645	0.5332
Trypanosoma cruzi	cysteine proteinase, putative	0.0633	0.2645	0.2626
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0087	0.0234	1
Entamoeba histolytica	cysteine protease, putative	0.0271	0.1048	0.2081
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0271	0.1048	0.1048
Onchocerca volvulus		0.1152	0.4937	1
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0087	0.0234	0.0209
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0039	0.0026	0.0026
Schistosoma mansoni	cathepsin B (C01 family)	0.0271	0.1048	0.1048
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0166	0.014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.1152	0.4937	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.1152	0.4937	0.4924
Giardia lamblia	Cathepsin L precursor	0.0271	0.1048	0.2696
Echinococcus granulosus	chromobox protein 1	0.0071	0.0166	0.014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0482	0.1979	0.3977
Leishmania major	cathepsin L-like protease	0.1681	0.7273	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.1048	0.1048
Trypanosoma cruzi	cysteine peptidase, putative	0.1681	0.7273	0.7266
Giardia lamblia	Cathepsin B precursor	0.0271	0.1048	0.2696
Entamoeba histolytica	cysteine proteinase 2	0.0633	0.2645	0.5332
Onchocerca volvulus		0.1152	0.4937	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0362	0.1449	0.1449
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0076	0.005
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0076	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0028	0.0004
Echinococcus granulosus	lamin	0.006	0.0116	0.009
Entamoeba histolytica	cysteine protease, putative	0.0271	0.1048	0.2081
Echinococcus granulosus	cathepsin l1	0.1152	0.4937	0.4924
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0026	0.0026
Echinococcus multilocularis	cathepsin L	0.0633	0.2645	0.2626
Entamoeba histolytica	cysteine proteinase, putative	0.0633	0.2645	0.5332
Brugia malayi	Cathepsin L-like precursor	0.1152	0.4937	0.4937
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0466	0.191	0.191
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0271	0.1048	0.2023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1152	0.4937	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0633	0.2645	0.2626
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0057	0.0102	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 1 uM	DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro.	ChEMBL.	No reference
IC90 (functional)	> 1 uM	DNDI: Inhibition of Chagas Disease parasite Trypanosoma cruzi (Tulahuen LacZ, Clone C4), in vitro.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Trypanosoma cruzi	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1863318

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1055283