Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 1 | 1 |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.0069 | 0.5 |
Onchocerca volvulus | 0.0261 | 0.2556 | 0.2556 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0261 | 0.2556 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.2556 | 0.2556 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0194 | 0 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0455 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0261 | 0.2556 | 0.2556 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0261 | 0.2556 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.2556 | 0.2556 |
Onchocerca volvulus | 0.0261 | 0.2556 | 0.2556 | |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.2556 | 0.2556 |
Echinococcus multilocularis | geminin | 0.0196 | 0.0069 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0261 | 0.2556 | 0.2556 |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0455 | 1 | 1 |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0261 | 0.2556 | 0.2556 |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0196 | 0.0069 | 0.5 |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Onchocerca volvulus | 0.0455 | 1 | 1 | |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0455 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.2556 | 0.2556 |
Loa Loa (eye worm) | hypothetical protein | 0.0261 | 0.2556 | 0.2556 |
Echinococcus granulosus | geminin | 0.0196 | 0.0069 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0261 | 0.2556 | 0.2556 |
Brugia malayi | hypothetical protein | 0.0261 | 0.2556 | 0.2556 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 3 % | DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.