Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine beta-hydroxylase (dopamine beta-monooxygenase) | Starlite/ChEMBL | References |
Bos taurus | Dopamine beta-hydroxylase | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine beta-hydroxylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | dopamine-beta-monooxygenase | Get druggable targets OG5_129281 | All targets in OG5_129281 |
Schistosoma japonicum | ko:K00503 dopamine beta-monooxygenase [EC1.14.17.1], putative | Get druggable targets OG5_129281 | All targets in OG5_129281 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.3418 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2363 | 0.5896 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.3157 | 0.8985 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.3157 | 0.8985 | 0.8416 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2754 | 0.7419 | 0.8258 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.3157 | 0.8985 | 0.8416 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2363 | 0.5896 | 0.1027 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.3157 | 0.8985 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.177 | 0.3588 | 0.3994 |
Schistosoma mansoni | alpha-glucosidase | 0.177 | 0.3588 | 0.3994 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.3157 | 0.8985 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3418 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2754 | 0.7419 | 0.8258 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.3157 | 0.8985 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.2754 | 0.7419 | 0.7099 |
Loa Loa (eye worm) | hypothetical protein | 0.1859 | 0.3936 | 0.0542 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3418 | 1 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.2754 | 0.7419 | 0.7099 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.2754 | 0.7419 | 0.7099 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3418 | 1 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1431 | 0.2269 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.2242 | 0.5427 | 0.5352 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3418 | 1 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.2754 | 0.7419 | 0.7099 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.3157 | 0.8985 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3418 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.3418 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 5.82 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
-Log IC50 (binding) | = 5.82 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
Decrease (functional) | ND 0 mM | Mean arterial blood pressure at 4 h post drug at ip dose of 100 mg/kg for the indicated number of SHR (spontaneous hypertensive rats) relative to blood pressure before dosing;ND is defined as no-data. | ChEMBL. | 3820219 |
Decrease (functional) | = 32 mM | Mean arterial blood pressure at 4 h post drug at ip dose of 100 mg/kg for the indicated number of SHR (spontaneous hypertensive rats) relative to blood pressure before dosing | ChEMBL. | 3820219 |
IC50 (binding) | = 5.82 | Inhibition of dopamine beta hydroxylase | ChEMBL. | 7783140 |
IC50 (binding) | = 5.82 | Inhibition of dopamine beta-hydroxylase (DbetaH) in hypertensive rats when administered orally (or) intraperitoneally | ChEMBL. | 2296023 |
IC50 (binding) | = 5.82 | Inhibition of dopamine beta-hydroxylase (DbetaH) enzyme | ChEMBL. | 9435905 |
IC50 (binding) | = 1.5 uM | Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (0.9-2.2) | ChEMBL. | 3820219 |
IC50 (binding) | = 1.5 uM | Inhibitory Concentration against bovine Dopamine beta hydroxylase (DBH); Range is between (0.9-2.2) | ChEMBL. | 3820219 |
Increase (functional) | = 78 % | Change in DA/NE (Dopamine/Norepinephrine) ratio after oral dosing (50 mg/kg) | ChEMBL. | 3820219 |
Kis (binding) | ND 0 uM | Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 6.0;ND is defined as no-data. | ChEMBL. | 3820219 |
Kis (binding) | ND 0 uM | Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 6.6;ND is defined as no-data. | ChEMBL. | 3820219 |
Kis (binding) | = 0.045 uM | Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 4.5. | ChEMBL. | 3820219 |
Kis (binding) | = 0.045 uM | Inhibitor dissociation constant vs. tyramine substrate against Dopamine beta hydroxylase at pH 4.5. | ChEMBL. | 3820219 |
logP (ADMET) | = 1.12 | Partition coefficient (logP) | ChEMBL. | 3820219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.