Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 3 (5-HT3) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ceramide glucosyltransferase | 0.6687 | 0.8944 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.5835 | 0.7315 | 0.7697 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.724 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.6687 | 0.8944 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.3031 | 0.1957 | 0.5 |
Echinococcus granulosus | bile acid beta glucosidase | 0.5835 | 0.7315 | 0.7697 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.6687 | 0.8944 | 0.87 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.6687 | 0.8944 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.6687 | 0.8944 | 0.87 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5006 | 0.5731 | 0.1027 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.5006 | 0.5731 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.6687 | 0.8944 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.724 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.724 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.724 | 1 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.5835 | 0.7315 | 0.7697 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.6687 | 0.8944 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.475 | 0.5242 | 0.5861 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.5835 | 0.7315 | 0.7697 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.724 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.724 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.724 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3939 | 0.3691 | 0.2237 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.5835 | 0.7315 | 0.7697 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.5835 | 0.7315 | 0.7697 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 3.5 nM kg-1 | Effective dose that causes 50% reduction of serotonin effect in rats intravenously | ChEMBL. | 1695682 |
Ki (binding) | = 2.07 nM | Concentration that inhibits the binding of radioligand, [3H]-ICS 205930, to 5-hydroxytryptamine 3 receptor from rat cortex | ChEMBL. | 1695682 |
Ki (binding) | = 2.07 nM | Concentration that inhibits the binding of radioligand, [3H]-ICS 205930, to 5-hydroxytryptamine 3 receptor from rat cortex | ChEMBL. | 1695682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.