Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0064 | 0.0064 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1349 | 0.4136 | 0.5 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0016 | 0.0016 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.3222 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0077 | 0.0154 | 0.0154 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0427 | 0.0463 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.2976 | 0.923 | 1 |
Brugia malayi | Ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0077 | 0.0154 | 0.0154 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Onchocerca volvulus | 0.12 | 0.367 | 0.3667 | |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Echinococcus granulosus | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Schistosoma mansoni | alpha glucosidase | 0.0171 | 0.0449 | 0.0487 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.2114 | 0.6531 | 0.6926 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.013 | 0.032 | 0.0184 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Leishmania major | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0171 | 0.0449 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.0847 | 0.0847 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0449 | 0.0449 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0122 | 0.0122 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0016 | 0.0016 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0064 | 0.0064 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.013 | 0.032 | 0.0184 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1753 | 0.54 | 0.54 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Echinococcus granulosus | geminin | 0.0164 | 0.0427 | 0.0463 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.0847 | 0.0918 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0064 | 0.0064 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0016 | 0.0017 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.0161 | 0.0161 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0171 | 0.0449 | 0.0315 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 100 mg kg-1 | Antiandrogenic activity as the dose required to inhibit testosterone propionate-induced rat ventral prostrate weight gain in castrated immature rat by 50%. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 1 hour. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 18 hours. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 1 hour. | ChEMBL. | 2374140 |
RBA (binding) | < 0.01 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 18 hours. | ChEMBL. | 2374140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.