Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic | References | |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic | References | |
Bos taurus | Serotonin 2a (5-HT2a) receptor | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 3 (5-HT3) receptor | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic | References | |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic | References | |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 3D, ionotropic | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.1793 | 0.3808 | 0.4137 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1793 | 0.3808 | 0.3808 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0172 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2409 | 0.5256 | 0.5256 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2906 | 0.6422 | 0.6422 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3569 | 0.7981 | 0.867 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3569 | 0.7981 | 0.867 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2906 | 0.6422 | 0.6422 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2906 | 0.6422 | 0.6422 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3569 | 0.7981 | 0.867 |
Leishmania major | glycosyl hydrolase-like protein | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2906 | 0.6422 | 0.6422 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2906 | 0.6422 | 0.6422 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0172 | 0 | 0.5 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0172 | 0 | 0.5 |
Onchocerca volvulus | 0.1205 | 0.2426 | 0.2636 | |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.4428 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3569 | 0.7981 | 0.867 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3062 | 0.679 | 0.679 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.409 | 0.9206 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4428 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.409 | 0.9206 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1793 | 0.3808 | 0.4137 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3569 | 0.7981 | 0.867 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0172 | 0 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.409 | 0.9206 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.409 | 0.9206 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3569 | 0.7981 | 0.867 |
Trypanosoma brucei | glucosidase, putative | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4428 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2906 | 0.6422 | 0.6422 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1854 | 0.3952 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.2906 | 0.6422 | 0.6976 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4428 | 1 | 1 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4428 | 1 | 1 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0172 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1793 | 0.3808 | 0.4137 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4428 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2906 | 0.6422 | 0.6422 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4428 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1793 | 0.3808 | 0.3808 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0172 | 0 | 0.5 |
Brugia malayi | Ceramide glucosyltransferase | 0.409 | 0.9206 | 0.9206 |
Schistosoma mansoni | alpha-glucosidase | 0.1793 | 0.3808 | 0.4137 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1793 | 0.3808 | 0.4137 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.409 | 0.9206 | 1 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.0921 | 0.0921 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0172 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3062 | 0.679 | 0.679 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.409 | 0.9206 | 0.9206 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
-Log IC50 (binding) | = 4.03 | Binding affinity for 5-hydroxytryptamine 1D receptor | ChEMBL. | 8642566 |
-Log IC50 (binding) | = 4.04 | Binding affinity for 5-hydroxytryptamine 1B receptor | ChEMBL. | 8642566 |
-Log IC50 (binding) | = 4.71 | Binding affinity towards 5-hydroxytryptamine 2A receptor | ChEMBL. | 8642566 |
-Log IC50 (binding) | = 5.23 | Binding affinity for 5-hydroxytryptamine 1A receptor | ChEMBL. | 8642566 |
-Log IC50 (binding) | = 5.43 | Binding affinity towards 5-hydroxytryptamine 2C receptor | ChEMBL. | 8642566 |
-Log IC50 (binding) | = 8.34 | Binding affinity towards 5-hydroxytryptamine 3 receptor | ChEMBL. | 8642566 |
-Log IC50 (binding) | = 8.34 | Binding affinity towards 5-hydroxytryptamine 3 receptor | ChEMBL. | 11229746 |
Change (functional) | = 48 % | Agonsitic activity of compound towards 5-hydroxytryptamine 3 receptor in Von Bezold-Jarisch Reflex in rats at 100 (microg/kg), evaluated as change in heart rate | ChEMBL. | 8642566 |
Change (functional) | = 48 % | Agonsitic activity of compound towards 5-hydroxytryptamine 3 receptor in Von Bezold-Jarisch Reflex in rats at 100 (microg/kg), evaluated as change in heart rate | ChEMBL. | 8642566 |
Change (functional) | = 67 % | Antagonsitic activity of compound towards 5-hydroxytryptamine 3 receptor in Von Bezold-Jarisch Reflex in rats at 100(microg/kg), evaluated as perecent inhibition of bradycardia | ChEMBL. | 8642566 |
Change (functional) | = 67 % | Antagonsitic activity of compound towards 5-hydroxytryptamine 3 receptor in Von Bezold-Jarisch Reflex in rats at 100(microg/kg), evaluated as perecent inhibition of bradycardia | ChEMBL. | 8642566 |
EC50 (functional) | = 30 nM | In vitro effective concentration of the compound against [14C]-Guanidinium uptake into NG 108-15 cells | ChEMBL. | 8642566 |
IC50 (binding) | = 4.03 | Binding affinity for 5-hydroxytryptamine 1D receptor | ChEMBL. | 8642566 |
IC50 (binding) | = 4.04 | Binding affinity for 5-hydroxytryptamine 1B receptor | ChEMBL. | 8642566 |
IC50 (binding) | = 4.71 | Binding affinity towards 5-hydroxytryptamine 2A receptor | ChEMBL. | 8642566 |
IC50 (binding) | = 5.23 | Binding affinity for 5-hydroxytryptamine 1A receptor | ChEMBL. | 8642566 |
IC50 (binding) | = 5.43 | Binding affinity towards 5-hydroxytryptamine 2C receptor | ChEMBL. | 8642566 |
IC50 (binding) | = 8.34 | Binding affinity towards 5-hydroxytryptamine 3 receptor | ChEMBL. | 8642566 |
IC50 (binding) | = 8.34 | Binding affinity towards 5-hydroxytryptamine 3 receptor | ChEMBL. | 11229746 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.