Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.4952 | 0.8016 | 0.8669 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4249 | 0.6846 | 0.6846 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.5676 | 0.922 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Schistosoma mansoni | alpha-glucosidase | 0.2537 | 0.3997 | 0.4221 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.2537 | 0.3997 | 0.3886 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.2537 | 0.3997 | 0.3886 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0244 | 0.0182 | 0.0182 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.4952 | 0.8016 | 0.8669 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0244 | 0.0182 | 0.5 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4952 | 0.8016 | 0.8669 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Leishmania major | glycosyl hydrolase-like protein | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.4032 | 0.6485 | 0.6974 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.6145 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2537 | 0.3997 | 0.4221 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0244 | 0.0182 | 0.5 |
Onchocerca volvulus | 0.1704 | 0.2613 | 0.2689 | |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.4952 | 0.8016 | 0.8669 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.5676 | 0.922 | 0.9205 |
Brugia malayi | Ceramide glucosyltransferase | 0.5676 | 0.922 | 0.9205 |
Loa Loa (eye worm) | hypothetical protein | 0.3343 | 0.5339 | 0.5252 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.4952 | 0.8016 | 0.8669 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.4952 | 0.8016 | 0.8669 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0244 | 0.0182 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2537 | 0.3997 | 0.4221 |
Schistosoma mansoni | alpha-glucosidase | 0.2537 | 0.3997 | 0.4221 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0244 | 0.0182 | 0.0182 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4249 | 0.6846 | 0.6846 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.5676 | 0.922 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4032 | 0.6485 | 0.6485 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2573 | 0.4057 | 0.5 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0244 | 0.0182 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.6145 | 1 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0244 | 0.0182 | 0.0182 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0244 | 0.0182 | 0.0182 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.2537 | 0.3997 | 0.4221 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Bmax1 (binding) | = 49 % | Bmax1 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
Bmax1 (binding) | = 49 % | Bmax1 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
Bmax2 (binding) | = 51 % | Bmax2 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
Bmax2 (binding) | = 51 % | Bmax2 from dihydropyridine receptor binding assay in guinea pig myocardial membranes | ChEMBL. | 2834556 |
IC50 (functional) | = 13.6 nM | Compound was tested for ability to relax potassium-con-tracted rabbit aorta smooth muscle | ChEMBL. | 2834556 |
Kd1 (binding) | = 0.95 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Kd1 (binding) | = 0.95 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Kd2 (binding) | = 74.4 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Kd2 (binding) | = 74.4 nM | Dissociation constant for inhibition of [3H]-nitrendipine binding to guinea pig myocardial membranes | ChEMBL. | 2834556 |
Log 1/EC50 (functional) | = 7.52 | Effective concentration required to produce mechanical response determined in muscle strips of guinea pig | ChEMBL. | 2846838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.