Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.3222 | 1 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0077 | 0.0154 | 0.0154 |
Echinococcus multilocularis | geminin | 0.0164 | 0.0427 | 0.0463 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0064 | 0.0064 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1349 | 0.4136 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0016 | 0.0016 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Schistosoma mansoni | alpha glucosidase | 0.0171 | 0.0449 | 0.0487 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0171 | 0.0449 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.0427 | 0.0463 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | beta-glucosidase, putative | 0.013 | 0.032 | 0.0184 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.2114 | 0.6531 | 0.6926 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1786 | 0.5504 | 0.5963 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Brugia malayi | Ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.2597 | 0.8043 | 0.8714 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.2976 | 0.923 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0077 | 0.0154 | 0.0154 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0 | 0.5 |
Onchocerca volvulus | 0.12 | 0.367 | 0.3667 | |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0064 | 0.0064 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0084 | 0.0176 | 0.0191 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0449 | 0.0449 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0122 | 0.0122 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0016 | 0.0016 |
Echinococcus multilocularis | snurportin 1 | 0.0299 | 0.0847 | 0.0918 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0064 | 0.0064 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glycoside hydrolases, putative | 0.013 | 0.032 | 0.0184 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Leishmania major | glycosyl hydrolase-like protein | 0.0171 | 0.0449 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0299 | 0.0847 | 0.0847 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.2976 | 0.923 | 0.923 |
Trypanosoma brucei | glucosidase, putative | 0.0171 | 0.0449 | 1 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0064 | 0.0064 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0171 | 0.0449 | 0.0315 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.0161 | 0.0161 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0016 | 0.0017 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Schistosoma mansoni | alpha-glucosidase | 0.1786 | 0.5504 | 0.5963 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1786 | 0.5504 | 0.5504 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0171 | 0.0449 | 0.0315 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0077 | 0.0154 | 0.0167 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0171 | 0.0449 | 0.0449 |
Loa Loa (eye worm) | hypothetical protein | 0.1753 | 0.54 | 0.54 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2976 | 0.923 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2228 | 0.6888 | 0.6844 |
Echinococcus granulosus | geminin | 0.0164 | 0.0427 | 0.0463 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3222 | 1 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.2597 | 0.8043 | 0.8714 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0171 | 0.0449 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0171 | 0.0449 | 0.0315 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2114 | 0.6531 | 0.6483 |
Schistosoma mansoni | hypothetical protein | 0.0299 | 0.0847 | 0.0918 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0171 | 0.0449 | 0.0487 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 100 mg kg-1 | Antiandrogenic activity as the dose required to inhibit testosterone propionate-induced rat ventral prostrate weight gain in castrated immature rat by 50%. | ChEMBL. | 2374140 |
Increase (functional) | = 50 % | Androgenic activity as percent increase in rat ventral prostrate (castrated immature rat) weight caused by 100 mg/kg per day x 10 oral dose | ChEMBL. | 2374140 |
Increase (functional) | = 50 % | Androgenic activity as percent increase in rat ventral prostrate (castrated immature rat) weight caused by 100 mg/kg per day x 10 oral dose | ChEMBL. | 2374140 |
RBA (binding) | = 0.1 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 18 hours. | ChEMBL. | 2374140 |
RBA (binding) | = 2.7 | Relative binding affinity against rat ventral prostrate androgen receptor using competition assay after 1 hour. | ChEMBL. | 2374140 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.