Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3891 | 0.7986 | 0.8673 |
Onchocerca volvulus | 0.1231 | 0.2269 | 0.2464 | |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0176 | 0 | 0.5 |
Trypanosoma brucei | glucosidase, putative | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3891 | 0.7986 | 0.8673 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0176 | 0 | 0.5 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.1832 | 0.3561 | 0.3867 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.4459 | 0.9208 | 0.9208 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3338 | 0.6798 | 0.6798 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2626 | 0.5268 | 0.5268 |
Schistosoma mansoni | alpha-glucosidase | 0.1832 | 0.3561 | 0.3867 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3891 | 0.7986 | 0.8673 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3891 | 0.7986 | 0.8673 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3167 | 0.6431 | 0.6985 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3891 | 0.7986 | 0.8673 |
Brugia malayi | Ceramide glucosyltransferase | 0.4459 | 0.9208 | 0.9208 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1832 | 0.3561 | 0.3561 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0176 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.1057 | 0.1894 | 0.2057 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.4459 | 0.9208 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3338 | 0.6798 | 0.6798 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Trypanosoma brucei | glycosyl hydrolase-like protein | 0.0176 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Giardia lamblia | Ceramide glucosyltransferase | 0.2021 | 0.3967 | 0.5 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3891 | 0.7986 | 0.8673 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4459 | 0.9208 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3167 | 0.6431 | 0.6431 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.4827 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.1832 | 0.3561 | 0.3867 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1832 | 0.3561 | 0.3561 |
Leishmania major | glycosyl hydrolase-like protein | 0.0176 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4827 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Inhibitory concentration against human cytomegalovirus(HCMV) in plaque reduction assay | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Inhibitory concentration against HCMV in plaque reduction assay | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected monkey kidney cells (BSC-1) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
Inhibition (functional) | > 100 % | Cytotoxicity against human neoplastic cell line(KB cells) | ChEMBL. | 2846837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.