Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.2607 | 1 | 1 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.2607 | 1 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.2101 | 0.6662 | 0.5432 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.2408 | 0.8687 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.2101 | 0.6662 | 0.5432 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2607 | 1 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1736 | 0.4254 | 0.2675 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2607 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.171 | 0.4084 | 0.4381 |
Echinococcus granulosus | bile acid beta glucosidase | 0.2101 | 0.6662 | 0.5432 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2607 | 1 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.2101 | 0.6662 | 0.5432 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2607 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2101 | 0.6662 | 0.5432 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.2408 | 0.8687 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1091 | 0 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2408 | 0.8687 | 1 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.2408 | 0.8687 | 0.8326 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.2101 | 0.6662 | 0.5432 |
Brugia malayi | Ceramide glucosyltransferase | 0.2408 | 0.8687 | 0.7714 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1802 | 0.4692 | 0.1027 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.2408 | 0.8687 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2607 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.2408 | 0.8687 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1802 | 0.4692 | 0.1027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | > 100 uM | Inhibitory concentration against human cytomegalovirus(HCMV) in plaque reduction assay at 100 uM concentration | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Inhibitory concentration against HCMV in plaque reduction assay | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected monkey kidney cells (BSC-1) | ChEMBL. | 2846837 |
IC50 (functional) | > 100 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
Inhibition (functional) | = 80 % | Cytotoxicity against human neoplastic cell line(KB cells) | ChEMBL. | 2846837 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.