Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.1458 | 0.5336 | 0.1027 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1458 | 0.5336 | 0.1027 |
Brugia malayi | Ceramide glucosyltransferase | 0.1947 | 0.8846 | 0.8462 |
Echinococcus granulosus | bile acid beta glucosidase | 0.1699 | 0.7067 | 0.7197 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.1947 | 0.8846 | 0.8462 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0883 | 0.1213 | 0.5 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.1947 | 0.8846 | 1 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.1699 | 0.7067 | 0.7197 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.1699 | 0.7067 | 0.7197 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1699 | 0.7067 | 0.7197 |
Loa Loa (eye worm) | hypothetical protein | 0.1147 | 0.3107 | 0.0813 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.1383 | 0.4802 | 0.5428 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.1699 | 0.7067 | 0.7197 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.1947 | 0.8846 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.1699 | 0.7067 | 0.7197 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.2108 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.2108 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (functional) | = 13 uM | Cytotoxicity against uninfected human foreskin fibroblast(HFF cells) | ChEMBL. | 2846837 |
I50 (functional) | = 31 uM | Inhibitory concentration against human cytomegalovirus(HCMV) in plaque reduction assay | ChEMBL. | 2846837 |
Inhibition (functional) | = 4 % | Cytotoxicity against human neoplastic cell line(KB cells) | ChEMBL. | 2846837 |
Log IC50 (binding) | = 1.62 | Concentration required for 50% inhibition of the adenosine kinase (AK) activity. | ChEMBL. | 15149648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.