TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.422 | Formula: C22H22N2O3
H donors: 0 H acceptors: 3 LogP: 3.64 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC1CC(C)CN(C1)C(=O)c1cccc(c1)N1C(=O)c2c(C1=O)cccc2
InChi: 1S/C22H22N2O3/c1-14-10-15(2)13-23(12-14)20(25)16-6-5-7-17(11-16)24-21(26)18-8-3-4-9-19(18)22(24)27/h3-9,11,14-15H,10,12-13H2,1-2H3
InChiKey: WOAJEAHNEXZLSY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	cathepsin CPL	0.0626	0.4519	1
Echinococcus multilocularis	cysteine protease	0.0626	0.4519	0.4519
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1213	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1213	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0911	0.7183	0.7183
Brugia malayi	cathepsin F-like cysteine proteinase	0.0196	0.05	0.05
Giardia lamblia	Cathepsin B precursor	0.0474	0.3093	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Loa Loa (eye worm)	fibroinase	0.0626	0.4519	0.4519
Echinococcus granulosus	cathepsin l1	0.043	0.2687	0.2687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0339	0.1832	0.1832
Echinococcus multilocularis	cathepsin L cysteine protease	0.0626	0.4519	0.4519
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0626	0.4519	0.4519
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Onchocerca volvulus		0.0626	0.4519	1
Giardia lamblia	Cathepsin B precursor	0.0474	0.3093	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0196	0.05	0.05
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0474	0.3093	0.3093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.043	0.2687	0.2687
Brugia malayi	Cathepsin L-like precursor	0.0626	0.4519	0.4519
Onchocerca volvulus		0.0626	0.4519	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Leishmania major	cysteine peptidase A (CPA)	0.0626	0.4519	0.3487
Loa Loa (eye worm)	ctsf protein	0.0626	0.4519	0.4519
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Plasmodium vivax	vivapain-3	0.0339	0.1832	0.4054
Echinococcus multilocularis	cathepsin b	0.1213	1	1
Brugia malayi	Cathepsin L-like precursor	0.0626	0.4519	0.4519
Brugia malayi	Cathepsin L-like precursor	0.0196	0.05	0.05
Onchocerca volvulus	Cathepsin F homolog	0.0626	0.4519	1
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.1832	0.4054
Entamoeba histolytica	cysteine proteinase 1, putative	0.0339	0.1832	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0339	0.1832	0.1832
Echinococcus multilocularis	cathepsin b	0.1213	1	1
Leishmania major	cathepsin L-like protease	0.0626	0.4519	0.3487
Leishmania major	cathepsin L-like protease	0.0911	0.7183	1
Schistosoma mansoni	cathepsin F (C01 family)	0.043	0.2687	0.2687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.1832	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0339	0.1832	0.1832
Giardia lamblia	Cathepsin B precursor	0.0474	0.3093	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Echinococcus multilocularis	cysteine protease	0.0626	0.4519	0.4519
Onchocerca volvulus		0.043	0.2687	0.5946
Onchocerca volvulus	Cathepsin L homolog	0.0626	0.4519	1
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0715	0.5351	0.5351
Plasmodium vivax	vivapain-2	0.0626	0.4519	1
Echinococcus granulosus	cathepsin b	0.1213	1	1
Plasmodium vivax	unspecified product	0.0339	0.1832	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0626	0.4519	1
Brugia malayi	Cathepsin L-like precursor	0.043	0.2687	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Echinococcus multilocularis	cathepsin L cysteine protease	0.0626	0.4519	0.4519
Brugia malayi	Cathepsin L-like precursor	0.0626	0.4519	0.4519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Leishmania major	cathepsin L-like protease	0.0626	0.4519	0.3487
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0196	0.05	0.05
Echinococcus granulosus	cathepsin l1	0.0626	0.4519	0.4519
Trypanosoma cruzi	cruzipain precursor, putative	0.0196	0.05	0.05
Brugia malayi	Papain family cysteine protease containing protein	0.0626	0.4519	0.4519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Loa Loa (eye worm)	cathepsin B	0.0474	0.3093	0.3093
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0339	0.1832	0.1832
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0626	0.4519	0.4519
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0339	0.1832	0.1832
Trypanosoma cruzi	cysteine proteinase, putative	0.0339	0.1832	0.1832
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0474	0.3093	0.2356
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Brugia malayi	Papain family cysteine protease containing protein	0.0339	0.1832	0.1832
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0428	0.2664	0.2664
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Brugia malayi	Cathepsin L-like precursor	0.0626	0.4519	0.4519
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0474	0.3093	0.3093
Schistosoma mansoni	cathepsin s	0.0196	0.05	0.05
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.043	0.2687	0.5946
Trypanosoma cruzi	cysteine protease, putative	0.0339	0.1832	0.1832
Entamoeba histolytica	cysteine proteinase, putative	0.043	0.2687	0.5946
Toxoplasma gondii	cathepsin B	0.0474	0.3093	0.6844
Loa Loa (eye worm)	hypothetical protein	0.0196	0.05	0.05
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0626	0.4519	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Leishmania major	cathepsin L-like protease	0.0626	0.4519	0.3487
Onchocerca volvulus	Cathepsin L homolog	0.0626	0.4519	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0474	0.3093	0.6844
Brugia malayi	cathepsin L-like precursor	0.043	0.2687	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0196	0.05	0.05
Leishmania major	cathepsin L-like protease	0.0911	0.7183	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0339	0.1832	0.1832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0626	0.4519	0.4519
Trypanosoma cruzi	cysteine peptidase, putative	0.0911	0.7183	0.7183
Trypanosoma cruzi	cruzipain precursor, putative	0.0911	0.7183	0.7183
Loa Loa (eye worm)	hypothetical protein	0.043	0.2687	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Brugia malayi	MH2 domain containing protein	0.0144	0.0015	0.0015
Echinococcus granulosus	cathepsin L	0.0339	0.1832	0.1832
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Loa Loa (eye worm)	hypothetical protein	0.043	0.2687	0.2687
Loa Loa (eye worm)	hypothetical protein	0.0626	0.4519	0.4519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Plasmodium vivax	vivapain-2	0.0626	0.4519	1
Onchocerca volvulus		0.0626	0.4519	1
Brugia malayi	Cathepsin L-like precursor	0.043	0.2687	0.2687
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Loa Loa (eye worm)	hypothetical protein	0.1213	1	1
Loa Loa (eye worm)	cysteine protease	0.0626	0.4519	0.4519
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1213	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Brugia malayi	Cathepsin L-like precursor	0.0626	0.4519	0.4519
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0196	0.05	0.05
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0015	0.0015
Echinococcus granulosus	cathepsin L cysteine protease	0.0339	0.1832	0.1832
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.043	0.2687	0.5946
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0626	0.4519	0.4519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0626	0.4519	0.4519
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0339	0.1832	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Loa Loa (eye worm)	hypothetical protein	0.0196	0.05	0.05
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.1832	0.4054
Leishmania major	cathepsin L-like protease	0.0626	0.4519	0.3487
Entamoeba histolytica	cysteine proteinase, putative	0.0626	0.4519	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1213	1	1
Echinococcus granulosus	cathepsin b	0.1213	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0626	0.4519	0.4519
Plasmodium vivax	vivapain-1	0.0339	0.1832	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0339	0.1832	0.4054
Echinococcus multilocularis	cathepsin L	0.0339	0.1832	0.1832
Onchocerca volvulus		0.0626	0.4519	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.1832	0.4054
Echinococcus granulosus	cysteine protease	0.0339	0.1832	0.1832
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0626	0.4519	0.4519
Entamoeba histolytica	cysteine proteinase 2	0.0339	0.1832	0.4054
Brugia malayi	Cathepsin L-like precursor	0.0626	0.4519	0.4519
Trypanosoma cruzi	cysteine peptidase, putative	0.0911	0.7183	0.7183
Onchocerca volvulus		0.0626	0.4519	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0626	0.4519	1
Loa Loa (eye worm)	hypothetical protein	0.043	0.2687	0.2687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0626	0.4519	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0626	0.4519	1
Leishmania major	cathepsin L-like protease	0.0626	0.4519	0.3487
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1213	1	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0626	0.4519	0.4519
Entamoeba histolytica	cysteine protease, putative	0.0626	0.4519	1
Plasmodium vivax	unspecified product	0.0196	0.05	0.1107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0626	0.4519	1
Entamoeba histolytica	cysteine protease, putative	0.0339	0.1832	0.4054
Onchocerca volvulus		0.0626	0.4519	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0626	0.4519	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0626	0.4519	1
Leishmania major	cathepsin L-like protease	0.0911	0.7183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Entamoeba histolytica	cysteine proteinase, putative	0.0339	0.1832	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0626	0.4519	0.4519
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0911	0.7183	1
Brugia malayi	Papain family cysteine protease containing protein	0.0339	0.1832	0.1832
Onchocerca volvulus		0.0626	0.4519	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0015	0.0015

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.9953 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1865471

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1062908