Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0351 | 0.1362 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0076 | 1 |
Mycobacterium ulcerans | formate hydrogenlyase HycD | 0.0289 | 0.2573 | 0.2563 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0036 | 0.0179 | 0.0219 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0188 | 0.0188 |
Schistosoma mansoni | hypothetical protein | 0.1072 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0014 | 0.0017 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0162 | 0.1375 | 0.1375 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0036 | 0.0179 | 0.0695 |
Wolbachia endosymbiont of Brugia malayi | NADH dehydrogenase subunit H | 0.1072 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0267 | 0.1037 |
Brugia malayi | NADH dehydrogenase subunit 1, identical | 0.0289 | 0.2573 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0036 | 0.0179 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0162 | 0.1375 | 0.5343 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0076 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0179 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0267 | 0.0267 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0179 | 1 |
Schistosoma mansoni | NADH dehydrogenase subunit 1 | 0.0289 | 0.2573 | 0.2573 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0179 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0076 | 0.373 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0179 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0351 | 0.1362 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0076 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0267 | 0.0326 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0267 | 0.0267 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0014 | 0.0014 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0036 | 0.0179 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0179 | 1 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0036 | 0.0179 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0014 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0076 | 0.373 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.1581 | 0.1581 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0036 | 0.0179 | 0.0179 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0179 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0014 | 0.0014 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0014 | 0.5 |
Echinococcus multilocularis | geminin | 0.0184 | 0.1581 | 0.1933 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.088 | 0.8179 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0076 | 0.373 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.0958 | 0.3721 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.1161 | 0.1161 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0076 | 0.373 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0188 | 0.0732 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0267 | 0.0267 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0179 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0179 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0014 | 0.0055 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.1375 | 0.1681 |
Mycobacterium tuberculosis | Possible formate hydrogenlyase HycD (FHL) | 0.0289 | 0.2573 | 0.2563 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0351 | 0.1362 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.0958 | 0.3721 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0014 | 0.0014 |
Brugia malayi | NADH dehydrogenase subunit 1 | 0.0289 | 0.2573 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0267 | 0.0326 |
Trypanosoma brucei | glucosidase, putative | 0.0036 | 0.0179 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0076 | 0.373 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0188 | 0.0732 |
Mycobacterium ulcerans | NADH dehydrogenase subunit H | 0.1072 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0267 | 0.1037 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0267 | 0.0267 |
Onchocerca volvulus | 0.0289 | 0.2573 | 1 | |
Brugia malayi | hypothetical protein | 0.0289 | 0.2573 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0162 | 0.1375 | 0.1681 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0036 | 0.0179 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0036 | 0.0179 | 0.0179 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0351 | 0.1362 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0014 | 0.0055 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0036 | 0.0179 | 0.0695 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0076 | 0.0294 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0162 | 0.1375 | 0.5343 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.0958 | 0.3721 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0036 | 0.0179 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0184 | 0.1581 | 0.1581 |
Schistosoma mansoni | alpha-glucosidase | 0.014 | 0.1161 | 0.1161 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0267 | 0.0267 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0036 | 0.0179 | 1 |
Loa Loa (eye worm) | NADH dehydrogenase subunit 1 | 0.0289 | 0.2573 | 1 |
Onchocerca volvulus | 0.0289 | 0.2573 | 1 | |
Echinococcus granulosus | geminin | 0.0184 | 0.1581 | 0.1581 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0179 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0076 | 0.0294 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) | 0.1072 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.