Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0187 | 0.5004 | 0.8254 |
Schistosoma mansoni | tyrosine kinase | 0.0187 | 0.4981 | 0.4803 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0035 | 0.0344 | 0.0567 |
Leishmania major | oxidoreductase, putative | 0.0035 | 0.0344 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0035 | 0.0344 | 0.0567 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium ulcerans | zinc-type alcohol dehydrogenase AdhD | 0.0222 | 0.6062 | 1 |
Trypanosoma brucei | oxidoreductase, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD dependent AdhB | 0.0222 | 0.6062 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0189 | 0.5042 | 0.4866 |
Leishmania major | zinc binding dehydrogenase-like protein | 0.0035 | 0.0344 | 1 |
Mycobacterium ulcerans | zinc-containing alcohol dehydrogenase NAD-dependent AdhB | 0.0222 | 0.6062 | 1 |
Onchocerca volvulus | 0.0035 | 0.0344 | 0.0567 | |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0035 | 0.0344 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0344 | 0.0344 |
Mycobacterium ulcerans | short-chain dehydrogenase | 0.0035 | 0.0344 | 0.0567 |
Echinococcus multilocularis | 0.0109 | 0.2602 | 0.2338 | |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0035 | 0.0344 | 0.0567 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0035 | 0.0344 | 0.0567 |
Schistosoma mansoni | tyrosine kinase | 0.0112 | 0.2709 | 0.2449 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium tuberculosis | Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) | 0.0222 | 0.6062 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0035 | 0.0344 | 0.0567 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium ulcerans | NADPH quinone oxidoreductase FadB4 | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Possible oxidoreductase FadB5 | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase AdhA | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0035 | 0.0344 | 0.0567 |
Onchocerca volvulus | Putative alcohol dehydrogenase | 0.0222 | 0.6062 | 1 |
Leishmania major | quinone oxidoreductase, putative | 0.0035 | 0.0344 | 1 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase Adh | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium leprae | Probable alcohol dehydrogenase AdhA | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | S-nitrosomycothiol reductase MscR | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium leprae | PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC | 0.0035 | 0.0344 | 0.0567 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0189 | 0.5042 | 0.4866 |
Wolbachia endosymbiont of Brugia malayi | NADPH:quinone reductase | 0.0035 | 0.0344 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0112 | 0.2709 | 0.2449 |
Leishmania major | NADP-dependent alcohol dehydrogenase, putative | 0.0035 | 0.0344 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0035 | 0.0344 | 0.0567 |
Schistosoma mansoni | alcohol dehydrogenase | 0.0222 | 0.6062 | 0.5922 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0035 | 0.0344 | 0.0567 |
Schistosoma mansoni | tyrosine kinase | 0.0351 | 1 | 1 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0035 | 0.0344 | 0.5 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0035 | 0.0344 | 0.0344 |
Mycobacterium tuberculosis | Probable NADP-dependent alcohol dehydrogenase AdhC | 0.0035 | 0.0344 | 0.0567 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0351 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0344 | 0.0344 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0344 | 0.0344 |
Mycobacterium leprae | Probable oxidireductase | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase AdhE2 | 0.0222 | 0.6062 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0112 | 0.2709 | 0.2449 |
Mycobacterium tuberculosis | Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 | 0.0187 | 0.5004 | 0.8254 |
Mycobacterium ulcerans | NADP-dependent alcohol dehydrogenase AdhC | 0.0035 | 0.0344 | 0.0567 |
Trypanosoma cruzi | nuclear receptor binding factor, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0035 | 0.0344 | 0.0567 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0035 | 0.0344 | 1 |
Mycobacterium ulcerans | quinone reductase Qor | 0.0035 | 0.0344 | 0.0567 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase, putative | 0.0035 | 0.0344 | 1 |
Mycobacterium tuberculosis | Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) | 0.0035 | 0.0344 | 0.0567 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0351 | 1 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0035 | 0.0344 | 0.0567 |
Toxoplasma gondii | Zn-containing alcohol dehydrogenase | 0.0222 | 0.6062 | 1 |
Loa Loa (eye worm) | alcohol dehydrogenase class III | 0.0222 | 0.6062 | 0.6062 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0189 | 0.5042 | 0.4866 |
Mycobacterium ulcerans | quinone oxidoreductase | 0.0035 | 0.0344 | 0.0567 |
Brugia malayi | Protein kinase domain containing protein | 0.0112 | 0.2709 | 0.2709 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0035 | 0.0344 | 0.0567 |
Schistosoma mansoni | tyrosine kinase | 0.0189 | 0.5042 | 0.4866 |
Schistosoma mansoni | tyrosine kinase | 0.0187 | 0.4981 | 0.4803 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0035 | 0.0344 | 0.0567 |
Mycobacterium tuberculosis | Possible dehydrogenase | 0.0035 | 0.0344 | 0.0567 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0035 | 0.0344 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0035 | 0.0344 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0112 | 0.2709 | 0.2449 |
Schistosoma mansoni | tyrosine kinase | 0.0189 | 0.5042 | 0.4866 |
Mycobacterium ulcerans | oxidoreductase | 0.0035 | 0.0344 | 0.0567 |
Brugia malayi | Alcohol dehydrogenase class III | 0.0222 | 0.6062 | 0.6062 |
Trypanosoma cruzi | oxidoreductase, putative | 0.0035 | 0.0344 | 0.5 |
Mycobacterium ulcerans | Zn-dependent alcohol dehydrogenase, AdhX | 0.0035 | 0.0344 | 0.0567 |
Echinococcus multilocularis | insulin receptor | 0.0112 | 0.2709 | 0.2449 |
Trichomonas vaginalis | alcohol dehydrogenase, putative | 0.0035 | 0.0344 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0187 | 0.4981 | 0.4803 |
Mycobacterium ulcerans | zinc-dependent alcohol dehydrogenase | 0.0222 | 0.6062 | 1 |
Trypanosoma cruzi | NADP-dependent alcohol hydrogenase, putative | 0.0035 | 0.0344 | 0.5 |
Leishmania major | d-xylulose reductase, putative | 0.0035 | 0.0344 | 1 |
Mycobacterium leprae | Probable S-nitrosomycothiol reductase MscR | 0.0222 | 0.6062 | 1 |
Echinococcus granulosus | insulin receptor | 0.0112 | 0.2709 | 0.2449 |
Entamoeba histolytica | NADP-dependent alcohol dehydrogenase | 0.0035 | 0.0344 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0112 | 0.2709 | 0.2709 |
Mycobacterium tuberculosis | Probable alcohol dehydrogenase Adh | 0.0035 | 0.0344 | 0.0567 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0351 | 1 | 1 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0036 | 0.0373 | 0.0051 |
Mycobacterium ulcerans | oxidoreductase FadB5 | 0.0035 | 0.0344 | 0.0567 |
Trypanosoma brucei | oxidoreductase, putative | 0.0035 | 0.0344 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | PubChem BioAssay. Dose Response Confirmation of SKN-1 Inhibitor hits in a fluorescence ratio assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.