TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 434.344 | Formula: C20H14F4N4O3
H donors: 3 H acceptors: 3 LogP: 3.04 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Nc2ccc(cc2C(O1)(CNC(=O)c1ccc(cc1)F)C(F)(F)F)c1cn[nH]c1
InChi: 1S/C20H14F4N4O3/c21-14-4-1-11(2-5-14)17(29)25-10-19(20(22,23)24)15-7-12(13-8-26-27-9-13)3-6-16(15)28-18(30)31-19/h1-9H,10H2,(H,25,29)(H,26,27)(H,28,30)
InChiKey: WTGVCLMUVPTMSM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	ELOVL family member 6, elongation of long chain fatty acids (yeast)	Starlite/ChEMBL	References
Homo sapiens	ELOVL fatty acid elongase 6	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	fatty acid elongation protein 3	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma congolense	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Candida albicans	one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1)	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania major	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania major	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania infantum	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium berghei	long chain fatty acid elongation enzyme, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium yoelii	unnamed protein product, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania braziliensis	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Toxoplasma gondii	integral membrane protein, GNS1/SUR4 family protein, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania braziliensis	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Cryptosporidium hominis	fatty-acyl elongase	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania mexicana	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium falciparum	fatty acid elongation protein, GNS1/SUR4 family, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania mexicana	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania mexicana	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Brugia malayi	GNS1/SUR4 family protein	Get druggable targets OG5_127859	All targets in OG5_127859
Neospora caninum	GNS1/SUR4 family domain-containing protein, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Toxoplasma gondii	GNS1/SUR4 family protein	Get druggable targets OG5_127859	All targets in OG5_127859
Loa Loa (eye worm)	GNS1/SUR4 family protein	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma brucei	Fatty acid elongase	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania infantum	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma cruzi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania infantum	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Trypanosoma brucei gambiense	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Neospora caninum	GNS1/SUR4 domain containing protein, related	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania donovani	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium falciparum	long chain fatty acid elongation enzyme, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Candida albicans	one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1)	Get druggable targets OG5_127859	All targets in OG5_127859
Brugia malayi	Fatty acid elongation protein 3	Get druggable targets OG5_127859	All targets in OG5_127859
Cryptosporidium parvum	7 pass integral membrane proteinwith FLHWFHH motif shared with fatty-acyl elongase	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium knowlesi	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium yoelii	30 kDa glycoprotein	Get druggable targets OG5_127859	All targets in OG5_127859
Plasmodium vivax	GNS1/SUR4 domain containing protein	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania donovani	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania donovani	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania braziliensis	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859
Leishmania major	fatty acid elongase, putative	Get druggable targets OG5_127859	All targets in OG5_127859

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	Fatty acid elongase	ELOVL fatty acid elongase 6	265 aa	259 aa	34.4 %
Trypanosoma brucei	Fatty acid elongase	ELOVL family member 6, elongation of long chain fatty acids (yeast)	267 aa	258 aa	33.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0292	0.0487
Brugia malayi	fatty acid elongation protein 3	0.002	0.0124	0.0124
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.3581	0.5466
Schistosoma mansoni	nuclear hormone receptor	0.0023	0.0292	0.0266
Trypanosoma cruzi	fatty acid elongase, putative	0.01	0.5461	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Brugia malayi	fatty acid elongation protein 3	0.002	0.0124	0.0124
Brugia malayi	GNS1/SUR4 family protein	0.002	0.0124	0.0124
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0674	0.103
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0023	0.0292	0.0487
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0292	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171
Brugia malayi	RNA binding protein	0.0072	0.3581	0.3581
Leishmania major	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Brugia malayi	Steroid receptor seven-up type 2	0.0023	0.0292	0.0292
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0022	0.0228	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0292	0.0292
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0022	0.0228	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0023	0.0292	0.0292
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0023	0.0292	0.0487
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.01	0.5461	0.5404
Brugia malayi	Fatty acid elongation protein 3	0.01	0.5461	0.5461
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0053	0.2325	0.6369
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.3581	0.5466
Schistosoma mansoni	hypothetical protein	0.0115	0.6448	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0023	0.0292	0.0487
Trichomonas vaginalis	DNA polymerase eta, putative	0.0022	0.0228	0.5
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0023	0.0292	0.0292
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0023	0.0292	0.0487
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0168	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0053	0.2325	0.6369
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0023	0.0292	0.0266
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0228	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.3581	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0023	0.0292	0.0266
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0292	0.0292
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0674	0.103
Schistosoma mansoni	hypothetical protein	0.0053	0.2325	0.3481
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0228	0.0196
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0228	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0023	0.0292	1
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.3581	0.35
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Plasmodium vivax	GNS1/SUR4 domain containing protein	0.01	0.5461	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0023	0.0292	0.0487
Loa Loa (eye worm)	hypothetical protein	0.0053	0.2325	0.2229
Brugia malayi	latrophilin 2 splice variant baaae	0.0115	0.6448	0.6448
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.3581	0.5466
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.2222	0.6069
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.2222	0.2124
Brugia malayi	GNS1/SUR4 family protein	0.01	0.5461	0.5461
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0023	0.0292	0.0487
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.2222	0.3318
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0292	0.0292
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.2222	0.6069
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0023	0.0292	0.0266
Schistosoma mansoni	RAR-like nuclear receptor	0.0023	0.0292	0.0266
Brugia malayi	Hypothetical 34.1 kDa protein C40H1.4 in chromosome III	0.002	0.0124	0.0124
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.2222	0.3318
Brugia malayi	Latrophilin receptor protein 2	0.0053	0.2325	0.2325
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171
Plasmodium falciparum	fatty acid elongation protein, GNS1/SUR4 family, putative	0.01	0.5461	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Schistosoma mansoni	hypothetical protein	0.0053	0.2325	0.3481
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0228	0.0228
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.2222	0.6069
Schistosoma mansoni	hypothetical protein	0.0053	0.2325	0.3481
Brugia malayi	fatty acid elongation protein 3	0.002	0.0124	0.0124
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0053	0.2325	0.6369
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0023	0.0292	0.0487
Leishmania major	fatty acid elongase, putative	0.01	0.5461	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0023	0.0292	0.0171
Echinococcus multilocularis	dna polymerase kappa	0.0022	0.0228	0.0302
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.3581	0.5466
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0023	0.0292	0.0266
Loa Loa (eye worm)	fatty acid elongation protein 3	0.01	0.5461	0.5404
Leishmania major	fatty acid elongase, putative	0.01	0.5461	1
Echinococcus granulosus	dna polymerase kappa	0.0022	0.0228	0.0302
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0674	0.103
Echinococcus multilocularis	dna polymerase eta	0.0022	0.0228	0.0302
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0023	0.0292	0.0171
Plasmodium falciparum	long chain fatty acid elongation enzyme, putative	0.01	0.5461	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0023	0.0292	0.0292
Trypanosoma cruzi	fatty acid elongase, putative	0.01	0.5461	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0022	0.0228	0.0302
Schistosoma mansoni	hypothetical protein	0.0053	0.2325	0.3481
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0053	0.2325	0.2229
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0023	0.0292	0.0171
Brugia malayi	hypothetical protein	0.0028	0.0674	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0168	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0168	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0228	0.0106
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0022	0.0228	0.0165
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.3581	0.3581
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0674	0.103
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0023	0.0292	0.0171
Schistosoma mansoni	retinoic acid receptor RXR	0.0023	0.0292	0.0266
Trypanosoma brucei	Fatty acid elongase	0.01	0.5461	1
Brugia malayi	TAR-binding protein	0.0072	0.3581	0.3581
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.2222	0.3318
Echinococcus multilocularis	GPCR, family 2	0.0053	0.2325	0.6369
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Echinococcus granulosus	GPCR family 2	0.0053	0.2325	0.6369
Onchocerca volvulus		0.0023	0.0292	1
Leishmania major	fatty acid elongase, putative	0.01	0.5461	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0023	0.0292	0.0487
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0228	0.0196
Trypanosoma brucei	DNA polymerase eta, putative	0.0022	0.0228	0.0196
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0023	0.0292	0.0487
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0023	0.0292	0.0171
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0023	0.0292	0.0487
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0022	0.0228	0.0302
Brugia malayi	nuclear hormone receptor	0.0023	0.0292	0.0292
Onchocerca volvulus	Bile acid receptor homolog	0.0023	0.0292	1
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.3581	0.5466
Trypanosoma cruzi	fatty acid elongase, putative	0.01	0.5461	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0023	0.0292	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0023	0.0292	0.0292
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0023	0.0292	0.0266
Toxoplasma gondii	integral membrane protein, GNS1/SUR4 family protein, putative	0.01	0.5461	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0023	0.0292	0.0266
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0023	0.0292	0.0487
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0228	0.5
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0022	0.0228	0.0196
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0023	0.0292	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0115	0.6448	0.6403
Trypanosoma brucei	DNA polymerase IV, putative	0.0022	0.0228	0.0196
Leishmania major	hypothetical protein, conserved	0.0028	0.0674	0.103
Brugia malayi	fatty acid elongation protein 3	0.002	0.0124	0.0124
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0023	0.0292	0.0171
Loa Loa (eye worm)	RNA binding protein	0.0072	0.3581	0.35
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0228	0.5
Toxoplasma gondii	GNS1/SUR4 family protein	0.01	0.5461	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0674	0.103
Brugia malayi	photoreceptor-specific nuclear receptor	0.0023	0.0292	0.0292
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.3581	0.35
Brugia malayi	ecdysteroid receptor	0.0023	0.0292	0.0292
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.2222	0.2222
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.2222	0.6069
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0023	0.0292	0.0487
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0023	0.0292	0.0292
Echinococcus multilocularis	FTZ F1 alpha	0.0023	0.0292	0.0487
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0023	0.0292	0.0487
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0228	0.0106
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0022	0.0228	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0674	0.103
Echinococcus granulosus	tar DNA binding protein	0.0072	0.3581	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0228	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0053	0.2325	0.2325
Trypanosoma cruzi	DNA polymerase eta, putative	0.0022	0.0228	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0023	0.0292	0.0292
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0023	0.0292	0.0266
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0023	0.0292	0.0292
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0023	0.0292	0.0292
Trypanosoma cruzi	fatty acid elongase, putative	0.01	0.5461	1
Schistosoma mansoni	DNA polymerase eta	0.0022	0.0228	0.0165
Brugia malayi	Nuclear hormone receptor-like 1	0.0023	0.0292	0.0292
Loa Loa (eye worm)	steroid hormone receptor	0.0023	0.0292	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0674	0.0557
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0292	0.0266
Schistosoma mansoni	thyroid hormone receptor	0.0023	0.0292	0.0266
Onchocerca volvulus	Protein ultraspiracle homolog	0.0023	0.0292	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Schistosoma mansoni	coup transcription factor	0.0023	0.0292	0.0266
Echinococcus granulosus	FTZ F1 alpha	0.0023	0.0292	0.0487
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0022	0.0228	0.0196
Brugia malayi	steroid hormone receptor	0.0023	0.0292	0.0292
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0023	0.0292	0.0292
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0674	0.103
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171
Leishmania major	DNA polymerase eta, putative	0.0022	0.0228	0.0196
Trypanosoma brucei	unspecified product	0.0022	0.0228	0.0196
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0023	0.0292	0.0292
Brugia malayi	nuclear receptor NHR-88	0.0023	0.0292	0.0292
Echinococcus granulosus	dna polymerase eta	0.0022	0.0228	0.0302
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0053	0.2325	0.6369
Giardia lamblia	DINP protein human, muc B family	0.0022	0.0228	0.5
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0292	0.0171

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10 nM	Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay	ChEMBL.	19883081
IC50 (binding)	= 20 nM	Inhibition of mouse ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay	ChEMBL.	19883081
IC50 (binding)	= 22 nM	Inhibition of human ELOVL6 expressed in Pichia pastoris using palmitoyl-CoA by long chain fatty acyl-CoA elongation assay	ChEMBL.	19883081
IC50 (binding)	= 50 nM	Inhibition of ELOVL6 in mouse H2.35 cells assessed as elongation index	ChEMBL.	19883081

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL571698

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1065273