Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | B-Raf proto-oncogene, serine/threonine kinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Echinococcus multilocularis | raf serine:threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Schistosoma japonicum | ko:K04365 B-Raf proto-oncogene serine/threonine-protein kinase, putative | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Brugia malayi | Raf kinase | Get druggable targets OG5_130459 | All targets in OG5_130459 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0262 | 0.1382 | 0.1382 |
Loa Loa (eye worm) | raf kinase | 0.026 | 0.1374 | 0.1374 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0262 | 0.1382 | 0.1382 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hyaluronidase | 0.1613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.1196 | 0.1196 |
Schistosoma mansoni | Hyaluronidase | 0.1613 | 1 | 1 |
Loa Loa (eye worm) | TKL/RAF/RAF protein kinase | 0.0148 | 0.0659 | 0.0659 |
Brugia malayi | hypothetical protein | 0.0233 | 0.1196 | 0.1196 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.1196 | 0.1196 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.1613 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0016 | 0.0016 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0262 | 0.1382 | 0.1382 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.1196 | 0.1196 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0016 | 0.0016 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.1613 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0685 | 0.4083 | 0.4083 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.1613 | 1 | 1 |
Brugia malayi | Raf kinase | 0.0253 | 0.1324 | 0.1324 |
Onchocerca volvulus | 0.0047 | 0.0016 | 0.5 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19875283 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.