Detailed information for compound 1067246

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 654.962 | Formula: C40H66N2O5
  • H donors: 2 H acceptors: 3 LogP: 8.37 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: NCCCCCCNC(=O)[C@@]12CC[C@H]([C@@H]2[C@@H]2[C@](CC1)(C)[C@]1(C)CC[C@@H]3[C@]([C@H]1CC2)(C)CC[C@@H]([C@@]3(C)COC(=O)C)OC(=O)C)C(=C)C
  • InChi: 1S/C40H66N2O5/c1-26(2)29-15-20-40(35(45)42-24-12-10-9-11-23-41)22-21-38(7)30(34(29)40)13-14-32-36(5)18-17-33(47-28(4)44)37(6,25-46-27(3)43)31(36)16-19-39(32,38)8/h29-34H,1,9-25,41H2,2-8H3,(H,42,45)/t29-,30+,31+,32+,33-,34+,36-,37-,38+,39+,40-/m0/s1
  • InChiKey: YWCDQKUFVSUSAU-RAUXRALFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Glycogen phosphorylase, muscle form Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Glycogen phosphorylase, muscle form   843 aa 840 aa 70.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Cathepsin L precursor 0.0472 0.1098 0.2427
Brugia malayi Cathepsin L-like precursor 0.2031 0.5122 0.5122
Loa Loa (eye worm) hypothetical protein 0.1389 0.3464 0.3464
Trypanosoma brucei cysteine peptidase C (CPC) 0.1539 0.3851 0.312
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0472 0.1098 0.2139
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0695 0.1672 0.3134
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0695 0.1672 0.1672
Plasmodium vivax vivapain-3 0.1114 0.2755 0.529
Loa Loa (eye worm) hypothetical protein 0.0147 0.0259 0.0259
Echinococcus granulosus glycogen phosphorylase 0.013 0.0215 0.0215
Entamoeba histolytica cysteine proteinase, putative 0.1114 0.2755 0.5357
Onchocerca volvulus 0.2031 0.5122 1
Plasmodium falciparum serine repeat antigen 8 0.0472 0.1098 0.1991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1389 0.3464 0.6762
Entamoeba histolytica cysteine protease, putative 0.0472 0.1098 0.2106
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0472 0.1098 0.1098
Onchocerca volvulus Glycogen phosphorylase homolog 0.013 0.0215 0.042
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0472 0.1098 0.2139
Toxoplasma gondii cathepsin B 0.1539 0.3851 0.7471
Plasmodium vivax unspecified product 0.1114 0.2755 0.529
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0695 0.1672 0.3134
Onchocerca volvulus 0.2031 0.5122 1
Echinococcus multilocularis cysteine protease 0.2031 0.5122 0.5122
Giardia lamblia Cysteine protease 0.0472 0.1098 0.2427
Giardia lamblia Hypothetical protein 0.0472 0.1098 0.2427
Schistosoma mansoni glycogen phosphorylase 0.013 0.0215 0.0215
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0056 0.0024 1
Entamoeba histolytica cysteine proteinase 1, putative 0.1114 0.2755 0.5357
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Brugia malayi Cathepsin L-like precursor 0.1389 0.3464 0.3464
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0017 0.0017
Brugia malayi Papain family cysteine protease containing protein 0.0472 0.1098 0.1098
Trypanosoma cruzi cysteine proteinase, putative 0.1114 0.2755 0.1862
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.392 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0472 0.1098 0.2139
Echinococcus granulosus cathepsin L cysteine proteinase 0.2031 0.5122 0.5122
Entamoeba histolytica cysteine proteinase, putative 0.1114 0.2755 0.5357
Loa Loa (eye worm) hypothetical protein 0.0472 0.1098 0.1098
Entamoeba histolytica cysteine protease, putative 0.0472 0.1098 0.2106
Chlamydia trachomatis glycogen phosphorylase 0.013 0.0215 1
Trichomonas vaginalis chromobox protein, putative 0.008 0.0085 0.016
Toxoplasma gondii cathepsin CPC2 0.0557 0.1316 0.2424
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Schistosoma mansoni cathepsin F (C01 family) 0.2031 0.5122 0.5122
Brugia malayi Papain family cysteine protease containing protein 0.1114 0.2755 0.2755
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.392 1 1
Leishmania major cathepsin L-like protease 0.2475 0.6268 1
Brugia malayi cathepsin L precursor 0.0472 0.1098 0.1098
Trypanosoma cruzi cysteine peptidase, putative 0.2031 0.5122 0.452
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0642 0.1536 0.1536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0557 0.1316 0.2424
Leishmania major cathepsin L-like protease 0.2031 0.5122 0.5258
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0472 0.1098 0.2139
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Brugia malayi Papain family cysteine protease containing protein 0.0472 0.1098 0.1098
Brugia malayi Cathepsin L-like precursor 0.2031 0.5122 0.5122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Leishmania major cysteine peptidase A (CPA) 0.2031 0.5122 0.5258
Echinococcus granulosus cysteine protease 0.1114 0.2755 0.2755
Entamoeba histolytica cysteine proteinase, putative 0.1114 0.2755 0.5357
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2031 0.5122 1
Giardia lamblia Cathepsin B precursor 0.1539 0.3851 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0097 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.1389 0.3464 0.6749
Plasmodium falciparum serine repeat antigen 9 0.0472 0.1098 0.1991
Giardia lamblia Hypothetical protein 0.0472 0.1098 0.2427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0713 0.1719 0.3352
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0472 0.1098 0.1098
Echinococcus granulosus cathepsin L cysteine protease 0.1114 0.2755 0.2755
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Giardia lamblia Cathepsin L-like protease 0.0472 0.1098 0.2427
Trypanosoma cruzi cysteine proteinase, putative 0.1114 0.2755 0.1862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0472 0.1098 0.1991
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Giardia lamblia Cathepsin B precursor 0.0472 0.1098 0.2427
Loa Loa (eye worm) cathepsin B 0.1539 0.3851 0.3851
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.2031 0.5122 1
Schistosoma mansoni cathepsin F (C01 family) 0.1389 0.3464 0.3464
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.1098 0.1098
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0472 0.1098 0.1098
Plasmodium falciparum cysteine proteinase falcipain 3 0.2031 0.5122 1
Echinococcus multilocularis muscleblind protein 0.0147 0.0259 0.0259
Echinococcus multilocularis cathepsin b 0.392 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1114 0.2755 0.5377
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.0357 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Brugia malayi fibroinase precursor 0.0472 0.1098 0.1098
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Echinococcus multilocularis geminin 0.0184 0.0353 0.0353
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.0564 0.0564
Brugia malayi Cathepsin L-like precursor 0.2031 0.5122 0.5122
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0472 0.1098 0.1098
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0472 0.1098 0.2106
Brugia malayi Cathepsin L-like precursor 0.2031 0.5122 0.5122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Brugia malayi carbohydrate phosphorylase 0.013 0.0215 0.0215
Onchocerca volvulus 0.2031 0.5122 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1833 0.4611 0.3946
Echinococcus granulosus cathepsin b 0.392 1 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.0357 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Echinococcus multilocularis chromobox protein 1 0.008 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0017 0.0017
Plasmodium falciparum serine repeat antigen 7 0.0472 0.1098 0.1991
Giardia lamblia Cysteine protease 0.0472 0.1098 0.2427
Echinococcus granulosus chromobox protein 1 0.008 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.2031 0.5122 0.5122
Giardia lamblia Cysteine protease 0.0472 0.1098 0.2427
Giardia lamblia Cysteine protease 0.0472 0.1098 0.2427
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1114 0.2755 0.2755
Plasmodium vivax vivapain-2 0.2031 0.5122 1
Giardia lamblia Cathepsin L-like protease 0.0472 0.1098 0.2427
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.1098 0.1098
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.392 1 1
Loa Loa (eye worm) hypothetical protein 0.0472 0.1098 0.1098
Echinococcus multilocularis chromobox protein 1 0.008 0.0085 0.0085
Brugia malayi Cathepsin L-like precursor 0.2031 0.5122 0.5122
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0472 0.1098 0.2106
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0147 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0054 0.0017 0.0017
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0472 0.1098 0.1991
Plasmodium falciparum serine repeat antigen 4 0.0472 0.1098 0.1991
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0017 0.0017
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0557 0.1316 0.3027
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.392 1 1
Plasmodium falciparum serine repeat antigen 1 0.0472 0.1098 0.1991
Schistosoma mansoni cathepsin S (C01 family) 0.0472 0.1098 0.1098
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0713 0.1719 0.1719
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0695 0.1672 0.3134
Echinococcus multilocularis cathepsin L 0.0472 0.1098 0.1098
Entamoeba histolytica hypothetical protein 0.0472 0.1098 0.2106
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0472 0.1098 0.1991
Echinococcus granulosus cathepsin l1 0.1389 0.3464 0.3464
Brugia malayi cathepsin L-like cysteine proteinase 0.0472 0.1098 0.1098
Echinococcus granulosus cathepsin b 0.392 1 1
Onchocerca volvulus 0.2031 0.5122 1
Entamoeba histolytica cysteine protease, putative 0.0472 0.1098 0.2106
Entamoeba histolytica cysteine protease, putative 0.0472 0.1098 0.2106
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1098 0.2139
Brugia malayi cathepsin Z-like cysteine proteinase 0.0713 0.1719 0.1719
Plasmodium falciparum cysteine proteinase falcipain 2b 0.2031 0.5122 1
Plasmodium vivax unspecified product 0.0472 0.1098 0.1991
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0022 0.0022
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0097 1
Echinococcus granulosus muscleblind protein 0.0147 0.0259 0.0259
Leishmania major cathepsin L-like protease 0.2031 0.5122 0.5258
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2031 0.5122 0.5122
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0097 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0472 0.1098 0.1098
Brugia malayi cathepsin F-like cysteine proteinase 0.0642 0.1536 0.1536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0472 0.1098 0.2139
Brugia malayi Cathepsin L-like precursor 0.0642 0.1536 0.1536
Leishmania major cathepsin L-like protease 0.2475 0.6268 1
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0695 0.1672 0.4007
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0215 0.0375
Giardia lamblia Cathepsin B precursor 0.0472 0.1098 0.2427
Onchocerca volvulus 0.1389 0.3464 0.6764
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0472 0.1098 0.2139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0472 0.1098 0.2139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0472 0.1098 0.2139
Echinococcus granulosus glycogen phosphorylase 0.013 0.0215 0.0215
Brugia malayi Cathepsin L-like precursor 0.2031 0.5122 0.5122
Giardia lamblia Cathepsin L precursor 0.0472 0.1098 0.2427
Plasmodium falciparum serine repeat antigen 6 0.0472 0.1098 0.1991
Loa Loa (eye worm) MBCTL1 0.0054 0.0017 0.0017
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0472 0.1098 0.1991
Brugia malayi Heterochromatin protein 1 0.008 0.0085 0.0085
Plasmodium vivax vivapain-2 0.2031 0.5122 1
Giardia lamblia Cathepsin B precursor 0.1539 0.3851 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0472 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1389 0.3464 0.6762
Schistosoma mansoni cathepsin s 0.0642 0.1536 0.1536
Loa Loa (eye worm) cysteine protease 0.2031 0.5122 0.5122
Entamoeba histolytica cysteine protease, putative 0.2031 0.5122 1
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0472 0.1098 0.1991
Trypanosoma cruzi cysteine peptidase, putative 0.2475 0.6268 0.5808
Onchocerca volvulus 0.2031 0.5122 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0713 0.1719 0.3352
Trypanosoma cruzi cruzipain precursor, putative 0.0642 0.1536 0.0492
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1539 0.3851 0.3851
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0472 0.1098 0.1098
Echinococcus granulosus cathepsin L 0.1114 0.2755 0.2755
Schistosoma mansoni glycogen phosphorylase 0.0056 0.0024 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.1114 0.2755 0.1862
Echinococcus multilocularis cathepsin L cysteine protease 0.2031 0.5122 0.5122
Schistosoma mansoni glycogen phosphorylase 0.013 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0472 0.1098 0.1098
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1114 0.2755 0.2755
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.0215 0.0375
Echinococcus multilocularis cathepsin l cysteine peptidase 0.2031 0.5122 0.5122
Onchocerca volvulus 0.2031 0.5122 1
Toxoplasma gondii cathepsin CPC1 0.0695 0.1672 0.3134
Giardia lamblia Cathepsin B precursor 0.1539 0.3851 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Echinococcus granulosus geminin 0.0184 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.1389 0.3464 0.3464
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Giardia lamblia Cathepsin L precursor 0.0472 0.1098 0.2427
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0215 0.0215
Leishmania major cathepsin L-like protease 0.2031 0.5122 0.5258
Loa Loa (eye worm) fibroinase 0.2031 0.5122 0.5122
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Loa Loa (eye worm) hypothetical protein 0.2031 0.5122 0.5122
Brugia malayi Papain family cysteine protease containing protein 0.1114 0.2755 0.2755
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1539 0.3851 0.7517
Plasmodium vivax serine-repeat antigen (SERA) 0.0472 0.1098 0.1991
Schistosoma mansoni hypothetical protein 0.0184 0.0353 0.0353
Entamoeba histolytica cysteine proteinase 2 0.1114 0.2755 0.5357
Loa Loa (eye worm) hypothetical protein 0.0472 0.1098 0.1098
Brugia malayi Muscleblind-like protein 0.0147 0.0259 0.0259
Onchocerca volvulus 0.2031 0.5122 1
Brugia malayi cathepsin L-like precursor 0.1389 0.3464 0.3464
Schistosoma mansoni chromobox protein 0.008 0.0085 0.0085
Plasmodium falciparum serine repeat antigen 2 0.0472 0.1098 0.1991
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0048 0.0003 0.0006
Onchocerca volvulus 0.0472 0.1098 0.2143
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.392 1 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0713 0.1719 0.1719
Echinococcus granulosus cathepsin L 0.0472 0.1098 0.1098
Schistosoma mansoni cathepsin B (C01 family) 0.0472 0.1098 0.1098
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0097 0.0097
Leishmania major cathepsin L-like protease 0.2031 0.5122 0.5258
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0017 0.0017
Echinococcus granulosus chromobox protein 1 0.008 0.0085 0.0085
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0472 0.1098 0.2139
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0472 0.1098 0.2427
Echinococcus multilocularis cysteine protease 0.2031 0.5122 0.5122
Giardia lamblia Cathepsin L precursor 0.0472 0.1098 0.2427
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0472 0.1098 0.2139
Onchocerca volvulus Cathepsin F homolog 0.2031 0.5122 1
Schistosoma mansoni hypothetical protein 0.0286 0.0617 0.0617
Schistosoma mansoni hypothetical protein 0.0184 0.0353 0.0353
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1539 0.3851 0.3093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Trypanosoma cruzi cysteine peptidase, putative 0.0642 0.1536 0.0492
Loa Loa (eye worm) heterochromatin protein 1 0.008 0.0085 0.0085
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0713 0.1719 0.3352
Plasmodium falciparum serine repeat antigen 5 0.0472 0.1098 0.1991
Entamoeba histolytica cysteine proteinase, putative 0.2031 0.5122 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0642 0.1536 0.1536
Echinococcus multilocularis glycogen phosphorylase 0.013 0.0215 0.0215
Echinococcus multilocularis muscleblind protein 1 0.0147 0.0259 0.0259
Plasmodium falciparum serine repeat antigen 3 0.0472 0.1098 0.1991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0472 0.1098 0.2139
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0695 0.1672 0.3134
Schistosoma mansoni cathepsin F (C01 family) 0.2031 0.5122 0.5122
Echinococcus multilocularis cathepsin b 0.392 1 1
Schistosoma mansoni cathepsin C 0.0472 0.1098 0.1098
Entamoeba histolytica cysteine protease, putative 0.0472 0.1098 0.2106
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.2031 0.5122 0.5122
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.061 0.1454 0.2835
Trypanosoma cruzi cruzipain precursor, putative 0.2475 0.6268 0.5808
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0472 0.1098 0.2139
Trypanosoma cruzi cysteine peptidase, putative 0.2475 0.6268 0.5808
Brugia malayi follicle stimulating hormone receptor 0.0266 0.0564 0.0564
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Toxoplasma gondii preprocathepsin c precursor, putative 0.0695 0.1672 0.3134
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0713 0.1719 0.3352
Plasmodium vivax vivapain-1 0.1114 0.2755 0.529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0472 0.1098 0.1991
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0022 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1114 0.2755 0.5377
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0017 0.0017
Entamoeba histolytica cysteine protease, putative 0.0472 0.1098 0.2106
Loa Loa (eye worm) hypothetical protein 0.0642 0.1536 0.1536
Brugia malayi Papain family cysteine protease containing protein 0.2031 0.5122 0.5122
Echinococcus multilocularis cathepsin L cysteine protease 0.2031 0.5122 0.5122
Brugia malayi Cathepsin L-like precursor 0.1389 0.3464 0.3464
Loa Loa (eye worm) hypothetical protein 0.0472 0.1098 0.1098
Echinococcus granulosus cathepsin l1 0.2031 0.5122 0.5122
Entamoeba histolytica cysteine proteinase, putative 0.1114 0.2755 0.5357
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Toxoplasma gondii cathepsin CPL 0.2031 0.5122 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.1114 0.2755 0.529
Plasmodium vivax unspecified product 0.0642 0.1536 0.2863
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0097 0.0097
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.1114 0.2755 0.1862
Giardia lamblia Encystation-specific protease 0.0557 0.1316 0.3027
Giardia lamblia Cathepsin L precursor 0.0472 0.1098 0.2427
Loa Loa (eye worm) glycogen phosphorylase 0.013 0.0215 0.0215
Leishmania major cathepsin L-like protease 0.2031 0.5122 0.5258
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0472 0.1098 0.1098
Trypanosoma cruzi cysteine protease, putative 0.1114 0.2755 0.1862
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0215 0.0415
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0472 0.1098 0.1991
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0097 0.5
Brugia malayi Probable ClpP-like protease 0.0085 0.0097 0.0097
Entamoeba histolytica cysteine proteinase, putative 0.2031 0.5122 1
Giardia lamblia Cathepsin B precursor 0.0472 0.1098 0.2427
Loa Loa (eye worm) ctsf protein 0.2031 0.5122 0.5122
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.2031 0.5122 0.5122
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0097 1
Loa Loa (eye worm) hypothetical protein 0.0472 0.1098 0.1098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0097 0.0097
Echinococcus multilocularis cathepsin L 0.1114 0.2755 0.2755
Giardia lamblia Cathepsin L precursor 0.0472 0.1098 0.2427
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.0215 0.0415
Loa Loa (eye worm) hypothetical protein 0.1389 0.3464 0.3464
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0097 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.1114 0.2755 0.2755
Schistosoma mansoni chromobox protein 0.008 0.0085 0.0085
Giardia lamblia Cathepsin B precursor 0.0472 0.1098 0.2427
Loa Loa (eye worm) hypothetical protein 0.392 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.2475 0.6268 0.5808
Loa Loa (eye worm) hypothetical protein 0.0642 0.1536 0.1536
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0472 0.1098 0.2139
Plasmodium falciparum cysteine proteinase falcipain 2a 0.2031 0.5122 1
Trichomonas vaginalis chromobox protein, putative 0.008 0.0085 0.016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.2031 0.5122 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0916 0.2244 0.1288
Onchocerca volvulus Cathepsin L homolog 0.2031 0.5122 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.2031 0.5122 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.1389 0.3464 0.3464
Echinococcus multilocularis Glycosyl transferase, family 35 0.013 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.2475 0.6268 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0472 0.1098 0.1991
Onchocerca volvulus Cathepsin L homolog 0.0472 0.1098 0.2143
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0557 0.1316 0.2424
Entamoeba histolytica cysteine protease, putative 0.1114 0.2755 0.5357
Leishmania major cathepsin L-like protease 0.2475 0.6268 1
Brugia malayi Papain family cysteine protease containing protein 0.0472 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.0642 0.1536 0.1536
Onchocerca volvulus Cathepsin L homolog 0.2031 0.5122 1
Giardia lamblia Cathepsin B precursor 0.0713 0.1719 0.4135
Echinococcus granulosus Glycosyl transferase family 35 0.013 0.0215 0.0215
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0557 0.1316 0.3027

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3.5 uM Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins ChEMBL. 19889536

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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