Detailed information for compound 107041

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 526.504 | Formula: C21H33F3N4O8
  • H donors: 5 H acceptors: 6 LogP: -1.08 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.CCCCOC(=O)N[C@H](C(=O)O)CNC(=O)CC1ON=C(C1)CC1CCNCC1
  • InChi: 1S/C19H32N4O6.C2HF3O2/c1-2-3-8-28-19(27)22-16(18(25)26)12-21-17(24)11-15-10-14(23-29-15)9-13-4-6-20-7-5-13;3-2(4,5)1(6)7/h13,15-16,20H,2-12H2,1H3,(H,21,24)(H,22,27)(H,25,26);(H,6,7)/t15?,16-;/m0./s1
  • InChiKey: IYGZVOLPXIAYLJ-UFUZRDLVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Integrin alpha pat-2 precursor Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma mansoni integrin alpha Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) integrin alpha pat-2 Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus granulosus integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus multilocularis integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum ko:K06476 integrin alpha 2B, putative Get druggable targets OG5_129341 All targets in OG5_129341
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.002 0.025 0.0377
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0186 0.0404
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0184 0.3394 0.4572
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Onchocerca volvulus 0.03 0.5615 1
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0015 0.0159 0.2047
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0258 0.0296
Echinococcus granulosus neuropeptides capa receptor 0.03 0.5615 0.76
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Echinococcus multilocularis O glycosyltransferase 0.0041 0.0661 0.0846
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.2171 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.004 0.004
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0015 0.0167 0.2139
Echinococcus granulosus neuropeptides capa receptor 0.03 0.5615 0.76
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0258 0.0296
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0109 0.1956 0.8918
Loa Loa (eye worm) hypothetical protein 0.0008 0.0032 0.0032
Onchocerca volvulus 0.0059 0.101 0.1559
Loa Loa (eye worm) hypothetical protein 0.004 0.0633 0.0633
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0015 0.0159 0.0345
Echinococcus multilocularis Metazoa galactosyltransferase 0.0186 0.3438 0.4632
Schistosoma mansoni amine GPCR 0.03 0.5615 1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0258 0.039
Echinococcus multilocularis 6 phosphofructokinase 0.0109 0.1956 0.2613
Loa Loa (eye worm) hypothetical protein 0.014 0.2549 0.2549
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.03 0.5615 0.76
Trypanosoma cruzi thymidine kinase, putative 0.0248 0.4618 1
Brugia malayi phosphofructokinase 0.0109 0.1956 0.1924
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus multilocularis neuropeptide receptor 0.03 0.5615 0.76
Loa Loa (eye worm) neuropeptide F receptor 0.03 0.5615 0.5615
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0068 0.1172 0.4968
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0107 0.0107
Trichomonas vaginalis thymidine kinase, putative 0.0248 0.4618 0.8105
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.025 0.0542
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0258 0.0296
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0015 0.0159 0.0192
Onchocerca volvulus 0.03 0.5615 1
Schistosoma mansoni integrin alpha-ps 0.0043 0.0698 0.118
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0435 0.0764
Echinococcus granulosus beta 14 N acetylgalactosaminyltransferase 0.0049 0.0809 0.1048
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Onchocerca volvulus 0.03 0.5615 1
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1956 0.3438
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.03 0.5615 0.76
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Brugia malayi Rhodanese-like domain containing protein 0.0059 0.101 0.0974
Brugia malayi Cytochrome P450 family protein 0.0012 0.0107 0.0067
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.03 0.5615 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0258 0.0452
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0435 0.0764
Echinococcus multilocularis integrin alpha 3 0.0142 0.2585 0.347
Brugia malayi GnHR receptor homolog 0.03 0.5615 0.5597
Schistosoma mansoni lamin 0.0027 0.0386 0.0621
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0435 0.1434
Echinococcus multilocularis tachykinin peptides receptor 99D 0.03 0.5615 0.76
Echinococcus multilocularis lamin dm0 0.0027 0.0386 0.0472
Loa Loa (eye worm) hypothetical protein 0.0008 0.0032 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.03 0.5615 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0186 0.3438 0.6095
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0098 0.1752 0.3075
Echinococcus multilocularis neuropeptide Y receptor 0.03 0.5615 0.76
Schistosoma mansoni regulator of G protein signaling 0.002 0.0258 0.039
Schistosoma mansoni biogenic amine receptor 0.03 0.5615 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0049 0.0809 0.1379
Loa Loa (eye worm) hypothetical protein 0.0009 0.0039 0.0039
Echinococcus multilocularis neuropeptide receptor A26 0.03 0.5615 0.76
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0435 0.456
Onchocerca volvulus 0.03 0.5615 1
Brugia malayi DNA polymerase family B containing protein 0.0015 0.0159 0.012
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0258 0.0296
Echinococcus multilocularis allatostatin A receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.0059 0.101 0.101
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1956 0.4123
Leishmania major trypanothione reductase 0.0047 0.0779 0.1687
Echinococcus granulosus 7tm_1 domain containing protein 0.03 0.5615 0.76
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1956 0.3434
Brugia malayi intermediate filament protein 0.0027 0.0386 0.0348
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0186 0.2393
Echinococcus granulosus 7TM GPCR rhodopsin 0.03 0.5615 0.76
Loa Loa (eye worm) DNA polymerase epsilon catalytic subunit 0.0008 0.0032 0.0032
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.0041 0.0658 0.0658
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0015 0.0159 0.028
Schistosoma mansoni beta-14-galactosyltransferase 0.0049 0.0809 0.1379
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1956 0.3434
Brugia malayi G-protein coupled receptor 0.03 0.5615 0.5597
Leishmania major thymidine kinase, putative 0.0248 0.4618 1
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Onchocerca volvulus 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus granulosus bloom syndrome protein 0.0021 0.0279 0.0326
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0015 0.0159 0.0261
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.025 0.0286
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Schistosoma mansoni amine GPCR 0.03 0.5615 1
Onchocerca volvulus 0.0098 0.1752 0.2919
Echinococcus multilocularis g protein coupled receptor 0.03 0.5615 0.76
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0159 0.0154
Schistosoma mansoni phenylalanine decarboxylase 0.0049 0.0809 0.1379
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0098 0.1752 0.3075
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0258 0.0296
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.03 0.5615 0.76
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0258 0.0296
Loa Loa (eye worm) phosphofructokinase 0.0109 0.1956 0.1956
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Echinococcus granulosus 6 phosphofructokinase 0.0109 0.1956 0.2613
Onchocerca volvulus Neuropeptide F receptor homolog 0.03 0.5615 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0186 0.0214
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0386 0.0386
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0258 0.0218
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0258 0.0258
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0186 0.0327
Brugia malayi PXA domain containing protein 0.002 0.0258 0.0218
Echinococcus multilocularis G protein coupled receptor 139 0.03 0.5615 0.76
Schistosoma mansoni neuropeptide F-like receptor 0.03 0.5615 1
Brugia malayi putative neuropeptide receptor NPR1 0.03 0.5615 0.5597
Echinococcus granulosus somatostatin receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Trypanosoma brucei trypanothione reductase 0.0047 0.0779 0.1522
Echinococcus granulosus rhodopsin orphan GPCR 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1956 0.3434
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0148 0.0148
Brugia malayi hypothetical protein 0.002 0.0258 0.0218
Echinococcus granulosus lamin 0.0027 0.0386 0.0472
Trichomonas vaginalis thymidine kinase, putative 0.0248 0.4618 0.8105
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0258 0.039
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.003 0.0452 0.0793
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0015 0.0159 0.0192
Toxoplasma gondii DNA polymerase family B protein 0.0015 0.0159 0.1972
Brugia malayi larval opioid receptor 0.03 0.5615 0.5597
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0186 0.2305
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0779 0.1007
Echinococcus multilocularis fmrfamide receptor 0.03 0.5615 0.76
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.025 0.0211
Loa Loa (eye worm) hypothetical protein 0.0059 0.101 0.101
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0258 0.0218
Loa Loa (eye worm) G-protein coupled receptor 0.03 0.5615 0.5615
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0059 0.101 0.1773
Schistosoma mansoni integrin alpha-ps 0.0083 0.1459 0.2545
Brugia malayi Integrin alpha pat-2 precursor 0.0185 0.3411 0.3384
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0109 0.1956 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.03 0.5615 1
Echinococcus granulosus allatostatin A receptor 0.03 0.5615 0.76
Schistosoma mansoni hypothetical protein 0.03 0.5615 1
Echinococcus granulosus g protein coupled receptor 0.03 0.5615 0.76
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0258 0.0296
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.03 0.5615 0.76
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.03 0.5615 0.5615
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.101 0.1773
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.03 0.5615 0.5615
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0435 0.0764
Onchocerca volvulus 0.03 0.5615 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0435 0.0764
Echinococcus granulosus rhodopsin orphan GPCR 0.03 0.5615 0.76
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.03 0.5615 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.03 0.5615 0.76
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0258 0.0296
Brugia malayi Rhodanese-like domain containing protein 0.0059 0.101 0.0974
Echinococcus multilocularis integrin alpha ps 0.004 0.0633 0.0808
Onchocerca volvulus 0.03 0.5615 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0186 0.0147
Trichomonas vaginalis cdc25b, putative 0.0059 0.101 0.1773
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0435 0.0764
Loa Loa (eye worm) hypothetical protein 0.0075 0.1301 0.1301
Entamoeba histolytica hypothetical protein 0.002 0.0258 0.0452
Schistosoma mansoni myosin xvIII 0.03 0.5615 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0184 0.3394 0.6016
Schistosoma mansoni amine GPCR 0.03 0.5615 1
Schistosoma mansoni beta-14-galactosyltransferase 34-related 0.0049 0.0809 0.1379
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.03 0.5615 0.5597
Loa Loa (eye worm) melatonin receptor type 1A 0.03 0.5615 0.5615
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0159 0.0345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0279 0.049
Plasmodium falciparum DNA polymerase epsilon catalytic subunit A, putative 0.0008 0.0032 0.0406
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.025 0.0776
Schistosoma mansoni lamin 0.0027 0.0386 0.0621
Echinococcus multilocularis musashi 0.0027 0.0386 0.0472
Echinococcus granulosus hypothetical protein 0.03 0.5615 0.76
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0186 0.0214
Echinococcus multilocularis beta 1,4 galactosyltransferase 7 0.0049 0.0809 0.1048
Giardia lamblia Thymidine kinase 0.0248 0.4618 1
Brugia malayi 6-phosphofructokinase 0.0109 0.1956 0.1924
Loa Loa (eye worm) hypothetical protein 0.0145 0.265 0.265
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0186 0.0404
Echinococcus granulosus Metazoa galactosyltransferase 0.0186 0.3438 0.4632
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.194 0.8837
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0452 0.0978
Echinococcus multilocularis expressed protein 0.0392 0.7375 1
Schistosoma mansoni neuropeptide receptor 0.03 0.5615 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0258 0.0452
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0258 0.0296
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0054 0.0912 0.1188
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0098 0.1752 0.3739
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0098 0.1752 0.8894
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus granulosus neuropeptide s receptor 0.03 0.5615 0.76
Echinococcus granulosus g protein coupled receptor 0.03 0.5615 0.76
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0304 0.5697 1
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.101 0.1773
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0258 0.0452
Schistosoma mansoni beta-14-galactosyltransferase 34-related 0.002 0.0256 0.0387
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0779 1
Brugia malayi G protein-coupled receptor 0.03 0.5615 0.5597
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0386 0.0348
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0054 0.0912 0.1188
Brugia malayi gonadotropin-releasing hormone receptor 2 0.03 0.5615 0.5597
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0054 0.0912 0.1563
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0016 0.0181 0.0004
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Onchocerca volvulus 0.0027 0.0386 0.0416
Giardia lamblia O-linked GlcNAc transferase 0.0024 0.0329 0.063
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0186 0.0619
Schistosoma mansoni neuropeptide receptor 0.03 0.5615 1
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.0013 0.012 0.012
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0279 0.024
Schistosoma mansoni regulator of G protein signaling 0.002 0.0258 0.039
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0435 0.5589
Schistosoma mansoni hypothetical protein 0.03 0.5615 1
Echinococcus granulosus fmrfamide receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0258 0.0296
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.03 0.5615 0.76
Echinococcus multilocularis g-protein coupled receptor 0.03 0.5615 0.76
Brugia malayi PXA domain containing protein 0.002 0.0258 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.03 0.5615 0.76
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.012 0.0109
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0779 0.1687
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0326 0.0706
Loa Loa (eye worm) neuropeptide F receptor 0.03 0.5615 0.5615
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0015 0.0159 0.0214
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0098 0.1752 0.3075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.025 0.0542
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0015 0.0159 0.028
Giardia lamblia O-linked GlcNAc transferase 0.0041 0.0652 0.1336
Loa Loa (eye worm) galactosyltransferase 0.0186 0.3438 0.3438
Echinococcus granulosus neuropeptide Y receptor 0.03 0.5615 0.76
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0258 0.0296
Brugia malayi sulfakinin receptor protein 0.03 0.5615 0.5597
Schistosoma mansoni opsin-like receptor 0.03 0.5615 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0103 0.0063
Leishmania major cytochrome p450-like protein 0.0012 0.0107 0.0231
Echinococcus granulosus neuropeptide receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0098 0.1752 0.3075
Schistosoma mansoni alpha-1 adrenergic receptor 0.03 0.5615 1
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0258 0.0296
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0258 0.0296
Mycobacterium tuberculosis Probable reductase 0.0108 0.194 0.8837
Brugia malayi Dopamine receptor protein 2 0.03 0.5615 0.5597
Echinococcus multilocularis g protein coupled receptor 0.03 0.5615 0.76
Trichomonas vaginalis ap endonuclease, putative 0.002 0.025 0.0439
Loa Loa (eye worm) glutathione reductase 0.0047 0.0779 0.0779
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0258 0.039
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Schistosoma mansoni beta-14-galactosyltransferase 0.0049 0.0809 0.1379
Echinococcus granulosus expressed protein 0.0392 0.7375 1
Loa Loa (eye worm) RecQ helicase 0.0021 0.0279 0.0279
Echinococcus multilocularis neuropeptide FF receptor 2 0.03 0.5615 0.76
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1956 0.3434
Brugia malayi Galactosyltransferase family protein 0.0186 0.3438 0.3411
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0184 0.3394 0.3367
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.004 0.0497
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Echinococcus granulosus integrin alpha ps 0.004 0.0633 0.0808
Echinococcus granulosus g-protein coupled receptor 0.03 0.5615 0.76
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.03 0.5615 0.76
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.009 0.0194
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Toxoplasma gondii hypothetical protein 0.0049 0.0809 1
Echinococcus granulosus sex peptide receptor 0.03 0.5615 0.76
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0258 0.0218
Brugia malayi ORL1-like opioid receptor 0.03 0.5615 0.5597
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) hypothetical protein 0.002 0.0256 0.0256
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.03 0.5615 0.5597
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.025 0.163
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0186 0.0431
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0098 0.1752 0.1752
Schistosoma mansoni hypothetical protein 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0197 0.0197
Echinococcus granulosus rhodopsin orphan GPCR 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.0043 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.03 0.5615 1
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0186 0.0228
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0258 0.0258
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.194 0.8837
Echinococcus granulosus polypeptide N acetylgalactosaminyltransferase 0.002 0.0256 0.0294
Brugia malayi Cytochrome P450 family protein 0.0012 0.0107 0.0067
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0186 0.0619
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0186 0.0834
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0186 0.0214
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1956 0.3434
Schistosoma mansoni hypothetical protein 0.03 0.5615 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0159 0.0345
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.03 0.5615 1
Schistosoma mansoni histamine h1 receptor 0.03 0.5615 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0148 0.0108
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1956 0.1956
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.025 0.0392
Toxoplasma gondii thioredoxin reductase 0.0047 0.0779 0.9632
Schistosoma mansoni integrin alpha 0.0185 0.3411 0.6047
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.025 0.025
Onchocerca volvulus 0.0059 0.101 0.1559
Schistosoma mansoni amine GPCR 0.03 0.5615 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0435 0.0764
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.004 0.0516
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0258
Echinococcus granulosus biogenic amine 5HT receptor 0.03 0.5615 0.76
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0258 0.0296
Entamoeba histolytica dual specificity protein phosphatase, putative 0.0304 0.5697 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0258 0.039
Schistosoma mansoni hypothetical protein 0.0137 0.2496 0.4406
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.03 0.5615 1
Brugia malayi Serotonin receptor 0.03 0.5615 0.5597
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0015 0.0159 0.0214
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0015 0.0159 0.0163
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.003 0.0452 0.0793
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0186 0.0262
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0015 0.0159 0.0163
Onchocerca volvulus 0.03 0.5615 1
Schistosoma mansoni amine GPCR 0.03 0.5615 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0386 0.0472
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0452 0.0978
Leishmania major hypothetical protein, conserved 0.003 0.0452 0.0978
Echinococcus multilocularis g protein coupled receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.025 1
Trichomonas vaginalis cdc25b, putative 0.0059 0.101 0.1773
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0044 0.0715 0.8846
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0015 0.0159 0.0163
Echinococcus multilocularis serotonin receptor 0.03 0.5615 0.76
Echinococcus multilocularis Ribosomal protein L34a 0.0137 0.2501 0.3355
Loa Loa (eye worm) beta-1,4-galactosyltransferase VII 0.0049 0.0809 0.0809
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0435 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0258 0.039
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0015 0.0159 0.0159
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.03 0.5615 0.76
Onchocerca volvulus 0.03 0.5615 1
Schistosoma mansoni neuropeptide F-like receptor 0.03 0.5615 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0049 0.0809 0.1379
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.03 0.5615 0.76
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0258 0.0218
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0015 0.0159 0.0261
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0186 0.2393
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0193 0.0275
Brugia malayi glutathione reductase 0.0047 0.0779 0.0742
Brugia malayi Serotonin receptor 0.03 0.5615 0.5597
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0059 0.101 0.1773
Echinococcus multilocularis beta 1,4 N acetylgalactosaminyltransferase 0.0049 0.0809 0.1048
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.101 0.1773
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.03 0.5615 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.025 0.3213
Echinococcus granulosus G protein coupled receptor 139 0.03 0.5615 0.76
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0258 0.039
Echinococcus granulosus neuropeptide receptor A26 0.03 0.5615 0.76
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0386 0.0386
Onchocerca volvulus 0.03 0.5615 1
Brugia malayi AKH receptor 0.03 0.5615 0.5597
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0103 0.0063
Echinococcus granulosus neuropeptide Y receptor 0.03 0.5615 0.76
Schistosoma mansoni beta-14-galactosyltransferase 0.0049 0.0809 0.1379
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0258 0.0452
Brugia malayi beta-1,4-galactosyltransferase VII 0.0049 0.0809 0.0772
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.025 0.0542
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0435 0.5383
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.03 0.5615 0.76
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0184 0.3394 0.3394
Brugia malayi neuropeptide F receptor 0.03 0.5615 0.5597
Loa Loa (eye worm) integrin alpha pat-2 0.0285 0.5327 0.5327
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Brugia malayi RE15519p 0.03 0.5615 0.5597
Schistosoma mansoni adenoreceptor 0.03 0.5615 1
Loa Loa (eye worm) G-protein coupled receptor 0.03 0.5615 0.5615
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Brugia malayi Serotonin/octopamine receptor family protein 7 0.03 0.5615 0.5597
Trypanosoma brucei thymidine kinase 0.0248 0.4618 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0386 0.0386
Echinococcus granulosus rhodopsin orphan GPCR 0.03 0.5615 0.76
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.025 0.0439
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0258 0.039
Schistosoma mansoni biogenic amine receptor 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Schistosoma mansoni n-acetylgalactosaminyltransferase 0.002 0.0256 0.0387
Echinococcus multilocularis neuropeptide receptor 0.03 0.5615 0.76
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.03 0.5615 0.5615
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.03 0.5615 1
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.0041 0.0661 0.1113
Schistosoma mansoni neuropeptide f receptor 76f 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0258
Echinococcus multilocularis fmrfamide receptor 0.03 0.5615 0.76
Schistosoma mansoni neuropeptide receptor 0.03 0.5615 1
Brugia malayi Dopamine receptor 0.03 0.5615 0.5597
Onchocerca volvulus 0.03 0.5615 1
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0015 0.0159 0.0345
Onchocerca volvulus 0.03 0.5615 1
Echinococcus granulosus beta 14 galactosyltransferase 7 0.0049 0.0809 0.1048
Echinococcus multilocularis orexin receptor type 2 0.03 0.5615 0.76
Echinococcus granulosus tm gpcr rhodopsin 0.03 0.5615 0.76
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.194 0.8837
Echinococcus multilocularis neuropeptides capa receptor 0.03 0.5615 0.76
Brugia malayi Melatonin receptor type 1A 0.03 0.5615 0.5597
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0107 0.0231
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0055 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0055 0.0921 0.0921
Entamoeba histolytica thymidine kinase, putative 0.0248 0.4618 0.8105
Onchocerca volvulus 0.03 0.5615 1
Echinococcus granulosus axis inhibition protein axin 0.002 0.0258 0.0296
Entamoeba histolytica hypothetical protein 0.002 0.0258 0.0452
Plasmodium falciparum thioredoxin reductase 0.0047 0.0779 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Echinococcus granulosus rhodopsin orphan GPCR 0.03 0.5615 0.76
Echinococcus multilocularis biogenic amine (5HT) receptor 0.03 0.5615 0.76
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0258 0.0296
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.194 0.8837
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0024 0.0326 0.0572
Entamoeba histolytica hypothetical protein 0.002 0.0258 0.0452
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0258
Echinococcus multilocularis neuropeptides capa receptor 0.03 0.5615 0.76
Echinococcus granulosus Ribosomal protein L34a 0.0137 0.2501 0.3355
Echinococcus granulosus g protein coupled receptor 0.03 0.5615 0.76
Echinococcus multilocularis lamin 0.0027 0.0386 0.0472
Echinococcus granulosus biogenic amine 5HT receptor 0.03 0.5615 0.76
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0186 0.0404
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.003 0.0452 0.08
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.2171 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.03 0.5615 0.76
Echinococcus granulosus neuropeptide receptor 0.03 0.5615 0.76
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.101 0.1773
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.025 0.0286
Entamoeba histolytica phosphofructokinase, putative 0.0109 0.1956 0.3434
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0109 0.1956 0.4237
Entamoeba histolytica recQ family helicase, putative 0.0011 0.009 0.0157
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0779 0.0779
Echinococcus granulosus integrin alpha 3 0.0142 0.2585 0.347
Echinococcus granulosus thyrotropin releasing hormone receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.0012 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus multilocularis alpha 1A adrenergic receptor 0.03 0.5615 0.76
Plasmodium falciparum glutathione reductase 0.0016 0.0186 0.2393
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0258 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0109 0.1956 0.0695
Trypanosoma cruzi thymidine kinase, putative 0.0248 0.4618 1
Leishmania major ATP-dependent phosphofructokinase 0.0109 0.1956 0.4237
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.03 0.5615 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0186 0.0199
Echinococcus granulosus O glycosyltransferase 0.0041 0.0661 0.0846
Plasmodium falciparum thioredoxin reductase 0.0016 0.0186 0.2393
Mycobacterium ulcerans 6-phosphofructokinase 0.0109 0.1956 1
Trichomonas vaginalis phosphofructokinase, putative 0.0109 0.1956 0.3434
Echinococcus multilocularis Metazoa galactosyltransferase 0.0157 0.2885 0.3879
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0008 0.0032 0.0056
Schistosoma mansoni 6-phosphofructokinase 0.0109 0.1956 0.3438
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0098 0.1752 0.3075
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0529 1 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0015 0.0159 0.0214
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.012 0.0109
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0098 0.1752 0.3075
Loa Loa (eye worm) 6-phosphofructokinase 0.0109 0.1956 0.1956
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0186 0.0834
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0015 0.0159 0.0163
Schistosoma mansoni axis inhibition protein axin 0.002 0.0258 0.039
Brugia malayi Thioredoxin reductase 0.0047 0.0779 0.0742
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0186 0.0431
Mycobacterium ulcerans hypothetical protein 0.0016 0.0181 0.0399
Loa Loa (eye worm) UDP-Galactose:b-N-acetylglucosamine b1,4-galactosyltransferase 4 0.0049 0.0809 0.0809
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0279 0.0326
Schistosoma mansoni biogenic amine (dopamine) receptor 0.03 0.5615 1
Plasmodium vivax DNA polymerase alpha, putative 0.0044 0.0715 0.8994
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0015 0.0159 0.0154
Echinococcus granulosus tm gpcr rhodopsin 0.03 0.5615 0.76
Schistosoma mansoni biogenic amine (5HT) receptor 0.03 0.5615 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Brugia malayi DNA polymerase delta catalytic subunit 0.0015 0.0159 0.012
Onchocerca volvulus 0.0059 0.101 0.1559
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0015 0.0159 0.0345
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0435 0.0764
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.03 0.5615 0.76
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0258 0.0258
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0779 0.1007
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.101 0.1773
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0059 0.101 0.1322
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0015 0.0167 0.0292
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0107 0.0231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.03 0.5615 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.03 0.5615 0.76
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.03 0.5615 0.76
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0015 0.0159 0.0192
Loa Loa (eye worm) hypothetical protein 0.0102 0.1824 0.1824
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0779 0.2985
Brugia malayi hypothetical protein 0.002 0.0258 0.0218
Toxoplasma gondii exonuclease III APE 0.002 0.025 0.3095
Schistosoma mansoni hypothetical protein 0.004 0.0633 0.1063
Brugia malayi 6-phosphofructokinase 0.0109 0.1956 0.1924
Echinococcus multilocularis serotonin receptor 0.03 0.5615 0.76
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.03 0.5615 0.76
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0258 0.0218
Brugia malayi putative neuropeptide receptor 0.03 0.5615 0.5597
Brugia malayi Dopamine receptor protein 1 0.03 0.5615 0.5597
Trichomonas vaginalis ap endonuclease, putative 0.002 0.025 0.0439
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Brugia malayi Galactosyltransferase family protein 0.0049 0.0809 0.0772
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0258 0.039
Schistosoma mansoni neuropeptide receptor 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0258
Plasmodium vivax glutathione reductase, putative 0.0047 0.0779 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0435 0.5383
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.002 0.0262 0.0397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0024 0.0326 0.0706
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0015 0.0159 0.0154
Brugia malayi neuropeptide F receptor 0.03 0.5615 0.5597
Echinococcus multilocularis G-protein coupled receptor, putative 0.03 0.5615 0.76
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0186 0.0199
Schistosoma mansoni opsin-like receptor 0.03 0.5615 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0279 0.049
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0015 0.0159 0.028
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.025 0.0459
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.2171 1
Echinococcus granulosus orexin receptor type 2 0.03 0.5615 0.76
Echinococcus multilocularis rhodopsin orphan GPCR 0.03 0.5615 0.76
Loa Loa (eye worm) TYRA-2 protein 0.03 0.5615 0.5615
Schistosoma mansoni ap endonuclease 0.002 0.025 0.0377
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.03 0.5615 0.5597
Echinococcus multilocularis neuropeptide Y receptor 0.03 0.5615 0.76
Echinococcus multilocularis sex peptide receptor 0.03 0.5615 0.76
Trichomonas vaginalis cdc25c, putative 0.0059 0.101 0.1773
Loa Loa (eye worm) hypothetical protein 0.002 0.0258 0.0258
Echinococcus granulosus axis inhibition protein axin 0.002 0.0258 0.0296
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0186 0.2305
Toxoplasma gondii glycosyl transferase 0.002 0.0256 0.3166
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.009 0.0157
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0015 0.0159 0.0163
Brugia malayi Integrin alpha cytoplasmic region family protein 0.014 0.2549 0.2519
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0015 0.0159 0.0163
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0107 0.0038
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0435 1
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Onchocerca volvulus 0.03 0.5615 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.0041 0.0652 0.8062
Brugia malayi G protein-coupled receptor F59B2.13 0.03 0.5615 0.5597
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.023 0.2948
Echinococcus granulosus rhodopsin orphan GPCR 0.03 0.5615 0.76
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.004 0.0497
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0184 0.3394 0.4572
Echinococcus granulosus dro:myosuppressin receptor 0.03 0.5615 0.76
Schistosoma mansoni axis inhibition protein axin 0.002 0.0258 0.039
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.03 0.5615 0.5615
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.03 0.5615 0.76
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0015 0.0159 0.028
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0435 0.456
Onchocerca volvulus 0.03 0.5615 1
Trichomonas vaginalis thymidine kinase, putative 0.0248 0.4618 0.8105
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0435 0.5383
Brugia malayi Tachykinin-like peptides receptor 99D 0.03 0.5615 0.5597
Echinococcus granulosus lamin dm0 0.0027 0.0386 0.0472
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0144 0.1781
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0186 0.0214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Giardia lamblia DNA polymerase alpha subunit A 0.0046 0.0752 0.1556
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0059 0.101 0.174
Onchocerca volvulus 0.03 0.5615 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.194 0.8837
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0435 0.0863
Onchocerca volvulus 0.03 0.5615 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0098 0.1752 0.3075
Echinococcus multilocularis somatostatin receptor 0.03 0.5615 0.76
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0258 0.0452
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0186 0.0319
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Schistosoma mansoni opsin-like receptor 0.03 0.5615 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0024 0.0326 0.0522
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.2171 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0049 0.0809 0.1379
Echinococcus multilocularis dro:myosuppressin receptor 0.03 0.5615 0.76
Schistosoma mansoni biogenic amine receptor 0.03 0.5615 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0186 0.0404
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.025 0.0355
Trichomonas vaginalis DNA polymerase II, putative 0.0024 0.0326 0.0572
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.03 0.5615 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0186 0.0431
Onchocerca volvulus 0.0027 0.0386 0.0416
Schistosoma mansoni beta-14-galactosyltransferase 0.0186 0.3438 0.6095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.004 0.004
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.03 0.5615 0.76
Echinococcus multilocularis integrin alpha ps 0.0083 0.1459 0.1934
Schistosoma mansoni regulator of G protein signaling 0.002 0.0258 0.039
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0258 0.0452
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.009 0.0194
Echinococcus granulosus integrin alpha ps 0.0083 0.1459 0.1934
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0059 0.101 0.1322
Echinococcus granulosus tachykinin peptides receptor 99D 0.03 0.5615 0.76
Echinococcus granulosus neuropeptide FF receptor 2 0.03 0.5615 0.76
Schistosoma mansoni rhodopsin-like orphan GPCR 0.03 0.5615 1
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Trypanosoma brucei RNA helicase, putative 0.0137 0.2496 0.5315
Echinococcus multilocularis integrin alpha ps 0.0083 0.1459 0.1934
Treponema pallidum NADH oxidase 0.0016 0.0186 0.0033
Echinococcus granulosus tm gpcr rhodopsin 0.03 0.5615 0.76
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0258 0.0452
Loa Loa (eye worm) galactosyltransferase 0.0049 0.0809 0.0809
Echinococcus multilocularis neuropeptide s receptor 0.03 0.5615 0.76
Loa Loa (eye worm) RGS-3 protein 0.002 0.0258 0.0258
Schistosoma mansoni intermediate filament proteins 0.0027 0.0386 0.0621
Toxoplasma gondii DNA polymerase 0.0015 0.0159 0.1972
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0435 0.5589
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0258 0.0296
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.101 0.1773
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0186 0.0404
Brugia malayi G-protein coupled receptor 0.03 0.5615 0.5597
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0107 0.0107
Schistosoma mansoni growth hormone secretagogue receptor 0.03 0.5615 1
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0186 0.0327
Brugia malayi DNA polymerase alpha catalytic subunit 0.0044 0.0715 0.0678
Loa Loa (eye worm) hypothetical protein 0.0026 0.0377 0.0377
Loa Loa (eye worm) glycosyl transferase 0.002 0.0256 0.0256
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.0041 0.0658 0.062
Toxoplasma gondii N-acetylgalactosaminyl transferase 0.002 0.0256 0.3166
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0098 0.1752 0.3075
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0075 0.1301 0.2092
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0015 0.0159 0.012
Brugia malayi hypothetical protein 0.03 0.5615 0.5597
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0258 0.039
Loa Loa (eye worm) hypothetical protein 0.0012 0.0111 0.0111
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0186 0.0404
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0098 0.1752 0.1718
Schistosoma mansoni hypothetical protein 0.0029 0.0425 0.069
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0435 0.0764
Onchocerca volvulus 0.0059 0.101 0.1559
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0258 0.0296
Echinococcus granulosus serotonin receptor 0.03 0.5615 0.76
Loa Loa (eye worm) hypothetical protein 0.03 0.5615 0.5615
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.025 0.0322
Schistosoma mansoni beta-14-galactosyltransferase 0.0029 0.0425 0.069
Plasmodium falciparum glutathione reductase 0.0047 0.0779 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM In vitro inhibition of ADP-induced platelet aggregation in human platelet rich plasma (hPRP) ChEMBL. 9207948
IC50 (functional) = 10 uM In vitro inhibition of ADP-induced platelet aggregation in human platelet rich plasma (hPRP) ChEMBL. 9207948

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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