Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | glycogen phosphorylase | 0.3521 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.3521 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.3521 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3521 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.3521 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.1522 | 0.3994 | 0.5 |
Giardia lamblia | Glycogen phosphorylase | 0.3521 | 1 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.3521 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3521 | 1 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3521 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.3521 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.3521 | 1 | 0.5 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.3521 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.3521 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.3521 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.3521 | 1 | 0.5 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.1522 | 0.3994 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.3521 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 524 nM | Inhibitory activity against binding to Thrombin receptor 1 (PAR-1) | ChEMBL. | 10450984 |
IC50 (binding) | = 524 nM | Inhibitory activity against binding to Thrombin receptor 1 (PAR-1) | ChEMBL. | 10450984 |
IC50 (functional) | = 600 nM | Compound was evaluated for the inhibition of aggregation induced by 300 nM ha-TRAP(high affinity thrombin receptor agonist peptide) | ChEMBL. | 10450984 |
IC50 (functional) | = 600 nM | Compound was evaluated for the inhibition of aggregation induced by 300 nM ha-TRAP(high affinity thrombin receptor agonist peptide) | ChEMBL. | 10450984 |
Inhibition (functional) | % | Compound was evaluated for the inhibition of aggregation induced by 0.1 U/mL thrombin at 10 microM concentration and determined at 2 min; NA = Not active | ChEMBL. | 10450984 |
Inhibition (functional) | 0 % | Compound was evaluated for the inhibition of aggregation induced by 0.1 U/mL thrombin at 10 microM concentration and determined at 2 min; NA = Not active | ChEMBL. | 10450984 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10450984 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.