Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase | 0.0227 | 0.6122 | 0.9174 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0227 | 0.6122 | 0.9382 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0041 | 0.0034 | 0.0051 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0227 | 0.6122 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0069 | 0.0945 | 0.0019 |
Echinococcus multilocularis | 0.0068 | 0.0934 | 0.14 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0237 | 0.6464 | 0.9139 |
Echinococcus granulosus | RUN | 0.0041 | 0.0034 | 0.0051 |
Onchocerca volvulus | 0.0041 | 0.0034 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0068 | 0.0934 | 0.128 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0945 | 0.0019 |
Loa Loa (eye worm) | cytochrome P450 | 0.0068 | 0.0934 | 0.128 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0227 | 0.6122 | 0.9382 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0041 | 0.0034 | 0.0051 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0227 | 0.6122 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0227 | 0.6122 | 0.8653 |
Brugia malayi | follicle stimulating hormone receptor | 0.0256 | 0.7069 | 1 |
Onchocerca volvulus | 0.0041 | 0.0034 | 0.5 | |
Brugia malayi | Cytochrome P450 family protein | 0.0237 | 0.6464 | 0.9139 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0945 | 0.1416 |
Leishmania major | cytochrome p450-like protein | 0.0237 | 0.6464 | 1 |
Mycobacterium tuberculosis | Probable penicillin-binding protein PbpA | 0.0231 | 0.6248 | 0.5963 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.0945 | 0.1416 |
Mycobacterium ulcerans | penicillin-binding membrane protein PbpB | 0.0154 | 0.3747 | 0.3156 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0227 | 0.6122 | 0.9382 |
Mycobacterium leprae | Probable penicillin-binding protein PbpA | 0.0231 | 0.6248 | 0.5963 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0256 | 0.7069 | 1 |
Schistosoma mansoni | lipoxygenase | 0.017 | 0.4274 | 0.6387 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0041 | 0.0034 | 0.0051 |
Schistosoma mansoni | lipoxygenase | 0.0244 | 0.6673 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0945 | 0.0019 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0227 | 0.6122 | 1 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0041 | 0.0034 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0227 | 0.6122 | 0.917 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0244 | 0.6673 | 1 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0945 | 0.1373 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0227 | 0.6122 | 0.9174 |
Mycobacterium tuberculosis | Possible penicillin-binding lipoprotein | 0.0341 | 0.9846 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0068 | 0.0934 | 0.128 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0237 | 0.6464 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0227 | 0.6122 | 0.8653 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0069 | 0.0945 | 0.0019 |
Schistosoma mansoni | cytochrome P450 | 0.0068 | 0.0934 | 0.1356 |
Brugia malayi | Cytochrome P450 family protein | 0.0068 | 0.0934 | 0.128 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0041 | 0.0034 | 0.0051 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0227 | 0.6122 | 0.9174 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.0945 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0237 | 0.6464 | 0.9139 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0227 | 0.6122 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0068 | 0.0934 | 0.14 |
Mycobacterium ulcerans | penicillin-binding protein PbpA | 0.0231 | 0.6248 | 0.5963 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0227 | 0.6122 | 0.5 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0041 | 0.0034 | 0.0051 |
Echinococcus multilocularis | RUN | 0.0041 | 0.0034 | 0.0051 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.0945 | 0.1295 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0227 | 0.6122 | 0.9382 |
Mycobacterium leprae | POSSIBLE PENICILLIN-BINDING LIPOPROTEIN | 0.0341 | 0.9846 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0041 | 0.0034 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.0945 | 0.1295 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0237 | 0.6464 | 0.6205 |
Trypanosoma brucei | cytochrome P450, putative | 0.0237 | 0.6464 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0237 | 0.6464 | 0.9139 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0237 | 0.6464 | 0.9139 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0227 | 0.6122 | 0.9174 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0227 | 0.6122 | 0.9382 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.423 | 0.5965 |
Mycobacterium ulcerans | penicillin-binding lipoprotein | 0.0341 | 0.9846 | 1 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0041 | 0.0034 | 0.0051 |
Brugia malayi | cytochrome P450 | 0.0068 | 0.0934 | 0.128 |
Trypanosoma brucei | protein kinase, putative | 0.0227 | 0.6122 | 0.9382 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0237 | 0.6464 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0227 | 0.6122 | 0.9382 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0227 | 0.6122 | 0.9382 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0934 | 0.1356 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0244 | 0.6673 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0227 | 0.6122 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 25 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 35218 after 24 hrs by MTT method | ChEMBL. | 19423200 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.