Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.00271936 | 0.0668152 | 0.0726478 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.00271936 | 0.0668152 | 0.0726478 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.00271936 | 0.0668152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00271936 | 0.0668152 | 0.0726478 |
Wolbachia endosymbiont of Brugia malayi | phosphatase | 0.000800652 | 0 | 0.5 |
Echinococcus multilocularis | synaptic glycoprotein sc2 | 0.00271936 | 0.0668152 | 0.167062 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0148171 | 0.488096 | 0.488096 |
Echinococcus granulosus | hormone sensitive lipase | 0.0122856 | 0.399942 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.00271936 | 0.0668152 | 0.0726478 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0122856 | 0.399942 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.00271936 | 0.0668152 | 0.0726478 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.00271936 | 0.0668152 | 0.0726478 |
Onchocerca volvulus | 0.00271936 | 0.0668152 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.00271936 | 0.0668152 | 0.0726478 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.00271936 | 0.0668152 | 0.0726478 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.00271936 | 0.0668152 | 0.0726478 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.00271936 | 0.0668152 | 0.167062 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0272117 | 0.919713 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0148171 | 0.488096 | 0.488096 |
Treponema pallidum | phosphoglycolate phosphatase | 0.000800652 | 0 | 0.5 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0272117 | 0.919713 | 1 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0272117 | 0.919713 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122856 | 0.399942 | 0.434855 |
Plasmodium vivax | polyprenol reductase, putative | 0.00271936 | 0.0668152 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0272117 | 0.919713 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.00271936 | 0.0668152 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0272117 | 0.919713 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0122856 | 0.399942 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0272117 | 0.919713 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0122856 | 0.399942 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.00271936 | 0.0668152 | 0.0726478 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.00271936 | 0.0668152 | 0.0726478 |
Chlamydia trachomatis | phosphoglycolate phosphatase | 0.000800652 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0272117 | 0.919713 | 0.919713 |
Echinococcus granulosus | 3 oxo 5 alpha steroid 4 dehydrogenase C terminal | 0.00271936 | 0.0668152 | 0.167062 |
Loa Loa (eye worm) | hypothetical protein | 0.0272117 | 0.919713 | 1 |
Echinococcus multilocularis | 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal | 0.00271936 | 0.0668152 | 0.167062 |
Echinococcus granulosus | synaptic glycoprotein sc2 | 0.00271936 | 0.0668152 | 0.167062 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.0295173 | 1 | 1 |
Brugia malayi | Synaptic glycoprotein SC2 | 0.00271936 | 0.0668152 | 0.0726478 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.0295173 | 1 | 1 |
Treponema pallidum | phosphoglycolate phosphatase | 0.000800652 | 0 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0272117 | 0.919713 | 1 |
Plasmodium falciparum | polyprenol reductase, putative | 0.00271936 | 0.0668152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00271936 | 0.0668152 | 0.0726478 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0272117 | 0.919713 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.00271936 | 0.0668152 | 1 |
Schistosoma mansoni | synaptic glycoprotein sc2 related | 0.00271936 | 0.0668152 | 0.167062 |
Mycobacterium leprae | Probable hydrolase | 0.000800652 | 0 | 0.5 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.00271936 | 0.0668152 | 0.0726478 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0272117 | 0.919713 | 1 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0122856 | 0.399942 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0272117 | 0.919713 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.3 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 48 hrs by beta-plate liquid scintillation counting | ChEMBL. | 18973386 |
IC50 (functional) | = 9.2 uM | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 by fluorescence assay | ChEMBL. | 18973386 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei gambiense | 18973386 | ||
Plasmodium falciparum | 18973386 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.