Detailed information for compound 107554

Basic information

Technical information
  • TDR Targets ID: 107554
  • Name: 3-[[3-[3-(1H-imidazol-2-ylamino)phenyl]phenyl ]sulfonylamino]-3-phenylpropanoic acid
  • MW: 462.521 | Formula: C24H22N4O4S
  • H donors: 4 H acceptors: 5 LogP: 3.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CC(c1ccccc1)NS(=O)(=O)c1cccc(c1)c1cccc(c1)Nc1[nH]ccn1
  • InChi: 1S/C24H22N4O4S/c29-23(30)16-22(17-6-2-1-3-7-17)28-33(31,32)21-11-5-9-19(15-21)18-8-4-10-20(14-18)27-24-25-12-13-26-24/h1-15,22,28H,16H2,(H,29,30)(H2,25,26,27)
  • InChiKey: ZYHLKGSZXSXNIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[3-[3-(1H-imidazol-2-ylamino)phenyl]phenyl]sulfonylamino]-3-phenyl-propanoic acid
  • 3-[[3-[3-(1H-imidazol-2-ylamino)phenyl]phenyl]sulfonylamino]-3-phenyl-propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis integrin beta 2 0.1351 0.7316 0.7728
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0158 0.0167
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Loa Loa (eye worm) hypothetical protein 0.0421 0.222 0.222
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0166 0.0822 0.0869
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0013 0.0039
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0037 0.0069
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0436 0.23 0.6672
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0045 0.0158 0.0167
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0008 0.0034
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trichomonas vaginalis ran, putative 0.0021 0.0025 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Onchocerca volvulus 0.006 0.0239 0.0876
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Brugia malayi calpain family protein 1 0.0043 0.0148 0.0148
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Leishmania major hypothetical protein, conserved 0.0071 0.03 0.0873
Brugia malayi cathepsin L-like precursor 0.0421 0.222 0.222
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0436 0.23 0.243
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0041 0.0119
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0194
Echinococcus multilocularis cathepsin L cysteine protease 0.0436 0.23 0.243
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0152 0.0743 0.3229
Echinococcus granulosus cathepsin l1 0.0436 0.23 0.243
Trypanosoma cruzi cysteine proteinase, putative 0.0166 0.0822 0.0869
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0069
Onchocerca volvulus Cathepsin L homolog 0.0436 0.23 1
Onchocerca volvulus 0.0071 0.03 0.115
Trypanosoma cruzi major cysteine proteinase, putative 0.0152 0.0743 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Loa Loa (eye worm) fibroinase 0.0436 0.23 0.23
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0403 0.0425
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0152 0.0743 0.0785
Loa Loa (eye worm) hypothetical protein 0.0049 0.0182 0.0182
Mycobacterium ulcerans hypothetical protein 0.0071 0.03 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Giardia lamblia Cathepsin B precursor 0.0644 0.3441 1
Toxoplasma gondii cathepsin B 0.0644 0.3441 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0025
Echinococcus granulosus geminin 0.0333 0.1733 0.1831
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0152 0.0743 0.319
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0152 0.0743 0.3229
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0027
Loa Loa (eye worm) hypothetical protein 0.0287 0.1484 0.1484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.03 0.0317
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.03 0.0317
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Loa Loa (eye worm) cysteine protease 0.0436 0.23 0.23
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Echinococcus granulosus cysteine protease 0.0166 0.0822 0.0869
Brugia malayi Importin beta-1 subunit 0.0028 0.0066 0.0066
Brugia malayi calpain family protein 1 0.0043 0.0148 0.0148
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0066 0.012
Plasmodium falciparum cysteine proteinase falcipain 3 0.0436 0.23 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0025 0.0052
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.0743 0.2128
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.0822 0.0822
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0152 0.0743 0.0785
Plasmodium falciparum serine repeat antigen 8 0.0152 0.0743 0.3207
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Brugia malayi cathepsin B-like cysteine proteinase 0.1744 0.9466 0.9466
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0184 0.0184
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0041 0.0119
Giardia lamblia Hypothetical protein 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine proteinase, putative 0.0421 0.222 0.9652
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.03 0.1242
Brugia malayi Hemopexin family protein 0.006 0.0239 0.0239
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.03 0.0317
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0025 0.0027
Leishmania major importin beta-1 subunit, putative 0.0023 0.0037 0.0107
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0421 0.222 0.2346
Schistosoma mansoni cathepsin S (C01 family) 0.0152 0.0743 0.0785
Trypanosoma cruzi major cysteine proteinase, putative 0.0152 0.0743 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Echinococcus granulosus dna polymerase eta 0.0019 0.0013 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0013 0.0046
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0066 0.007
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.0558 0.0558
Leishmania major cysteine peptidase A (CPA) 0.0436 0.23 0.6685
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0013 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Onchocerca volvulus 0.0049 0.0182 0.0625
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Onchocerca volvulus 0.0436 0.23 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0118
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Schistosoma mansoni cathepsin F (C01 family) 0.0421 0.222 0.2346
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0166 0.0822 0.0869
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0152 0.0743 0.3229
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.0179
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Onchocerca volvulus 0.0071 0.03 0.115
Entamoeba histolytica hypothetical protein 0.0152 0.0743 0.319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0013 0.0014
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0403 0.0425
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0014
Plasmodium falciparum importin beta, putative 0.0028 0.0066 0.0256
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.03 0.0838
Schistosoma mansoni hypothetical protein 0.0333 0.1733 0.1831
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0152 0.0743 0.2128
Mycobacterium ulcerans hydrolase 0.0051 0.0192 0.6306
Plasmodium vivax vivapain-2 0.0436 0.23 1
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Schistosoma mansoni hypothetical protein 0.0333 0.1733 0.1831
Trypanosoma cruzi cysteine protease, putative 0.0166 0.0822 0.0869
Plasmodium falciparum serine repeat antigen 2 0.0152 0.0743 0.3207
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0153 0.0752 0.0794
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0152 0.0743 0.3229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.03 0.03
Brugia malayi beta-lactamase family protein 0.0071 0.03 0.03
Mycobacterium leprae conserved hypothetical protein 0.0071 0.03 1
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0025 0.0049 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Brugia malayi cathepsin L-like cysteine proteinase 0.0152 0.0743 0.0743
Toxoplasma gondii cathepsin CPC2 0.0152 0.0743 0.2101
Schistosoma mansoni hypothetical protein 0.006 0.0239 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine proteinase 1, putative 0.0166 0.0822 0.3538
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Echinococcus granulosus cathepsin l1 0.0421 0.222 0.2346
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.03 0.1242
Plasmodium falciparum serine repeat antigen 1 0.0152 0.0743 0.3207
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0041 0.1123
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Brugia malayi hypothetical protein 0.0025 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Loa Loa (eye worm) integrin beta-2 0.1841 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Echinococcus multilocularis dna polymerase eta 0.0019 0.0013 0.0014
Onchocerca volvulus 0.0152 0.0743 0.3108
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0016 0.0017
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Loa Loa (eye worm) hypothetical protein 0.0042 0.0142 0.0142
Loa Loa (eye worm) calpain family protein 1 0.0043 0.0148 0.0148
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Echinococcus multilocularis cysteine protease 0.0436 0.23 0.243
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.03 0.1242
Echinococcus granulosus cathepsin b 0.1744 0.9466 1
Brugia malayi beta-lactamase family protein 0.0071 0.03 0.03
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Mycobacterium leprae Probable lipase LipE 0.0071 0.03 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1744 0.9466 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0013 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0152 0.0743 0.0743
Plasmodium vivax serine-repeat antigen (SERA) 0.0152 0.0743 0.3229
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Mycobacterium tuberculosis Conserved protein 0.0071 0.03 0.1242
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Echinococcus granulosus cathepsin L 0.0152 0.0743 0.0785
Echinococcus multilocularis cathepsin b 0.1744 0.9466 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0118
Onchocerca volvulus Matrilysin homolog 0.0042 0.0142 0.0448
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0041 0.0119
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0644 0.3441 0.3635
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.03 0.03
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0152 0.0743 0.2128
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0049 0.0069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0184 0.0184
Echinococcus granulosus tumor protein p63 0.0338 0.1763 0.1863
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Onchocerca volvulus 0.0027 0.0058 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0041 0.0118
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Echinococcus granulosus cathepsin b 0.1744 0.9466 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Onchocerca volvulus Cathepsin L homolog 0.0436 0.23 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0152 0.0743 0.3207
Giardia lamblia Cathepsin L-like protease 0.0152 0.0743 0.2128
Schistosoma mansoni hypothetical protein 0.0303 0.1574 0.1662
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1744 0.9466 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0066
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0152 0.0743 0.3229
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0287 0.1484 0.1484
Echinococcus granulosus dna polymerase kappa 0.0019 0.0013 0.0014
Mycobacterium tuberculosis Conserved protein 0.0071 0.03 0.1242
Schistosoma mansoni cathepsin F (C01 family) 0.0436 0.23 0.243
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.1123
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.23 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0037 0.0039
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Loa Loa (eye worm) hypothetical protein 0.0027 0.0058 0.0058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1744 0.9466 1
Mycobacterium ulcerans lipase LipD 0.0071 0.03 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Schistosoma mansoni ran 0.0021 0.0025 0.0027
Plasmodium vivax vivapain-1 0.0166 0.0822 0.3576
Loa Loa (eye worm) hypothetical protein 0.0421 0.222 0.222
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0013 0.0014
Echinococcus multilocularis snurportin 1 0.0303 0.1574 0.1662
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0042 0.0142 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Leishmania major hypothetical protein, conserved 0.0025 0.0049 0.0142
Mycobacterium leprae PROBABLE HYDROLASE 0.0051 0.0192 0.5838
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0436 0.23 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0152 0.0743 0.0743
Brugia malayi Matrixin family protein 0.0102 0.047 0.047
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0182 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0073
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0066 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0421 0.222 0.6439
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Loa Loa (eye worm) hypothetical protein 0.005 0.0184 0.0184
Loa Loa (eye worm) matrixin family protein 0.0094 0.0424 0.0424
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0644 0.3441 0.3635
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0436 0.23 0.6672
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.03 0.1242
Onchocerca volvulus Cathepsin L homolog 0.0152 0.0743 0.3108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0403 0.0425
Leishmania major DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0153 0.0752 0.0794
Echinococcus multilocularis tumor protein p63 0.0338 0.1763 0.1863
Giardia lamblia Cathepsin B precursor 0.0644 0.3441 1
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Entamoeba histolytica cysteine protease, putative 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0039
Onchocerca volvulus Matrilysin homolog 0.0094 0.0424 0.1695
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0436 0.23 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.03 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.03 0.0317
Onchocerca volvulus 0.0042 0.0142 0.0448
Leishmania major DNA polymerase eta, putative 0.0019 0.0013 0.0039
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0743 0.2128
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.03 0.1242
Loa Loa (eye worm) hypothetical protein 0.0038 0.0121 0.0121
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0043 0.0148 0.0156
Onchocerca volvulus 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0743 0.2128
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0013 0.0039
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0041 0.0159
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1744 0.9466 1
Entamoeba histolytica cysteine proteinase 2 0.0166 0.0822 0.3538
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.03 0.1242
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0152 0.0743 0.3207
Plasmodium vivax vivapain-3 0.0166 0.0822 0.3576
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.03 0.0838
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Loa Loa (eye worm) hypothetical protein 0.0032 0.0085 0.0085
Brugia malayi Cathepsin L-like precursor 0.0421 0.222 0.222
Loa Loa (eye worm) hypothetical protein 0.0042 0.0142 0.0142
Loa Loa (eye worm) hypothetical protein 0.0421 0.222 0.222
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0076
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0743 0.2128
Brugia malayi Cathepsin L-like precursor 0.0421 0.222 0.222
Brugia malayi Papain family cysteine protease containing protein 0.0436 0.23 0.23
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0025 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0041 0.0159
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.03 0.0838
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0152 0.0743 0.0785
Onchocerca volvulus 0.0436 0.23 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0041
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0403 0.0425
Loa Loa (eye worm) calpain family protein 1 0.0032 0.0085 0.0085
Echinococcus multilocularis calpain A 0.0045 0.0158 0.0167
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0051 0.0192 0.0192
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.0822 0.0822
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0743 0.2128
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Echinococcus granulosus cathepsin l cysteine peptidase 0.0436 0.23 0.243
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.0052
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0184 0.0184
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.1574 0.1574
Echinococcus multilocularis cathepsin L cysteine protease 0.0436 0.23 0.243
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0436 0.23 0.243
Trypanosoma brucei cysteine peptidase C (CPC) 0.0644 0.3441 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.03 0.0838
Loa Loa (eye worm) cathepsin B 0.0644 0.3441 0.3441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0166 0.0822 0.239
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0049 0.0142
Schistosoma mansoni importin beta-1 0.0028 0.0066 0.007
Loa Loa (eye worm) hypothetical protein 0.1744 0.9466 0.9466
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0152 0.0743 0.3229
Brugia malayi cathepsin F-like cysteine proteinase 0.0152 0.0743 0.0743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Brugia malayi MH2 domain containing protein 0.0118 0.0558 0.0558
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0436 0.23 0.23
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.03 0.1242
Loa Loa (eye worm) beta-lactamase 0.0071 0.03 0.03
Schistosoma mansoni ran 0.0021 0.0025 0.0027
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Onchocerca volvulus Cathepsin F homolog 0.0436 0.23 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.0743 0.0743
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0152 0.0743 0.0743
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Plasmodium falciparum serine repeat antigen 9 0.0152 0.0743 0.3207
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0152 0.0743 0.319
Brugia malayi cathepsin L precursor 0.0152 0.0743 0.0743
Toxoplasma gondii preprocathepsin c precursor, putative 0.0152 0.0743 0.2101
Onchocerca volvulus 0.0071 0.03 0.115
Plasmodium vivax hypothetical protein, conserved 0.0071 0.03 0.1307
Echinococcus granulosus cathepsin L cysteine protease 0.0166 0.0822 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0016 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0049 0.0212
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0041 0.1123
Loa Loa (eye worm) hypothetical protein 0.0436 0.23 0.23
Brugia malayi Kelch motif family protein 0.0287 0.1484 0.1484
Plasmodium falciparum serine repeat antigen 7 0.0152 0.0743 0.3207
Entamoeba histolytica cysteine proteinase, putative 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.0822 0.236
Loa Loa (eye worm) hypothetical protein 0.0051 0.0192 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.0822 0.236
Brugia malayi Papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Loa Loa (eye worm) ctsf protein 0.0436 0.23 0.23
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0008 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Onchocerca volvulus 0.0421 0.222 0.9647
Mycobacterium ulcerans hypothetical protein 0.0024 0.0041 0.1123
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.0558 0.0558
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0166 0.0822 0.239
Onchocerca volvulus 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0152 0.0743 0.2128
Giardia lamblia Cathepsin B precursor 0.0644 0.3441 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0008 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.03 0.03
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Brugia malayi hypothetical protein 0.0287 0.1484 0.1484
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0403 0.0425
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Schistosoma mansoni integrin beta subunit 0.1064 0.5742 0.6066
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0066 0.0193
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0403 0.0403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Trypanosoma cruzi cysteine peptidase, putative 0.0436 0.23 0.243
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0403 0.0425
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0041
Giardia lamblia Hypothetical protein 0.0152 0.0743 0.2128
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0019 0.0013 0.0013
Echinococcus multilocularis cathepsin L 0.0166 0.0822 0.0869
Loa Loa (eye worm) matrix metalloproteinase 0.0042 0.0142 0.0142
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0049 0.0052
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.03 1
Brugia malayi fibroinase precursor 0.0152 0.0743 0.0743
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Echinococcus granulosus importin subunit beta 1 0.0028 0.0066 0.007
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.03 0.0838
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0152 0.0743 0.3229
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0152 0.0743 0.3229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0152 0.0743 0.2128
Onchocerca volvulus 0.0436 0.23 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Plasmodium vivax unspecified product 0.0152 0.0743 0.3229
Plasmodium falciparum serine repeat antigen 5 0.0152 0.0743 0.3207
Plasmodium vivax vivapain-2 0.0436 0.23 1
Plasmodium falciparum serine repeat antigen 3 0.0152 0.0743 0.3207
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0152 0.0743 0.2128
Toxoplasma gondii cathepsin CPL 0.0436 0.23 0.666
Giardia lamblia Cysteine protease 0.0152 0.0743 0.2128
Schistosoma mansoni cathepsin C 0.0152 0.0743 0.0785
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0152 0.0743 0.3229
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0644 0.3441 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0152 0.0743 0.3207
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.0436 0.23 0.23
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0455 0.2402 1
Echinococcus granulosus snurportin 1 0.0303 0.1574 0.1662
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0152 0.0743 0.0785
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0013 0.0046
Schistosoma mansoni cathepsin F (C01 family) 0.0436 0.23 0.243
Mycobacterium tuberculosis Conserved protein 0.0071 0.03 0.1242
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0037 0.0069
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Echinococcus multilocularis cathepsin b 0.1744 0.9466 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0094 0.0424 0.1695
Brugia malayi beta-lactamase 0.0071 0.03 0.03
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Toxoplasma gondii cathepsin CPC1 0.0152 0.0743 0.2101
Trypanosoma cruzi cruzipain precursor, putative 0.0436 0.23 0.243
Loa Loa (eye worm) hypothetical protein 0.0042 0.0142 0.0142
Schistosoma mansoni cathepsin B (C01 family) 0.0152 0.0743 0.0785
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.0743 0.0785
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.1123
Giardia lamblia Encystation-specific protease 0.0152 0.0743 0.2128
Echinococcus multilocularis cysteine protease 0.0436 0.23 0.243
Schistosoma mansoni hypothetical protein 0.0034 0.0097 0.0103
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1744 0.9466 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0049 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Plasmodium falciparum serine repeat antigen 6 0.0152 0.0743 0.3207
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0152 0.0743 0.2128
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0152 0.0743 0.0743
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0421 0.222 0.6439
Schistosoma mansoni DNA polymerase eta 0.0019 0.0013 0.0014
Echinococcus granulosus cathepsin L cysteine proteinase 0.0436 0.23 0.243
Echinococcus multilocularis cathepsin L 0.0152 0.0743 0.0785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0041 0.1123
Plasmodium vivax unspecified product 0.0166 0.0822 0.3576
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0166 0.0822 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Trypanosoma cruzi cysteine proteinase, putative 0.0166 0.0822 0.0869
Onchocerca volvulus 0.0436 0.23 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0152 0.0743 0.2128
Echinococcus granulosus integrin beta 2 0.1351 0.7316 0.7728
Trichomonas vaginalis esterase, putative 0.0071 0.03 0.0838
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.03 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0013 0.0039
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Brugia malayi Cathepsin L-like cysteine proteinase 0.0421 0.222 0.222
Brugia malayi RNA, U transporter 1 0.0081 0.0354 0.0354
Echinococcus granulosus cathepsin L 0.0166 0.0822 0.0869
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0644 0.3441 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0436 0.23 0.6685
Onchocerca volvulus 0.0436 0.23 1
Entamoeba histolytica hypothetical protein 0.0023 0.0037 0.0103
Leishmania major GTP-binding protein, putative 0.0021 0.0025 0.0073
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0013 0.0014
Loa Loa (eye worm) matrixin family protein 0.0102 0.047 0.047
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0025 0.0025
Plasmodium falciparum cysteine proteinase falcipain 1 0.0166 0.0822 0.3554
Echinococcus granulosus calpain A 0.0045 0.0158 0.0167
Brugia malayi Matrixin family protein 0.0042 0.0142 0.0142
Echinococcus multilocularis calpain family protein 1, d 0.0032 0.0085 0.009
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0152 0.0743 0.2128
Giardia lamblia Cathepsin B precursor 0.0152 0.0743 0.2128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0041 0.1123
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0045 0.0158 0.0167
Trypanosoma cruzi cysteine peptidase, putative 0.0166 0.0822 0.0869
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.03 0.0317
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0403 0.0403
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.03 0.0873
Giardia lamblia Cathepsin L-like protease 0.0152 0.0743 0.2128
Plasmodium vivax serine-repeat antigen (SERA) 0.0152 0.0743 0.3229
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0436 0.23 0.23
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0166 0.0822 0.0869
Brugia malayi cathepsin Z-like cysteine proteinase 0.0152 0.0743 0.0743
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.03 1
Toxoplasma gondii ABC1 family protein 0.0071 0.03 0.0806
Trypanosoma brucei unspecified product 0.0019 0.0013 0.0039
Entamoeba histolytica cysteine protease, putative 0.0152 0.0743 0.319
Entamoeba histolytica cysteine protease, putative 0.0166 0.0822 0.3538
Leishmania major cathepsin L-like protease 0.0436 0.23 0.6685
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0025 0.011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0436 0.23 0.6672
Plasmodium falciparum serine repeat antigen 4 0.0152 0.0743 0.3207
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0051 0.0192 0.0792
Entamoeba histolytica cysteine proteinase, putative 0.0166 0.0822 0.3538
Echinococcus multilocularis geminin 0.0333 0.1733 0.1831
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0013 0.0014
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0152 0.0743 0.3229
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0013 0.0194
Giardia lamblia Cathepsin L precursor 0.0152 0.0743 0.2128
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0041 0.1123
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0436 0.23 0.6672
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0045 0.0158 0.0167
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0025 0.0027
Loa Loa (eye worm) hypothetical protein 0.0043 0.0148 0.0148
Plasmodium vivax importin-beta 2, putative 0.0028 0.0066 0.0289
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0013 0.0014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0403 0.0425

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 180 nM In vitro activity in an vitronectin receptor (alpha v beta3) scintillation bead assay using 125-I labelled echistatin as a radioligand ChEMBL. 11755355
Ki (binding) = 180 nM In vitro activity in an vitronectin receptor (alpha v beta3) scintillation bead assay using 125-I labelled echistatin as a radioligand ChEMBL. 11755355

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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