Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Fatty acid elongase | ELOVL fatty acid elongase 6 | 265 aa | 259 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.005 | 0.33 | 0.33 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0018 | 0.0689 | 1 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0018 | 0.0689 | 0.1884 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0018 | 0.0689 | 0.1884 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Loa Loa (eye worm) | ELO-9 protein | 0.001 | 0.0083 | 0.0083 |
Plasmodium vivax | GNS1/SUR4 domain containing protein | 0.005 | 0.33 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1884 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0083 | 0.0083 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Trypanosoma brucei | Fatty acid elongase | 0.005 | 0.33 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.1884 |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.001 | 0.0083 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Echinococcus multilocularis | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.005 | 0.33 | 0.33 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.1884 |
Loa Loa (eye worm) | GNS1/SUR4 family protein | 0.001 | 0.0083 | 0.0083 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Onchocerca volvulus | 0.001 | 0.0083 | 0.5 | |
Onchocerca volvulus | Elongation of very long chain fatty acids protein homolog | 0.001 | 0.0083 | 0.5 |
Brugia malayi | GNS1/SUR4 family protein | 0.005 | 0.33 | 0.33 |
Toxoplasma gondii | integral membrane protein, GNS1/SUR4 family protein, putative | 0.005 | 0.33 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Echinococcus granulosus | elongation of very long chain fatty acids | 0.001 | 0.0083 | 0.1205 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Brugia malayi | GNS1/SUR4 family protein | 0.001 | 0.0083 | 0.0083 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Brugia malayi | isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0018 | 0.0689 | 0.1884 |
Schistosoma mansoni | fatty acid acyl transferase-related | 0.001 | 0.0083 | 0.1205 |
Plasmodium falciparum | fatty acid elongation protein, GNS1/SUR4 family, putative | 0.005 | 0.33 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.1884 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0018 | 0.0689 | 1 |
Brugia malayi | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Brugia malayi | Isocitrate dehydrogenase | 0.0018 | 0.0689 | 0.0689 |
Brugia malayi | Hypothetical 34.1 kDa protein C40H1.4 in chromosome III | 0.001 | 0.0083 | 0.0083 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Schistosoma mansoni | elongation of fatty acids protein 1 | 0.001 | 0.0083 | 0.1205 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Trypanosoma cruzi | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Plasmodium falciparum | long chain fatty acid elongation enzyme, putative | 0.005 | 0.33 | 1 |
Onchocerca volvulus | 0.001 | 0.0083 | 0.5 | |
Leishmania major | fatty acid elongase, putative | 0.005 | 0.33 | 1 |
Loa Loa (eye worm) | fatty acid elongation protein 3 | 0.001 | 0.0083 | 0.0083 |
Onchocerca volvulus | Elongation of very long chain fatty acids protein 5 homolog | 0.001 | 0.0083 | 0.5 |
Toxoplasma gondii | GNS1/SUR4 family protein | 0.005 | 0.33 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0018 | 0.0689 | 0.1884 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0018 | 0.0689 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0018 | 0.0689 | 0.1884 |
Brugia malayi | Fatty acid elongation protein 3 | 0.005 | 0.33 | 0.33 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 130 nM | Inhibition of C-terminal V5-epitope-tagged human ELOVL6 expressed in african green monkey COS7 cells | ChEMBL. | 19596583 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.