Detailed information for compound 1084083

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.406 | Formula: C22H20N2O3
  • H donors: 1 H acceptors: 1 LogP: 2.77 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO[C@@H]1CC=C2[C@@](O1)(CC(=O)N2c1ccc2c(c1)cc[nH]2)c1ccccc1
  • InChi: 1S/C22H20N2O3/c1-26-21-10-9-19-22(27-21,16-5-3-2-4-6-16)14-20(25)24(19)17-7-8-18-15(13-17)11-12-23-18/h2-9,11-13,21,23H,10,14H2,1H3/t21-,22+/m0/s1
  • InChiKey: CDCNUSFWUUXJQK-FCHUYYIVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0002 0.0015
Trypanosoma cruzi fatty acid elongase, putative 0.0208 0.0652 0.2275
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0066 0.0186 0.1274
Loa Loa (eye worm) hypothetical protein 0.0191 0.0597 0.1187
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.0313 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.0313 0.139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0061 0.0167 0.0441
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.0879 0.2861 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0191 0.0597 0.1187
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0369 0.0734
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0037 0.0091 0.0241
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0048 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0048 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0015
Brugia malayi Isocitrate dehydrogenase 0.0014 0.0013 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0005 0.0008
Loa Loa (eye worm) beta-lactamase 0.0105 0.0313 0.0622
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.0879 0.2861 1
Echinococcus granulosus geminin 0.0196 0.0614 0.1618
Loa Loa (eye worm) fatty acid elongation protein 3 0.0208 0.0652 0.1296
Brugia malayi hypothetical protein 0.0016 0.002 0.0039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0225 0.0709 0.141
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0057 0.0157 0.0518
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.013 0.0447
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0021 0.0066
Onchocerca volvulus 0.0057 0.0156 0.107
Loa Loa (eye worm) GNS1/SUR4 family protein 0.1539 0.5033 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0019 0.0133
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0106 0.547
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0002 0.0000012031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0225 0.0709 0.187
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0014 0.0013 0.0013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.013 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.013 0.0343
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0015
Onchocerca volvulus 0.0109 0.0327 0.2241
Schistosoma mansoni alpha-glucosidase 0.0162 0.0502 0.1325
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0057 0.0157 0.0157
Brugia malayi hypothetical protein 0.0089 0.0259 0.0515
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0013 0.0009 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0106 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0035 0.0237
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0418 0.1101
Brugia malayi Intermediate filament tail domain containing protein 0.005 0.0133 0.0265
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0004
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0152 0.0302
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0014 0.0013 0.0034
Trichomonas vaginalis esterase, putative 0.0105 0.0313 0.2144
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.0313 0.139
Brugia malayi DKFZp564C0469 protein 0.001 0.0002 0.0004
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0021 0.0144
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0019 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0009 0.0065
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0093 0.7094
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0002 0.0114
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0431 0.0856
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0021 0.0606
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0021 0.0042
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0016 0.0019 0.006
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0104 0.0713
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0013 0.0009 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.0313 0.139
Schistosoma mansoni hypothetical protein 0.0069 0.0194 0.051
Mycobacterium ulcerans DNA polymerase IV 0.0016 0.0021 0.0606
Schistosoma mansoni survival motor neuron protein 0.0056 0.0152 0.04
Echinococcus granulosus lamin 0.005 0.0133 0.0351
Loa Loa (eye worm) ELO-9 protein 0.0208 0.0652 0.1296
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0013 0.0013
Schistosoma mansoni lamin 0.005 0.0133 0.0351
Echinococcus granulosus elongation of very long chain fatty acids 0.0222 0.0699 0.1842
Loa Loa (eye worm) hypothetical protein 0.0105 0.0313 0.0622
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0037 0.0091 0.0287
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0024 0.0048 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0073 0.0502
Loa Loa (eye worm) inositol-1 0.0066 0.0186 0.037
Brugia malayi cytoplasmic intermediate filament protein 0.0027 0.0057 0.0112
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.013 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0041 0.0281
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0194 0.0194
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0021 0.0042
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0014 0.0013 0.0038
Entamoeba histolytica hypothetical protein 0.001 0.0002 0.0114
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.005 0.0133 0.0265
Brugia malayi hypothetical protein 0.0024 0.0048 0.0096
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0021 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0409
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0004
Echinococcus multilocularis GPCR, family 2 0.0061 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0131 0.0398 0.0791
Schistosoma mansoni intermediate filament proteins 0.005 0.0133 0.0351
Loa Loa (eye worm) hypothetical protein 0.0089 0.0259 0.0515
Onchocerca volvulus 0.005 0.0133 0.0912
Onchocerca volvulus Elongation of very long chain fatty acids protein 5 homolog 0.0208 0.0652 0.4469
Trypanosoma cruzi fatty acid elongase, putative 0.0879 0.2861 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0016 0.0019 0.0133
Schistosoma mansoni hypothetical protein 0.0131 0.0398 0.105
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0048 0.0161
Onchocerca volvulus 0.0105 0.0313 0.2144
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0037 0.0091 0.0312
Brugia malayi fatty acid elongation protein 3 0.0208 0.0652 0.1296
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0037 0.0091 0.0312
Brugia malayi hypothetical protein 0.001 0.0002 0.0004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0156 0.0156
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0059 0.0163 0.5181
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0061 0.0167 0.0332
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0013 0.0038
Echinococcus multilocularis muscleblind protein 0.0274 0.0869 0.0869
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0037 0.0091 0.0241
Brugia malayi hypothetical protein 0.001 0.0002 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0057 0.0157 0.0668
Trypanosoma cruzi fatty acid elongase, putative 0.0879 0.2861 1
Schistosoma mansoni alpha glucosidase 0.0042 0.0106 0.0279
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.0313 0.0825
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0107 0.0282
Echinococcus multilocularis elongation of very long chain fatty acids 0.0222 0.0699 0.0699
Brugia malayi Pre-SET motif family protein 0.0398 0.1279 0.2541
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0013 0.0009 0.0025
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0191 0.0597 0.1187
Loa Loa (eye worm) fatty acid elongation protein 3 0.0879 0.2861 0.5684
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0093 0.4794
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0225 0.0709 0.0709
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0066 0.0453
Schistosoma mansoni topbp1 0.001 0.0002 0.0006
Brugia malayi Glycosyl hydrolases family 31 protein 0.0042 0.0106 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0106 0.0725
Echinococcus granulosus elongation of very long chain fatty acids 0.0208 0.0652 0.172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0009 0.0065
Loa Loa (eye worm) hypothetical protein 0.0049 0.013 0.0259
Loa Loa (eye worm) hypothetical protein 0.0023 0.0045 0.0089
Loa Loa (eye worm) hypothetical protein 0.0274 0.0869 0.1727
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0106 0.0725
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0106 0.0725
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0106 0.0725
Toxoplasma gondii fatty acid elongase 0.0222 0.0699 0.2437
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0156 0.0412
Trypanosoma brucei elongation of very long chain fatty acids protein, putative 0.0222 0.0699 0.2437
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0042 0.0106 0.0725
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0059 0.0163 0.0696
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0042 0.0106 0.547
Onchocerca volvulus 0.005 0.0133 0.0912
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0042 0.0286
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0013 0.0009 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0157 0.4987
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0037 0.0091 0.0312
Leishmania major alpha glucosidase II subunit, putative 0.0042 0.0106 0.0338
Echinococcus multilocularis neutral alpha glucosidase AB 0.0042 0.0106 0.0106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0156 0.0412
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Trypanosoma brucei protein kinase, putative 0.0049 0.013 0.0447
Trichomonas vaginalis sucrase-isomaltase, putative 0.0042 0.0106 0.0725
Echinococcus granulosus neutral alpha glucosidase AB 0.0042 0.0106 0.0279
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0157 0.0414
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0015
Toxoplasma gondii target of rapamycin (TOR), putative 0.0028 0.006 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0051 0.0347
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0313 0.1087
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0225 0.0709 0.141
Mycobacterium tuberculosis Possible penicillin-binding protein 0.067 0.2172 1
Trypanosoma cruzi target of rapamycin kinase 3 0.003 0.0066 0.0224
Trichomonas vaginalis set domain proteins, putative 0.0453 0.146 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0019 0.1005
Entamoeba histolytica hypothetical protein 0.0069 0.0194 1
Schistosoma mansoni aldehyde dehydrogenase 0.0057 0.0157 0.0414
Schistosoma mansoni microtubule-associated protein tau 0.1163 0.3793 1
Schistosoma mansoni DNA polymerase eta 0.0016 0.0021 0.0055
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.013 0.089
Loa Loa (eye worm) intermediate filament protein 0.005 0.0133 0.0265
Trypanosoma cruzi fatty acid elongase, putative 0.0208 0.0652 0.2275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0225 0.0709 0.187
Toxoplasma gondii aldehyde dehydrogenase 0.0057 0.0157 0.0542
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0104 0.0357
Leishmania major long chain polyunsaturated fatty acid elongation enzyme-like protein 0.0222 0.0699 0.2417
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.013 0.089
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0002 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0104 0.0275
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0019 0.0133
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0157 0.4987
Mycobacterium tuberculosis Conserved protein 0.0105 0.0313 0.139
Schistosoma mansoni elongation of fatty acids protein 1 0.0208 0.0652 0.172
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0004 0.0011
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.0313 1
Schistosoma mansoni inositol monophosphatase 0.0066 0.0186 0.0491
Leishmania major fatty acid elongase, putative 0.0879 0.2861 1
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.0313 0.139
Loa Loa (eye worm) hypothetical protein 0.0042 0.0107 0.0212
Echinococcus granulosus dna polymerase kappa 0.0016 0.0021 0.0055
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0208 0.0652 0.4469
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0013 0.0013
Brugia malayi fatty acid elongation protein 3 0.0208 0.0652 0.1296
Schistosoma mansoni eyes absent homolog 0.0089 0.0259 0.0684
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0189 0.0589 0.117
Loa Loa (eye worm) hypothetical protein 0.0105 0.0313 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0035 0.0237
Trypanosoma cruzi fatty acid elongase, putative 0.0208 0.0652 0.2275
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.0869 0.0869
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0096
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0431 0.0431
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0037 0.0091 0.4714
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0093 0.0317
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0019 0.006
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0037 0.0091 0.0287
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0021 0.0055
Leishmania major DNA polymerase kappa, putative 0.0016 0.0021 0.0041
Plasmodium vivax elongation of very long chain fatty acids protein 3, putative 0.0208 0.0652 0.2275
Echinococcus multilocularis nibrin 0.001 0.0002 0.0002
Plasmodium vivax SET domain protein, putative 0.0057 0.0156 0.0539
Schistosoma mansoni inositol monophosphatase 0.0066 0.0186 0.0491
Echinococcus granulosus replication factor c subunit 1 0.001 0.0002 0.0006
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0013 0.0013
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0313 0.2144
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0066 0.0453
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0048 0.0161
Echinococcus granulosus microtubule associated protein 2 0.1163 0.3793 1
Schistosoma mansoni hypothetical protein 0.0196 0.0614 0.1618
Loa Loa (eye worm) latrophilin receptor protein 2 0.0061 0.0167 0.0332
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0018 0.0026 0.0085
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0104 0.0713
Onchocerca volvulus 0.0453 0.146 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0066 0.0186 0.062
Trypanosoma cruzi fatty acid elongase, putative 0.0222 0.0699 0.2437
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0066 0.0453
Loa Loa (eye worm) phosphatidylinositol 3 0.0037 0.0091 0.0181
Brugia malayi Fatty acid elongation protein 3 0.0879 0.2861 0.5684
Brugia malayi Latrophilin receptor protein 2 0.0061 0.0167 0.0332
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0313 0.2144
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0066 0.0186 0.5916
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0004
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0066 0.0186 0.0643
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0035 0.0237
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0021 0.0066
Leishmania major DNA polymerase eta, putative 0.0016 0.0021 0.0041
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0194 0.051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0057 0.0156 0.0412
Onchocerca volvulus 0.0042 0.0107 0.0732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0225 0.0709 0.187
Loa Loa (eye worm) hypothetical protein 0.0016 0.0019 0.0039
Leishmania major hypothetical protein, conserved 0.0105 0.0313 0.1065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0225 0.0709 0.187
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0019 0.006
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.0313 0.139
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0021 0.0066
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.0313 0.0313
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0021 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0009 0.0065
Mycobacterium tuberculosis Conserved protein 0.0105 0.0313 0.139
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0066 0.0186 0.0643
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0037 0.0091 0.0312
Loa Loa (eye worm) hypothetical protein 0.0105 0.0313 0.0622
Echinococcus granulosus GPCR family 2 0.0061 0.0167 0.0441
Trypanosoma cruzi fatty acid elongase, putative 0.0222 0.0699 0.2437
Mycobacterium ulcerans lipase LipD 0.0105 0.0313 1
Giardia lamblia GTOR 0.0037 0.0091 0.6973
Trypanosoma brucei unspecified product 0.0011 0.0005 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0014 0.0013 0.0013
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0037 0.0091 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0313 0.0825
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.013 0.089
Brugia malayi fatty acid elongation protein 3 0.0208 0.0652 0.1296
Echinococcus multilocularis inositol monophosphatase 1 0.0066 0.0186 0.0186
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0057 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0208 0.0652 0.1296
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.013 0.0343
Plasmodium vivax hypothetical protein, conserved 0.0105 0.0313 0.1087
Plasmodium vivax GNS1/SUR4 domain containing protein 0.0879 0.2861 1
Loa Loa (eye worm) hypothetical protein 0.0274 0.0869 0.1727
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0156 0.0412
Mycobacterium ulcerans hypothetical protein 0.0105 0.0313 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0021 0.0037
Loa Loa (eye worm) hypothetical protein 0.005 0.0133 0.0265
Echinococcus multilocularis lamin 0.005 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0004
Schistosoma mansoni fatty acid acyl transferase-related 0.0222 0.0699 0.1842
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.0313 0.1087
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Loa Loa (eye worm) hypothetical protein 0.0274 0.0869 0.1727
Mycobacterium leprae conserved hypothetical protein 0.0105 0.0313 1
Brugia malayi Hypothetical 34.1 kDa protein C40H1.4 in chromosome III 0.0208 0.0652 0.1296
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0313 0.2144
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0014 0.0013 0.0038
Trypanosoma brucei unspecified product 0.0016 0.0021 0.0066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0589 0.0589
Schistosoma mansoni topbp1 0.001 0.0002 0.0006
Leishmania major fatty acid elongase, putative 0.0879 0.2861 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0061 0.0167 0.0441
Entamoeba histolytica hypothetical protein 0.0069 0.0194 1
Mycobacterium tuberculosis Conserved protein 0.0105 0.0313 0.139
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Echinococcus granulosus dna polymerase eta 0.0016 0.0021 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0035 0.0237
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0021 0.0041
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0104 0.0357
Brugia malayi Glycosyl hydrolases family 31 protein 0.0189 0.0589 0.117
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.013 0.013
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0013 0.0009 0.0009
Trypanosoma brucei glucosidase, putative 0.0042 0.0106 0.0363
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0019 0.0039
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.0313 0.0622
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.013 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0409
Brugia malayi Muscleblind-like protein 0.0274 0.0869 0.1727
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0014 0.0013 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0005 0.0008
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Schistosoma mansoni hypothetical protein 0.0061 0.0167 0.0441
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Schistosoma mansoni elongation of fatty acids protein 1 0.0222 0.0699 0.1842
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0013 0.0009 0.0025
Chlamydia trachomatis DNA ligase 0.001 0.0002 0.5
Echinococcus granulosus tumor protein p63 0.0288 0.0916 0.2413
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0061 0.0167 0.0167
Trypanosoma brucei DNA polymerase kappa, putative 0.0011 0.0005 0.0008
Brugia malayi beta-lactamase 0.0105 0.0313 0.0622
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0369 0.0734
Treponema pallidum DNA ligase (lig) 0.001 0.0002 0.5
Trypanosoma brucei Fatty acid elongase 0.0879 0.2861 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0042 0.0286
Schistosoma mansoni hypothetical protein 0.0061 0.0167 0.0441
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.013 0.0258
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.013 0.0447
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0035 0.0237
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0057 0.0157 0.0414
Onchocerca volvulus 0.0105 0.0313 0.2144
Loa Loa (eye worm) hypothetical protein 0.0089 0.0259 0.0515
Echinococcus multilocularis isocitrate dehydrogenase 0.0014 0.0013 0.0013
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0106 0.0725
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0037 0.0091 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Brugia malayi GNS1/SUR4 family protein 0.1539 0.5033 1
Onchocerca volvulus Elongation of very long chain fatty acids protein homolog 0.0208 0.0652 0.4469
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0057 0.0156 0.031
Brugia malayi MAP kinase sur-1 0.0049 0.013 0.0258
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0021 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.0313 0.139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0194 0.051
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.013 0.0343
Loa Loa (eye worm) fatty acid elongation protein 3 0.0208 0.0652 0.1296
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0066 0.0186 0.9611
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.0332
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.013 0.0423
Entamoeba histolytica hypothetical protein 0.0069 0.0194 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0045 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0048 0.0329
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0409
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0061 0.0167 0.0167
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0019 0.006
Onchocerca volvulus 0.0056 0.0152 0.104
Schistosoma mansoni hypothetical protein 0.0196 0.0614 0.1618
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0014 0.0013 0.0038
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0019 0.0133
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.0879 0.2861 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0042 0.0286
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0004 0.0004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0156 0.0412
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0021 0.0021
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0019 0.0133
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.013 0.0447
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0105 0.0313 0.0622
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0002 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0409
Leishmania major fatty acid elongase, putative 0.0879 0.2861 1
Schistosoma mansoni elongation of fatty acids protein 1 0.0222 0.0699 0.1842
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0066 0.0453
Brugia malayi hypothetical protein 0.0274 0.0869 0.1727
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0015
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.013 0.0447
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0066 0.0186 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0409
Toxoplasma gondii GNS1/SUR4 family protein 0.0879 0.2861 1
Brugia malayi topoisomerase 0.001 0.0002 0.0004
Loa Loa (eye worm) isocitrate dehydrogenase 0.0014 0.0013 0.0026
Brugia malayi GNS1/SUR4 family protein 0.0879 0.2861 0.5684
Echinococcus multilocularis dna polymerase eta 0.0016 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0061 0.0167 0.0441
Schistosoma mansoni lamin 0.005 0.0133 0.0351
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0027 0.0057 0.0112
Trypanosoma brucei target of rapamycin kinase 3, putative 0.003 0.0066 0.0224
Echinococcus multilocularis muscleblind protein 1 0.0274 0.0869 0.0869
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.0313 0.2144
Echinococcus multilocularis microtubule associated protein 2 0.1163 0.3793 0.3793
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0014 0.0013 0.0034
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0013 0.0038
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0055 0.0149 0.0393
Brugia malayi Pre-SET motif family protein 0.0057 0.0156 0.031
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0024 0.0048 0.0126
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.0313 0.139
Mycobacterium ulcerans aldehyde dehydrogenase 0.0057 0.0157 0.4987
Brugia malayi MH2 domain containing protein 0.0122 0.0369 0.0734
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.003 0.0066 0.0199
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0048 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0035 0.0237
Schistosoma mansoni hypothetical protein 0.0011 0.0004 0.0011
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0014 0.0013 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0004
Brugia malayi fatty acid elongation protein 3 0.0208 0.0652 0.1296
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0042 0.0106 0.021
Brugia malayi intermediate filament protein 0.005 0.0133 0.0265
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0021 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0002 0.0015
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0019 0.0133
Echinococcus multilocularis lysosomal alpha glucosidase 0.0189 0.0589 0.0589
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0019 0.0133
Giardia lamblia DINP protein human, muc B family 0.0016 0.0021 0.1473
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0057 0.0156 0.0539
Entamoeba histolytica hypothetical protein 0.0069 0.0194 1
Trypanosoma brucei unspecified product 0.0011 0.0005 0.0008
Mycobacterium tuberculosis Conserved hypothetical protein 0.0016 0.0021 0.0037
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.0313 0.2144
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0042 0.0106 0.0363
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0066 0.0186 0.1274
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Brugia malayi latrophilin 2 splice variant baaae 0.0131 0.0398 0.0791
Brugia malayi hypothetical protein 0.0069 0.0194 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0066 0.0453
Schistosoma mansoni hypothetical protein 0.0056 0.0152 0.04
Plasmodium vivax long chain polyunsaturated fatty acid elongation enzyme, putative 0.0222 0.0699 0.2437
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0021 0.0066
Echinococcus multilocularis musashi 0.005 0.0133 0.0133
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0431 0.1135
Loa Loa (eye worm) hypothetical protein 0.001 0.0002 0.0004
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0019 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.001 0.0001 0.0008
Onchocerca volvulus 0.0208 0.0652 0.4469
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0037 0.0091 0.4714
Loa Loa (eye worm) fatty acid elongation protein 3 0.0208 0.0652 0.1296
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.0313 0.0825
Schistosoma mansoni alpha-glucosidase 0.0162 0.0502 0.1325
Mycobacterium leprae Probable lipase LipE 0.0105 0.0313 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0409
Schistosoma mansoni hypothetical protein 0.0061 0.0167 0.0441
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0035 0.0237
Loa Loa (eye worm) acetyltransferase 0.0141 0.0431 0.0856
Echinococcus multilocularis lamin dm0 0.005 0.0133 0.0133
Onchocerca volvulus 0.001 0.0002 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0225 0.0709 0.187
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0104 0.0357
Brugia malayi Calcitonin receptor-like protein seb-1 0.0191 0.0597 0.1187
Leishmania major fatty acid elongase, putative 0.0208 0.0652 0.2255
Loa Loa (eye worm) hypothetical protein 0.0024 0.0048 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0106 0.0363
Echinococcus granulosus lysosomal alpha glucosidase 0.0189 0.0589 0.1552
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0019 0.0133
Trypanosoma cruzi fatty acid elongase, putative 0.0208 0.0652 0.2275
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Onchocerca volvulus 0.0105 0.0313 0.2144
Echinococcus multilocularis tumor protein p63 0.0288 0.0916 0.0916
Trypanosoma brucei Fatty acid elongase 0.0208 0.0652 0.2275
Brugia malayi beta-lactamase family protein 0.0105 0.0313 0.0622
Trichomonas vaginalis maltase-glucoamylase, putative 0.0042 0.0106 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0625
Schistosoma mansoni DNA ligase IV 0.001 0.0002 0.0006
Entamoeba histolytica deoxycytidyl transferase, putative 0.0016 0.0021 0.1086
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.0869 0.2291
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.0313 0.1087
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0225 0.0709 0.0709
Brugia malayi isocitrate dehydrogenase 0.0014 0.0013 0.0026
Echinococcus granulosus lamin dm0 0.005 0.0133 0.0351
Echinococcus granulosus nibrin 0.001 0.0002 0.0006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0398 0.1279 0.2541
Trypanosoma cruzi fatty acid elongase, putative 0.0879 0.2861 1
Echinococcus granulosus muscleblind protein 0.0274 0.0869 0.2291
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0021 0.0021
Brugia malayi beta-lactamase family protein 0.0105 0.0313 0.0622
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.0313 0.0622
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0002 0.0015
Trypanosoma brucei Fatty acid elongase 0.0208 0.0652 0.2275
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0009 0.0065
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0002 0.0015
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0021 0.0055
Loa Loa (eye worm) hypothetical protein 0.0105 0.0313 0.0622
Echinococcus granulosus inositol monophosphatase 1 0.0066 0.0186 0.0491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0041 0.0281
Toxoplasma gondii isocitrate dehydrogenase 0.0014 0.0013 0.0038
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0066 0.0186 0.0643
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0013 0.0009 0.0025
Schistosoma mansoni elongation of fatty acids protein 1 0.0208 0.0652 0.172
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0048 0.0161
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0048 0.0161
Echinococcus multilocularis elongation of very long chain fatty acids 0.0208 0.0652 0.0652
Brugia malayi Inositol-1 0.0066 0.0186 0.037
Trypanosoma cruzi fatty acid elongase, putative 0.0879 0.2861 1
Loa Loa (eye worm) GNS1/SUR4 family protein 0.0879 0.2861 0.5684
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0013 0.0009 0.0019
Toxoplasma gondii ABC1 family protein 0.0105 0.0313 0.1087
Mycobacterium ulcerans beta-lactamase 0.0105 0.0313 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0013 0.0009 0.0065
Leishmania major hypothetical protein, conserved 0.0024 0.0048 0.0136
Echinococcus granulosus intermediate filament protein 0.005 0.0133 0.0351
Trichomonas vaginalis inositol monophosphatase, putative 0.0066 0.0186 0.1274
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.013 0.089
Plasmodium falciparum long chain polyunsaturated fatty acid elongation enzyme, putative 0.0222 0.0699 0.2437
Loa Loa (eye worm) hypothetical protein 0.0105 0.0313 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.006 0.0409
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0002 0.0002
Leishmania major fatty acid elongase, putative 0.0222 0.0699 0.2417
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0066 0.0186 0.0643
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Loa Loa (eye worm) phosphatidylinositol 3 0.0013 0.0009 0.0019
Onchocerca volvulus 0.0208 0.0652 0.4469
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0625
Echinococcus multilocularis geminin 0.0196 0.0614 0.0614
Trypanosoma brucei Long chain fatty acyl elongase 0.0222 0.0699 0.2437
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.013 0.0423
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0042 0.0106 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0091 0.0625
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.013 0.013

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1.3 uM Cytotoxicity against human SK-BR-3 cells after 48 hrs by SRB assay ChEMBL. 20691507
IC50 (functional) = 4.1 uM Cytotoxicity against human DU145 cells after 48 hrs by SRB assay ChEMBL. 20691507
IC50 (functional) = 4.4 uM Cytotoxicity against human SK-N-SH cells after 48 hrs by SRB assay ChEMBL. 20691507
IC50 (functional) = 5.1 uM Cytotoxicity against human A549 cells after 48 hrs by SRB assay ChEMBL. 20691507
IC50 (functional) = 5.3 uM Cytotoxicity against human HCT116 cells after 48 hrs by SRB assay ChEMBL. 20691507

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 20691507

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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