TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 350.365 | Formula: C16H15FN2O4S
H donors: 1 H acceptors: 3 LogP: 2.44 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)OS(=O)(=O)c1ccc(cc1)N1CCCNC1=O
InChi: 1S/C16H15FN2O4S/c17-12-2-6-14(7-3-12)23-24(21,22)15-8-4-13(5-9-15)19-11-1-10-18-16(19)20/h2-9H,1,10-11H2,(H,18,20)
InChiKey: QVCHTACETVZXSS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Fatty acid elongation protein 3	0.0804	0.4728	0.4727
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Onchocerca volvulus		0.0034	0.0152	0.1231
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.005	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0309	1
Loa Loa (eye worm)	CYP4Cod1	0.0097	0.0525	0.0514
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.005	0.0175
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0312	0.2666
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0017	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0004
Schistosoma mansoni	jumonji domain containing protein	0.007	0.0364	0.1286
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.005	0.0102
Echinococcus granulosus	cathepsin l1	0.0017	0.005	0.0175
Echinococcus granulosus	cathepsin L cysteine protease	0.0009	0.0001	0.0004
Loa Loa (eye worm)	cytochrome P450 family protein	0.0097	0.0525	0.0514
Leishmania major	cytochrome p450-like protein	0.0048	0.0234	0.0395
Brugia malayi	follicle stimulating hormone receptor	0.0278	0.1602	0.1601
Trypanosoma cruzi	fatty acid elongase, putative	0.0197	0.1118	0.2362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Loa Loa (eye worm)	hypothetical protein	0.0019	0.006	0.0048
Schistosoma mansoni	elongation of fatty acids protein 1	0.0212	0.1211	0.4276
Echinococcus multilocularis	cysteine protease	0.0017	0.005	0.0175
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0019	0.006	0.0125
Onchocerca volvulus		0.0017	0.005	0.03
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0197	0.1118	0.3945
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.005	0.0175
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Leishmania major	fatty acid elongase, putative	0.0804	0.4728	1
Onchocerca volvulus		0.0017	0.005	0.03
Schistosoma mansoni	cpg binding protein	0.0036	0.0164	0.0578
Brugia malayi	fatty acid elongation protein 3	0.0197	0.1118	0.1117
Schistosoma mansoni	phd/f-box containing protein	0.0019	0.006	0.0213
Brugia malayi	jmjC domain containing protein	0.0019	0.006	0.0059
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0312	0.1101
Brugia malayi	Hypothetical 34.1 kDa protein C40H1.4 in chromosome III	0.0197	0.1118	0.1117
Echinococcus granulosus	lysine specific demethylase 5A	0.0072	0.0376	0.1327
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Brugia malayi	Cytochrome P450 family protein	0.0097	0.0525	0.0524
Loa Loa (eye worm)	cytochrome P450	0.0048	0.0234	0.0222
Echinococcus multilocularis	cysteine protease	0.0017	0.005	0.0175
Giardia lamblia	Kinase, CMGC MAPK	0.006	0.0309	0.5
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Echinococcus multilocularis	dnaJ subfamily B	0.0485	0.2833	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Echinococcus granulosus	jumonji domain containing 1A	0.0019	0.006	0.0213
Schistosoma mansoni	cpg binding protein	0.0036	0.0164	0.0578
Onchocerca volvulus		0.0197	0.1118	1
Loa Loa (eye worm)	fibroinase	0.0017	0.005	0.0037
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0309	0.109
Schistosoma mansoni	elongation of fatty acids protein 1	0.0197	0.1118	0.3945
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.005	0.0048
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0058	0.0297	0.0627
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0197	0.1118	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.007	0.0364	0.1286
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0021	0.0072	0.0253
Brugia malayi	Cytochrome P450 family protein	0.0097	0.0525	0.0524
Leishmania major	cathepsin L-like protease	0.0064	0.033	0.06
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0048	0.0234	0.0494
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0012	0.0044
Trypanosoma brucei	Fatty acid elongase	0.0197	0.1118	0.2362
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.007	0.0364	0.1286
Plasmodium vivax	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0212	0.1211	0.2561
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0048	0.0234	0.0395
Echinococcus granulosus	cytochrome P450 2K1	0.0048	0.0234	0.0828
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0012	0.001
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0312	0.2666
Trypanosoma cruzi	fatty acid elongase, putative	0.0212	0.1211	0.2561
Onchocerca volvulus	Elongation of very long chain fatty acids protein homolog	0.0197	0.1118	1
Brugia malayi	jmjC domain containing protein	0.0072	0.0376	0.0375
Leishmania major	fatty acid elongase, putative	0.0212	0.1211	0.2484
Onchocerca volvulus		0.0017	0.005	0.03
Brugia malayi	fatty acid elongation protein 3	0.0197	0.1118	0.1117
Echinococcus granulosus	mitogen activated protein kinase	0.006	0.0309	0.109
Echinococcus multilocularis	lysine specific demethylase 6a	0.0019	0.006	0.0213
Schistosoma mansoni	hypothetical protein	0.0048	0.0234	0.0828
Brugia malayi	Cathepsin L-like precursor	0.0017	0.005	0.0048
Plasmodium falciparum	long chain polyunsaturated fatty acid elongation enzyme, putative	0.0212	0.1211	0.2561
Brugia malayi	GNS1/SUR4 family protein	0.0804	0.4728	0.4727
Echinococcus multilocularis	cpg binding protein	0.0036	0.0164	0.0578
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0309	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0197	0.1118	0.1107
Plasmodium vivax	GNS1/SUR4 domain containing protein	0.0804	0.4728	1
Leishmania major	long chain polyunsaturated fatty acid elongation enzyme-like protein	0.0212	0.1211	0.2484
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0019	0.006	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0019	0.006	0.0048
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0072	0.0376	0.1327
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0152	0.014
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0019	0.006	0.0023
Echinococcus multilocularis	jumonji domain containing 1A	0.0019	0.006	0.0213
Schistosoma mansoni	phosphatidylserine receptor	0.0019	0.006	0.0213
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0309	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.005	0.0037
Plasmodium falciparum	long chain fatty acid elongation enzyme, putative	0.0804	0.4728	1
Schistosoma mansoni	jumonji domain containing protein	0.0019	0.006	0.0213
Loa Loa (eye worm)	cytochrome P450 family protein	0.0097	0.0525	0.0514
Echinococcus granulosus	phd:f box containing protein	0.0019	0.006	0.0213
Brugia malayi	jmjC domain containing protein	0.007	0.0364	0.0363
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0001	0.0004
Trypanosoma brucei	protein kinase, putative	0.006	0.0309	0.0651
Leishmania major	fatty acid elongase, putative	0.0804	0.4728	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.005	0.0175
Trypanosoma cruzi	fatty acid elongase, putative	0.0804	0.4728	1
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.006	0.0125
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.006	0.0309	0.0554
Trypanosoma cruzi	fatty acid elongase, putative	0.0197	0.1118	0.2362
Loa Loa (eye worm)	hypothetical protein	0.0019	0.006	0.0048
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.005	0.0175
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.006	0.0309	0.0651
Trypanosoma cruzi	fatty acid elongase, putative	0.0197	0.1118	0.2362
Schistosoma mansoni	cpg binding protein	0.0034	0.0152	0.0537
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0004
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0309	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.006	0.0309	0.109
Brugia malayi	Cytochrome P450 family protein	0.0048	0.0234	0.0233
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.006	0.0048
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Echinococcus multilocularis		0.0048	0.0234	0.0828
Brugia malayi	jmjC domain containing protein	0.0019	0.006	0.0059
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0072	0.0376	0.1327
Echinococcus granulosus	mitogen activated protein kinase 3	0.006	0.0309	0.109
Brugia malayi	fatty acid elongation protein 3	0.0197	0.1118	0.1117
Echinococcus granulosus	JmjC domain containing protein 4	0.0019	0.006	0.0213
Plasmodium vivax	elongation of very long chain fatty acids protein 3, putative	0.0197	0.1118	0.2362
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Echinococcus granulosus	cysteine protease	0.0009	0.0001	0.0004
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0097	0.0525	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0017	0.0501
Schistosoma mansoni	cytochrome P450	0.0048	0.0234	0.0828
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0017	0.0015
Leishmania major	cathepsin L-like protease	0.0064	0.033	0.06
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Echinococcus multilocularis	JmjC domain containing protein 4	0.0019	0.006	0.0213
Schistosoma mansoni	protein phosphatase 2C	0.0019	0.006	0.0213
Mycobacterium leprae	putative cytochrome p450	0.0048	0.0234	0.5
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0241	0.0229
Onchocerca volvulus		0.0017	0.005	0.03
Trypanosoma cruzi	fatty acid elongase, putative	0.0804	0.4728	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.006	0.0309	0.0554
Plasmodium falciparum	fatty acid elongation protein, GNS1/SUR4 family, putative	0.0804	0.4728	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.005	0.03
Brugia malayi	MAP kinase sur-1	0.006	0.0309	0.0308
Toxoplasma gondii	aldehyde dehydrogenase	0.0061	0.0312	0.0561
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.005	0.0175
Echinococcus granulosus	elongation of very long chain fatty acids	0.0212	0.1211	0.4276
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.005	0.0175
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.005	0.0037
Trypanosoma cruzi	cytochrome P450, putative	0.0097	0.0525	0.1109
Trypanosoma cruzi	cruzipain precursor, putative	0.0064	0.033	0.0696
Schistosoma mansoni	hypothetical protein	0.0485	0.2833	1
Mycobacterium leprae	Conserved hypothetical protein	0.0048	0.0234	0.5
Plasmodium vivax	vivapain-2	0.0017	0.005	0.0102
Echinococcus granulosus	elongation of very long chain fatty acids	0.0197	0.1118	0.3945
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0309	0.0651
Trypanosoma brucei	elongation of very long chain fatty acids protein, putative	0.0212	0.1211	0.2561
Echinococcus granulosus	cathepsin l1	0.0011	0.0017	0.0059
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.0048	0.0234	0.0494
Schistosoma mansoni	elongation of fatty acids protein 1	0.0197	0.1118	0.3945
Leishmania major	fatty acid elongase, putative	0.0197	0.1118	0.2283
Echinococcus granulosus	cpg binding protein	0.0036	0.0164	0.0578
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.005	0.0175
Loa Loa (eye worm)	jmjC domain-containing protein	0.0072	0.0376	0.0364
Toxoplasma gondii	GNS1/SUR4 family protein	0.0804	0.4728	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.005	0.1574
Onchocerca volvulus		0.0017	0.005	0.03
Trypanosoma cruzi	fatty acid elongase, putative	0.0804	0.4728	1
Loa Loa (eye worm)	hypothetical protein	0.0197	0.1118	0.1107
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Schistosoma mansoni	aldehyde dehydrogenase	0.0061	0.0312	0.1101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.006	0.0048
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.005	0.03
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0064	0.033	0.0696
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0019	0.006	0.0125
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.006	0.0309	0.0651
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0001	0.0004
Leishmania major	cathepsin L-like protease	0.0064	0.033	0.06
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0061	0.0312	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0012	0.0044
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0309	0.0651
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0048	0.0234	0.0494
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.033	0.0696
Echinococcus multilocularis	mitogen activated protein kinase	0.006	0.0309	0.109
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.007	0.0364	0.1286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0061	0.0312	0.0561
Leishmania major	cytochrome p450-like protein	0.0048	0.0234	0.0395
Schistosoma mansoni	fatty acid acyl transferase-related	0.0212	0.1211	0.4276
Trypanosoma cruzi	cytochrome P450, putative	0.0097	0.0525	0.1109
Brugia malayi	jmjC domain containing protein	0.0019	0.006	0.0059
Plasmodium vivax	vivapain-2	0.0017	0.005	0.0102
Loa Loa (eye worm)	cytochrome P450 family protein	0.0135	0.0753	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0048	0.0234	0.0494
Onchocerca volvulus		0.0197	0.1118	1
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.005	0.03
Brugia malayi	Cathepsin L-like precursor	0.0017	0.005	0.0048
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0019	0.006	0.0125
Trypanosoma cruzi	fatty acid elongase, putative	0.0212	0.1211	0.2561
Brugia malayi	fatty acid elongation protein 3	0.0197	0.1118	0.1117
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0061	0.0312	0.2666
Brugia malayi	cytochrome P450	0.0048	0.0234	0.0233
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.005	0.0102
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0017	0.0015
Trypanosoma cruzi	fatty acid elongase, putative	0.0804	0.4728	1
Onchocerca volvulus		0.0017	0.005	0.03
Loa Loa (eye worm)	jmjC domain-containing protein	0.0019	0.006	0.0048
Brugia malayi	Cathepsin L-like precursor	0.0017	0.005	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0004
Brugia malayi	Cathepsin L-like precursor	0.0017	0.005	0.0048
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.006	0.0309	0.0297
Onchocerca volvulus		0.0017	0.005	0.03
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0152	0.0151
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0061	0.0312	0.1101
Leishmania major	cytochrome p450-like protein	0.0097	0.0525	0.1017
Loa Loa (eye worm)	cysteine protease	0.0017	0.005	0.0037
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.1691	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0021	0.0072	0.0253
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.0379	0.1338
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0804	0.4728	0.4721
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0017	0.0501
Echinococcus multilocularis	phd:f box containing protein	0.0019	0.006	0.0213
Trypanosoma cruzi	major cysteine proteinase, putative	0.005	0.0249	0.0524
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.006	0.0309	0.0651
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0061	0.0312	0.1101
Trypanosoma brucei	cytochrome P450, putative	0.0097	0.0525	0.1109
Brugia malayi	Cytochrome P450 family protein	0.0135	0.0753	0.0752
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.005	0.0037
Leishmania major	hypothetical protein, conserved	0.0019	0.006	0.0023
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Echinococcus granulosus	lysine specific demethylase 6a	0.0019	0.006	0.0213
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.005	0.0102
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.005	0.0102
Loa Loa (eye worm)	ctsf protein	0.0017	0.005	0.0037
Plasmodium vivax	JmjC domain containing protein	0.0019	0.006	0.0125
Schistosoma mansoni	elongation of fatty acids protein 1	0.0212	0.1211	0.4276
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.005	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.005	0.1574
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0278	0.1602	0.1591
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.006	0.0309	0.0554
Trypanosoma brucei	Long chain fatty acyl elongase	0.0212	0.1211	0.2561
Onchocerca volvulus	Elongation of very long chain fatty acids protein 5 homolog	0.0197	0.1118	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.033	0.0696
Toxoplasma gondii	integral membrane protein, GNS1/SUR4 family protein, putative	0.0804	0.4728	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0064	0.033	0.0696
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0009	0.0001	0.0004
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0197	0.1118	0.1107
Echinococcus multilocularis	cathepsin L	0.0009	0.0001	0.0004
Trypanosoma cruzi	fatty acid elongase, putative	0.0197	0.1118	0.2362
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0065	0.0333	0.0606
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Brugia malayi	Cathepsin L-like precursor	0.0017	0.005	0.0048
Echinococcus granulosus	dnaJ subfamily B	0.0485	0.2833	1
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0048	0.0234	0.0395
Loa Loa (eye worm)	fatty acid elongation protein 3	0.0197	0.1118	0.1107
Echinococcus granulosus	cathepsin L	0.0009	0.0001	0.0004
Brugia malayi	cathepsin L-like precursor	0.0011	0.0017	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.005	0.1574
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0017	0.0059
Leishmania major	fatty acid elongase, putative	0.0804	0.4728	1
Trypanosoma brucei	Fatty acid elongase	0.0197	0.1118	0.2362
Entamoeba histolytica	cysteine protease, putative	0.0017	0.005	1
Echinococcus multilocularis	elongation of very long chain fatty acids	0.0212	0.1211	0.4276
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0017	0.0015
Loa Loa (eye worm)	ELO-9 protein	0.0197	0.1118	0.1107
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.005	0.0175
Trypanosoma brucei	Fatty acid elongase	0.0804	0.4728	1
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0019	0.006	0.0023
Loa Loa (eye worm)	GNS1/SUR4 family protein	0.0804	0.4728	0.4721
Brugia malayi	jmjC domain containing protein	0.0019	0.006	0.0059
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.005	0.1574
Toxoplasma gondii	fatty acid elongase	0.0212	0.1211	0.2484
Brugia malayi	Cathepsin L-like precursor	0.0017	0.005	0.0048

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 1000 nM	Antiproliferative activity against human HT-29 cells after 48 hrs by sulforhodamine B assay	ChEMBL.	21604746
IC50 (functional)	> 1000 nM	Antiproliferative activity against human M21 cells after 48 hrs by sulforhodamine B assay	ChEMBL.	21604746
IC50 (functional)	> 1000 nM	Antiproliferative activity against human MCF7 cells after 48 hrs by sulforhodamine B assay	ChEMBL.	21604746

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	21604746

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1802497

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1084618