Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0499 | 0.8733 | 0.8733 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0102 | 0.1363 | 0.1363 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0499 | 0.8733 | 0.855 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.3946 | 0.3946 |
Echinococcus multilocularis | bifunctional protein NCOAT | 0.0568 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1855 | 0.1855 |
Schistosoma mansoni | survival motor neuron protein | 0.0102 | 0.1363 | 0.0112 |
Schistosoma mansoni | Hyaluronidase | 0.0568 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0128 | 0.1855 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0128 | 0.1855 | 0.1855 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0097 | 0.1266 | 0.1266 |
Brugia malayi | hypothetical protein | 0.0499 | 0.8733 | 0.8733 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | bifunctional protein NCOAT | 0.0568 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.1363 | 0.0112 |
Schistosoma mansoni | aminopeptidase P homologue (M24 family) | 0.0568 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0128 | 0.1855 | 1 |
Loa Loa (eye worm) | hyaluronidase | 0.0568 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0499 | 0.8733 | 0.855 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0097 | 0.1266 | 0.1266 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.1855 | 0.1855 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 23 % | Inhibition of 11beta-HSD1 in human microsomes at 10 uM by HTRF cortisol assay | ChEMBL. | 20045318 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.