Detailed information for compound 109360

Basic information

Technical information
  • TDR Targets ID: 109360
  • Name: (2R,3R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S, 5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan -2-yl]oxyhexanal
  • MW: 342.296 | Formula: C12H22O11
  • H donors: 8 H acceptors: 9 LogP: -5.02 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC[C@H](C([C@@H]([C@H](C=O)O)O)O[C@@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O)O
  • InChi: 1S/C12H22O11/c13-1-4(16)7(18)11(5(17)2-14)23-12-10(21)9(20)8(19)6(3-15)22-12/h1,4-12,14-21H,2-3H2/t4-,5+,6+,7+,8-,9-,10+,11?,12-/m0/s1
  • InChiKey: DKXNBNKWCZZMJT-HWCAIPQBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R,3R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-hexanal
  • (2R,3R,5R)-2,3,5,6-tetrahydroxy-4-[[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-tetrahydropyranyl]oxy]hexanal
  • (2R,3R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-hexanal
  • (2R,3R,5R)-2,3,5,6-tetrahydroxy-4-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxy-hexanal
  • Lactose
  • 4-O-alpha-D-galactopyranosyl-D-galactose
  • AIDS-123124
  • AIDS123124
  • d-Glucose, 4-O-.beta.-D-Galactopyranosyl

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0572 0.0218
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0011 0.0011
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0667 0.4405 0.4196
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0286 0.0286
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0572 0.0568
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0147 0.0143
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0177 0.0173
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Loa Loa (eye worm) beta-lactamase 0.0108 0.0572 0.0568
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.1482 1 1
Brugia malayi beta-lactamase 0.0108 0.0572 0.0568
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0667 0.4405 0.4403
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Loa Loa (eye worm) hypothetical protein 0.0056 0.0215 0.0211
Leishmania major hypothetical protein, conserved 0.0108 0.0572 0.0568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0013 0.0009
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0498 0.3247 0.3247
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0572 0.0401
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.1482 1 1
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.1482 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0361 0.0357
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0215 0.0215
Brugia malayi MH2 domain containing protein 0.0027 0.0011 0.0007
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0691 0.4573 0.4475
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0286 0.0286
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0112 0.0596 0.0592
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Mycobacterium ulcerans beta-lactamase 0.0108 0.0572 0.0218
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.09 0.0896
Leishmania major mitochondrial DNA polymerase beta 0.033 0.2091 0.2088
Schistosoma mansoni hypothetical protein 0.0144 0.0816 0.0816
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0699
Echinococcus granulosus microtubule associated protein 2 0.1412 0.9516 0.9516
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Echinococcus multilocularis smad 0.0027 0.0011 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0389 0.2499 0.2496
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0083 0.0079
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0667 0.4405 1
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0572 0.0401
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0361 0.0361
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1482 1 1
Brugia malayi RNA binding protein 0.0063 0.026 0.0256
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0011 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.1273 0.1269
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0186 0.0182
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0182
Echinococcus granulosus histone acetyltransferase KAT2B 0.0159 0.0919 0.0919
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0572 0.0401
Loa Loa (eye worm) Smad1 0.0027 0.0011 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0186 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0177 0.0095
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.0968 0.0968
Echinococcus multilocularis musashi 0.0116 0.0628 0.0628
Brugia malayi PHD-finger family protein 0.0031 0.0045 0.0041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0572 0.0401
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0083 0.0007
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0116 0.0628 0.0624
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0572 0.0401
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0498 0.3247 0.7323
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0667 0.4405 1
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0572 0.1273
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.1273 0.1269
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0186 0.0186
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.021 0.1273 0.1269
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0083 0.0079
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Onchocerca volvulus 0.0108 0.0572 0.897
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0083 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Toxoplasma gondii ABC1 family protein 0.0108 0.0572 0.0568
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0667 0.4405 0.4405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Loa Loa (eye worm) hypothetical protein 0.0078 0.0364 0.0361
Leishmania major solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Toxoplasma gondii hypothetical protein 0.0027 0.0013 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0083 0.0079
Brugia malayi MAP kinase sur-1 0.0052 0.0186 0.0182
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.0968 0.0965
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0754 0.5002 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0182
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC1 (polyprenyl pyrophosphate synthetase) 0.0169 0.0988 0.0824
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0186 0.0182
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.1482 1 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.008 0.008
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0186 0.0182
Echinococcus multilocularis GPCR, family 2 0.0067 0.0286 0.0286
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0177 0.0177
Loa Loa (eye worm) transcription factor SMAD2 0.0389 0.2499 0.2496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.0968 0.0968
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.1482 1 1
Brugia malayi MH2 domain containing protein 0.0027 0.0011 0.0007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0454 0.045
Loa Loa (eye worm) hypothetical protein 0.0042 0.012 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0286 0.0282
Loa Loa (eye worm) polyprenyl synthetase 0.0667 0.4405 0.4403
Trypanosoma brucei protein kinase, putative 0.0052 0.0186 0.0182
Trypanosoma cruzi polyprenyl synthase, putative 0.0754 0.5002 0.5
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0177 0.0173
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0286 0.0282
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0454 0.0454
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0454 0.0454
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0011 0.0007
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0667 0.4405 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0186 0.0182
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0083 0.0083
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0132 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0572 0.0568
Echinococcus multilocularis Smad4 0.0027 0.0011 0.0011
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0257 0.0253
Echinococcus granulosus lamin 0.0116 0.0628 0.0628
Echinococcus granulosus zinc finger protein 0.0026 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0036 0.008 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Mycobacterium leprae Probable lipase LipE 0.0108 0.0572 0.1273
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0186 0.0182
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0425
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0083 0.0007
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0177 0.0095
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0572 0.0401
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0186 0.0186
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0361 0.0357
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Entamoeba histolytica cysteine protease, putative 0.0037 0.0083 0.0007
Brugia malayi Smad1 0.0027 0.0011 0.0007
Brugia malayi beta-lactamase family protein 0.0108 0.0572 0.0568
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0572 0.0568
Schistosoma mansoni Smad4 0.0027 0.0011 0.0011
Toxoplasma gondii hypothetical protein 0.0053 0.0194 0.019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0572 0.0572
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0572 0.0572
Onchocerca volvulus 0.0108 0.0572 0.897
Brugia malayi intermediate filament protein 0.0116 0.0628 0.0624
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.008 0.008
Brugia malayi TAR-binding protein 0.0063 0.026 0.0256
Loa Loa (eye worm) hypothetical protein 0.0114 0.0613 0.061
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0572 0.0218
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0498 0.3247 0.3125
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Plasmodium vivax vivapain-2 0.0037 0.0083 0.0079
Brugia malayi Bromodomain containing protein 0.0087 0.0424 0.042
Brugia malayi Probable ClpP-like protease 0.0078 0.0361 0.0357
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0498 0.3247 0.7136
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0667 0.4405 1
Echinococcus granulosus farnesyl pyrophosphate synthase 0.1482 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0177 0.0173
Loa Loa (eye worm) RNA binding protein 0.0063 0.026 0.0256
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0498 0.3247 0.3247
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.1482 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0083 0.0083
Mycobacterium ulcerans lipase LipD 0.0108 0.0572 0.0218
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0754 0.5002 0.5
Loa Loa (eye worm) fibroinase 0.0037 0.0083 0.0079
Echinococcus multilocularis lamin 0.0116 0.0628 0.0628
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0667 0.4405 0.4403
Brugia malayi hypothetical protein 0.0036 0.008 0.0076
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0186 0.0186
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.09 0.0896
Echinococcus multilocularis tar DNA binding protein 0.0063 0.026 0.026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0454 0.0454
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0011 0.0007
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0667 0.4405 0.4405
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0178 0.0178
Schistosoma mansoni bromodomain containing protein 0.0074 0.0336 0.0336
Echinococcus multilocularis zinc finger protein 0.0026 0.0005 0.0005
Echinococcus granulosus tar DNA binding protein 0.0063 0.026 0.026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0286 0.0286
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0498 0.3247 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0361
Loa Loa (eye worm) TAR-binding protein 0.0063 0.026 0.0256
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0498 0.3247 0.3125
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0572 0.0572
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0112 0.0596 0.0596
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0498 0.3247 0.3125
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Onchocerca volvulus 0.0116 0.0628 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0178 0.0178
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0572 0.0572
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0286 0.0286
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.0816 0.0813
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0011 0.0011
Brugia malayi Polyprenyl synthetase family protein 0.0667 0.4405 0.4403
Trypanosoma cruzi cruzipain precursor, putative 0.0141 0.0795 0.0791
Brugia malayi Bromodomain containing protein 0.0046 0.0147 0.0143
Trypanosoma cruzi polyprenyl synthase, putative 0.0754 0.5002 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.02 0.0196
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0013 0.0009
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0083 0.0079
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0286 0.0282
Echinococcus granulosus intermediate filament protein 0.0116 0.0628 0.0628
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0361 0.0794
Brugia malayi beta-lactamase family protein 0.0108 0.0572 0.0568
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0572 0.0493
Loa Loa (eye worm) hypothetical protein 0.0116 0.0628 0.0624
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Schistosoma mansoni farnesyl pyrophosphate synthase 0.1482 1 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0572 0.0568
Echinococcus granulosus GPCR family 2 0.0067 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0051 0.018 0.0176
Echinococcus granulosus cathepsin l1 0.0037 0.0083 0.0083
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Schistosoma mansoni zinc finger protein 0.0026 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.0108 0.0572 0.0218
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0454 0.0454
Echinococcus multilocularis cysteine protease 0.0037 0.0083 0.0083
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0361
Loa Loa (eye worm) hypothetical protein 0.0067 0.0286 0.0282
Echinococcus granulosus smad 0.0027 0.0011 0.0011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0361 0.0357
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0498 0.3247 0.2994
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0132 0.0128
Echinococcus granulosus Smad4 0.0027 0.0011 0.0011
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.007 0.0309 0.0309
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0101 0.0101
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0454 0.045
Trypanosoma cruzi cysteine peptidase, putative 0.0141 0.0795 0.0791
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.9516 0.9516
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0083 0.0079
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Schistosoma mansoni tar DNA-binding protein 0.0063 0.026 0.026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.1021 0.0858
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0083 0.0083
Leishmania major cathepsin L-like protease 0.0141 0.0795 0.0791
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.1482 1 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0572 0.0568
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0361 0.0357
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0112 0.0596 0.0596
Schistosoma mansoni smad 0.0027 0.0011 0.0011
Leishmania major farnesyl pyrophosphate synthase 0.1482 1 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0011 0.0011
Loa Loa (eye worm) cysteine protease 0.0037 0.0083 0.0079
Brugia malayi Cathepsin L-like precursor 0.0037 0.0083 0.0079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.007 0.0309 0.0309
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.09 0.0896
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0667 0.4405 0.4403
Schistosoma mansoni lamin 0.0116 0.0628 0.0628
Schistosoma mansoni trans-prenyltransferase 0.0667 0.4405 0.4405
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0112 0.0596 0.0592
Loa Loa (eye worm) hypothetical protein 0.0049 0.0165 0.0161
Trypanosoma brucei mitochondrial DNA polymerase beta 0.033 0.2091 0.2088
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0083 0.0079
Onchocerca volvulus 0.0116 0.0628 1
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0572 0.0568
Loa Loa (eye worm) hypothetical protein 0.0054 0.02 0.0196
Brugia malayi MH2 domain containing protein 0.0389 0.2499 0.2496
Brugia malayi MH1 domain containing protein 0.0027 0.0011 0.0007
Giardia lamblia Farnesyl diphosphate synthase 0.1482 1 1
Trichomonas vaginalis esterase, putative 0.0108 0.0572 0.0493
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0011 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0116 0.0628 0.0624
Loa Loa (eye worm) polyprenyl synthetase 0.1482 1 1
Schistosoma mansoni intermediate filament proteins 0.0116 0.0628 0.0628
Schistosoma mansoni glutathione synthetase 0.0498 0.3247 0.3247
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2091 0.2088
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0186 0.0186
Onchocerca volvulus 0.0108 0.0572 0.897
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0129 0.0711 0.0708
Brugia malayi Intermediate filament tail domain containing protein 0.0116 0.0628 0.0624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Mycobacterium ulcerans hypothetical protein 0.0174 0.1021 0.0684
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0572 0.0401
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0104 0.0544 0.0541
Trypanosoma brucei farnesyl pyrophosphate synthase 0.1482 1 1
Loa Loa (eye worm) ctsf protein 0.0037 0.0083 0.0079
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0243
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0667 0.4405 0.4403
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0083 0.0083
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0178 0.0377
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0083 0.0083
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.026 0.0256
Leishmania major polyprenyl synthase, putative 0.0754 0.5002 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0112 0.0596 0.0596
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.1273 0.1269
Plasmodium vivax vivapain-2 0.0037 0.0083 0.0079
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2091 0.2088
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0112 0.0596 0.0243
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0215 0.0215
Mycobacterium tuberculosis Conserved protein 0.0108 0.0572 0.0401
Echinococcus granulosus lamin dm0 0.0116 0.0628 0.0628
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.026 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Toxoplasma gondii cathepsin CPL 0.0037 0.0083 0.0079
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.1482 1 1
Schistosoma mansoni lamin 0.0116 0.0628 0.0628
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0186 0.0104
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0186 0.0055
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0147 0.0143
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0572 0.0568
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0186 0.0182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0454 0.0454
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0754 0.5002 0.5002
Treponema pallidum octaprenyl-diphosphate synthase 0.0754 0.5002 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0083 0.0079
Echinococcus multilocularis lamin dm0 0.0116 0.0628 0.0628
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0667 0.4405 0.4403
Loa Loa (eye worm) hypothetical protein 0.0078 0.0361 0.0357
Loa Loa (eye worm) acetyltransferase 0.0166 0.0968 0.0965
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.1482 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0572 0.0493
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0186 0.0182
Loa Loa (eye worm) hypothetical protein 0.0144 0.0816 0.0813
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.9516 0.9516
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.008 0.008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0141 0.0795 0.0791
Echinococcus multilocularis cysteine protease 0.0037 0.0083 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0217 0.0213
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0257 0.0253
Leishmania major cathepsin L-like protease 0.0037 0.0083 0.0079
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.0588 0.0585
Schistosoma mansoni hypothetical protein 0.0067 0.0286 0.0286
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0572 0.0493
Schistosoma mansoni smad1 5 8 and 0.0027 0.0011 0.0011
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0083 0.0083

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) < 50 % Inhibition against HIV-1 integrase at 1 mM ChEMBL. 10841789
Inhibition (binding) < 50 % Inhibition against HIV-1 integrase at 200 microM ChEMBL. 10841789
Inhibition (binding) < 50 % Inhibition against HIV-1 integrase at 1 mM ChEMBL. 10841789
Inhibition (binding) < 50 % Inhibition against HIV-1 integrase at 200 microM ChEMBL. 10841789

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

45 literature references were collected for this gene.

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