Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | endoplasmic reticulum oxidoreductin, putative | 0.00727244 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.00777066 | 0.000723351 | 0.0115008 |
Echinococcus multilocularis | hormone sensitive lipase | 0.696045 | 1 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.014991 | 0.0112063 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.00777066 | 0.000723351 | 0.000723351 |
Trichomonas vaginalis | Esterase, putative | 0.014991 | 0.0112063 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.014991 | 0.0112063 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0295306 | 0.0323157 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.00777066 | 0.000723351 | 0.000723351 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.014991 | 0.0112063 | 0.5 |
Plasmodium vivax | endoplasmic reticulum oxidoreductin, putative | 0.00727244 | 0 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0295306 | 0.0323157 | 1 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.014991 | 0.0112063 | 1 |
Loa Loa (eye worm) | aryl-acylamidase | 0.014991 | 0.0112063 | 0.0112063 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.696045 | 1 | 1 |
Mycobacterium leprae | Possible lipase LipU | 0.014991 | 0.0112063 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.00777066 | 0.000723351 | 0.000723351 |
Echinococcus multilocularis | acetylcholinesterase | 0.00777066 | 0.000723351 | 0.000723351 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.014991 | 0.0112063 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.014991 | 0.0112063 | 1 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.014991 | 0.0112063 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.014991 | 0.0112063 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.014991 | 0.0112063 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.014991 | 0.0112063 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.00777066 | 0.000723351 | 0.000723351 |
Loa Loa (eye worm) | hypothetical protein | 0.00777066 | 0.000723351 | 0.000723351 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.014991 | 0.0112063 | 0.0112063 |
Echinococcus granulosus | acetylcholinesterase | 0.00777066 | 0.000723351 | 0.000723351 |
Loa Loa (eye worm) | ammd protein | 0.014991 | 0.0112063 | 0.0112063 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.0431373 | 0.0520707 | 0.0520707 |
Leishmania major | hypothetical protein, conserved | 0.014991 | 0.0112063 | 1 |
Echinococcus granulosus | hormone sensitive lipase | 0.696045 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.00777066 | 0.000723351 | 0.000723351 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.014991 | 0.0112063 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.696045 | 1 | 1 |
Brugia malayi | aryl-acylamidase | 0.014991 | 0.0112063 | 0.178173 |
Loa Loa (eye worm) | hypothetical protein | 0.00777066 | 0.000723351 | 0.000723351 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.027451 | 0.0292964 | 1 |
Onchocerca volvulus | 0.014991 | 0.0112063 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.00777066 | 0.000723351 | 0.000723351 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.696045 | 1 | 1 |
Leishmania major | ecotin, putative | 0.014991 | 0.0112063 | 1 |
Brugia malayi | Serotonin receptor | 0.0505933 | 0.0628957 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.00777066 | 0.000723351 | 0.000723351 |
Brugia malayi | Carboxylesterase family protein | 0.00777066 | 0.000723351 | 0.0115008 |
Loa Loa (eye worm) | hypothetical protein | 0.696045 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 15 nM | The compound was tested in vitro for antimalarial activity against P. falciparum D-6 clone | ChEMBL. | 1597862 |
IC50 (functional) | = 15 nM | The compound was tested in vitro for antimalarial activity against P. falciparum D-6 clone | ChEMBL. | 1597862 |
IC50 (functional) | = 83 nM | The compound was tested in vitro for antimalarial activity against P. falciparum W-2 clone. | ChEMBL. | 1597862 |
IC50 (functional) | = 83 nM | The compound was tested in vitro for antimalarial activity against P. falciparum W-2 clone. | ChEMBL. | 1597862 |
Resistance index (functional) | = 5.5 | Resistance index of the compound was measured as the ratio of IC50 of P. falciparum W-2 clone / IC50 of P. falciparum D-6 clone | ChEMBL. | 1597862 |
T-C (functional) | = 0.2 day | The compound was tested in vivo for antimalarial activity against P. berghei at the dose of 40 mg/kg in mice | ChEMBL. | 1597862 |
T-C (functional) | = 0.2 day | The compound was tested in vivo for antimalarial activity against P. berghei at the dose of 40 mg/kg in mice | ChEMBL. | 1597862 |
T-C (functional) | = 0.4 day | The compound was tested in vivo for antimalarial activity against P. berghei at the dose of 160 mg/kg in mice | ChEMBL. | 1597862 |
T-C (functional) | = 0.4 day | The compound was tested in vivo for antimalarial activity against P. berghei at the dose of 160 mg/kg in mice | ChEMBL. | 1597862 |
T-C (functional) | = 1.2 day | The compound was tested in vivo for antimalarial activity against P. berghei at the dose of 640 mg/kg in mice | ChEMBL. | 1597862 |
T-C (functional) | = 1.2 day | The compound was tested in vivo for antimalarial activity against P. berghei at the dose of 640 mg/kg in mice | ChEMBL. | 1597862 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 1597862 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.