TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 468.595 | Formula: C24H36N8O2
H donors: 2 H acceptors: 3 LogP: 2.75 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCNC1OCCN(C1)c1nc(nc(n1)N1CCCc2c1cccc2)N1CCOC(C1)NCC
InChi: 1S/C24H36N8O2/c1-3-25-20-16-30(12-14-33-20)22-27-23(31-13-15-34-21(17-31)26-4-2)29-24(28-22)32-11-7-9-18-8-5-6-10-19(18)32/h5-6,8,10,20-21,25-26H,3-4,7,9,11-17H2,1-2H3
InChiKey: YLEBUHQPMSSAGS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.1132	0.2138
Leishmania major	cathepsin L-like protease	0.2939	0.6717	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.1132	0.2138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.1711	0.3875	0.5749
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1557	0.3519	0.6771
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.1132	0.2138
Loa Loa (eye worm)	hypothetical protein	0.0526	0.1132	0.1132
Echinococcus multilocularis	cathepsin L cysteine protease	0.2276	0.5183	0.518
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.4357	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.2276	0.5183	1
Brugia malayi	Papain family cysteine protease containing protein	0.1245	0.2796	0.2796
Giardia lamblia	Cysteine protease	0.0526	0.1132	0.2865
Onchocerca volvulus		0.2276	0.5183	1
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.004	0.004
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Entamoeba histolytica	cysteine proteinase 2	0.1245	0.2796	0.539
Entamoeba histolytica	cysteine protease, putative	0.2276	0.5183	1
Loa Loa (eye worm)	fibroinase	0.2276	0.5183	0.5183
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1245	0.2796	0.2796
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1245	0.2796	0.4135
Brugia malayi	Cathepsin L-like cysteine proteinase	0.1557	0.3519	0.3519
Loa Loa (eye worm)	hypothetical protein	0.0526	0.1132	0.1132
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Loa Loa (eye worm)	cathepsin B	0.1711	0.3875	0.3875
Entamoeba histolytica	cysteine protease, putative	0.0526	0.1132	0.2177
Giardia lamblia	Cathepsin L-like protease	0.0526	0.1132	0.2865
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4357	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1245	0.2796	0.5367
Trypanosoma cruzi	cysteine peptidase, putative	0.2939	0.6717	0.6707
Entamoeba histolytica	hypothetical protein	0.0526	0.1132	0.2177
Brugia malayi	Cathepsin L-like precursor	0.2276	0.5183	0.5183
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0602	0.1308	0.0433
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.2276	0.5183	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0719	0.1578	0.1578
Trypanosoma cruzi	cysteine proteinase, putative	0.1245	0.2796	0.2774
Onchocerca volvulus		0.2276	0.5183	1
Trichomonas vaginalis	conserved hypothetical protein	0.0526	0.1132	0.2138
Echinococcus granulosus	cysteine protease	0.1245	0.2796	0.2792
Loa Loa (eye worm)	hypothetical protein	0.0526	0.1132	0.1132
Loa Loa (eye worm)	hypothetical protein	0.1557	0.3519	0.3519
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1245	0.2796	0.2796
Brugia malayi	fibroinase precursor	0.0526	0.1132	0.1132
Echinococcus multilocularis	cathepsin b	0.4357	1	1
Echinococcus multilocularis	snurportin 1	0.0304	0.0618	0.0614
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.1245	0.2796	0.2774
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.1132	0.2138
Giardia lamblia	Hypothetical protein	0.0526	0.1132	0.2865
Toxoplasma gondii	cathepsin CPC2	0.0602	0.1308	0.2478
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Leishmania major	cathepsin L-like protease	0.2276	0.5183	0.7705
Giardia lamblia	Cathepsin B precursor	0.0742	0.1632	0.4165
Trypanosoma cruzi	cysteine peptidase, putative	0.2276	0.5183	0.5168
Entamoeba histolytica	cysteine protease, putative	0.0526	0.1132	0.2177
Giardia lamblia	Cathepsin L precursor	0.0526	0.1132	0.2865
Echinococcus granulosus	cathepsin L	0.1245	0.2796	0.2792
Toxoplasma gondii	cathepsin CPL	0.2276	0.5183	1
Onchocerca volvulus		0.1557	0.3519	0.5893
Brugia malayi	hypothetical protein	0.0039	0.0005	0.0005
Echinococcus multilocularis	cathepsin L cysteine protease	0.2276	0.5183	0.518
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0526	0.1132	0.1132
Entamoeba histolytica	cysteine proteinase, putative	0.1557	0.3519	0.6787
Giardia lamblia	Cathepsin B precursor	0.0526	0.1132	0.2865
Giardia lamblia	Cathepsin L precursor	0.0526	0.1132	0.2865
Brugia malayi	RNA, U transporter 1	0.0081	0.0102	0.0102
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.1245	0.2796	0.4135
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.1711	0.3875	0.7461
Brugia malayi	MAP kinase sur-1	0.005	0.0031	0.0031
Brugia malayi	Cathepsin L-like precursor	0.2276	0.5183	0.5183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1557	0.3519	0.6771
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0742	0.1632	0.3107
Entamoeba histolytica	cysteine protease, putative	0.0526	0.1132	0.2177
Trypanosoma brucei	cysteine peptidase C (CPC)	0.1711	0.3875	0.5749
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0726	0.1594	0.1141
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0526	0.1132	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0526	0.1132	0.1132
Brugia malayi	Papain family cysteine protease containing protein	0.0526	0.1132	0.1132
Schistosoma mansoni	cathepsin F (C01 family)	0.2276	0.5183	0.5183
Entamoeba histolytica	cysteine protease, putative	0.0526	0.1132	0.2177
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0526	0.1132	0.2138
Onchocerca volvulus		0.2276	0.5183	1
Echinococcus granulosus	cathepsin l1	0.2276	0.5183	0.518
Trichomonas vaginalis	conserved hypothetical protein	0.0526	0.1132	0.2138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.1132	0.2138
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0726	0.1594	0.1141
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0719	0.1578	0.1578
Trypanosoma cruzi	cysteine peptidase, putative	0.2939	0.6717	0.6707
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.004	0.004
Toxoplasma gondii	cathepsin CPC1	0.0726	0.1594	0.3035
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.1245	0.2796	0.5367
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Loa Loa (eye worm)	hypothetical protein	0.1557	0.3519	0.3519
Brugia malayi	Cathepsin L-like precursor	0.1557	0.3519	0.3519
Leishmania major	cathepsin L-like protease	0.2276	0.5183	0.7705
Brugia malayi	Papain family cysteine protease containing protein	0.0526	0.1132	0.1132
Loa Loa (eye worm)	hypothetical protein	0.4357	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0526	0.1132	0.1132
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0526	0.1132	0.2865
Leishmania major	cathepsin L-like protease	0.2276	0.5183	0.7705
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0742	0.1632	0.1632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0526	0.1132	0.2138
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.1132	0.2138
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Giardia lamblia	Hypothetical protein	0.0526	0.1132	0.2865
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0526	0.1132	0.2138
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0742	0.1632	0.3107
Trypanosoma cruzi	major cysteine proteinase, putative	0.0526	0.1132	0.1105
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0726	0.1594	0.4067
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0526	0.1132	0.1132
Schistosoma mansoni	cathepsin B (C01 family)	0.0526	0.1132	0.1132
Echinococcus multilocularis	cathepsin L	0.0526	0.1132	0.1128
Echinococcus granulosus	cathepsin b	0.4357	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0526	0.1132	0.2138
Plasmodium vivax	vivapain-2	0.2276	0.5183	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0526	0.1132	0.1132
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0526	0.1132	0.2138
Loa Loa (eye worm)	hypothetical protein	0.0526	0.1132	0.1132
Echinococcus multilocularis	cathepsin b	0.4357	1	1
Loa Loa (eye worm)	hypothetical protein	0.0719	0.1578	0.1578
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Leishmania major	cathepsin L-like protease	0.2939	0.6717	1
Giardia lamblia	Cathepsin B precursor	0.0526	0.1132	0.2865
Loa Loa (eye worm)	hypothetical protein	0.0054	0.004	0.004
Loa Loa (eye worm)	cysteine protease	0.2276	0.5183	0.5183
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Brugia malayi	Papain family cysteine protease containing protein	0.1245	0.2796	0.2796
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.0031	0.0026
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0029	0.0025
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0526	0.1132	0.1132
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0029	0.0029
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0029	0.0029
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.2276	0.5183	0.5183
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0526	0.1132	0.1132
Echinococcus multilocularis	cysteine protease	0.2276	0.5183	0.518
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0526	0.1132	0.2177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Brugia malayi	Cathepsin L-like precursor	0.2276	0.5183	0.5183
Echinococcus granulosus	cathepsin b	0.4357	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.222	0.5053	0.5038
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0029	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0029	0.0025
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Giardia lamblia	Cathepsin L precursor	0.0526	0.1132	0.2865
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.0031	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0526	0.1132	0.2138
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Loa Loa (eye worm)	hypothetical protein	0.0719	0.1578	0.1578
Schistosoma mansoni	hypothetical protein	0.0039	0.0005	0.0005
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0726	0.1594	0.3035
Giardia lamblia	Cathepsin B precursor	0.0526	0.1132	0.2865
Brugia malayi	cathepsin L precursor	0.0526	0.1132	0.1132
Onchocerca volvulus		0.2276	0.5183	1
Giardia lamblia	Cysteine protease	0.0526	0.1132	0.2865
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0526	0.1132	0.1132
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.4357	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1711	0.3875	0.3875
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0726	0.1594	0.1141
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.2276	0.5183	1
Trypanosoma cruzi	cysteine peptidase, putative	0.1245	0.2796	0.2774
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0029	0.0025
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.2276	0.5183	0.5183
Echinococcus granulosus	snurportin 1	0.0304	0.0618	0.0614
Loa Loa (eye worm)	ctsf protein	0.2276	0.5183	0.5183
Giardia lamblia	Cathepsin B precursor	0.0526	0.1132	0.2865
Entamoeba histolytica	cysteine protease, putative	0.0526	0.1132	0.2177
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0029	0.0029
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.0031	0.0031
Entamoeba histolytica	cysteine proteinase, putative	0.1245	0.2796	0.539
Giardia lamblia	Cysteine protease	0.0526	0.1132	0.2865
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0005	0.0005
Leishmania major	cathepsin L-like protease	0.2276	0.5183	0.7705
Brugia malayi	cathepsin L-like precursor	0.1557	0.3519	0.3519
Brugia malayi	Papain family cysteine protease containing protein	0.0526	0.1132	0.1132
Giardia lamblia	Cysteine protease	0.0526	0.1132	0.2865
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4357	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0742	0.1632	0.3107
Giardia lamblia	Cathepsin L-like protease	0.0526	0.1132	0.2865
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0526	0.1132	0.2177
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Echinococcus multilocularis	cysteine protease	0.2276	0.5183	0.518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Plasmodium vivax	vivapain-3	0.1245	0.2796	0.4107
Entamoeba histolytica	cysteine proteinase, putative	0.1245	0.2796	0.539
Giardia lamblia	Cathepsin B precursor	0.1711	0.3875	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0029	0.0029
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0742	0.1632	0.3107
Plasmodium falciparum	cysteine proteinase falcipain 3	0.2276	0.5183	1
Toxoplasma gondii	cathepsin B	0.1711	0.3875	0.7461
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.0031	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Echinococcus granulosus	cathepsin L	0.0526	0.1132	0.1128
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1711	0.3875	0.3856
Echinococcus granulosus	cathepsin L cysteine proteinase	0.2276	0.5183	0.518
Onchocerca volvulus		0.2276	0.5183	1
Entamoeba histolytica	cysteine proteinase, putative	0.2276	0.5183	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Giardia lamblia	Cathepsin B precursor	0.1711	0.3875	1
Brugia malayi	Cathepsin L-like precursor	0.0719	0.1578	0.1578
Trypanosoma cruzi	major cysteine proteinase, putative	0.1189	0.2666	0.2644
Onchocerca volvulus		0.2276	0.5183	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0526	0.1132	0.1132
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Leishmania major	cathepsin L-like protease	0.2276	0.5183	0.7705
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Giardia lamblia	Cathepsin L precursor	0.0526	0.1132	0.2865
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Onchocerca volvulus		0.2276	0.5183	1
Giardia lamblia	Cathepsin L precursor	0.0526	0.1132	0.2865
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.2276	0.5183	1
Giardia lamblia	Cathepsin B precursor	0.1711	0.3875	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0526	0.1132	0.1132
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0726	0.1594	0.1141
Loa Loa (eye worm)	hypothetical protein	0.1557	0.3519	0.3519
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.2276	0.5183	0.518
Schistosoma mansoni	cathepsin C	0.0526	0.1132	0.1132
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0602	0.1308	0.3321
Giardia lamblia	Encystation-specific protease	0.0602	0.1308	0.3321
Trypanosoma cruzi	cruzipain precursor, putative	0.2939	0.6717	0.6707
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0526	0.1132	0.1132
Trypanosoma cruzi	cysteine protease, putative	0.1245	0.2796	0.2774
Loa Loa (eye worm)	hypothetical protein	0.0719	0.1578	0.1578
Onchocerca volvulus	Cathepsin L homolog	0.2276	0.5183	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0742	0.1632	0.1632
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.065	0.1419	0.2694
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0602	0.1308	0.0433
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2276	0.5183	0.518
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Echinococcus granulosus	cathepsin L cysteine protease	0.1245	0.2796	0.2792
Brugia malayi	Cathepsin L-like precursor	0.1557	0.3519	0.3519
Brugia malayi	Cathepsin L-like precursor	0.2276	0.5183	0.5183
Loa Loa (eye worm)	hypothetical protein	0.2276	0.5183	0.5183
Leishmania major	cathepsin L-like protease	0.2939	0.6717	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0602	0.1308	0.3321
Plasmodium falciparum	cysteine proteinase falcipain 1	0.1245	0.2796	0.4107
Entamoeba histolytica	cysteine protease, putative	0.0526	0.1132	0.2177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.4357	1	1
Schistosoma mansoni	cathepsin s	0.0719	0.1578	0.1578
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.2276	0.5183	0.518
Brugia malayi	Papain family cysteine protease containing protein	0.2276	0.5183	0.5183
Schistosoma mansoni	cathepsin F (C01 family)	0.2276	0.5183	0.5183
Loa Loa (eye worm)	hypothetical protein	0.0526	0.1132	0.1132
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.0031	0.0031
Plasmodium vivax	vivapain-1	0.1245	0.2796	0.4107
Echinococcus granulosus	cathepsin l1	0.1557	0.3519	0.3516
Onchocerca volvulus	Cathepsin L homolog	0.2276	0.5183	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.0031	0.0026
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.004	0.004
Onchocerca volvulus	Cathepsin F homolog	0.2276	0.5183	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.1245	0.2796	0.2796
Schistosoma mansoni	hypothetical protein	0.0304	0.0618	0.0618
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0526	0.1132	0.1132
Brugia malayi	Cathepsin L-like precursor	0.2276	0.5183	0.5183
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Leishmania major	cysteine peptidase A (CPA)	0.2276	0.5183	0.7705
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2276	0.5183	1
Schistosoma mansoni	cathepsin F (C01 family)	0.1557	0.3519	0.3519
Brugia malayi	cathepsin F-like cysteine proteinase	0.0526	0.1132	0.1132
Echinococcus multilocularis	cathepsin L	0.1245	0.2796	0.2792
Entamoeba histolytica	cysteine protease, putative	0.1245	0.2796	0.539
Trypanosoma cruzi	cysteine proteinase, putative	0.1245	0.2796	0.2774
Plasmodium vivax	unspecified product	0.0719	0.1578	0.11
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Plasmodium vivax	unspecified product	0.1245	0.2796	0.4107
Trypanosoma cruzi	cruzipain precursor, putative	0.0719	0.1578	0.1552
Entamoeba histolytica	cysteine proteinase, putative	0.1245	0.2796	0.539
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.2276	0.5183	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0742	0.1632	0.1632
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.2276	0.5183	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0304	0.0618	0.0618
Entamoeba histolytica	cysteine proteinase 1, putative	0.1245	0.2796	0.539
Brugia malayi	Cathepsin L-like precursor	0.2276	0.5183	0.5183
Giardia lamblia	Cathepsin L precursor	0.0526	0.1132	0.2865
Trypanosoma cruzi	cysteine peptidase, putative	0.0719	0.1578	0.1552
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0719	0.1578	0.1578
Plasmodium vivax	vivapain-2	0.2276	0.5183	1
Entamoeba histolytica	cysteine proteinase, putative	0.1245	0.2796	0.539
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0029	0.0029
Trypanosoma cruzi	cysteine peptidase, putative	0.2939	0.6717	0.6707
Brugia malayi	cathepsin L-like cysteine proteinase	0.0526	0.1132	0.1132
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.2939	0.6717	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0726	0.1594	0.1594

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1209926

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1099648