Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Staphylococcus aureus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3284 | 1 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0359 | 0.8528 | 0.8451 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.008 | 0.1225 | 0.1225 |
Entamoeba histolytica | pyruvate:ferredoxin oxidoreductase | 0.0052 | 0.0494 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0116 | 0.2165 | 0.1758 |
Mycobacterium ulcerans | hypothetical protein | 0.0359 | 0.8528 | 0.8451 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0205 | 0.4506 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.3587 | 0.3587 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0052 | 0.0494 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 1 |
Giardia lamblia | Pyruvate-flavodoxin oxidoreductase | 0.0052 | 0.0494 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3284 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.017 | 0.3587 | 0.3587 |
Loa Loa (eye worm) | ILVBL protein | 0.0217 | 0.4819 | 0.4819 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0359 | 0.8528 | 0.8451 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0205 | 0.4506 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3284 | 0.4779 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0033 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0137 | 0.2713 | 0.2713 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0052 | 0.0494 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0359 | 0.8528 | 0.84 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0052 | 0.0494 | 0.5 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.008 | 0.1225 | 0.1225 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0064 | 0.0798 | 0.0319 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0052 | 0.0494 | 0.5 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0205 | 0.4506 | 0.4221 |
Mycobacterium ulcerans | acetolactate synthase | 0.0205 | 0.4506 | 0.4221 |
Schistosoma mansoni | acetolactate synthase | 0.0307 | 0.716 | 0.716 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0033 | 0 | 0.5 |
Treponema pallidum | pyruvate oxidoreductase | 0.0052 | 0.0494 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0359 | 0.8528 | 0.8451 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0137 | 0.2713 | 0.2713 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0359 | 0.8528 | 0.84 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0206 | 0.4516 | 0.4516 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Schistosoma mansoni | thyroid hormone receptor | 0.017 | 0.3587 | 0.3587 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0052 | 0.0494 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0159 | 0.3284 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0137 | 0.2713 | 0.2713 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0154 | 0.3148 | 0.2792 |
Trichomonas vaginalis | pyruvate-flavodoxin oxidoreductase, putative | 0.0052 | 0.0494 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0205 | 0.4506 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0307 | 0.716 | 0.716 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0033 | 0 | 0.5 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0359 | 0.8528 | 0.8528 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0205 | 0.4506 | 0.4221 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0359 | 0.8528 | 0.8451 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.66 nM | Inhibition of Staphylococcus aureus DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spectrophotometry | ChEMBL. | 21831637 |
Ki (binding) | = 27.5 nM | Inhibition of human DHFR assessed as oxidation of NADPH using dihydrofolate as substrate pre-incubated for 10 mins before substrate addition by spectrophotometry | ChEMBL. | 21831637 |
MIC (functional) | = 16 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 35218 by CLSI microdilution method | ChEMBL. | 21831637 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.